Widely Distributed Pigeon Paramyxovirus Sub-Genotypes Pose a Risk to Immunocompromised Humans.

Introduction: Pigeon paramyxovirus type 1 (PPMV-1) is an antigenic variant of Avian Orthoavulavirus 1 (AOAV-1) (Newcastle disease virus) with a global distribution that causes lethal infections in pigeon and dove species. AOAV-1's infecting humans normally cause mild, self-limiting conjunctivitis, but since 2003, PPMV-1 has been associated with an increased number of severe and lethal respiratory and neurological infections in immunocompromised persons in the Netherlands, the USA, France, China and Australia.

Methods: PPMV-1's isolated from free-living pigeons and doves across South Africa from 2012 to 2024 were sequenced using conventional or next generation technologies.

The Impact of Family-Centered Care on Oral Health for Children With Special Health Care Needs.

Aim: To examine the association of family-centered care (FCC) with oral health indicators among children with special health care needs (CSHCN).

Methods: Data includes the CSHCN population from the 2017 to 2019 National Survey of Children's Health (NSCH). Four parent- and caregiver-reported binary oral health outcomes were assessed: preventive dental visits (PDVs), cavities, condition of teeth, and oral health problems.

A pilot study of the anatomical self-efficacy instrument for clinical clerkships (ASEI-CC).

Self-efficacy and anatomical knowledge have been shown to be important in the development of medical students. Validated instruments designed to measure the construct of anatomical self-efficacy during the clinical years of medical school are limited. In this study, the Anatomical Self-Efficacy Instrument for Clinical Clerkships (ASEI-CC) was developed, and evidence for the reliability of the scores and the validity of the interpretations of the scores was gathered.

Hyperreflective, Pyramidal-Like Lesions of the Outer Retina and Retinal Pigmented Epithelium in Non-Syphilitic Uveitis: A Case Series.

Purpose: To report pyramidal-like, hyperreflective changes of the outer retina and retinal pigmented epithelium (RPE) in three patients with an atypical non-syphilitic outer retinopathy.

Study Design/materials And Methods: Single institutional case series conducted at the National Eye Institute, National Institutes of Health.

Results: Hyperreflective, pyramidal lesions of the outer retina and RPE have been described in patients with syphilitic posterior segment uveitis.

Moyamoya Syndrome in Patients With Down Syndrome and Acute Lymphoblastic Leukemia.

Moyamoya syndrome (MMS) is a chronic vasculopathy characterized by progressive stenosis of intracerebral arteries, leading to an increased risk of stroke. Children with Down syndrome (DS) are at an increased risk of co-occurring medical conditions, including MMS and leukemia. We report four patients with the triad of DS, MMS, and acute lymphoblastic leukemia (ALL).

Impact of Childhood Neighborhood Deprivation on White Matter and Functional Connectivity During Adolescence.

Background And Purpose: Socioeconomic determinants of health impact childhood development and adult health outcomes. One key aspect is the physical environment and neighborhood where children live and grow. Emerging evidence suggests that neighborhood deprivation, often measured by the Area Deprivation Index (ADI), may influence neurodevelopment, but longitudinal and multimodal neuroimaging analyses remain limited.

Tumor-Specific Critical Intraoperative Findings Influence Multidisciplinary Therapy.

Background: Local control strategies in pediatric oncology are guided by disease-specific considerations. Effective communication of the goals of surgical procedure and associated intraoperative events plays a crucial role in shaping subsequent treatment decisions. However, accurately and comprehensively documenting these findings remains challenging, with considerable variability across different tumor types.

Predicting venous thromboembolism among hospitalized adults: a protocol for development and validation of an implementable real-time prognostic model.

Background: Hospital-acquired venous thromboembolism (HA-VTE) is a leading cause of morbidity and mortality among hospitalized adults. Numerous prognostic models have been developed to identify those patients with elevated risk of HA-VTE. None, however, has met the necessary criteria to guide clinical decision-making.

Tirzepatide for the Maintenance of Body Weight Reduction: Rationale, Design, and Baseline Characteristics of SURMOUNT-MAINTAIN.

Objective: SURMOUNT-MAINTAIN aims to evaluate the efficacy and safety of reducing the tirzepatide dose and/or continuing the maximum tolerated dose (MTD) versus placebo in maintaining body weight (BW) reduction achieved with tirzepatide MTD.

Methods: This Phase 3b, multicenter, randomized, parallel-arm, double-blinded, placebo-controlled, 52-week clinical trial is in progress comparing treatment with once weekly tirzepatide (5 mg and/or MTD of 15 mg or 10 mg) versus placebo in achieving BW reduction maintenance from the initial 60-week open-label weight-loss period on tirzepatide MTD, in adults with obesity (BMI ≥ 30 kg/m or ≥ 27 kg/m with ≥ 1 obesity-related comorbidity, excluding type 2 diabetes). The primary endpoint is percent maintenance of BW reduction achieved during the weight-loss period at Week 112 among those who reached a BW plateau (i.

Injectable contraceptive continuation and user experiences in Punjab, Pakistan: a non-randomized prospective cohort study protocol.

Background: Evidence from multiple pilots and post-introduction scale-up initiatives have demonstrated that self-administered subcutaneous depot-medroxyprogesterone acetate (DMPA-SC) has potential to improve contraceptive continuation rates and expand contraceptive access to populations with limited utilization of facility-based health services. Only a few of these studies have been conducted in South Asian countries, and none where most contraceptive use is of non-hormonal methods that require limited to no contact with the health system, leaving policymakers in countries like Pakistan with limited context-specific evidence to guide decisions on whether, how, and for whom to introduce DMPA-SC.

