Comprehensive analysis of the systemic immune landscape across breast cancer subtypes and disease stages.

Background: Breast cancer is a systemic disease, yet the impact of tumor molecular subtype and disease stage on the systemic immune landscape remains poorly understood. In this study, we comprehensively analyzed the systemic immune landscape in a large cohort of breast cancer patients, encompassing all molecular subtypes and disease stages, alongside a control group of healthy donors.

Materials And Methods: Using multi-parameter flow cytometry, we assessed the abundance, phenotype, and activation status of diverse innate and adaptive immune cell populations across peripheral blood samples from 355 breast cancer patients and 65 healthy donors.

OpenML: Insights from 10 years and more than a thousand papers.

OpenML is an open-source platform that democratizes machine-learning evaluation by enabling anyone to share datasets in uniform standards, define precise machine-learning tasks, and automatically share detailed workflows and model evaluations. More than just a platform, OpenML fosters a collaborative ecosystem where scientists create new tools, launch initiatives, and establish standards to advance machine learning. Over the past decade, OpenML has inspired over 1,500 publications across diverse fields, from scientists releasing new datasets and benchmarking new models to educators teaching reproducible science.

ASReview LAB v.2: Open-source text screening with multiple agents and a crowd of experts.

ASReview LAB v.2 introduces an advancement in AI-assisted systematic reviewing by enabling collaborative screening with multiple experts ("a crowd of oracles") using a shared AI model. The platform supports multiple AI agents within the same project, allowing users to switch between fast general-purpose models and domain-specific, semantic, or multilingual transformer models.

Transmission networks of long-term and short-term knowledge in a foraging society.

Cultural transmission across generations is key to cumulative cultural evolution. While several mechanisms-such as vertical, horizontal, and oblique transmission-have been studied for decades, how these mechanisms change across the life course, beyond childhood, remains unclear. Furthermore, it is under-explored whether different mechanisms apply to distinct learning processes: long-term learning-where individuals invest time and effort to acquire skills-and short-term learning-where individuals share information of immediate use.

Humans exercising in the heat: A review on sweat models and a comparison to recent experimental datasets.

Sweating is a vital thermoregulatory mechanism in humans for maintaining thermal balance during exercise and exposure to hot environments. The development of models that predict sweat rate based on body temperature has been ongoing for over half a century. Here, we compared predicted water loss rates (WLR) from these models to actual observations collected during 780 participant-exposures in three independent laboratory-based experiments.

Arbuscular mycorrhizal fungi enhance nitrate ammonification in hyphosphere soil.

Microbial nitrate ammonification is a crucial process to retain nitrogen (N) in soils, thereby reducing N loss. Nitrate ammonification has been studied in enrichment and axenic bacterial cultures but so far has been merely ignored in environmental studies. In particular, the capability of arbuscular mycorrhizal fungi (AMF) to regulate nitrate ammonification has not yet been explored.

[Important medical-dental interactions. Oral manifestations of systemic auto-immune diseases].

Systemic auto-immune diseases are relatively common. This article describes the oral manifestations of disorders that might be seen in patients with the most prevalent auto-immune diseases, specifically rheumatoid arthritis, systemic lupus erythematosus and Sjögren's disease. The article gives guidelines for dentists and other carers within the oral care system for this category of patients.

[Pain education for patients with chronic facial pain].

In dental practice, it regularly happens: a patient presents with a prolonged pain complaint where there appears to be no sign of tissue damage (any longer). Patients with chronic facial pain may be experiencing altered nociception. This is associated with processes of sensitization and impaired signal inhibition in the somatosensory system.

[Occlusal dysaesthesia: an unusual, persistent somatic symptom].

Occlusal dysaesthesia - also known as phantom bite - is the perception of an altered bite without any objectively verifiable occlusal discrepancy. Approximately 75% of cases arise following dental treatment or trauma. The sensation of a changed bite often occurs in dental practice as a temporary discomfort following a dental procedure.

[A PhD completed. The effect of haematopoietic cell transplantation on hyposalivation, xerostomia and caries progression].

Haematopoietic cell transplantation is a widely used treatment option for (malignant) blood diseases like leukaemia. This treatment, which is preceded by chemotherapy and sometimes by total body radiation therapy, can cause serious side effects, often including the oral cavity. This thesis describes the development of hyposalivation, xerostomia and caries progression after haematopoietic cell transplantation.

Predictive value of postoperative CRP levels for endoscopic recurrence in patients with Crohn's disease undergoing ileocolic resection.

Background And Aims: Patients with Crohn's disease (CD) undergoing ileocolic resection (ICR) develop higher postoperative C-reactive protein (CRP) levels compared to colorectal cancer (CRC) patients, suggesting an increased postoperative inflammatory response. This study investigates whether postoperative C-reactive protein (CRP) levels are associated with endoscopic recurrence (ER) after ICR.

Methods: All CD patients who underwent ICR between 2007 and 2022 at two referral centers were identified from prospectively maintained databases.

A Network Analysis of Fear-Avoidance Beliefs, Mood and Disability in Chronic Pain.

