2 results match your criteria: "University of Warwick CV4 7AL UK m.i.gibson@warwick.ac.uk.[Affiliation]"
Polymer-tethered glyconanoparticle colourimetric biosensors for lectin binding: structural and experimental parameters to ensure a robust output.
RSC Adv
November 2022
Department of Chemistry, University of Warwick CV4 7AL UK
Article Synopsis
- - Glycan-lectin interactions are critical in biological processes like pathogen attachment and immune response, but current methods to study these interactions are often expensive and not widely accessible.
- - Recently developed glycosylated plasmonic nanoparticles offer a cost-effective biosensor alternative that detects glycan-protein binding through noticeable color changes, which can be analyzed with simple equipment.
- - This research suggests optimal parameters (gold core size and polymer tether length) for using these nanoparticles, allowing lab users to efficiently investigate new glycan/protein interactions with minimal optimization needed.
Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands.
Chem Sci
November 2020
Department of Chemistry, University of Warwick CV4 7AL UK
Galectins are potential biomarkers and therapeutic targets. However, galectins display broad affinity towards β-galactosides meaning glycan-based (nano)biosensors lack the required selectivity and affinity. Using a polymer-stabilized nanoparticle biosensing platform, we herein demonstrate that the specificity of immobilised lacto--biose towards galectins can be 'turned on/off' by using site-specific glycan fluorination and in some cases reversal of specificity can be achieved.
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