Methods: A prospective cohort study will be conducted in 41 health facilities and surrounding communities in Punjab, Pakistan.

Systematic approach to the post-Whipple CT: clinical cases and problem-solving strategies.

Pancreaticoduodenectomy, also known as the classic Whipple procedure, is the most common surgical treatment for pancreatic adenocarcinoma. Postoperative complications are common and occur in approximately 50% of patients. Prompt detection and management of these complications is vital for improving patient outcomes.

Clinical and social determinants of survivorship clinic attendance in head and neck cancer.

Purpose: Despite its importance, little is known about the patterns and predictors of Survivorship Clinic attendance in head and neck cancer (HNC). We sought to determine the cumulative incidence of Survivorship Clinic attendance stratified by demographic, clinical, and socioeconomic factors, and to identify factors independently associated with attendance.

Methods: Our analysis population consisted of 2,252 patients diagnosed with primary HNC and seen at our institution's HNC Survivorship Clinic after completing treatment from 2016-2021.

Ongoing pregnancy rate is associated with trigger-day progesterone level in letrozole/clomiphene intrauterine insemination cycles.

Purpose: Prior studies in fresh embryo transfer IVF cycles have associated elevated serum progesterone level on day of ovulatory trigger, particularly if ≥ 1.5 ng/ml, with decreased pregnancy rates. A similar association has been found in intrauterine insemination (IUI) cycles using gonadotropins for ovulation induction.

Hemoglobin levels and frailty status in generally healthy and active community-dwelling adults age 70 years and older in the three-year DO-HEALTH study.

While frailty and anemia are prevalent conditions in aging linked to adverse outcomes, their relationship remains understudied in generally healthy older adults. We conducted a post-hoc observational study among all participants of DO-HEALTH, the largest European clinical trial designed to support healthy aging. Our analysis examined whether baseline hemoglobin levels and anemia are associated with being at least pre-frail at baseline and any yearly follow-up time point over three years.

Associations between comorbid conditions with mild cognitive impairment and Alzheimer's disease by race-ethnicity and sex based on NACC data.

Introduction: We investigated the associations between diabetes (type 2), hypertension and hypercholesterolemia with mild cognitive impairment (MCI) and Alzheimer's disease (AD) diagnoses by race-ethnicity and sex.

Methods: Data (n = 22,950) were derived via the National Alzheimer's Coordinating Center. Logistic regression was used to assess the relationship between each comorbid condition and MCI and AD.

Deadness: psychoanalytic reflections.

This paper elucidates the subjective experience of 'deadness.' Categorizing it into melancholic (due to pervasive ego inhibitions secondary to guilt) and schizoid (due to the internalization of profound early neglect) types, the paper describes the manifestations of deadness in the realms of self-experience, interpersonal relations, and attitudes towards life and death. It also outlines therapeutic strategies to ameliorate 'deadness.

BRAF positive Langerhans cell sarcoma arising from CALR positive myeloproliferative neoplasm: evidence of a clonal progenitor.

Langerhans cell sarcoma (LCS) is an aggressive malignant neoplasm with a Langerhans cell immunophenotype and high-grade cytological features. Occasionally, it can coexist with other hematopoietic neoplasms with proven clonal relationship. Most of these neoplasms were found to be of lymphoid origin.

Supporting decision making for individuals living with dementia and their care partners with knowledge translation: An umbrella review.

Living with dementia requires decision making about numerous topics including daily activities and advance care planning (ACP). Both individuals living with dementia and care partners require informed support for decision making. We conducted an umbrella review to assess knowledge translation (KT) interventions supporting decision making for individuals living with dementia and their informal care partners.

Investigating the early-stage emissions of formaldehyde/VOCs from building materials and their influencing factors.

As urbanization accelerates, the issue of pollutant discharge from building materials has become the focus of public attention. Conducted in a ventilated environmental chamber, the experiments investigated the emission characteristics of VOCs from dry and wet building materials, focusing on the influencing factors, such as temperature, relative humidity (RH), ventilation, and seasonality. The impact of influencing factors was quantified using a one-factor-at-a-time control method.

Neutron diffraction reveals protonation states in pyridoxal-5'-phosphate-free and glycine external aldimine-bound serine hydroxymethyltransferase.

Serine hydroxymethyltransferase (SHMT) is a critical enzyme in the one-carbon (1C) metabolism pathway catalyzing the reversible conversion of L-Ser into Gly and concurrent transfer of 1C unit to tetrahydrofolate (THF) to give 5,10-methylene-THF (5,10-MTHF), which is used in the downstream syntheses of biomolecules critical for cell proliferation. The cellular 1C metabolism is hijacked by many cancer types to support cancer cell proliferation, making SHMT a promising target for the design and development of novel small-molecule antimetabolite chemotherapies. To advance structure-assisted drug design, knowledge of SHMT catalysis is crucial, but can only be fully realized when the atomic details of each reaction step governed by the acid-base catalysis are elucidated by visualizing active site hydrogen atoms.

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration-resistant prostate cancer.

Prostate cancer (PCa) is the second most lethal cancer in men in the US. African American (AA) men have twice the incidence and death rate of European American (EA) men. Advanced PCa shows increased expression and activity of the DNA damage/repair pathway enzyme, poly (ADP-ribose) polymerase 1 (PARP1).