Objectives: Although the multifactorial nature of chronic pain is well established, research has predominantly examined isolated variables or singular pathways that may contribute to this condition. We use a complex systems perspective to examine the interplay of psychological factors in the context of chronic pain.

Methods: We analyzed two cross-sectional datasets (N=935 and 1366) collected at a pain clinic and rehabilitation center in Belgium from individuals primarily with musculoskeletal pain.

The Effect of Eating Rate of Ultra-Processed Foods on Dietary Intake, Eating Behaviour, Body Composition and Metabolic Responses-Rationale, Design and Outcomes of the Restructure Randomised Controlled Trial.

Extensive epidemiological research and the findings from one randomised controlled feeding trial (RCT) have shown associations between the consumption of ultra-processed foods (UPFs) and higher energy intakes. To date the specific properties of UPF foods and diets that may be responsible for driving higher energy intakes remain unclear. A comparison of the diets in the single RCT to date showed a significantly higher eating rate (g/min, ER) for meals in the UPF diet compared to those in the minimally processed diet.

Intergenerational transmission of problem behavior: Genetic and environmental pathways.

Despite the growing body of research on the intergenerational transmission of problem behavior, there is a need for more integrative approaches that consider the interplay between genetic and environmental factors. This study uses unique longitudinal data from TRAILS (analytic sample = 2202), a prospective multiple-generation cohort study in the Netherlands to examine whether parents' problem behavior (parents' self-reported lifetime antisocial behavior and substance use, reported at mean age 40 years) predicts offspring problem behavior nearly two decades later (offspring self-reported aggression and delinquency at mean ages 29 and 32 years). In path analyses, independent and relative contributions of genetic (polygenic scores of parents and offspring) and environmental (harsh parenting) pathways were tested.

Improving research on developmental psychopathology with Registered Reports.

The quality of research across psychology needs improvement. Ample evidence has indicated that publication bias, specifically making publication decisions based on a study's results, has led to a distorted literature (e.g.

European Myeloma Network Consensus Statement on Functional High-Risk Multiple Myeloma.

Multiple myeloma (MM) is an incurable blood cancer characterized by clonal bone marrow plasmacytosis, hypercalcemia, renal failure, anemia, and osteolytic bone disease. Approximately 20% of NDMM patients, not predicted to have high-risk disease at diagnosis, progress early, despite optimal induction +/- ASCT and lenalidomide maintenance, and are subsequently categorized as functional high-risk (FHR) disease. Standardized risk-stratification models incorporate biomarkers of tumor burden, existence of high-risk cytogenetics, with the presence/absence of plasma cell leukemia/extramedullary disease to attribute high-risk at diagnosis; however, depth/duration of response to novel agent-based induction (NA-IND) as dynamic markers of disease risk have not been defined.

The European Health Data Space in communicable diseases surveillance and monitoring of medicines and vaccines: achievements of a pilot project examining the user journey.

The future European Health Data Space (EHDS), a network for secure cross-border data use, could be beneficial for public health initiatives. The HealthData@EU pilot project evaluated possibilities of secondary data use based on five use cases and established a pilot IT infrastructure. This article reports overarching experiences from two public health use cases and the IT development.

Microbiome-Mediated Resistance of Wild Tomato to the Invasive Insect Prodiplosis longifila.

Plant roots are colonised by diverse communities of microorganisms that can affect plant growth and enhance plant resistance to (a) biotic stresses. We investigated the role of the indigenous soil microbiome in the resistance of tomato to the invasive sap-sucking insect Prodiplosis longifila (Diptera: Cecidomyiidae). Native and agricultural soils were sampled from the Andes in Southern Ecuador and tested, in greenhouse bioassays, for leaf tissue damage caused by P.

Advice-taking in carbon footprint assessments: How psychological and cultural factors shape reliance on experts' advice.

In this pre-registered experiment conducted in the Netherlands and Türkiye (N = 550), we investigated how the source of advice (peer vs. expert) influences people's decision-making when assessing the carbon footprint of a flight between two cities. We also examined whether this effect was influenced by their conspiracy mentality, collective narcissism, epistemic individualism, and climate change scepticism.

Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport.

The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth score. Using a Luminex cytokine assay and liquid chromatography-mass spectrometry-based proteomics we explored the plasma proteins associating with the difference in 100 extreme scoring individuals selected from two large population cohorts, the Leiden Longevity Study (LLS) and the Rotterdam Study (RS), and discordant monozygotic twin pairs from the Netherlands Twin Register (NTR).

Bacillus drives functional states in synthetic plant root bacterial communities.

Background: Plant roots release root exudates to attract microbes that form root communities, which in turn promote plant health and growth. Root community assembly arises from millions of interactions between microbes and the plant, leading to robust and stable microbial networks. To manage the complexity of natural root microbiomes for research purposes, scientists have developed reductionist approaches using synthetic microbial inocula (SynComs).

Resolving a century-old enigma: potato 'Bolters' originate from instability of the StCDF1.3 allele.

Potato bolters are caused by excision of a transposon from the StCDF1.3 allele, resulting in a somatic mutant with late maturity. Somatic mutations during vegetative propagation can lead to novel genotypes, known as sports.