Exploration of compositional, functional, nutraceutical, and metabolites of Ram kandmool (Agave sisalana Perrine) for potential application in food systems.

The present study examined the food value, techno-functional properties, and potential metabolites of Agave sisalana Perrine (Ram kandmool, RKM) flour. The proximate analysis revealed that RKM flour has a moisture content (10.74 %), fat content (1.

Impact of capacity building training on emergency medical services for chardham yatra: a pre-test post-test study in a hilly region of North India.

Background: The Char Dham Yatra in Uttarakhand, India, poses significant healthcare challenges due to high altitude, limited medical infrastructure, and increased risk of emergencies, including high-altitude illnesses and cardiovascular events. To address these challenges, a capacity-building program was implemented for medical officers, aiming to enhance their emergency medicine skills.

Method: The study was conducted at the Emergency Medicine and Trauma Surgery Department, AIIMS Rishikesh.

Single-molecule profiling of per- and polyfluoroalkyl substances by cyclodextrin mediated host-guest interactions within a biological nanopore.

Biological nanopores are increasingly used in molecular sensing due to their single-molecule sensitivity. The detection of per- and polyfluoroalkyl substances (PFAS) like perfluorooctanoic acid and perfluorooctane sulfonic acid is critical due to their environmental prevalence and toxicity. Here, we investigate selective interactions between PFAS and four cyclodextrin (CD) variants (α-, β-, γ-, and 2-hydroxypropyl-γ-CD) within an α-hemolysin nanopore.

Socioeconomic Risk Factors in Neurocysticercosis.

NCC is responsible for around 30% of active epilepsy in endemic countries such as India. Knowing socioeconomic factors associated with NCC can help in decreasing the incidence of this disease. We intend to study socioeconomic risk factors in NCC patients and how these factors are different from patients without NCC.

Structure, orientation, and dynamics of per- and polyfluoroalkyl substance (PFAS) surfactants at the air-water interface: Molecular-level insights.

Hypothesis: Understanding the intricate molecular-level details of toxic per- and polyfluoroalkyl substances (PFAS) partitioning to the air-water interface holds paramount importance in evaluating their fate and transport, as well as for finding safer alternatives for various applications, including aqueous film forming foams. The behavior of these substances at interfaces strongly depends on molecular architecture, chemistry, and concentration, which define molecular packing, self-assembly, interfacial diffusion, and the surface tension.

Simulations: Modeling of three PFAS surfactants, namely, longer-tail (perfluorooctanoate (PFOA)) and shorter-tail (perfluorobutanoate (PFBA) and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy) propanoate (GenX)) has been conducted using atomistic molecular dynamics simulations.

Oxidative Amidation of Ferrocenyl Aldehydes with Amines Catalyzed by Chalcogenised FeSe(CO) Cluster: Direct Transformation of Aldehyde to Amides.

With the interest and knowing the importance of ferrocenyl conjugates, a direct amidation of ferrocenyl aldehyde has been developed under feasible conditions. Varieties of amines has been oxidatively coupled with ferrocene aldehyde in the presence of highly economical and robustly stable iron chalcogenide ironcarbonyl clusters [FeE(CO), E= S, Se, and Te] and TBHP. The reaction worked in greener solvent water at a moderate temperature of 70 °C and the ferrocenyl-amides in just 30 minutes.

Confinement-induced clustering of H and CO gas molecules in hydrated nanopores.

Gas molecule clustering within nanopores holds significance in the fields of nanofluidics, biology, gas adsorption/desorption, and geological gas storage. However, the intricate roles of nanoconfinement and surface chemistry that govern the formation of gas clusters remain inadequately explored. In this study, through free energy calculation in molecular simulations, we systematically compared the tendencies of H and CO molecules to aggregate within hydrated hydrophobic pyrophyllite and hydrophilic gibbsite nanopores.

Cable Ties: Poor Man's Top Closure System.

Scalp electrical burns unsuitable for primary closure after debridement have traditionally been treated by modalities that cause significant morbidity and are aesthetically inferior to tension-free primary wound closure. Due to advances in research on the biomechanical properties of skin, various devices for skin stretching and safe wound closure have been reported in the literature that are expensive and inaccessible to poor people in the developing countries. We present our experience using cable ties as an effective, easy to use, readily available, and inexpensive top closure system.

Impact of COVID-19 on Guillain-Barre Syndrome in India: A Multicenter Ambispective Cohort Study.

Introduction/aims: Studies conducted during the coronavirus disease 2019 (COVID-19) pandemic have reported varied data regarding the incidence of Guillain-Barre syndrome (GBS). The present study investigated demographic and clinical features, management, and outcomes of patients with GBS during a specified period of the COVID-19 pandemic, and compared these features to those of GBS in the previous year.

Methods: A multicenter, ambispective cohort study including 26 centers across India was conducted.

Exposure to is not Associated with New-Onset Epilepsy.

