Vaccine-based therapeutic interventions in lung cancer management: A recent perspective.

The incidence of lung cancer continues to grow globally, contributing to an ever-increasing load on healthcare systems. Emerging evidence has indicated lowered efficacy of conventional treatment strategies, such as chemotherapy, surgical interventions and radiotherapy, prompting the need for exploring alternative interventions. A growing focus on immunotherapy and the development of personalized medicine has paved the way for vaccine-based delivery in lung cancer.

Garcinol in gastrointestinal cancer prevention: recent advances and future prospects.

Gastrointestinal cancers continue to pose a significant global health challenge, with millions of new cases diagnosed each year. Despite advancements in treatment, the prognosis for many patients remains poor. This article explores the potential of garcinol, a polyisoprenylated benzophenone found in various Garcinia species, as a therapeutic agent against gastrointestinal malignancies.

Strengthening microbial cell factories for efficient production of bioactive molecules.

High demand of bioactive molecules (food additives, antibiotics, plant growth enhancers, cosmetics, pigments and other commercial products) is the prime need for the betterment of human life where the applicability of the synthetic chemical product is on the saturation due to associated toxicity and ornamentations. It has been noticed that the discovery and productivity of such molecules in natural scenarios are limited due to low cellular yields as well as less optimized conventional methods. In this respect, microbial cell factories timely fulfilling the requirement of synthesizing bioactive molecules by improving production yield and screening more promising structural homologues of the native molecule.

L. as a source of anticancer agents: phytochemistry to mechanistic insight.

(.) is a genus of perennial flowering plants in the family Boraginaceae with approximately 250 species widely dispersed in temperate, tropical, and subtropical areas. It is traditionally used to treat rheumatism, fever, asthma, stomach irritation, and inflammatory ailments.

Recent developments in microbial degradation of polypropylene: Integrated approaches towards a sustainable environment.

Fossil-fuel-based plastics have many enticing properties, but their production has resulted in significant environmental issues that require immediate attention. Despite the fact that these polymers are manmade, some bacteria can degrade and metabolise them, suggesting that biotechnologies based on the principle of plastic biodegradation could be beneficial. Among different types of plastics, polypropylene (PP), either having low or high density, is one of the most consumed plastics (18.

Role of Silver Nanoparticle-Doped 2-Aminodiphenylamine Polymeric Material in the Detection of Dopamine (DA) with Uric Acid Interference.

A viable electrochemical approach for the detection of dopamine (DA) in uric acid (UA) utilizing a silver nanoparticle-doped 2-aminodiphenylamine (AgNPs-2ADPA) electrode was invented. The electrochemical performance of DA showed that the incorporated electrode displayed outstanding electrocatalytic performance to the electrochemical oxidation of DA. In our study, the AgNPs-2ADPA exhibits remarkable catalytic activity, retaining high current value and resilience when employed as a working electrode component for electrocatalytic detection of DA.

Novel synthesis methods and applications of MXene-based nanomaterials (MBNs) for hazardous pollutants degradation: Future perspectives.

MXenes are a quickly growing and extended group of two-dimensional (2D) substances that have earned unbelievable analysis credits for various application areas within different manufacturing areas. Due to novel essential architectural and physicochemical properties shows good properties, such as elevated exterior area, living adaptability, strong electrochemistry, and great hydrophilicity. Given the fast progress within the structure and synthesis of MBNs for water treatment, quick updates on this research field are required to remove toxic substances, such as production approaches and characterization methods for the advantages and constraints of MXenes for pollutant degradation.

Key ingredients and recycling strategy of personal protective equipment (PPE): Towards sustainable solution for the COVID-19 like pandemics.

The COVID-19 pandemic has intensified the complications of plastic trash management and disposal. The current situation of living in fear of transmission of the COVID-19 virus has further transformed our behavioural models, such as regularly using personal protective equipment (PPE) kits and single-use applications for day to day needs etc. It has been estimated that with the passage of the coronavirus epidemic every month, there is expected use of 200 billion pieces of single-use facemasks and gloves.

Synthesis and selection of de novo proteins that bind and impede cellular functions of an essential mycobacterial protein.

Recent advances in nonrational and part-rational approaches to de novo peptide/protein design have shown increasing potential for development of novel peptides and proteins of therapeutic use. We demonstrated earlier the usefulness of one such approach recently developed by us, called "codon shuffling," in creating stand-alone de novo protein libraries from which bioactive proteins could be isolated. Here, we report the synthesis and selection of codon-shuffled de novo proteins that bind to a selected Mycobacterium tuberculosis protein target, the histone-like protein HupB, believed to be essential for mycobacterial growth.

Nucleoside diphosphate kinase from Mycobacterium tuberculosis cleaves single strand DNA within the human c-myc promoter in an enzyme-catalyzed reaction.

The reason for secretion of nucleoside diphosphate kinase (NdK), an enzyme involved in maintaining the cellular pool of nucleoside triphosphates in both prokaryotes and eukaryotes, by Mycobacterium tuberculosis is intriguing. We recently observed that NdK from M.tuberculosis (mNdK) localizes within nuclei of HeLa and COS-1 cells and also nicks chromosomal DNA in situ (A.

Role of Mycobacterium tuberculosis Ser/Thr kinase PknF: implications in glucose transport and cell division.

Protein kinases have a diverse array of functions in bacterial physiology, with a distinct role in the regulation of development, stress responses, and pathogenicity. pknF, one of the 11 kinases of Mycobacterium tuberculosis, encodes an autophosphorylating, transmembrane serine/threonine protein kinase, which is absent in the fast-growing, nonpathogenic Mycobacterium smegmatis. Herein, we investigate the physiological role of PknF using an antisense strategy with M.

Nuclear localization and in situ DNA damage by Mycobacterium tuberculosis nucleoside-diphosphate kinase.

Nucleoside-diphosphate kinase of Mycobacterium tuberculosis (mNdK) is a secretory protein, but the rationale behind secreting an enzyme involved in the maintenance of cellular pool of nucleoside triphosphates is not clearly understood. To elucidate the biological significance of mNdK secretion, we expressed mNdK fused to green fluorescent protein in HeLa and COS-1 cells. Interestingly, mNdK was detected in the nuclei of HeLa and COS-1 cells.