Ultrasound-guided, minimally invasive, biceps brachii tenotomy in a standing horse.

Objective: To describe the long-term outcome of a horse that underwent a standing, ultrasound-guided, minimally invasive, biceps brachii tenotomy.

Study Design: Case report.

Animal: A 17-year-old Tennessee Walking Horse gelding.

Digital Cueing With Laser Shoes Does Not Improve Walking in Parkinson's Disease: Evidence Across Disease Severity and Freezing Status.

Background: Gait impairment in Parkinson's disease (PD) occurs early and pharmaceutical interventions do not fully restore this function. Visual cueing has been shown to improve gait and alleviate freezing of gait (FOG) in PD. Technological development of digital laser shoe visual cues now allows for visual cues to be used continuously when walking.

Where we Live matters: Varied Disease Burden and Treatment Patterns in Psoriatic Arthritis in the United States.

Objective: To evaluate the clinical characteristics, social deprivation, insurance coverage, and medication use across regional subsets of patients with psoriatic arthritis (PsA) in the US.

Methods: A cross-sectional study of PsA patients in the Rheumatology Informatics System for Effectiveness (RISE) registry between January 2020 and March2023 was conducted. Distribution of high disease activity (HDA - RAPID3>12), high comorbidity (RxRisk ≥90 percentile), high Area Deprivation Index (ADI ≥80), insurance coverage, prednisone ≥10mg daily, and all DMARD therapies across geographic regions were evaluated.

Distinct interleukin-6 production in IPL and TAFRO subtypes of idiopathic multicentric Castleman disease.

Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder characterized by systemic inflammation and lymphadenopathy. Two major clinical subtypes, idiopathic plasmacytic lymphadenopathy (iMCD-IPL) and iMCD with thrombocytopenia, anasarca, fever, renal dysfunction/reticulin fibrosis, and organomegaly (iMCD-TAFRO), exhibit distinct pathophysiologic mechanisms. While interleukin-6 (IL-6) is known to be elevated in iMCD, the differences in IL-6 production sources between subtypes remain unclear.

The glutaminase activity of ASNS fuels glutamine metabolism in leukemia.

Not available.

Pulmonary Function Test Reference Equations May Affect Classification of Restrictive Lung Disease Severity in Systemic Sclerosis.

Background: Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in systemic sclerosis (SSc), particularly among Black patients. Pulmonary function tests (PFTs) are critical to screen for and monitor SSc-ILD. We examined whether race-specific and race-neutral PFT reference equations impact classification of restrictive lung disease (RLD) severity in Black and White patients with SSc.

Crop growth model-enabled genetic mapping of biomass accumulation dynamics in photoperiod-sensitive sorghum.

Crop growth rate is a critical physiological trait for forage and bioenergy crops like sorghum [Sorghum bicolor (L.) Moench], influencing overall crop productivity, particularly in photoperiod-sensitive (PS) types. Crop growth rate studies focus on either a physiological approach utilizing a few genotypes to analyze biomass accumulation or a genetic approach characterizing easily scorable proxy traits in larger populations.

Eliminating Disparities in Otolaryngology Resident Application Selection.

Objective: To develop, implement, and evaluate a novel process used for residency application review that deemphasizes metrics known to create bias with the goal of interviewing and matching a more diverse resident cohort.

Methods: Between 2020 and 2023, a novel standardized rubric and application review process were developed and implemented at the authors' academic training program. The rubric deemphasized USMLE scores, honor society membership, and number of publications while utilizing an AI-driven pre-sort of applications, facilitating holistic review.

Dynein-2 requires HSP90 chaperone activity to ensure robust retrograde IFT and ciliogenesis.

The microtubule motor dynein-2 is responsible for retrograde intraflagellar transport (IFT), a process critical for cilia assembly and cilium-dependent signaling. Mutations in genes encoding dynein-2 subunits interfere with ciliogenesis and are among the most frequent causes of skeletal ciliopathies. Despite its importance, little is known regarding dynein-2 assembly and regulation.

Buprenorphine Adherence Trajectories and Their Impact on Opioid Overdose and Healthcare Costs.

Introduction: Buprenorphine is effective for opioid use disorder (OUD), yet adherence remains suboptimal. This study aimed to identify adherence trajectories, explore their predictors, and assess their association with opioid overdose risk and healthcare costs.

Methods: A retrospective cohort study was conducted using the Merative MarketScan Commercial Database, which includes a nationally representative sample of individuals with private, employer-sponsored health insurance in the United States.

Persisting Lyme Disease in the Pediatric Population.

A total of 101 patients with a clinical picture of persisting Lyme disease seen at the University of Connecticut Health Center and Boston Medical Center were recruited for the study to determine whether persistent infection is the likely cause. Brain SPECT imaging and responses to antibiotic treatments were recorded. Patients had more than 5 symptoms lasting more than 6 months.

Zinc oxide-curcumin nanoparticles supplementation during oocyte maturation improves bovine embryo production.

This work investigated the effect of zinc oxide nanoparticles functionalized with curcumin (ZnO+CUR) supplementation during the maturation (IVM) of bovine oocytes on the embryo production and the cellular antioxidant response. A total of 1,625 cumulus-oocyte complexes (COCs) were cultured in the maturation medium in the absence (0 µM - control) or presence of different concentrations of ZnO+CUR (3 µM, 6 µM or 12 µM). After IVM, COCs were destined either to 1) embryo production or 2) analysis of reactive oxygen species production, superoxide dismutase (SOD) activity, catalase (CAT) activity and total antioxidant capacity (FRAP).

