Ninety-day surgery-related outcomes of laparoscopic hysterectomy, bilateral salpingo-oophorectomy and sentinel node mapping in apparent early-stage endometrial cancer: a secondary analysis of a prospective single-arm study.

Objective: Limited prospective data are available on the outcomes and performance of sentinel node mapping (SNM) in patients with endometrial cancer (EC). This study aimed to describe the surgical outcomes related to laparoscopic staging and the performance of SNM in patients with apparent early-stage EC.

Methods: This is a secondary analysis of a prospective single-arm study focusing on predictors of nodal disease in apparent early-stage EC.

Design aspects for prognostic factor studies.

Prognostic research is clinically relevant and ultimately facilitates stratified medicine. However, its quality and output are limited. More guidance is needed to improve understanding and thus quality.

Effects of Nighttime Eating Behavior on Cardiometabolic Health and Sleep: A Crossover Study.

Background And Aims: The impact of night-eating behavior (NEB) on metabolic health remains underexplored, particularly in healthy populations. We have hypothesized that NEB adversely affects metabolic parameters, liver function, and sleep via circadian disruption and neurohormonal alterations.

Methods And Results: In this single-center crossover study, sixteen healthy adults (aged 18-35 years) with no comorbidities, no medication use, and a body mass index between 18 and 30 kg/m participated in two one-week dietary regimens: regular eating (no food after 7:30 p.

Risk differences and underlying factors of cardiovascular events and mortality in patients with type 2 diabetes versus type 1 diabetes: a longitudinal cohort study of Swedish nationwide register data.

Background: Despite improvements in diabetes care and risk factor management, the residual risk for cardiovascular disease and premature death remains substantially elevated in people both with type 1 and type 2 diabetes. This study aimed to compare the risk of cardiovascular disease and mortality, as well as the contibution of underlying risk factors, between type 1 and type 2 diabetes.

Methods: In this nationwide, population-based cohort study, all living people with diabetes aged 18-84 years reported in the Swedish National Diabetes Register (NDR) by Jan 1, 2016, were followed-up over a period of 5 years until Dec 31, 2020.

Exploring the definitions of gender bias in healthcare literature: a scoping review protocol.

Introduction: Despite growing recognition of gender bias in healthcare, there is a lack of clarity on how gender bias is defined and understood in the literature. Existing definitions often did not consider modern gender constructs, limiting their applicability to current healthcare practices. In order to address these issues, we aim to perform a scoping review (ScR) to systematically explore what definitions and which characteristics of gender bias are found in the literature.

Bortezomib-melphalan-prednisone versus lenalidomide-dexamethasone in elderly patients with multiple myeloma: the Real MM phase IV trial.

Not available.

Long term fluid volume fluctuations and mortality in kidney failure patients on long term hemodialysis treatment.

Background: The prognosis for kidney failure (KF) patients on long-term hemodialysis is poor, with fluid overload being a significant modifiable risk factor for mortality. Previous studies have focused on static measurements of fluid status, but the impact of long-term fluid fluctuations on clinical outcomes has not been thoroughly investigated.

Methods: We studied a cohort of 9,178 incident KF patients at Fresenius NephroCare dialysis centers across seven countries in Europe and the Middle East.

Assessing vaccination intentions and perceptions among pregnant women in Italy: A multicenter cross-sectional study in the context of mandatory policies and the COVID-19 pandemic.

Background/objectives: Vaccinations significantly reduce the incidence of preventable diseases. Despite their benefits, childhood vaccination rates have declined in Italy since the mid-2010s, prompting the government to mandate certain vaccinations. This cross-sectional study aims to assess the intention to vaccinate their children and the perception of mandatory vaccinations among pregnant women in Italy after the COVID-19 pandemic and post-mandatory vaccination policies.

The impact of intensive care strain on patients' outcomes-a multinational observational cohort (UNITE-COVID) study.

Purpose: Intensive care unit (ICU) strain is associated with increased mortality. Most strain metrics focus on 'simple' measures such as bed occupancy or admission rates. There is limited data on mitigation strategies, such as procedure teams or staff well-being services on strain, or the impact of increased patient-to-nurse ratios and non-ICU trained nurses working in ICU.

Triglyceride-glucose index threshold for cardiovascular mortality in hypertensive individuals - URRAH project.

Aims: The triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance (IR). Data regarding this topic is constantly increasing, however, few and heterogeneous data are available on the relationship between this index and cardiovascular mortality risk in hypertensive populations. In this context, we aimed to explore the relationship between TyG and cardiovascular mortality in a large sample of hypertensive individuals from the URRAH cohort.

Accuracy of ChatGPT-3.5, ChatGPT-4o, Copilot, Gemini, Claude, and Perplexity in advising on lumbosacral radicular pain against clinical practice guidelines: cross-sectional study.

Introduction: Artificial Intelligence (AI) chatbots, which generate human-like responses based on extensive data, are becoming important tools in healthcare by providing information on health conditions, treatments, and preventive measures, acting as virtual assistants. However, their performance in aligning with clinical practice guidelines (CPGs) for providing answers to complex clinical questions on lumbosacral radicular pain is still unclear. We aim to evaluate AI chatbots' performance against CPG recommendations for diagnosing and treating lumbosacral radicular pain.

Platelet transfusion practice in the intensive care unit: the Nine-I international platelet transfusion survey.

