Assessing service quality and its impact on patient experience and satisfaction in prosthetics and orthotics: a SERVQUAL-based cross-sectional study.

Background: Service quality plays a crucial role in shaping patient experience and satisfaction in prosthetic and orthotic services. However, limited research has examined the specific impact of SERVQUAL dimensions (Reliability, Assurance, Tangibility, Responsiveness, and Empathy) on patient satisfaction and patient experience in this field. This study aimed to assess the relationships between service quality, patient experience, and satisfaction, providing insights for healthcare improvement.

Consensus on the management of traumatic brain injury in older adults: Results from a Delphi study.

Introduction: As the world population is rapidly becoming older, the incidence of traumatic brain injury (TBI) is increasing among older adults with vast implications for brain health of older adults in Europe. Due to differences from younger patients, there are areas of uncertainty in the assessment, diagnosis and management of TBI in older adults.

Research Question: To reach a consensus among experts on statements regarding the definition of old age, assessment, diagnosis and management of traumatic brain injury in older adults.

Correction: Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.

[This corrects the article DOI: 10.3389/fphar.2024.

PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding.

Peroxisome proliferator-activated receptor γ (PPARγ), which is expressed in a variety of malignancies, governs biological functions through transcriptional programs. Defining the molecular mechanisms governing the selection of canonical versus non-canonical PPARγ binding sequences may provide the opportunity to design regulators with distinct functions and side effects. Acetylation at K268/293 in mouse Pparγ2 participates in the regulation of adipose tissue differentiation, and the conserved lysine residues (K154/155) in mouse Pparγ1 governs lipogenesis in breast cancer cells.

Sarcopenia risk as a predictor of urinary incontinence in women aged 50 and older: a cross-sectional analysis.

Urinary Incontinence (UI) has multiple negative effects on women's health. Multiple risk factors were investigated previously in different settings and populations. This study aims to determine the association between UI and the risk of sarcopenia and other associated risk factors among women above the age of 50 years in Hungary.

Root resorption caused by aligners, self-ligating appliances, and conventional fixed appliances: a CBCT-based meta-analysis.

Background: Orthodontically induced inflammatory root resorption (OIIRR) is a common adverse effect of orthodontic treatments. Radiographs are routinely used to diagnose OIIRR; however, 3-dimensional cone beam computed tomography (CBCT) studies have recently been conducted to assess hard tissue loss more accurately. There is controversial evidence of differences between aligners and fixed appliances in terms of OIIRR.

Dietary Aluminum Exposure Is More Closely Linked to Antioxidant Dynamics than to Body Mass Index.

The association between aluminum exposure and obesity remains uncertain. This study investigated whether aluminum exposure (dietary, serum, and urinary) is linked to obesity and whether dietary antioxidant capacity moderates this relationship. A total of 54 adult women (26 obese, 28 normal weight) were recruited from a private weight loss clinic in Türkiye.

Viscoelastic Point-of-Care Testing (ClotPro) to Guide Intravenous Thrombolysis in Acute Ischemic Stroke Patients on DOACs: Replacing History with Hemostasis in a Proof-of-Concept Study.

Background: Administering intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) on direct oral anticoagulants (DOACs) remains a clinical challenge. Current guidelines restrict IVT within 48 h of DOAC intake unless anticoagulant activity can be confidently excluded. However, reliable medication histories are often unavailable, and conventional coagulation tests inadequately detect DOAC activity.

Phenotypic and genotypic description of GMPPA-congenital disorder of glycosylation: A review of 26 cases.

GMPPA-Congenital Disorder of Glycosylation (CDG) is an ultra-rare autosomal recessive CDG caused by pathogenic variants in GMPPA that affects the N-linked glycosylation pathway. Affected individuals present with three major symptoms: achalasia, alacrima, and impaired intellectual development during infancy. Current management of GMPPA-CDG is targeted to address patients' symptoms.

