Exploring Exercise-induced Long QT: A Scoping Review of Reversibility Through Detraining and Distinction from Long QT Syndrome.

Exercise-induced long QT may mimic congenital long QT syndrome (LQTS), risking misdiagnosis and unnecessary treatment. This scoping review explores its reversibility through detraining and differentiation from congenital LQTS. A systematic search of five databases identified six studies involving 196 subjects.

Photoinduced Immobilization on Two-Dimensional Nano Borophene Spatially Orients Capture Antibody for Highly Sensitive Biological Interactions.

Two-dimensional (2D) nanomaterials are of great interest due to their unique properties and broad biological applications. Among these, borophene, a single-atom-thick boron sheet with a honeycomb structure, exhibits exceptional structural, electronic, and mechanical characteristics, making it a promising candidate for sensing, electronics, and biosensing. In this study, we report on a liquid-phase exfoliation method to synthesize stable borophene nanosheets and introduce a photoinduced immobilization technique to functionalize their surfaces with antibodies.

Enhancing Healthcare Facility Preparedness for Emerging Infectious Diseases: The Role of the ASPAK Dashboard in Indonesia.

This paper discusses the development and evaluation of the ASPAK Dashboard, an integrated health information system, to monitor the readiness of health facilities in handling EID and improve decision-making through real-time data visualization and analysis. Development involved collaboration involving key stakeholders from the Ministry of Health and local health facilities, followed by testing and validation through user feedback and evaluation of system effectiveness. The ASPAK dashboard successfully integrated and visualized readiness data for 20 priority EID disease indicators.

Long-term conservation agriculture to enhance soil properties and quality in rice-wheat cropping system.

Conservation agriculture (CA) presents a promising substitute to the tillage-intensive rice-wheat cropping system (RWS) prevalent in the Indo-Gangetic plains (IGPs). In the northwestern IGPs, on-farm studies examining the impact of CA durations on soil properties and quality are limited. This study assessed the effects of CA practised for 2 (CA2), 4 (CA4), 8 (CA8), and 12 (CA12) years and conventional tillage (CT) on soil quality in the Nilokheri block of Haryana, India.

Iridium-Lewis Acid Bifunctional Catalyst-Enabled Regio- and Enantioselective C(sp)-H -Borylation of α,α-Diarylcarboxamides.

Enantioselective C(sp)-H activation typically relies on forming rigid 5- or 6-membered metallacyclic intermediates. Examples involving direct metalation at remote C(sp)-H bonds, which require larger metallacycles, remain scarce. Herein, we report a series of 1,1'-bi-2-naphthol (BINOL)-derived chiral bipyridine ligands that enable iridium-catalyzed regio- and enantioselective -borylation of α,α-diarylcarboxamides, generating an all-carbon quaternary stereocenter in high yields and excellent regio- and enantioselectivities.

Evaluating user satisfaction and engagement in mHealth: Insights from the Integrated Digital Health Engagement Model (IDHEM).

Introduction: In recent years, mobile health (mHealth) applications have revolutionized healthcare by improving accessibility, boosting patient engagement, and simplifying health management processes. However, despite their increasing popularity, there is still a significant lack of understanding regarding how demographic factors shape user perceptions and interactions with these tools.

Objective: This research aims to assess user satisfaction and the perceived value of the Sehhaty app among residents of Hail City, Saudi Arabia, while also examining how demographic variables influence user engagement.

Does carbapenem resistance influence clinical outcomes in ICU patients with Klebsiella pneumoniae bacteraemia? A comparative analysis of Carbapenem-resistant and susceptible isolates.

Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a critical pathogen associated with high mortality in bloodstream infections, particularly in regions with high antimicrobial resistance. Aim of this study was to identify antimicrobial resistance patterns, clinical outcomes, and independent risk factors for mortality among patients with K. pneumoniae bacteraemia (KPB), comparing CRKP and carbapenem sensitive K.

Waste paper degradation by terrestrial slug: an alternative to manage waste using biological resource.

Paper waste constitutes a major part of municipal solid waste across the globe. Degradation of the paper wastes with the aid of the terrestrial slug Laevicaulis alte (Gastropoda: Veronicellidae) was assessed to deduce the biological degradation of waste paper and subsequent accessibility of cellulose from faecal matter. L.

Synergistic effects of antibiotics and efflux pump inhibitors on multidrug-resistant Escherichia coli and Klebsiella pneumoniae.