Introduction to the soft wearable sensors themed collection.

Soft wearable sensors offer promising potential for advanced diagnostics, therapeutics, and human-machine interfaces. Unlike conventional devices that are bulky and rigid, often compromising skin integrity, comfort, and user compliance, soft wearable sensors are flexible, conformable, and better suited to the dynamic skin surface. This improved mechanical integration enhances signal fidelity and device performance, while also enabling safer, more comfortable, and continuous physiological monitoring in real-world environments.

Photocatalytic cyclization reaction of 2-vinylarylamines with CFSONa and arylaldehydes to access 3-(2,2,2-trifluoroethyl)-3-indoles.

A visible-light-catalyzed three-component cyclization reaction of 2-vinylarylamines with CFSONa and arylaldehydes is developed to build a series of 3-(2,2,2-trifluoroethyl)-3-indoles. This protocol features mild reaction conditions using an 18 W blue LED as the light source at room temperature. The desired 3-indole products can be successfully transformed into valuable tetrahydroindole scaffolds through either reduction or cross-coupling reactions.

Revolutionizing Agriculture With CRISPR Technology: Applications, Challenges, and Future Perspectives.

CRISPR technologies are rapidly transforming agriculture by enabling precise and programmable modifications across a wide range of organisms. This review provides an overview of CRISPR applications in crops, livestock, aquaculture, and microbial systems, highlighting key advances in sustainable agriculture. In crops, CRISPR has accelerated the improvement of traits such as drought tolerance, nutrient efficiency, and pathogen resistance.

Non-ST elevation myocardial infarction with multivessel disease and anoxic brain injury: a case report.

A 71-year-old black male with a history of hypertension, dyslipidemia, type 2 diabetes, history of bladder cancer status-post resection now in remission, history of multiple transient ischemic attacks, and coronary artery disease (CAD) presented with non-exertional substernal chest pain radiating to the left arm, accompanied by shortness of breath and nausea. Initial evaluation revealed elevated troponins and nonspecific electrocardiogram changes, consistent with non-ST elevation myocardial infarction. Coronary angiography demonstrated severe multivessel disease, including critical left main stenosis.

perspectives on surface photocatalysis: advances, challenges, and opportunities.

Surface photocatalysis holds significant promise for converting solar energy into chemical fuels and addressing environmental challenges. While calculations provide critical insights into the thermodynamic and kinetic aspects of catalytic reactions, applying these methods to surface photocatalysis remains challenging. In this work, we discuss the key challenges that need to be addressed when using calculations to understand surface photocatalytic processes, the reasons behind these challenges, and the potential directions and opportunities for overcoming them in the future.

Switch of Open-Source Automated Insulin Delivery (AID) System-AndroidAPS to Commercially Available AID Systems in Type 1 Diabetes: The Extension of the CODIAC Study.

This study was designed to investigate the switch between the open-source automated insulin delivery (OS-AID) system AndroidAPS (AAPS) and commercially available AID systems Control-IQ (CIQ) and MiniMed 780G (780G) conducted in a new extended follow-up study. In this prospective open-label single-arm clinical trial, 41 adults with type 1 diabetes (age 35 ± 11 years, glycated hemoglobin [HbA1c] 6.4 ± 2.

Associations Between VHA Clinical Resource Hubs Delivering Telemental Health Services.

The Veterans Health Administration (VHA) Clinical Resource Hubs (CRHs) provide telemental health (TMH) services to improve access for Veterans, but use varies greatly across clinics. A retrospective FY23 analysis examined all VHA outpatient mental health encounters. Clinics were categorized by CRH-MH use and level of CRH-MH penetration.

Women's Unique Health Needs and the Sustainable Development Goals: A Meeting Report from the 79th United Nations General Assembly Science Summit.

Biological sex, hormones, and gender uniquely affect health and disease, often resulting in disparities for women across the lifespan and from different racial and ethnic groups, geographical locations, and socioeconomic backgrounds. Without intentional investment and infrastructure to support good health and wellbeing for women, half of the world's population remains vulnerable to preventable morbidity and mortality. The Society for Women's Health Research and ECHAlliance-The Global Health Connector convened a women's health program as part of the 10th Annual Science Summit during the United Nations 79th General Assembly.

Short-Course Antibiotic Agent Therapy for Early Ventilator-Associated Pneumonia in Patients with Trauma.

Patients with traumatic injuries who develop ventilator-associated pneumonia (VAP) incur a higher risk of developing multi-drug resistance. Shorter duration of antibiotic agents for early VAP at five days may reduce antibiotic agent exposure without worsening patient outcomes. This retrospective cohort study performed at a Level I Trauma Center included adult (≥16 years old) patients with trauma diagnosed with bronchoalveolar lavage (BAL)-proven early (within four days of intubation) bacterial VAP.

Helicopter Rescue at Very High Altitude: Recommendations of the International Commission for Mountain Emergency Medicine (ICAR MedCom) 2025.

McLaughlin, Kyle, Charley Shimanski, Ken Zafren, Ian Jackson, Gerold Biner, Maurizio Folini, Andreas Hermansky, Eric Ridington, Peter Hicks, Giacomo Strapazzon, Marika Falla, Alastair Hopper, Dave Weber, Ryan Jackson, and Hermann Brugger. Helicopter rescue at very high altitude: Recommendations of the International Commission for Mountain Emergency Medicine (ICAR MedCom) 2025. 00:00-00, 2025.