Experimental and numerical study on FRP-rehabilitated RC beam-column joints at high temperature with artificial neural network.

This research explores the structural integrity and thermal durability of reinforced concrete beam-column joints rehabilitated with fiber-reinforced polymer (FRP) laminates under elevated temperatures reaching 800 °C. The work addresses a significant knowledge deficiency by combining computational, experimental, and machine learning methodologies to thoroughly assess FRP performance under thermal stress, a subject inadequately explored in previous literature. A total of 36 models, including 9 conventional and 27 rehabilitated configurations, were analyzed through coupled thermo-mechanical simulations using finite element software.

Variational quantum classifier-based early identification and classification of chronic kidney disease using sparse autoencoder and LASSO shrinkage.

The two leading causes of chronic kidney disease (CKD) are excessive blood pressure and diabetes. Researchers worldwide utilize the rate of globular filtration and kidney inflammation biomarkers to identify chronic kidney disease that gradually reduces renal function. The mortality rate for CKD is high, and thus, a person with this illness is more likely to pass away at a younger age.

Utilization and access to metered-dose inhalers and sustainable alternatives among older adults in the United States: a population-based study.

Background: Attaining the Paris Agreement goal of limiting global temperature rise to below 1.5-2 °C requires the healthcare sector to achieve net-zero emissions by 2050. This necessitates adopting diverse strategies, including replacing carbon-intensive metered-dose inhalers (MDIs) with more environmentally sustainable dry powder inhalers (DPIs) and soft mist inhalers (SMIs).

Toroidal displacement of by is a unique mechanism to avoid competition for iron.

Unlabelled: Competition for resources is one of the major drivers for evolution and retention of new traits in microbial communities. Quorum sensing-dependent traits of the opportunistic human pathogen allow it to survive and thrive in the presence of other microbes. Here, we report a unique mechanism that employs specifically against to displace it on solid surfaces.

Development and Validation of School Adolescents Mental health Assessment Tool (SAMAT).

Background: Teachers are the first line of contact for children for any concerns. They are crucial in identifying all health issues, including mental health issues. However, the teachers may not have adequate knowledge of the concerns with children's and adolescents' mental health in schools.

Structural and functional insights into the nuclear role of Parkinson's disease-associated α-synuclein as a histone chaperone.

α-Synuclein (αSyn) plays a critical role in the pathogenesis of 'Synucleinopathies'. Although increased nuclear αSyn localization induces neurotoxicity, its definitive physiological role remains elusive. Previous studies on nuclear αSyn are limited to its interactions with individual histones and dsDNA, leaving a significant gap in understanding its interactions with assembled histone H2a-H2b dimer and (H3-H4) tetramer, as well as its role in chromatin regulation.

Co-development of efflux pump inhibitors with antibiotics on targeting structural and mutational aspects of AcrB subunit.

The rise of antimicrobial resistance (AMR) of the routinely used antibiotics is ineffective against drug-resistant pathogenic strains of Escherichia coli, set off with limited treatment choices, costs, and increasing mortality rates. Multidrug efflux pumps have been identified as crucial determinants of AMR, flushing numerous antibiotics from cells in a non-specific way, and have emerged as promising drug targets to overcome AMR. Herein, the work focuses on determining structural and mutational insights of tripartite efflux pump subunit AcrB by executing multiple sequence alignment (MSA); the residues 615 and 617 at the substrate-binding site were identified mutated from an aromatic amino acid, phenylalanine, to an aliphatic amino acid, alanine.

Computational framework for minimizing off-target toxicity in capecitabine treatment using natural compounds.

Antineoplastic drugs are becoming prevalent due to increasing cancer casualties around the globe. However, the adverse effects of these drugs are evident due to limited insight into the underlying mechanisms that result in non-specific binding and consequent off-target toxicity. The study investigates the side effects of an antineoplastic drug, Capecitabine, a prodrug converted into fluorouracil by Thymidine Phosphorylase (TP) and degrades the RNA of cancerous cells.

Dietary Modification Patterns and Interventions Among Weight Loss Seekers in Tamil Nadu, South India: A Cross-Sectional Analysis of Intermittent Fasting and Alternative Dietary Approaches.

Background The escalating global obesity epidemic requires comprehensive investigations for effective weight management strategies. Understanding the patterns, barriers, and facilitators of dietary interventions is crucial for developing effective weight management protocols. This research aims to assess dietary modification interventions among weight loss subjects in Tamilnadu, South India.

Current Perspectives in Detection of Bioactive Compounds From Through GC-MS and LC-MS/MS: Antioxidant Properties and In Silico Analysis for Industrial Applications.

Members of the genus are the conventional medicinal plants used in the therapeutic management of numerous ailments, especially for their antioxidant and pharmacological activities. The crude extract of was profiled using high-resolution GC-MS and LC-MS/MS techniques to determine possible bioactive compounds that are vital to the antioxidant activity. A total of 52 and 63 bioactive compounds have been detected in GC-MS chromatograms using different solvents (methanol and ethanol) in leaf extracts, representing the presence of certain bioactive compounds.

