Effect of Statin Therapy on Neurological Outcomes in Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis of 1464 Patients.

Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition complicated by cerebral vasospasm and deterioration of neurological functions. Statins have been proven to reduce the incidence of vasospasm and limit the neurological deterioration with controversial data. We aimed to give a comprehensive assessment of statins in patients with aSAH.

Erratum: Cisternal Neurocysticercosis: A Systematic Review and Meta-Analysis of Therapeutic Efficacy, Safety, and Outcomes.

[This corrects the article DOI: 10.1055/a-2642-8152.].

High-value recycling strategies for retired wind turbine blades in China: A spatiotemporal adaptability framework.

Wind energy holds substantial potential to mitigate climate change and address energy supply challenges, driving global consensus to accelerate the development of the wind power industry. However, as wind turbines reach end-of-service life, substantial amounts of glass fiber-reinforced polymers (GFRP) materials face periodic disposal due to performance degradation or compromised safety. Scaling the disposal of retired wind turbine blades (RWTB) has become critical for the sustainable development of the wind energy sector.

Cisternal Neurocysticercosis: A Systematic Review and Meta-Analysis of Therapeutic Efficacy, Safety, and Outcomes.

Background: Recent studies show potential benefits of albendazole in managing cisternal neurocysticercosis (NCC), which reduces parasitic burden. This systematic review and meta-analysis aim to evaluate the efficacy of albendazole and other pharmacological treatments in cisternal NCC, considering the heterogeneity of disease manifestations and the need for effective treatment strategies.

Methods: Comprehensive searches were conducted across PubMed, Web of Science, Scopus, CENTRAL, and Embase up to March 2024, focusing on RCTs and observational studies that examined albendazole's impact on cisternal NCC.

Icariin mitigates experimental contrast-induced nephropathy: Mechanistic insights.

Background: Currently, the use of contrast agents in interventional procedures and imaging has been increasing. Icariin, an active component of Epimedium, offers beneficial biological activities such as antioxidation and anti-inflammation. Therefore, our study aimed to investigate the protective role of icariin and its underlying mechanisms against contrast-induced nephropathy (CIN).

Oxidative stress responses and histological changes in the liver of Nile tilapia exposed to silver bulk and nanoparticles.

The increased utilization of silver nanoparticles (AgNPs) in multiple applications is leading to a rise in environmental contamination caused by their release, particularly in aquatic ecosystems. This study investigates the effects of different concentrations of AgNPs (10, 20, 50, and 100 µg/L) and bulk silver nitrate (AgNO) at 100 µg/L, on the hepatic antioxidant defense system, oxidative stress markers, and liver histopathology of Nile tilapia (Oreochromis niloticus), with sampling conducted biweekly over six weeks. AgNPs were chemically synthesized using trisodium acetate, yielding an average crystallite size of 29.

Chemically Surface-Engineered Mesoporous Silica for the Toxic Metal Ions Uptake: Insights from Experiment and Density Functional Calculations.

Robust chemical modification of mesoporous silica was conducted using 3-mercaptopropyltriethoxysilane via a chemical surface-engineered postgrafting of mesoporous silica KIT-6 with acidic propylsulfonate groups to obtain mesoporous KIT-6-SOH. A fabricated -KIT-6-SOH-modified quartz crystal microbalance sensor with KIT-6-SOH layers coating on a QCM electrode is utilized to detect Pb, Cd, and Cs ions with high sensing affinity. The functionalized KIT-SOH exhibits adsorption capacities () of 123.

Evaluating the spatial pattern of water quality of the Nile River, Egypt, through multivariate analysis of chemical and biological indicators.

The Nile River, known as the "giver of life," serves as Egypt's main source of fresh water. A total of 28 sites along the Nile River were selected during the winter and summer of 2022 to illustrate spatial-temporal variation and indicate potential sources of pollution. The study showed that all chemical and physical parameters are within permissible limits.

