Publications by authors named "Adrian Pona"

Lupus erythematosus tumidus (LET) is a rare photosensitive der-matosis that was considered a subtype of chronic cutaneous lupus erythematosus (CLE); however, its clinical course and favorable prognosis led to its reclassification into another category called intermittent CLE. Although known for more than 100 years, LET's association with systemic lupus erythematosus (SLE), autoantibody profile, and disease prognosis is not well characterized. The purpose of this study was to describe the demographics, clinical characteristics, autoantibody profile, comorbidities, and treatment of LET.

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Article Synopsis
  • The study explores the challenges in determining when to safely discontinue transmission-based precautions for hospitalized COVID-19 patients, highlighting the contrasting guidelines from the CDC.
  • A review of 196 patients revealed that many faced delays in leaving isolation due to repeated positive PCR tests, resulting in extended hospital stays and significant costs.
  • The findings suggest that clinicians should consider additional data, such as cycle threshold (Ct) values from PCR tests, to make better-informed decisions on discontinuing precautions, especially for potentially contagious patients.
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Kikuchi-Fujimoto disease (KFD) is a rare, benign, self-limiting necrotizing lymphadenitis of unknown etiology. The disease can affect people of all ages and of any sex and ethnicity. Tissue biopsy is needed for accurate diagnosis.

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Physicians have a fiduciary duty to be honest and to act in the patients' best interest. There are times when these two duties conflict. Honesty is paramount in supporting the physician-patient relationship and loss of patient trust is devastating.

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Although tattoo artists provide tattoo aftercare instructions to their clients, recommendations are often not cost-effective or supported by evidence. A 22-year-old man developed a pruritic red rash over his healing tattoo one week after receiving the tattoo. Although multiple queries were negative, the patient did note use of a scented lotion before the eruption.

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Objective: To review the use of gentian violet in dermatology.

Design: A comprehensive literature search on gentian violet in dermatology practice was performed through PubMed.

Results: Gentian violet is effective in treating methicillin-resistant Staphylococcus aureus-colonized skin lesions; mean number of days for complete eradication was 9.

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Onychomycosis was described by early investigators as the presence of an abnormal nail unit and a member of the order Mycota, producing the abnormality. This interpretation has caused more than 50 years of confusion in the dermatologic literature. Unquestionably, the clinician sees more abnormal toenails than fingernails, and investigators have described a multitude of fungi as the cause of the clinically abnormal toenail.

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While biologics are highly effective, most psoriasis patients do not achieve complete skin clearance with their biologic monotherapy. How to achieve complete skin clearance in psoriasis patients who fail their biologic is not well characterized. To describe treatment approaches in psoriasis patients who fail to achieve complete clearance from their biologic, we modeled and assessed the efficacy, cost, and safety of three treatment approaches– adding a topical agent with their biologic, escalating the biologic dose, and switching to a different biologic.

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BACKGROUND: The incidence of melanoma and non-melanoma skin cancer in the Hispanic population has increased. Hispanics are more likely to present with advance-staged melanoma and worse overall prognosis. Thus, public health campaigns are necessary to target the underrepresented Hispanic population.

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Phototherapy is an effective treatment for multiple dermatoses. However, patient inconvenience and poor access to office-based phototherapy may jeopardize adherence and treatment outcome. Home phototherapy offers a convenient, accessible, and effective therapy.

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Introduction: Introduction: Although future atopic dermatitis (AD) clinical research is intended to improve standard-of-care treatment, how patients are currently treated is not well characterized. The purpose of this study was to determine the most frequent medications prescribed in all ages of AD. Methods: The National Ambulatory Medical Care Survey (NAMCS) is a nationally representative survey of United States office-based ambulatory visits and records demographics, diagnoses, and treatments.

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Article Synopsis
  • Topical corticosteroid treatments vary in their delivery methods, with sprays potentially enhancing patient convenience and adherence while maintaining strong efficacy against skin conditions.
  • In clinical trials, clobetasol propionate spray showed significant improvement in skin severity for psoriasis compared to the control, with 87% of subjects achieving a low disease severity score within two weeks.
  • Desoximetasone and betamethasone sprays also demonstrated effectiveness in reducing symptoms, while triamcinolone showed clear benefits for inflammatory skin conditions, with similar adverse effects reported across the different corticosteroid sprays.
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BACKGROUND: Topical corticosteroids are efficacious treatment options for multiple dermatoses. However, ointments and cream corticosteroid vehicles can be cumbersome to patients and may act as a barrier to adherence. Foam vehicles may be preferred by some patients.

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Background: Treatment of childhood atopic dermatitis (AD) is hindered by nonadherence, but caregiver reassurance may help overcome this hurdle.

Objectives: To assess caregivers' willingness to treat childhood AD with a corticosteroid when presented with clinical trial evidence, anecdote, or both.

Methods: A total of 476 caregivers were recruited through a dermatology clinic and online crowdsourcing platform.

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Background: Patients with psoriasis have a growing interest in managing their disease through diet.

Objective: This review paper aims to analyze dietary interventions for psoriasis and their outcome.

Methods: Terms "psoriasis AND diet" were used to search PubMed database and 63 articles describing dietary changes influencing psoriasis were selected.

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Background: Topical retinoids are a first-line treatment for acne vulgaris.

Objective: This systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris.

Methods: A PubMed and Embase search was conducted using the search terms 'adapalene,' 'tretinoin,' 'tazarotene,' and 'acne vulgaris.

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