[Monoclonal antibodies in the treatment of recurrent polyposis rhinosinusitis. Literature review].

This article is devoted to the problem of the effectiveness of therapy of recurrent polyposis rhinosinusitis and the choice of the most effective drug from the group of monoclonal antibodies. The wide prevalence of the disease, as well as the low level of effectiveness of existing treatment methods, such as glucocorticosteroid (topical and topical) therapy, antibacterial therapy and available surgical methods of treatment (polypotomy, endoscopic polysinusitomy) allow us to conclude that the existing methods of treatment for recurrent polyposis process do not allow to achieve a stable positive result. Various undesirable phenomena with prolonged use of steroidal drugs, as well as the need for repeated rhinosinusosurgery in case of recurrence of this process, make doctors-otorhinolaryngologists around the world to look for new treatment options for polyposis rhinosinusitis, one of these methods is the use of monoclonal antibodies.

[Clinical efficiency of polyvalent piobacteriophage in the complex treatment of nosocomial sinusitis].

The article presents the results of the study of polyvalent pyobacteriophage in the complex therapy of nosocomial sinusitis in 30 patients of intensive care units of a multidisciplinary hospital in Moscow. The etiologic factors of nosocomial sinusitis manifestation were the following microorganisms: According to the results of the study it was revealed that at the empirical phage therapy the regression of the main clinical symptomatology was achieved in 90% of patients. The average number of days of this therapy before registration of clinical sanation of the maxillary sinus was 4±1.

[Efficacy and safety of topical antibiotic therapy in patients with acute external bacterial otitis: results of a retrospective study].

Otitis externa is one of the most common diseases in otorhinolaryngological practice frequently requiring prescription of analgesic medications and antimicrobials. The total of 2714 patients were included in the retrospective study to evaluate bacterial etiology, effectiveness, and safety of topical empirical treatment of patients with diagnosed otitis externa during 2018-2023. The most common pathogens isolated were (38.

[Etiologic features of nosocomial sinusitis].

Unlabelled: The article presents a study of the qualitative and quantitative structure of etiologically significant microorganisms received from patients with nosocomial sinusitis from intensive care units of multiprofile and infectious diseases hospitals.

Objective: To evaluate the qualitative and quantitative composition of the causative agents of nosocomial sinusitis and their sensitivity to antibacterial chemotherapy drugs in modern conditions.

Material And Methods: During the period 2022-2023, we selected 45 patients from 6 ICU based on a multidisciplinary hospital and 11 patients from the ICU based on an infectious profile hospital, who were diagnosed with nosocomial sinusitis based on anamnesis, clinical picture, and computed tomography results.

[On the issue of the etiology of acute inflammatory pathology of the pharynx in children].

Objective: To compare the microbiota of the oropharynx in healthy children and children with acute tonsillitis and pharyngitis.

Material And Methods: The study included two groups of patients (139 people) aged from 1 year to 17 years inclusive. The main group consisted of children with acute tonsillitis and acute pharyngitis (111 patients, average age 7±4 years), the control group consisted of 28 healthy children (average age 7±6 years) without signs of upper respiratory tract infection.