Bronchiectasis in France: data on disease characteristics in 630 patients from the European Bronchiectasis registry (EMBARC).

Background: Little is known about the characteristics of adults with bronchiectasis in France.

Methods: A descriptive cross-sectional study was conducted to describe the characteristics of adults (≥18 years) with clinically-significant bronchiectasis, diagnosed on a combination of respiratory symptoms and CT scan findings, and followed in 18 participating centers. Data on, etiology, lung function, symptoms, microbiology, treatments and quality of life were collected.

Paternal factors affecting under-five immunization status in Sub-Saharan Africa: A systematic review and meta-analysis.

While maternal influences on childhood immunization have been extensively studied in sub-Saharan Africa (SSA), paternal socioeconomic factors remain underexplored despite their potential impact on vaccination outcomes. This systematic review and meta-analysis aimed to synthesize current evidence on the influence of paternal characteristics on full childhood immunization status in SSA. A comprehensive literature search was conducted in PubMed, Google Scholar, Embase, and Scopus for studies published between January 2014 and March 2025.

Longitudinal patterns and predictors of COVID-19 vaccine confidence from pre-vaccine rollout to mass vaccination: A population-based cohort study.

Background: Vaccine confidence is crucial for achieving high vaccination rates against COVID-19, yet vaccine confidence varied significantly throughout the pandemic. This study assessed the trajectories and predictors of COVID-19 vaccine confidence from prior to the vaccine rollout to mass vaccination.

Methods: It is a population-based cohort study with nine waves of longitudinal data from September 2020 to February 2023, spanning the pre-vaccine rollout to COVID-19 mass vaccination in Hong Kong.

Worldwide researches on broiler breeders: A 25-year bibliometric review.

The poultry industry plays a key role in meeting global protein needs amid changing demographics and lifestyles, and is constantly growing and evolving. Genetic selection and optimization of broiler breeder flocks have been key drivers of growth, making the maintenance of their health and performance essential both for chick production and for the long-term sustainability of the industry. Despite the high importance of broiler breeder flocks, no systematic bibliometric study has yet been conducted that specifically focuses on research in this area.

Calprotectin and neurofilament serum levels correlate with treatment response in myasthenia gravis under intensified therapy-A pilot study.

Objective: New therapeutic options have recently emerged for patients with highly active, acetylcholine receptor antibody-positive (AChR-Ab) generalized myasthenia gravis (gMG), including fast-acting, endplate-protective agents such as complement C5 inhibitors (C5-I) and neonatal Fc receptor inhibitors (FcRn-I). However, objective biomarkers beyond clinical scoring systems are lacking to guide individualized treatment decisions.

Methods: In this exploratory, prospective real-world study, we assessed serum calprotectin (sCLP) and serum neurofilament light chain (sNfL) levels in a total of 22 AChR-Ab gMG patients, who were treatment-naïve for either C5-I or FcRn-I.

Trends in cell collection and apheresis practices: Insights from a cross-sectional study on the use of Spectra Optia in collection and transplant centers.

Background: This study, conducted among collection and transplant centers in France, Germany, Japan, the United Kingdom (UK), and the United States (USA), aimed to better understand current trends, challenges, and future directions in cell collection and apheresis practices, focusing on the Spectra Optia™ Apheresis System.

Methods: This cross-sectional study was conducted from July to November 2023 among facilities using the Spectra Optia™ Apheresis System, which could also be using other comparable cell collection technologies, with expertise in cell collection and therapeutics. Respondents completed an online questionnaire.

Chemical forensic profiling of compounds related to the chemical weapons convention using 2D and 3D diffusion-ordered NMR spectroscopy.

The ongoing use of chemical warfare agents (CWAs) in conflicts, assassinations, and terrorist attacks means that the detection and identification of these compounds are crucial. The forensic identification of organophosphorus nerve agents (OPNAs) and their precursors and degradation products remains challenging due to the destructive nature and extensive preparation required for conventional chromatographic methods. In this study, we characterise precursor and degradation products of Novichok analogues, including 1,1,3,3-tetramethylguanidine, N,N-diethylpentanimidamide, N,N-dipropylbutanimidamide, using 2D ¹H-¹³C heteronuclear multiple quantum coherence (HMQC) NMR.

