Publications by authors named "A Clare Sparling"
Background: Community-engaged research relies on the strength of partnerships to achieve and sustain shared goals. The You & Me: Test and Treat (YMTT) project aimed to promote COVID-19 test and treatment access using a tiered model of community engagement and a codeveloped toolkit to foster robust community-academic partnerships. This study assesses the YMTT project's strengths, identifies partnership lessons learned, and evaluates the toolkit's utility.
View Article and Find Full Text PDFBackground: Guideline-directed medical therapy (GDMT) for patients with heart failure with reduced ejection fraction (HFrEF) is under-prescribed. Real-world data regarding contemporary GDMT prescribing and the impact of scalable interdisciplinary heart failure (HF) teams are needed.
Methods And Results: We retrospectively identified 2121 patients with HFrEF seen in 2022 in 4 community-based cardiology-practice sites that contained an embedded interdisciplinary HF team.
Article Synopsis
- The study aimed to identify differences in serum protein levels between adult and juvenile dermatomyositis (DM and JDM) patients compared to healthy controls to find potential biomarkers for disease activity.
- A multiplex immunoassay was used to analyze serum protein expression from 17 active DM and JDM patients, revealing 78 out of 172 proteins were differentially expressed, with specific proteins highlighted for each patient group.
- The analysis showed activated signaling pathways in both DM and JDM, with several proteins correlating with disease activity, suggesting potential candidates for monitoring the condition's severity.
Paracelsus was a transmutational alchemist: For most of his career, he believed that one metal could be turned into another. In an alchemical text, the he explored the theoretical foundations of transmutation and hinted at recipes for bringing it about. He proposed that from plants, gems, metals, and minerals might be prepared a class of marvelous medicaments, which he called (first entities).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates sex differences in mitochondrial function and toxicant susceptibility in the model organism Caenorhabditis elegans, highlighting factors that may contribute to these differences, like hormonal influence and genetic factors.
- Results showed minimal differences in mitochondrial function between the sexes of C. elegans, though there were notable differences in the uptake of the mitochondrial toxicant rotenone.
- Altered non-mitochondrial respiration was observed in specific strains, which could provide further insights into how sex-related mitochondrial health affects responses to environmental stressors.