Thymus-like phenotype in benign lymphoepithelial neoplasms of salivary glands: clinicopathological and molecular characterization and reappraisal of relationship to non-sebaceous lymphadenoma.

Benign lymphoepithelial tumors of salivary glands had been restricted to sebaceous and non-sebaceous (NSLA) lymphadenomas. However, salivary neoplasms recapitulating carcinoma showing thymus-like elements (CASTLE) have been the subject of recent case reports. We reviewed clinicopathological, immunohistochemical, and molecular findings in 20 salivary gland tumors with thymus-like phenotype (18 histologically benign and two with malignant component).

Emotion regulation as mechanism of change in the treatment of depression - a latent change score analysis.

Deficits in emotion regulation (ER) are associated with major depressive disorder (MDD). Therefore, enhancing ER is a promising target in the treatment of MDD. In this study, we examined ER as a mechanism of change in outpatient, group-based ER-focused psychotherapy for MDD, conducting secondary analysis of randomized controlled trial (RCT) data.

Proposal of a specific classification of primary periphyseal stress injuries in adolescent rock climbers.

Introduction: Primary Periphyseal Stress Injuries (PPSI) of the hand and fingers are relatively uncommon but are most frequently seen in adolescent rock climbers. A major limitation in the current literature on PPSIs is the lack of a standardized nomenclature and radiological classification. This gap complicates the accurate diagnosis, treatment, and comparison of outcomes across studies.

Visual Attention Patterns Toward Female Bodies in Anorexia Nervosa-An Eye-Tracking Study with Adolescents and Adults.

Attentional biases seem to play an important role in anorexia nervosa (AN). The objective of this study was to measure visual attention patterns toward female bodies in adolescents and adults with and without AN in order to explore developmental and disease-specific aspects. Female adult and adolescent patients with AN (n = 38) and control participants (n = 39) viewed standardized photographic stimuli showing women's bodies from five BMI categories.

Relative Energy Deficiency in Sport in Rock Climbers: A Narrative Review.

Tan, K and Schöffl, V. Relative energy deficiency in sport in rock climbers: a narrative review. J Strength Cond Res 39(8): 908-917, 2025-Rock climbing has experienced immense growth in popularity over the years and was incorporated into the summer Olympic program as of the 2020 Tokyo Olympics.

Exploring the internalization pathways of silica nanoparticles for targeted intracellular delivery: a discussion of recent results.

The advances in nanotechnology and nanomedicine have enabled the development of minimally invasive, high-performance drug delivery systems with enhanced targeting and therapeutic abilities. In this context, the high biocompatibility, tunable surface chemistry and physicochemical properties of SiO nanoparticles (SNPs), have placed them as key representatives in this field. However, the clinical success of SNP-based systems highly depends on the mechanism involved in their internalization process, which further determines their intracellular fate and therapeutic function.

Impact of age-related stereotype threat on subjective age, awareness of age-related change, and physical performance in older adults.

Age-related stereotype threat-the fear of being judged based on negative age stereotypes-can affect physical performance in older adults. This study postulated that stereotype threat influences sports motor performance and that self-perceptions of aging (SPA), specifically subjective age (SA) and awareness of age-related change (AARC), reinforce this relationship. A total of 86 adults aged 65 and over participated in the study (65-85; M = 72.

Glutaminolysis impairment and immunometabolic dysregulation in U937 cells: Key mechanisms in occupational and environmental skin exposure to UV and benzo[a]pyrene.

Dermal exposure to polycyclic aromatic hydrocarbons (PAHs) and UV irradiation in occupational and environmental settings poses a health risk by inducing skin toxicity, including immunomodulatory effects. This study investigated the effects of benzo[a]pyrene (B[a]P), a well-characterized PAH, at three concentrations (0.04 nM, 4 nM, and 4 µM) and UV irradiation on human monocytic U937 cells, employing both single and combined exposure scenarios.

Interdisciplinary neurovascular networks in Germany: update 2025.