A nationwide forensic case-series of femicides in Italy - Part 1: Clues to the motives of the murder.

Understanding the motives behind femicides is crucial to design effective prevention strategies and to support women's self-determination, free from threats to their mental and physical integrity. We conducted a retrospective, multicenter forensic study involving 27 Italian Institutes of Legal Medicine, analyzing 1238 female homicides (1950-2023). Cases were classified as femicide or non-femicide female homicide according to the medico-legal definition of femicide as the murder due to the failure to recognize women's right to self-determination.

Antifungal profile of menadione tethered to 1H-1,2,3-triazolyl-selenoester: synthesis, in vitro and in silico analyses.

Invasive Candidiasis infections are a clinical challenge, with limited effective therapeutic agents and increasing resistance. The discovery of new antifungal agents is urgently required. Here, we developed a new series of 2-methyl-1,4-naphthoquinone (Menadione) Tethered to 1H-1,2,3-triazolyl-selenoester in good yields, which exhibit antifungal potential activity against Candida species.

Cirsiliol confers cardio-protection against sunitinib induced cardiotoxicity via synergistic modulation of SIRT1/FOXO3a and endothelin axis: A biochemical, histopathological, and computational experimentation.

Cardiotoxicity remains a major clinical challenge associated with various environmental and chemotherapeutic toxicants. Sunitinib (SNB) is a potent targeted cancer drug that is reported to induce severe organ damage including renal failure. Cirsiliol (CSL) is a natural flavone that exhibits marvelous pharmacological properties.

Microwave Spectroscopy and Structure of the 1-Fluoronaphthalene···HO Complex: Two Hydrogen Bonds Make the Complex a Rigid Rotor.

The microwave spectrum of the complex formed between 1-fluoronaphthalene and HO has been recorded using a chirped pulse Fourier transform microwave spectrometer within the frequency range of 2.0 to 8.0 GHz, with neon as the carrier gas.

Principles of Industry-Academic Partnerships Informed by Digital Mental Health Collaboration: Mixed Methods Study.

Background: Cross-sector collaboration is increasingly recognized as essential for addressing complex health challenges, including those in mental health. Industry-academic partnerships play a vital role in advancing research and developing health solutions, yet differing priorities and perspectives can make collaboration complex.

Objective: This study aimed to identify key principles to support effective industry-academic partnerships, from the perspective of industry partners, and develop this into actionable guidance, which can be applied across sectors.

Correction: Factors Affecting the Receptiveness of Chinese Internists and Surgeons Toward Artificial Intelligence-Driven Drug Prescription: Protocol for a Systematic Survey Study.

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Understanding and Addressing Challenges With Electronic Health Record Use in Gynecological Oncology: Cross-Sectional Survey of Multidisciplinary Professionals in the United Kingdom and Co-Design of an Integrated Informatics Platform to Support Clinical Decision-Making.

Background: Electronic health records (EHRs) are a cornerstone of modern health care delivery, but their current configuration often fragments information across systems, impeding timely and effective clinical decision-making. In gynecological oncology, where care involves complex, multidisciplinary coordination, these limitations can significantly impact the quality and efficiency of patient management. Few studies have examined how EHR systems support clinical decision-making from the perspective of end users.

Marburg Virus Disease in Rwanda, 2024 - Public Health and Clinical Responses.

Background: On September 27, 2024, Rwanda reported an outbreak of Marburg virus disease (MVD), after a cluster of cases of viral hemorrhagic fever was detected at two urban hospitals.

Methods: We report key aspects of the epidemiology, clinical manifestations, and treatment of MVD during this outbreak, as well as the overall response to the outbreak. We performed a retrospective epidemiologic and clinical analysis of data compiled across all pillars of the outbreak response and a case-series analysis to characterize clinical features, disease progression, and outcomes among patients who received supportive care and investigational therapeutic agents.

