Human papillomavirus: problems and prospects for women's reproductive health (systematic review).

Objective: Aim: To consider the specific activity of drops and suppositories of PROTEFLAZID® at the stage of preclinical study, to assess the effectiveness and safety of use in clinical practice in papillomavirus-associated diseases of the female reproductive system..

Patients And Methods: Materials and Methods: Analysis of scientific publications on the treatment of palilomavirus infection with PROTEFLAZID® in women over the past decade.

The national health service of Ukraine as a purchaser of medical services and medicines under the medical guarantees programme during martial law.

Objective: Aim: To analyse the effectiveness of the National Health Service of Ukraine, which performs the functions of a purchaser of medical services and medicines under the Medical Guarantees Programme during wartime, as well as to identify and characterise the key challenges it faces and to propose effective solutions based on statistical data and comparative analysis concerning the provision of high-quality and effective medical care to the population, along with suggesting the development of promising directions for improving the performance of the National Health Service..

Patients And Methods: Materials and Methods: Retrospective, analytical, and modelling methods were used to assess the main processes related to the activities of the National Health Service of Ukraine as a key actor in the financing of medical services within the healthcare system under martial law conditions in Ukraine.

Protection of the rights of drug addicts and the right to a fair trial: Practice of the European court of human rights.

Objective: Aim: To identify violations of the rights of persons who use psychoactive substances through the analysis of decisions of the European Court of Human Rights within the framework of the implementation of the right to a fair trial in cases related to illicit drug trafficking, and to propose directions for reducing their negative impact on public health..

Patients And Methods: Materials and Methods: The methodological basis of the article is a set of methods and techniques of scientific knowledge.

Practical application of motivation theories for engaging and retaining medical staff.

Objective: Aim: To provide a scientific rationale for various approaches to the practical application of individual motivation theories in order to develop a motivated medical workforce as the foundation for strengthening healthcare systems.

Patients And Methods: Materials and Methods: Based on comparative analysis, as well as systematic and analytical approaches to understanding selected motivation theories - namely Maslow's Hierarchy of Needs, Herzberg's Two-Factor Theory, Adams's Equity Theory, Vroom's Expectancy Theory, and Deci and Ryan's Self-Determination Theory - the authors propose integrating these theories into managerial strategies.

Conclusion: Conclusions: A well-functioning healthcare workforce system requires not only a sufficient number of professionals but also effective motivation strategies based on various theories, such as those by Maslow, Herzberg, and Vroom, to enhance job satisfaction and retention.

Morphological features of the great saphenous vein in patients with chronic venous disease of the lower extremities undergoing the most common endovenous treatment techniques.

Objective: Aim: The purpose was to identify the morphological features of the great saphenous vein in patients with chronic venous disease of the lower extremities undergoing treatment with endovenous high-frequency electric welding in automatic mode, endovenous laser ablation, and ultrasound-guided microfoam sclerotherapy.

Patients And Methods: Materials and Methods: The material for the comprehensive morphological study consisted of fragments of the great saphenous vein obtained from 32 patients with chronic venous disease of the lower extremities. The material was divided into three groups according to the endovenous treatment techniques applied.

Rational nutrition as a factor of healthy lifestyle and prevention of chronic non-communicable diseases.

Objective: Aim: The aim is to conduct medical and sociological research on public awareness of the impact of rational nutrition on promoting human health and preventing chronic non-communicable diseases.

Patients And Methods: Materials and Methods: The research was conducted in 2022-2024 and involved 214 respondents of different ages and genders who were patients of outpatient clinics in Zhytomyr (Ukraine). Research methods included theoretical analysis of literary sources, medical and sociological (questionnaire), mathematical and statistical, system analysis, and logical generalization.

Analysis of the work of the inpatient military hospital during the Russian-Ukrainian war.

Objective: Aim: The aim of this work is to analyze the provision of medical care to military personnel on the example of the activities of the Poltava Military Hospital (Poltava, Ukraine) for the period 2021-2023.

Patients And Methods: Materials and Methods: The design of our study was descriptive. During the research, the reporting and accounting documentation of the Poltava Military Hospital for the relevant years was used.

Coronavirus disease 2019 (Covid-19) during pregnancy: Pathomorphological changes in the terminal villi of the placenta.

Objective: .Aim: To investigate the pathomorphological changes in the terminal chorionic villi during COVID-19 in pregnant women.