Background: Neurovascular networks (NVNs) in Germany are supra-regional care structures for patients with neurovascular diseases. Each NVN consists of a tertiary care center serving as the coordinating center-in some cases, two or three coordinating centers-and at least three partner hospitals. Since 2018, 19 neurovascular networks (NVNs) have been audited and certified.

Reaction of N-Ferrocenylcarbamates with Nitric Oxide: An Application for Detection of Inflammatory Sites In Vivo.

Electron-deficient aminoferrocenes (edAFs) exhibit anticancer activity both in vitro and in vivo. However, their mechanism of action remains unclear. Studies using fluorogenic edAF derivatives suggest that the ferrocenyl moiety undergoes oxidation or decomposition within cells, resulting in the formation of unknown products.

Innovative therapeutic modalities of purified platelet-derived growth factors on PDX1, Neurog3, and renin expressions in STZ-induced diabetic nephropathy and pancreatic injury.

Diabetic nephropathy is the predominant etiology of advanced renal disease, and its prevalence has increased significantly over recent years. The primary management strategy focuses on controlling identified risk factors; however, this approach only slows disease progression and cannot halt or reverse it. Therefore, novel therapeutic strategies are urgently needed.

Tannic acid-loaded zinc- and copper-doped mesoporous bioactive glass nanoparticles: Potential antioxidant nanocarriers for wound healing.

Polyphenols such as tannic acid (TA) with antibacterial and antioxidant activities have recently attracted significant attention for wound healing applications. Mesoporous bioactive glass nanoparticles (MBGNs) have also garnered considerable interest to be employed as nanocarriers of therapeutic biomolecules. This study focuses on the fabrication of TA-loaded MBGNs which were doped with two well-known biologically active elements, copper (Cu) and zinc (Zn).

Novel Antioxidant and Antibacterial Injectable Hydrogels Incorporating Clove Oil-Loaded Mesoporous Bioactive Glass Nanoparticles: A Promising Strategy for Enhanced Bone Regeneration.

Alginate (Alg)-gelatin (Gel)-xanthan gum (Xan) injectable hydrogels incorporating mesoporous bioactive glass nanoparticles (MBGNs) loaded with different concentrations of clove oil (MBGNs+CLV) were developed for bone regeneration applications. The hydrogels exhibited an interconnected network of pores, with their dimensions fulfilling the requirements for bone tissue engineering. MBGNs+CLV were successfully embedded within the Alg-Gel-Xan matrix.

Achieving nanosecond time resolution with a two-dimensional X-ray detector.

The fastest pixel array X-ray detectors can record images with nanosecond resolution. This is accomplished by storing only a few images in in-pixel memory cells. In this study, we demonstrate nanosecond resolution over a large number of images by operating a prototype detector in an event driven mode.

Moving beyond gender: a systematic review of diversity data gaps in prospective trauma research.

To better understand heterogeneity in PTSD development and to ensure that knowledge of risk and intervention mechanisms is available for a diverse group of trauma exposed individuals, psychotraumatology needs to consider diversity in sample characteristics. In a comprehensive overview, we evaluated how nine diversity domains including age, socioeconomic status (SES), race/ethnicity, sexual orientation, care responsibilities, religion/worldview, mental health, physical health, and disability status were considered in prospective PTSD research. In in-depth analyses, we further investigated the assessment and representation of population groups with regard to age, SES and race/ethnicity.

Digital health economics education: perspectives, potential and barriers at German medical universities.

Background: The increasing economization of healthcare systems highlights the need to integrate health economics more systematically into medical education.

Objective: This study examines the perspectives of deans of German medical faculties on the integration of health economics content into medical studies. It also focuses on determining their ideas about suitable teaching formats and identifying potential obstacles to implementation.

Benign Mesenchymal Tumor of the Vulva: A Case Report and Narrative Review of the Literature.

Acrochordons are benign skin neoplasms that originate from mesenchymal and ectodermal tissues. These lesions are commonly found in regions of the skin that experience friction or folding. This report presents a 48-year-old female patient who exhibited a 3 cm acrochordon located on the right labia majora of her vulva.

Electrospun Polymeric Composite Fibers Containing Te-Doped Bioactive Glass Powders.