A machine learning-based strategy to elucidate the identification of antibiotic resistance in bacteria.

Microorganisms, crucial for environmental equilibrium, could be destructive, resulting in detrimental pathophysiology to the human host. Moreover, with the emergence of antibiotic resistance (ABR), the microbial communities pose the century's largest public health challenges in terms of effective treatment strategies. Furthermore, given the large diversity and number of known bacterial strains, describing treatment choices for infected patients using experimental methodologies is time-consuming.

Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants.

Osseointegration is a crucial property of biomaterials used for bone defect repair. While titanium is the gold standard in craniofacial surgeries, various polymeric biomaterials are being explored as alternatives. However, polymeric materials can be bioinert, hindering integration with surrounding tissues.

Synergistic effects of fly ash and graphene oxide composites at high temperatures and prediction using ANN and RSM approach.

Fly ash (FA) is a consequence of burning coal and is widely used in construction because of its pozzolanic qualities, which increase the strength and longevity of materials. Graphene oxide (GO) is a functionalized version of graphene with low electrical conductivity, high mechanical strength, and a large surface area. By examining the behavior of fly ash and GO composites at high temperatures, new materials with improved mechanical and functional qualities that are appropriate for a range of industrial uses can be created.

Exploring the plastic-fed Indian mealworm (Tenebrio molitor) gut bacterial strain (Bacillus subtilis AP-04) - A potential driver of polyethylene degradation.

Plastic biodegradation by microbes is an environmentally friendly and sustainable approach that has no negative consequences. In this study, mealworms were fed with 9 different diets with expanded polystyrene (EPS) and polyethylene foam (PF), after 28 days of incubation mealworm survival rates were highest at 93.3 % when fed wheat bran alone whereas 83.

Cocktail vaccine for the management of and .

Introduction: Globally, ticks rank second only to mosquitoes as vectors of deadly pathogens affecting humans and first in transmitting animal pathogens, presenting a significant challenge to human wellness and sustainability of livestock-based industries. Traditional tick control via chemical acaricides impacts on the environment and has led to the emergence of multi-acaricide-resistant tick populations. Use of immunoprophylactic, along with other components of integrated tick management, holds the potential to mitigate tick infestations in a sustainable manner.

Computational approaches for identifications of altered ion channels in keratoconus.

Background: Keratoconus is an etiologically complex, degenerative corneal disease that eventually leads to loss of corneal integrity. Cells in corneal epithelium and endothelium express various types of ion channels that play important roles in ocular pathology. This emphasizes the need of understanding alterations of ion channels in keratoconus.

Embryonal exposure to 4-methylbenzylidene camphor induces reproduction impairment in adult zebrafish (Danio rerio).

This study investigated how early exposure to xenobiotics can lead to disease in adulthood, which is challenging for toxicologists. We employed a 'cradle to grave' approach using zebrafish (Danio rerio) embryos exposed to 4-methylbenzylidene camphor (4-MBC), a commonly used organic UV filter. Molecular docking and simulation studies confirmed the predictive toxicity and stable interaction of 4-MBC with androgen and estrogen receptors, with binding energies of -9.

Field Exploration for Colony Selection: Evaluating Hygienic Behavior in Colonies.

Hygienic behavior (HB) emerges as a pivotal trait, impacting colony resistance to diseases. This study aimed to understand the behavioral traits of colonies, with a focus on HB and other key characteristics crucial for colony health, and to screen and identify colonies with superior hygienic behavior and better performance to combat prevailing diseases and pests. This research spans a comprehensive field analysis with different seasons and locations, encompassing the distinct environmental and management factors that influence honey bee behavior.

Factors Affecting Survival in Severe and Very Severe COPD after Admission in ICUs of Tertiary Care Centers of India (FAST COPD): Study Protocol for a Multicentric Cohort Study.

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. However, there is a lack of comprehensive data from low- and middle-income countries (LMICs) regarding factors influencing COPD outcomes, particularly in regions where biomass exposure is prevalent.

Objective: The Factors Affecting Survival in Severe and Very Severe COPD Patients Admitted to Tertiary Centers of India (FAST) study aims to address this gap by evaluating factors impacting survival and exacerbation rates among COPD patients in LMICs like India, with a specific focus on biomass exposure, clinical phenotypes, and nutritional status in patients admitted to the Intensive Care Unit (ICU).

Management of Pustular Psoriasis; The Way Ahead.

Pustular psoriasis is a specialized variant of psoriasis which can be life threatening if not treated at the earliest. The pathogenesis has been recently linked to the role of interleukin 36. Apart from the corticosteroids, systemic antipsoriatics like acitretin, cyclosporine and methotrexate have been used with some success though unpredictable.

Small Molecules in the Management of Psoriasis and Psoriatic Arthritis.

Psoriasis is a common chronic, immune-mediated inflammatory skin disease associated with various comorbidities. Managing psoriasis is often challenging as the therapy is decided based on the area of the disease, associated comorbidities and impairment in quality of life, besides the patient's preference. Making progress in the development of new molecules that can be used topically or orally, effectively controlling the disease with minimal side effects and providing long-lasting remissions are the needs of the hour.