Light scattering levels from intraocular lenses extracted from donor eyes.

Purpose: To assess light scatter levels of intraocular lenses (IOLs) extracted from donor eyes to understand straylight elevation documented earlier in pseudophakic population studies and identify potential sources of light scattering in IOLs.

Setting: Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands.

Design: Experimental study.

Straylight from glistenings in intraocular lenses: In vitro study.

Purpose: To assess light scattering from intraocular lenses (IOLs) with different numbers of laboratory-induced glistenings and create a model for predicting glistening effects on straylight.

Setting: Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands.

Design: Experimental study.

Comparison of ocular straylight after implantation of multifocal intraocular lenses.

Unlabelled: A comprehensive review of the effect of multifocal intraocular lens (IOL) designs on postoperative ocular straylight was performed. Studies reporting straylight values obtained with the natural pupil using the C-Quant device after uneventful multifocal IOL implantation were included. The IOLs were categorized based on their material characteristics; that is, hydrophobicity and presence of colored chromophores.

Ocular straylight in the normal pseudophakic eye.

Purpose: To assess normal values for straylight in the pseudophakic eye as a function of age and to develop a model to predict the improvement in straylight after lens extraction based on preoperative straylight levels.

Setting: Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands.

Design: Review with retrospective cross-study analysis.

Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response.

Background: Deep brain stimulation (DBS) has been proposed as an alternative to ablative neurosurgery for severe treatment-resistant Obsessive-Compulsive Disorder (OCD), although with partially discrepant results probably related to differences in anatomical targetting and stimulation conditions. We sought to determine the efficacy and tolerability of DBS in OCD and the existence of clinical predictors of response using meta-analysis.

Methods: We searched the literature on DBS for OCD from 1999 through January 2014 using PubMed/MEDLINE and PsycINFO.

Cognitive effects of deep brain stimulation in patients with obsessive-compulsive disorder.

Background: Deep brain stimulation (DBS) is a promising treatment for treatment-refractory obsessive-compulsive disorder (OCD). However, the effects of DBS on cognitive functioning remain unclear. Therefore, we aimed to assess cognitive safety of DBS for treatment-refractory OCD and the association between clinical changes and cognitive functioning.

Cerebellar motor learning deficits in medicated and medication-free men with recent-onset schizophrenia.

Background: The notion that cerebellar deficits may underlie clinical symptoms in people with schizophrenia is tested by evaluating 2 forms of cerebellar learning in patients with recent-onset schizophrenia. A potential medication effect is evaluated by including patients with or without antipsychotics.

Methods: We assessed saccadic eye movement adaptation and eyeblink conditioning in men with recent-onset schizophrenia who were taking antipsychotic medication or who were antipsychotic-free and in age-matched controls.