Health implications of lower extremity amputations in Jordan: A retrospective analysis of demographic patterns and causes.

Lower extremity amputation (LEA) is a significant health concern in Jordan, yet comprehensive data on its demographic and clinical characteristics remain limited. This retrospective analysis evaluated 893 LEA cases collected from Al-Basheer Hospital and six private prosthetic clinics in Amman between 2017 and 2023. Transtibial amputations (68.

Physiotherapy for endometriosis-associated pelvic pain: A systematic review and meta-analysis.

Background: Endometriosis is a disease often associated with chronic pelvic pain (CPP). It affects around 190 million females of reproductive age globally.

Objectives: To investigate the effect of physiotherapy techniques (PTs) in relieving endometriosis-associated pain.

Case report: A young woman with acute peri‑myocarditis and acute myeloid leukaemia with myelodysplasia-related changes.

Background: Clinical presentation in acute myeloid leukaemia (AML) can result in a wide variety of clinical phenotypes.

Case Report: We report the case of a 34-year-old woman who presented with severe peri‑myocarditis and concomitant AML. The patient was treated with 5-azacitidine and venetoclax followed by haploidentical allogenic haematopoetic stem cell transplantation.

Analysis of heavy metal content in protein powders available on the Hungarian market: a reassuring snapshot, but not a reassuring quality guarantee.

Amateur and professional athletes often consume protein supplements to accelerate muscle gain; however, it has been suggested that these products not only are associated with risks when consumed excessively. Several recent reports have indicated that certain products are contaminated with heavy metals. Therefore, in this study, we aimed to investigate protein powders in Hungary for heavy metal contamination.

Food Price Changes, Household Food and Nutrition Security in Ethiopia: Evidence From Household Level Analysis Through a Gender Lens.

This study investigates the impact of food price changes on food security and diet quality in Ethiopia using recent Living Standard Measurement Surveys. Household-level food security and diet quality were assessed using the Household Diet Diversity Score, Food Insecurity Experience Scale, and proportion of food consumption expenditure. Employing a random effects panel regression and Oaxaca-Blinder decomposition, this study examined the differential effects of price changes across household types, guided by the Harvard gender analysis framework.

Relationship between self-rated health, sense of coherence and physical activity in a survey of secondary school students: A correlational study.

The aim of the present research was to assess the physical activity of secondary school students and to understand its effect on subjective general health, vitality and mental health. A quantitative cross-sectional study was conducted among adolescents aged 15-19 (n = 448) years attending a full-time secondary school. The paper-based questionnaire included self-reported questions on physical activity in addition to socio-demographic variables, while the standardised instrument measured dimensions of subjective health (Health Thermometer - EuroQol scale, EQ VAS, Health Survey Short Form SF-36 Questionnaire) and Sense of Coherence (SOC 13).

Comparative efficacy of patient-specific and stock implants in temporomandibular joint replacement: a systematic review and meta-analysis.

Evidence for the superiority of patient-specific implants (PSI) over stock implants in temporomandibular joint (TMJ) replacement remains inconclusive. The objective of this study was to provide guidance for clinical decisions by evaluating whether PSI offer advantages over stock systems in rehabilitation of the TMJ. A systematic search was performed in three databases to identify studies reporting mouth opening, pain, and diet outcomes for PSI and/or stock TMJ implants.

The Arabic Version of the Patient Health Questionnaire-2 (PHQ-2): Psychometric Evaluation Among Mothers of Children With Intellectual Disabilities.

Mothers of children with intellectual disabilities are particularly vulnerable to mental distress due to demanding and exhausting caregiving. However, in the Arab world, they are seldom screened for depression because of limited diagnostic resources. Addressing the urgent need for brief and reliable screening tools, this study evaluated the psychometric properties of the Arabic version of the Patient Health Questionnaire-2 (PHQ-2) among 85 Saudi mothers.