Patients And Methods: Materials and Methods: A total of 123 placentas were studied in cases of live term births (groups І) and antenatal asphyxia (groups ІІ).

Prevention of pseudoexfoliation glaucoma in patients with age-related cataract in the background of pseudoexfoliation syndrome.

Objective: Aim: To evaluate the possibility of using cataract phacoemulsification with simultaneous intraocular lens (IOL) implantation in patients with age-related cataract (ARC) combined with pseudoexfoliation syndrome (PES) as an algorithm for the pseudoexfoliation glaucoma (PEG) prevention..

Patients And Methods: Materials and Methods: A retrospective case-control study was conducted using data from medical records of 610 outpatients (813 eyes) with ARC aged from 49 to 79 years (average age 69 ± 3 years).

The peculiarities of biochemical and morphological changes in the heart of the rats under chronic hypodynamia in the development of adrenalin damage of heart.

Objective: Aim: To evaluate the state of oxidation processes and morphological changes in the heart of rats with chronic hypodynamia during the development of epinephrine heart damage (EHD)..

Patients And Methods: Materials and Methods: The study was performed on 144 white male Wistar rats.

Digital differential diagnostics of thyroid pathology by interference scanning of ellipticity polarization maps of microscopic images of native histological sections.

Objective: Aim: To find out new objective criteria for laser histological differential diagnosis of thyroid pathology based on the use of a digital method of layer-by-layer polarization-interference mapping of polarization ellipticity maps of microscopic images of native histological sections of thyroid biopsy.

Patients And Methods: Materials and Methods: Four groups of patients were studied: control group 1 - healthy donors (51 patients); study group 2 - patients with nodular goiter (51 patients); study group 3 - patients with autoimmune thyroiditis (51 patients); study group 4 - patients with papillary cancer (51 patients). Methods used: polarization-interference, statistical.

Probing the Quantum Capacitance of Rydberg Transitions of Surface Electrons on Liquid Helium via Microwave Frequency Modulation.

We present a method for probing the quantum capacitance associated with the Rydberg transition of surface electrons on liquid helium using radio-frequency (rf) reflectometry. Resonant microwave excitation of the Rydberg transition induces a redistribution of image charges on capacitively coupled electrodes, giving rise to a quantum capacitance originating from adiabatic state transitions and the finite curvature of the energy bands. By applying frequency-modulated resonant microwaves to drive the Rydberg transition, we systematically measured a capacitance sensitivity of 0.

Evidence for Similar Collectivity of High Transverse-Momentum Particles in p-Pb and Pb-Pb Collisions.

Charged hadron elliptic anisotropies (v_{2}) are presented over a wide transverse momentum (p_{T}) range for proton-lead (pPb) and lead-lead (PbPb) collisions at nucleon-nucleon center-of-mass energies of 8.16 and 5.02 TeV, respectively.

1/5 and 1/3 Magnetization Plateaux in the Spin 1/2 Chain System YbAlO_{3}.

Quasi-one-dimensional magnets can host an ordered longitudinal spin-density wave state (LSDW) in magnetic field at low temperature, when longitudinal correlations are strengthened by Ising anisotropies. In the S=1/2 Heisenberg antiferromagnet YbAlO_{3} this happens via Ising-like interchain interactions. Here, we report the first experimental observation of magnetization plateaux at 1/5 and 1/3 of the saturation value via thermal transport and magnetostriction measurements in YbAlO_{3}.

Plasma-Tunable Metasurfaces for SERS Nanosensing of Hazardous Chemicals.

The demand for rapid, field-deployable detection of hazardous substances has intensified the search for plasmonic sensors with both high sensitivity and fabrication simplicity. Conventional approaches to plasmonic substrates, however, often rely on lithographic precision or complex chemistries limiting scalability and reproducibility. Here, a facile, one-step synthesis of vertically aligned 2D nanosheets composed of intergrown CuO/CuO crystallites is presented, fabricated via oxygen plasma discharge on copper substrates.

[Vascular anatomy and its variants in pancreatic surgery].

A profound understanding of pancreatic anatomy and its vascular supply is essential for safely performing complex surgical procedures such as pancreaticoduodenectomy. Historically, anatomical exploration began with Herophilos and Ruphos of Ephesos in ancient times, evolving through major surgical innovations by Wirsung, Kausch and Whipple. The pancreas is located secondarily retroperitoneally and therefore has a close relationship of the pancreatic head to the superior mesenteric artery (SMA) and portal vein (PV) and the celiac trunc.