Quality of Life Outcomes in Children Following Surgical Management of Gastroschisis: A Systematic Review and Meta-analysis.

Background: The quality of life of pediatric patients born with gastroschisis has yet to be documented in a systematic review. Our objective is to quantitatively summarize the parent and child-reported quality of life outcomes of children born with gastroschisis.

Methods: Records were sourced from the MEDLINE, PsycInfo, EBM Reviews, and Embase databases.

Antioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects.

Oxidative stress (OS) is established as a key factor in the etiology of both male and female infertility, arising from an imbalance between reactive oxygen species (ROS) production and the endogenous antioxidant (AOX) defenses. In men, OS adversely affects sperm function by inducing DNA damage, reducing motility, significantly impairing sperm vitality through plasma membrane peroxidation and loss of membrane integrity, and ultimately compromising overall sperm quality. In women, OS is implicated in various reproductive disorders, including polycystic ovary syndrome, endometriosis, and premature ovarian failure, leading to diminished oocyte quality, disrupted folliculogenesis, and poorer reproductive outcomes.

Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways.

Introduction: Lipopolysaccharide (LPS), a constituent of the outer membrane of Gram-negative bacteria, is a powerful inducer of systemic inflammation and has been extensively utilized in experimental models to simulate inflammatory responses and septic disorders. Recent research indicates that oxytocin (OXY), a neuropeptide typically linked to social bonding and reproductive functions, may influence inflammatory processes. This work examines the impact of OXY on LPS-induced testicular damage, aiming to elucidate its therapeutic potential in addressing inflammatory disorders and broadening the comprehension of its functions beyond conventional neuroendocrine roles.

The Canadian Experience With Magnetic Esophageal Anastomosis: A Report From the Canadian Consortium for Research in Pediatric Surgery (CanCORPS).

Objective: Magnetic anastomosis is an innovative technique for establishing esophageal continuity in infants born with esophageal atresia. Few case series featuring this technology have been published, with even fewer reports on complications. We present the entire Canadian experience with this approach.

Beyond the usual challenges, a case of LV summit PVCs ablation in child with ASO for D-TGA.

Premature ventricular contractions (PVCs) are a common finding in patients with surgically repaired congenital heart defects including transposition of the great arteries (D-TGA). While often asymptomatic, PVCs can sometimes lead to palpitations, dyspnea, and hemodynamic compromise, requiring therapeutic intervention. The arterial switch operation is the preferred treatment for D-TGA, but these patients have a 2% incidence of ventricular arrhythmias and 1% incidence of sudden cardiac death post-operatively.

Drug-coated balloons versus drug-eluting stents in patients with in-stent restenosis: An updated meta-analysis with trial sequential analysis.

Background: Drug-coated balloons (DCB) have promising results in the management of in-stent restenosis (ISR), still their role remains a major challenge, and not well established in contemporary clinical practice.

Aims: To provide a comprehensive appraisal of the efficacy and safety of DCBs in patients with in-stent restenosis (ISR).

Methods: We searched PubMed, Scopus, web of Science, Ovid, and Cochrane Central from inception until 30 March, 2023.

Effect of New Antidiabetics on Steatosis in Nerve Tissues and Nerve Conduction Velocity: Possible Role of Nerve Growth Factor (NGF)/Synaptophysin and Nrf2/HO-1 Pathways.

Objectives: The current study aims to investigate the impact of the GLP1 analog (semaglutide) and SGLT2 inhibitor (dapagliflozin) on nerve functions, morphology, and the underlying mechanisms involving nerve growth factor (NGF)/synaptophysin and Nrf2/HO-1 pathways in obese rats.

Methods: Forty male Sprague Dawley rats, aged six to eight weeks, were classified into five groups; normal group (high-fat diet {HFD} for 12 weeks, metformin group (HFD for 12 weeks + metformin in last four weeks), dapagliflozin group (HFD for 12 weeks +dapagliflozin in last four weeks, semaglutide group (HFD for 12 weeks + semaglutide in last four weeks). At the end of the experiment, the sciatic nerve was collected for nerve conduction study, oxidative stress marker (malondialdehyde, i.