In this work, the electrospinning technique was used to prepare novel polymeric composite fibers containing Te-doped bioactive glass powders. Bioactive glass powders containing tellurium (STe5 glass) were chosen as fillers for the composites, owing to their bioactive, antibacterial, and antioxidant properties. The biopolymer poly (ϵ-caprolactone) (PCL) and acetic acid (AA) were used as raw materials for the preparation of the polymeric matrix.

In Vivo Wear Analysis of Leucite-Reinforced Ceramic Inlays/Onlays After 14 Years.

Material wear significantly impacts the clinical success and longevity of dental ceramic restorations. This in vivo study aimed to assess the wear behavior of IPS Empress glass-ceramic inlays and onlays over 14 years, considering the influence of different antagonist materials. Fifty-four indirect restorations of 21 patients were available for comprehensive wear analysis, with complete follow-up data for up to 14 years.

The expanding family of ALK-rearranged Mesenchymal Neoplasms.

The increasing use of next generation sequencing (NGS) technologies has resulted in a rapid increase in molecularly defined mesenchymal entities and enabled molecular characterization of existing phenotypically defined entities. These recent developments have expanded the clinicopathological spectrum of ALK-rearranged neoplasia, at same time highlighting a wide array of non-ALK fusions in many ALK immunoreactive neoplasms. This led to emergence of an "ALK vs.

Mesoporous bioactive glass nanoparticles exhibit intrinsic angiogenic potential in the chorioallantoic membrane assay, without the addition of exogenous cells.

Angiogenesis is an essential part of bone regeneration, as neovascularisation supports the supply of necessary oxygen, nutrients, and cellular transport. Bioactive glasses (BGs) have shown promise in enhancing both angiogenesis and bone regeneration. For the evaluation of the angiogenic potential of BGs, the chorioallantoic membrane (CAM) assay constitutes an attractive experimental model and has already gained increasing attention in BG-focused research.

Machine Learning Classification of Smoking Behaviours-From Social Environment to the Prefrontal Cortex.

The pronounced heterogeneity in smoking trajectories-ranging from occasional or heavy use to successful quitting -highlights substantial interindividual variation within the smoking population. Machine learning is particularly well suited to capture these complex patterns that may be challenging for traditional inferential statistics to uncover. In this study, we applied machine learning to data from a population-based cohort to identify multimodal markers that distinguish smokers from never smokers at baseline and predict long-term cessation success at a 10-year follow-up.

Multifunctional role of Lactoferrin in metal ion interactions and biomedical applications: A review.

Lactoferrin (Lf) is a multifunctional glycoprotein of the transferrin family that plays a crucial role in iron metabolism, immune regulation, and antimicrobial defense. This review explores the structural properties and metal-binding mechanisms of lactoferrin, highlighting its interactions with various metal ions including manganese, silver, zinc, copper, bismuth, vanadium, and lanthanides. These interactions occur through specific coordination at traditional iron-binding sites as well as via nonspecific surface interactions and redox-based mechanisms.

Evaluation of Ultra-High Molecular Weight Polyethylene (UHMWPE) Implants in Orbital Fracture Reconstruction: A Multicenter Cohort Study.

Purpose: Orbital wall reconstruction remains a challenge in reconstructive CMF surgery due to the delicate anatomical structures and their potential functional impairment due to inefficient treatment. The use of biomaterials in reconstructive surgery has revolutionised the therapy in this area. Ultra-high molecular weight polyethylene (UHMWPE) has shown promising results due to its biocompatibility, mechanical properties, and versatility.

Chitosan/Bioactive Glass Microparticles Enriched with Therapeutic Metal Ions for Bone Tissue Engineering.

The application of divalent bioactive metal ions, such as Cu, Zn, and Mn, emerges as a growth factor-free approach for bone defect regeneration. Delivery of those ions can be achieved by organic or inorganic phases through desirable rapid or sustainable release in order to stimulate specific cell responses. In this work, bioactive ions were incorporated into both phases, chitosan (Cht), via chelation reactions, and mesoporous bioactive glass nanoparticles (MBGNs), by doping.