Aim: The increasing prevalence of multidrug-resistant Escherichia coli and Klebsiella pneumoniae presents a critical threat to public health. As a first line of defence, efflux pumps promote antibiotic resistance among pathogens. This study aims to assess the potential of efflux pump inhibitors (EPIs) as adjuvants for enhancing antibiotic efficacy against resistant pathogens.

Isothermal Amplification Techniques: An Emerging Tool for On-Site Detection of Phytopathogens in Field Conditions.

This chapter reviews various isothermal amplification techniques, which are alternative to PCR for detecting plant pathogens. These methods, including NASBA, SDA, LAMP, HDA, and RPA, amplify nucleic acids at a constant temperature, making them potentially more suitable for point-of-care (POC) applications. The review compares these techniques regarding their mechanisms, advantages, and limitations, highlighting their potential for rapid, cost-effective, and on-site plant disease diagnosis, including the integration of these techniques with CRISPR-Cas systems and lab-on-a-chip technologies.

Sub-acute polyethylene microplastic inhalation exposure induced pulmonary toxicity in wistar rats through inflammation and oxidative stress.

Plastic waste, particularly polyethylene (PE) plastic bags and bottles, poses a significant environmental problem and health risk when degraded into microplastics. Recent atmospheric microplastic pollution increases inhalation exposure, necessitating a study on toxicity in the lungs. However, the inhalation toxicology of PE microplastics is poorly understood.

Reframing food addiction in childhood obesity: Cultural relevance and digital innovation needed.

This letter responds to the article by An et al. on the link between food addiction and emotional and behavioral problems in children with obesity. We highlight two key points.

Spatial Mapping of Intrinsic and Readout Nonlinearities in a Strongly Driven Micromechanical Membrane.

Recently, it was shown that strongly driven micromechanical resonators show mode shapes that strongly differ from the eigenmodes [F. Yang et al., Spatial modulation of nonlinear flexural vibrations of membrane resonators, Phys.

The German Diabetes Risk Score (GDRS) in action: Bridging risk stratification with cognitive behavioral lifestyle counseling.

Type 2 diabetes mellitus is a growing global health challenge, particularly in low- and middle-income countries. The recent study by Seidel-Jacobs et al. highlights the effectiveness of the German Diabetes Risk Score (GDRS) in enhancing lifestyle counseling and shared decision-making in primary care.

Triplet Excited Nitroarene Converts Aryl Alkynes to Ketones by Deleting a Carbon Atom.

In this study, triplet excited nitroarenes were used to convert internal alkynes to ketone fragments through simultaneous oxygen insertion and carbon deletion. The approach was effective across 33 diverse substrates, compatible with various functional groups, and applicable to bioactive molecule derivatives and large-scale synthesis. UV-vis spectroscopy revealed the role of visible light in exciting nitroarenes, while mechanistic experiments identified ketene and nitrosoarene as key intermediates, with the deleted carbon released as CO and CO.

Determining the Risk of Type 2 Diabetes for rs1801133 Genotypes in Multiethnic Populations: A Global Meta-Epidemiological Study.

The rs1801133 (C677T) polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene has been linked to type 2 diabetes (T2D) risk. This study aimed to assess the association between rs1801133 genotypes (CC, CT, TT) and T2D across multiethnic populations and to identify genotype- and region-specific risks. A global meta-epidemiological analysis was conducted using data from 19 studies comprising 6479 participants from Asia, Africa, Europe, and America.

Development of genome-wide SSR markers through mining of guava ( L.) genome for genetic diversity analysis and transferability studies across species and genera.

Guava ( L.) is one of the economically major fruit crops, abundant in nutrients and found growing in tropical-subtropical regions around the world. Ensuring sufficient genomic resources is crucial for crop species to enhance breeding efficiency and facilitate molecular breeding.

AI-based system for food and beverage selection towards precision nutrition in Indonesian restaurants.

The complexity surrounding food selection is attributable to the variability in foods, restaurants, and diners. The diversity of foods, where each dish may have a unique recipe across different restaurants, needs to be accounted for in personalized nutrition. However, personalized food selection poses a combinatorial challenge in selecting the most suitable food at a specific restaurant.

Urgent care centres for reducing the demand on emergency departments: a scoping review of published quantitative and qualitative studies.

Objectives: To identify published studies that examined the impact of urgent care centres on the numbers of presentations to emergency departments (EDs), or explored the experiences and views of patients and practitioners regarding urgent care centres as alternative sources of health care and advice.

Study Design: Scoping review of qualitative and quantitative studies published to 28 August 2024.

Data Sources: MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, and CINAHL databases; grey literature searches.