Overall Survival with Amivantamab-Lazertinib in -Mutated Advanced NSCLC.

Background: Previous results from this phase 3 trial showed that progression-free survival among participants with previously untreated (epidermal growth factor receptor)-mutated advanced non-small-cell lung cancer (NSCLC) was significantly improved with amivantamab-lazertinib as compared with osimertinib. Results of the protocol-specified final overall survival analysis in this trial have not been reported.

Methods: We randomly assigned, in a 2:2:1 ratio, participants with previously untreated -mutated (exon 19 deletion or L858R substitution), locally advanced or metastatic NSCLC to receive amivantamab-lazertinib, osimertinib, or lazertinib.

Lipid-based nanoparticles: advancing therapeutic strategies for vitiligo management.

Vitiligo, a chronic autoimmune disorder characterized by the presence of depigmented skin patches, remains a therapeutic challenge due to its multifactorial pathogenesis and the absence of highly effective treatment options. Although the exact etiology of vitiligo is not fully understood, factors such as genetic factors, oxidative stress, autoimmunity, and inflammation are implicated in the destruction of melanocytes. Current therapeutic strategies primarily focus on modulating immune responses and alleviating oxidative stress.

Retraction notice to "Fertilization value of municipal sewage sludge for plants" [Biotechnology Reports 13 (2017) 8-12].

[This retracts the article DOI: 10.1016/j.btre.

Pain, Agitation, Delirium, and Iatrogenic Withdrawal Syndrome Management in Children Who Are Critically Ill: Protocol for a European Clinical Practice Guideline Using the Grading of Recommendations Assessment, Development, and Evaluation Approach.

Background: In pediatric intensive care units, pain, sedation, delirium, and iatrogenic withdrawal syndrome (IWS) must be managed as interrelated conditions. Although clinical practice guidelines (CPGs) exist, new evidence needs to be incorporated, gaps in recommendations addressed, and recommendations adapted to the European context.

Objective: This protocol describes the development of the first patient- and family-informed European guideline for managing pain, sedation, delirium, and IWS by the European Society of Paediatric and Neonatal Intensive Care.

Effects of apigenin on the function of human α7-nicotinic acetylcholine receptors expressed in oocytes.

The effects of apigenin, a plant flavonoid, were investigated using the two-electrode voltage-clamp technique on the function of the cloned α7 subunit of the human nicotinic acetylcholine (α7-nACh) receptor expressed in oocytes. Currents induced by ACh (100 μM) were reversibly potentiated by apigenin with an EC value of 5.4 µM in a voltage-independent manner.

Unpacking the Mystery of the Ontario Healthcare System in Canada: Ukrainian Temporary Migrants and Healthcare System Navigation.

BackgroundIn response to the full-scale Russian invasion of Ukraine, the Government of Canada welcomed thousands of temporary migrants under the Canada-Ukraine Authorization for Emergency Travel (CUAET) program. Ukrainian temporary migrants who are settled in Ontario experience acute, chronic, and complex health issues, creating additional demand upon the healthcare system. Despite a collective awareness of difficulty in accessing existing healthcare resources, little is known about how Ukrainian temporary migrants experience and utilise the Ontario healthcare system.

Opioid agonist therapy for opioid use disorder in primary versus specialty care.

Background: Opioid use disorder (OUD) is commonly treated in specialized care settings with long-acting opioid agonists, also known as opioid agonist therapy, or OAT. Despite the rise in opioid use globally and evidence for a 50% reduction in mortality when OAT is employed, the proportion of people with OUD receiving OAT remains small. One initiative to improve the access and uptake of OAT could be to offer OAT in a primary care setting; primary care clinics are more numerous, might reduce the visibility and potential stigma of receiving treatment for OUD, and may facilitate the care of other medical conditions that are unrelated to OUD.

Wound infection and pain one month after trauma: an underestimated threat.

Background: Pain is a common complication after combat injuries to the extremities. The role of nerve damage in the development of post-traumatic pain is recognized and described in the literature, superinfection as a potential factor has not been studied sufficiently.

Objective: To establish the relationship between the characteristics of the wound microbiota, the intake of different groups of antibiotics and the development of chronic pain in patients with traumatic injuries of the extremities.