Artificial intelligence and machine learning models for predicting and evaluating the influence of shelf-life environments and packaging materials on garlic ( L) physicochemical and phytochemical compositions.

The nutritional content and quality of garlic, a crop widely consumed, must be preserved after harvesting by overcoming several challenges. The necessity of this study arises from the growing demand for effective postharvest management solutions that can extend shelf life, maintain the nutritional integrity of garlic and enhance consumer satisfaction. This study explores the application of machine learning (ML) and artificial intelligence (AI) to predict the effects of storage environments and packaging materials on garlic's physicochemical properties, enzymatic activities, phytochemical content, and antioxidant characteristics.

Comparative analysis of drying kinetics, thermodynamic properties, and mathematical modeling of pomegranate peel (Punica granatum L.) in a hybrid solar dryer and an oven dryer.

Drying pomegranate peels, a by-product of juice extraction, offers an effective means to preserve bioactive compounds while reducing waste. This study investigates the influence of drying temperature and layer thickness on the drying kinetics, thermodynamic properties, and modeling of pomegranate peels using a hybrid solar dryer (HSD) and a conventional oven dryer (OD). Fresh peels with an average initial MC of 325.

Feasibility of video-assisted cardiopulmonary resuscitation when the lay responder is alone with the victim: a randomized controlled crossover pilot study.

Video-assisted cardiopulmonary resuscitation (V-CPR) can improve the quality of bystander-performed CPR; however, its applicability has not been explored in situations where the lay responder is alone with the victim. This pilot study aimed to assess the feasibility of V-CPR in such scenarios. A randomized controlled crossover simulation study was conducted with 10 lay responders in two settings: a residential living room and a yard.

Muscle Biopsy Findings in Valosin-Containing Protein Multisystem Proteinopathy.

Background And Objectives: Valosin Containing Protein-associated multisystem proteinopathy (VCP-MSP) is a progressive, autosomal dominant disorder caused by pathogenic variants in the VCP gene, resulting in a heterogeneous clinical presentation. Muscle biopsy findings are characteristic but not pathognomonic. This study aimed to comprehensively analyse VCP-related myopathology and explore correlations with clinical phenotypes, genetic variants, and disease progression.

Targeting the miR-493-5p/OTUB1 axis to mitigate mitochondrial dysfunction in diabetic cardiomyopathy.

Aims: Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus and frequently progresses to heart failure. Although the deubiquitinase OTUB1 has demonstrated protective effects in DCM, the upstream regulatory mechanisms governing its expression and their influence on mitochondrial function remain unclear.

Methods: We used a short-term insulinopenic diabetic mouse model supplemented with exogenous protein C (PC) to investigate the role of activated protein C (aPC) in regulating OTUB1 during early-stage DCM.

Effects of the inhibition of miRNA biogenesis in the central ring ganglia of a widely used invertebrate model species, Lymnaea stagnalis.

MicroRNAs (miRNAs) are key regulators of gene expression, shaping neuroplasticity, stress responses, and neuromodulation. In the pond snail Lymnaea stagnalis, inhibition of the miRNA-processing enzyme Dicer with Poly-l-Lysine (PLL) has been shown to impair long-term memory (LTM) formation, yet the molecular pathways affected remain unclear. Here, we examined PLL injection's transcriptional and cellular/neurochemical effects in untrained (i.

Scoping Review of Psychological Therapies in Acute Pain Relief-To Whom, From Who, and Which Channels.

Purpose: Chronic pain remains a worldwide burden. This prolonged pain arises from acute pain, especially prolonged postoperative pain. Although there are available psychosocial interventions, the investigation of these interventions in an acute health care setting is underrated.

Risk Factors for Microscopic Colitis: A Systematic Review and Meta-Analysis.

Background: Microscopic colitis (MC) is still an underdiagnosed disease due to its primarily histological appearance. We aimed to address the scarcity and inconsistency of data on MC risk factors.

Methods: Our protocol was prospectively registered in PROSPERO (CRD42022286624).