Purpose: The association between exposure to Toxocara canis and epilepsy is at the best contentious. Most of previous studies were retrospective, community-based, and contradictory to one another. As the impact of a positive association on the magnitude of epilepsy will be huge especially in developing countries where toxocariasis is common owing to poor hygienic practices, this study was carried out to determine whether exposure to T.

Interaction of Short-Chain PFAS with Polycationic Gels: How Much Fluorination is Necessary for Efficient Adsorption?

The short-chain per- and polyfluorinated alkyl substances (PFAS), introduced to replace the legacy PFAS compounds, turned out to be as toxic and harmful as their longer-chain predecessors and even harder to sequester from contaminated water sources. In this work, molecular dynamics (MD) simulations are employed to investigate the adsorption mechanism of GenX, a representative compound for short-chain PFAS, on a polycationic hydrogel with various extents of fluorination in its backbone and cross-linkers. Simulations indicate that the presence of fluorinated segments next to cationic groups in the polymer gel structure provides the most efficient environment for GenX adsorption.

Green Polymer Electrolytes Based on Polycaprolactones for Solid-State High-Voltage Lithium Metal Batteries.

Solid polymer electrolytes (SPEs) have attracted considerable attention for high energy solid-state lithium metal batteries (LMBs). In this work, potentially ecofriendly, solid-state poly(ε-caprolactone) (PCL)-based star polymer electrolytes with cross-linked structures (xBt-PCL) are introduced that robustly cycle against LiNi Mn Co O (NMC622) composite cathodes, affording long-term stability even at higher current densities. Their superior features allow for sufficient suppression of dendritic lithium deposits, as monitored by Li solid-state NMR.

GenX in water: Interactions and self-assembly.

2,3,3,3-tetrafluoro-2-(heptafluoropropoxy) propanoate, a.k.a.

Experimental investigation and modelling the effect of humic acid on coagulation efficiency for sludge blanket clarifier.

The physicochemical process of coagulation has largely been used for turbidity removal for water treatment. However, lately, the intrusion of NOM (Natural organic matter) in the surface water sources due to climate change has impeded the dosing approaches and has presented a requirement to evaluate the effect of NOM on turbidity removal efficiency and the performance of coagulation reactors in general. In this work, a previously developed performance model for hydraulic flocculators was modified and tested for a sludge blanket clarifier (SBC) which is a type of hydraulic flocculator.

Newer magnetic resonance imaging techniques in neurocysticercosis.

Introduction: The definitive diagnosis of neurocysticercosis continues to be challenging. We evaluate the role of newer magnetic resonance imaging techniques including constructive interference in steady state, susceptibility-weighted imaging, arterial spin labelling and magnetic resonance spectroscopy in the diagnosis of neurocysticercosis.

Aims And Objectives: To study the utility of newer magnetic resonance imaging sequences in the diagnosis of neurocysticercosis.

The Eye Opener: Finding and Targeting the Midbrain Lesion.

Lesions of the central nucleus of the third cranial nerve in midbrain leads to bilateral ptosis. We present a case of a 14 year old boy, who was found to have B/L non-correctable ptosis and medial rectus palsy. There was a ring enhancing lesion in the midbrain in contrast MRI which resolved with treatment.

Flexible and Robust Piezoelectric Polymer Nanocomposites Based Energy Harvesters.

Environment friendly, flexible, and robust sensors have attracted considerable research attention due to their potential for a wide range of devices in energy generation and harvesting, sensing, and biomedical applications. In this manuscript, we demonstrate a lead-free, solution processed flexible piezoelectric energy generator based on a nanocomposite film, consisting of MgO nanoparticles of sizes around <50 nm, embedded in poly(vinylidene difluoride) [PVDF] and its copolymer with trifluoroethylene, that is, P(VDF-TrFE) matrix. Piezoelectric, ferroelectric, and leakage current measurements made on samples with various concentrations of MgO nanoparticles revealed a dramatic improvement in these characteristics at 2 wt % MgO with nearly 50% increase in the piezoelectric coefficient as compared to pure P(VDF-TrFE), attributed to the preferred conformation of P(VDF-TrFE) chain, improved crystallinity of the P(VDF-TrFE) matrix, and uniform distribution of nanoparticles.

Progressive myoclonic epilepsy and horizontal gaze palsy: a rare aetiology.

Gaucher's disease is a rare autosomal recessive, potentially fatal disorder but most common type among lysosomal storage disorders. The disease's incidence is around 1/40 000 to 1/60 000 births in the general population. A 32-year-old man, born out of non-consanguineous union, presented with generalised tonic-clonic seizures and myoclonus since 17 years of age.

Cerebellar ataxia due to Leptospirosis- a case report.

Background: Leptospirosis involves nervous system in around 10-15% of the cases, the commonest presentation being aseptic meningitis. Most of the clinical features of neuroleptospirosis are due to capillary endothelial damage and vasculitis. Ataxia is an extremely uncommon manifestation of Leptospirosis occuring in <5% of cases.