Chronic Cough Hypersensitivity as a Neuropathic Disorder: Implications for Management and New Treatments.

Chronic cough can coexist with or without pulmonary and extrapulmonary conditions and can be refractory to therapies that improve these associated conditions. It is underlined by cough hypersensitivity, which is characterized by increased cough responses to stimuli that affect the airways and vagally innervated tissues as well as by excessive cough responses to innocuous stimuli, and it is caused by neuroinflammatory and neuropathic mechanisms at both peripheral and central levels. The management of chronic cough starts with exclusion of associated conditions, followed by use of neuromodulators and speech and language therapy.

The PROtective VEntilation (PROVE) Network - advancing research and collaboration in mechanical ventilation.

The PROtective VEntilation (PROVE) Network is a globally-recognized collaborative research group dedicated to advancing research, education, and collaboration in the field of mechanical ventilation. Established to address critical questions in intraoperative and intensive care ventilation, the network focuses on improving outcomes for patients undergoing mechanical ventilation in diverse settings, including operating rooms, intensive care units, burn units, and resource-limited environments in low- and middle-income countries. The PROVE Network is committed to generating high-quality evidence through a comprehensive portfolio of investigations, including randomized clinical trials, observational research, and meta-analyses.

Bacterial infections and antimicrobial resistance patterns: a comprehensive analysis of health dynamics across regions in Pakistan (2013-2023).

Antimicrobial resistance (AMR) is a significant public health concern globally, and Pakistan is no exception. The misuse and overuse of antibiotics, inadequate regulation of their sale, and a lack of awareness contribute to the rising levels of AMR in the country. study presents a detailed analysis of blood and urine samples collected in Pakistan over various periods, focusing on pathogen prevalence, gender distribution, and age-wise patterns.

Age-Stratified Reference Ranges for Directly Measured Serum Free Testosterone in Community-Dwelling and Healthy Men.

Context: Direct measurement of serum free testosterone (FT) may help evaluate hypogonadism in men. However, up to present, availability of reference ranges for measured FT (mFT) is limited.

Objective: To establish age-stratified reference ranges for mFT in healthy and community-dwelling adult men.

Febrile temperature augments ring-stage Plasmodium falciparum adhesion to brain endothelial cells.

Sequestration of Plasmodium falciparum-infected erythrocytes (IE) in the microvasculature is a major virulence determinant. While the sequestration of mature stage parasites (trophozoite and schizonts) to vascular endothelium is well established, the conditions that promote ring-stage IE sequestration is less understood. Here, we observed in ring-stage parasites that febrile exposure increased transcript levels of several exported parasite genes involved in the trafficking of the P.

Imaging Valence Electron Rearrangement in a Chemical Reaction Using Hard X-Ray Scattering.

We have observed the signatures of valence electron rearrangement in photoexcited ammonia using ultrafast hard x-ray scattering. Time-resolved x-ray scattering is a powerful tool for imaging structural dynamics in molecules because of the strong scattering from the core electrons localized near each nucleus. Such core-electron contributions generally dominate the differential scattering signal, masking any signatures of rearrangement in the chemically important valence electrons.

Assessing Cosmological Evidence for Nonminimal Coupling.

The recent observational evidence of deviations from the Lambda cold dark matter model points toward the presence of evolving dark energy. The simplest possibility consists of a cosmological scalar field φ, dubbed "quintessence," driving the accelerated expansion. We assess the evidence for the existence of such a scalar field.

Positive Neutrino Masses with DESI DR2 via Matter Conversion to Dark Energy.

The Dark Energy Spectroscopic Instrument (DESI) is a massively parallel spectroscopic survey on the Mayall telescope at Kitt Peak, which has released measurements of baryon acoustic oscillations determined from over 14 million extragalactic targets. We combine DESI Data Release 2 with CMB datasets to search for evidence of matter conversion to dark energy (DE), focusing on a scenario mediated by stellar collapse to cosmologically coupled black holes (CCBHs). In this physical model, which has the same number of free parameters as ΛCDM, DE production is determined by the cosmic star formation rate density (SFRD), allowing for distinct early- and late-time cosmologies.