Background: Platelet transfusions are frequent in the Intensive Care Unit (ICU), either as prophylaxis against bleeding complications or as treatment for bleeding. The European Society of Intensive Care Medicine guidelines for ICU patients generally recommend not using prophylactic platelet transfusions unless the platelet count falls below 10 × 10 cells/L in non-bleeding patients and make no recommendation for platelet transfusion threshold in non-massively bleeding patients with thrombocytopenia. Therefore, the decision to transfuse platelets is often left to clinical assessment by the treating physician.

The prevalence of polypharmacy increases with age among patients with inflammatory bowel disease: A nationwide cohort study.

Aims: Polypharmacy is common in adult patients with inflammatory bowel disease (IBD). This study aims to quantify medication prescriptions and estimate the risk of polypharmacy over time in older adults with IBD.

Methods: In a nationwide cohort of adult incident IBD patients from 1 April 1996, to 31 December 2019, we examined medication prescriptions across calendar years among young adults (18-39 years), adults (40-59 years), older adults (60-79 years) and oldest adults (≥80 years).

Implementation of an enhanced recovery after surgery (ERAS) program in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: study protocol for a prospective multicenter interventional trial (EPICH study).

Objectives: This study aims to evaluate the clinical impact of introducing an Enhanced Recovery After Surgery (ERAS) protocol in the management of patients undergoing cytoreductive surgery (CRS), with or without hyperthermic intraperitoneal chemotherapy (HIPEC). By addressing a population at high risk of postoperative complications and delayed recovery, the study seeks to determine whether ERAS can improve short-term outcomes, optimize perioperative care, and promote faster and safer recovery in a standardized, evidence-based manner across multiple centers.

Methods: The EPICH study is a multicenter, prospective, interventional trial conducted across 20 centers in Italy.

Alteration of Lipid Metabolism in Patients with IPF and Its Association with Disease Severity and Prognosis: A Case-Control Study.

The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves complex interactions between epithelial, mesenchymal, immune, and endothelial cells, often aggravated by lipid metabolism dysfunction, mitochondrial, and peroxisomal abnormalities. Changes in lipid metabolism may drive fibrotic processes, suggesting the potential of lipid biomarkers for disease monitoring. We compared here the cholesterol metabolism and very-long-chain fatty acid profiles of patients with IPF with healthy controls.

Survey of Patient Understanding and Satisfaction in Glaucoma Filtering Surgery.

Objectives: To assess patients' understanding of glaucoma surgery and their postoperative satisfaction, to study the factors that may influence them, and to investigate correlations between these 2 determining factors.

Design: A multicenter observational study.

Subjects: Patients scheduled for glaucoma filtration surgery were included.

Incidence of spine-related diagnoses in Danish children: a nationwide registry-based study of hospital data.

Unlabelled: This study investigated the annual incidence rates of spine-related hospital diagnoses in Danish children aged 0-17 years from 2009 to 2021. It aimed to assess trends stratified by diagnostic groups, hospital departments, and residential regions. A nationwide register-based cohort study was conducted using data from the Danish National Patient Register and census data.

Cross-lagged analysis in nephrology.

Cross-lagged analysis is a statistical method employed to examine directional relationships between variables over time, making it especially valuable for addressing causality challenges in clinical research. This method is essential for comprehending complex bidirectional relationships, such as stress and immunity, dietary habits and metabolic conditions, or medication adherence and health outcomes. By analyzing longitudinal data, cross-lagged analysis establishes temporal precedence, tests reciprocal influences, and controls for confounding variables, thereby enhancing causal inferences.

Insights on the User Experience and Feasibility of an Electromyography-Driven Exergame Combined With Blood Flow Restriction for Strength Training in Hospitalized Older Adults: Mixed Methods Randomized Controlled Feasibility Study.

Background: Hospitalized older adults often spend prolonged periods of time bedridden, leading to decreased muscle strength and function. To tackle this, rehabilitation aims to keep patients active and train affected muscles. Exergames have proven to be effective in the rehabilitation of different patient populations and offer a motivating solution to combat inactivity associated with hospitalization.

Adequacy of the Diagnostic Workup of Suspected Physical Abuse in Young Children: An Audit in the Paris Metropolitan Area.

Objective: An adequate diagnostic workup of suspected child physical abuse (CPA) is crucial for an accurate diagnosis and to consider differential diagnoses. We aimed to audit the actual practices in Paris area hospitals and evaluate their adherence to current clinical guidelines.

Methods: We used specific discharge codes suggesting CPA in the Assistance Publique-Hôpitaux de Paris clinical data warehouse to identify cases of young children <2 years old hospitalized for suspected CPA in 2018-19 in 7 university hospitals.

Irritable Bowel Syndrome with Diarrhea (IBS-D): Effects of CBM588 Probiotic on Gastrointestinal Symptoms, Quality of Life, and Gut Microbiota in a Prospective Real-Life Interventional Study.

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional gastrointestinal disorder characterized by altered motility, abdominal pain, and dysbiosis-particularly reduced biodiversity and a lower abundance of butyrate-producing bacteria. Strategies that modulate the gut microbiota may offer therapeutic benefit. () CBM588 is a butyrate-producing probiotic with immunomodulatory properties and potential efficacy in treating gastrointestinal disorders.