Laparoscopic Sac Disconnection and Peritoneal Closure of Pediatric Inguinal Hernia.

Laparoscopic sac disconnection and peritoneal closure represents an alternative to open pediatric hernia repair. We performed a retrospective review of our data to evaluate this alternative method. With REB approval, a retrospective chart review of all patients who underwent laparoscopic indirect inguinal hernia repair between June 2013 and July 2016 was conducted.

Drug-coated balloons versus drug-eluting stents in patients with acute myocardial infarction undergoing percutaneous coronary intervention: an updated meta-analysis with trial sequential analysis.

Background: Drug-coated balloons (DCBs) are an established strategy for coronary artery disease. However, the new generation drug-eluting stent (DES) is recommended for patients with Acute myocardial infarction (AMI) for coronary artery revascularization. Our aim is to provide a comprehensive appraisal of the efficacy of DCBs in patients with AMI undergoing PCI.

Denosumab Use in Chronic Kidney Disease Associated Osteoporosis: A Narrative Review.

Chronic kidney disease (CKD) and hemodialysis (HD) patients have a high incidence of bone disease and increased fracture risk, making effective management of their bone health a clinical challenge. Denosumab, a human monoclonal antibody, has been investigated as a therapeutic option in this patient population. In this review, we summarize the current evidence on the efficacy and safety of denosumab in CKD and HD patients.

Elastic Electrically Conductive Composites Based on Vapor-Grown Carbon Fibers for Use in Sensors.

Elastic electrically conductive composites with an ethylene octene copolymer matrix (EOC) and vapor-grown carbon fibers (VGCF) were prepared by ultrasonication in a toluene solution, and their morphology, mechanical and electrical properties were also evaluated. EOC/CF composites were estimated for their mechanical and viscoelastic properties. The morphology of the composites was analyzed using scanning electron microscopy (SEM), and stress-strain curves were generated to measure the stress and tensile modulus of the composites.

Influence of Fusion Temperature on Nonisothermal Crystallization Kinetics of Polyamide 6.

The effect of fusion temperature and duration on the nonisothermal crystallization kinetics of polyamide 6 (PA6) was investigated using differential scanning calorimetry (DSC) and a polarized optical microscope (OM). The rapid cooling method involved heating the polymer above its melting point, holding it at this temperature to ensure complete melting, and then rapidly cooling it to the crystallization temperature. By monitoring the heat flow during cooling, the crystallization kinetics of PA6 were characterized, including the degree of crystallinity, crystallization temperature, and crystallization rate.

Establishing normal ranges for fetal and neonatal small and large intestinal lengths: results from a prospective postmortem study.

Objective: To establish reference intervals (RIs) for fetal and neonatal small and large intestinal lengths.

Methods: Linear measurements on small and large intestines were made upon postmortem examination of 131 preterm and term infants with gestational ages between 13 and 41 weeks. All cases were referred from the Eastern Ontario and Western Québec regions to a tertiary care hospital.

Development and evaluation of a patient decision aid for pediatric interval appendectomy.

Objective: One option for the treatment of perforated appendicitis in pediatric patients is interval appendectomy (IA). A patient decision aid (PDA) can be useful in the decision-making process regarding IA. The purpose of this study was to evaluate parents' decisional conflict before and after engaging with a developed PDA.

Quality of life outcomes in children after surgery for Hirschsprung disease and anorectal malformations: a systematic review and meta-analysis.

Background: No systematic review and meta-analysis to date has examined multiple child and parent-reported social and physical quality of life (QoL) in pediatric populations affected by Hirschsprung's disease (HD) and anorectal malformations (ARM). The objective of this systematic review is to quantitatively summarize the parent-reported and child-reported psychosocial and physical functioning scores of such children.

Methods: Records were sourced from the CENTRAL, EMBASE, and MEDLINE databases.