Metabolic and molecular regulation in skeletal muscle dysfunction and regeneration.

Skeletal muscle is an important organ in the human body for maintaining overall strength and mobility. Skeletal muscle has the capability of self-regeneration, which can be achieved by utilizing specific energy pathways. Therefore, understanding the energy metabolism of skeletal muscle is essential to exploring its regenerative mechanisms.

Feasibility Trial Protocol for a Remote Intentional Music Listening Intervention to Support Mental Health in Individuals with Chronic Stroke.

Introduction: Post-stroke depression affects approximately 30% of stroke survivors and is linked to worse functional outcomes, cognitive decline, reduced quality of life, and increased mortality. While early treatment of post-stroke mental health conditions is critical, current pharmacological options offer limited efficacy. Music listening interventions are a promising, low-risk, accessible, and affordable alternative that may enhance recovery through engagement of reward-related brain circuits.

Gastrointestinal Impact and Tool Performance in Juvenile Systemic Sclerosis Using the UCLA GIT 2.0 Assessment.

Objective: The objective of this study is to characterize gastrointestinal (GI) manifestations in juvenile-onset systemic sclerosis (jSSc) using the UCLA Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 (UCLA GIT 2.0) patient-reported outcome (PRO) instrument, and to evaluate its validity and responsiveness in this population.

A one-stop clinic improvement project for postmenopausal bleeding in NHS Forth Valley.

Background: Referrals for postmenopausal bleeding (PMB) were creating a pressure point within a general gynaecology outpatient clinic in NHS Forth Valley (NHSFV) in Scotland. This project originated in concerns around delays in time from referral to diagnosis as a result of this pressure point.

Aim: The aim of this project was to test the efficiency of a process change which reduced waiting time from referral to diagnosis for patients with PMB.

Synergistic Pesticide Effects on Complex Arthropod Trophic Interactions in Arable Systems.

Arable systems have a high dependence on diverse natural biota to support pest control, soil bioturbation, and nutrient recycling. However, pesticide regulatory assessments fail to consider complex trophic interactions, underestimating real-world risks. This problem may be exasperated when mixtures of pesticides interact synergistically.