Meteorological influences on seizure occurrence in children with epilepsy: a case-crossover analysis.

Purpose: Research on the association between meteorological conditions and epileptic seizures in children with epilepsy (CWE) remains limited. This study aimed to evaluate the effects of atmospheric pressure, temperature, and humidity on seizure occurrence in CWE.

Methods: We conducted a multicenter prospective observational study involving CWE under 16 years of age who had experienced seizures more than once per year but less than once per week over the past year.

Association Between Intracellular Dark Spots on Specular Microscopy and Endothelial Cell Loss After Penetrating Keratoplasty.

Purpose: To investigate the incidence and clinical implications of intracellular dark endothelial spots (IDES) following penetrating keratoplasty (PK) and their association with endothelial cell density (ECD) loss and graft failure.

Design: Retrospective clinical cohort study.

Methods: This study included 71 eyes that underwent PK and 33 control eyes that underwent cataract surgery.

Personalised & optimised therapy (POT) algorithm using five cognitive and behavioural skills for subthreshold depression.

Personalising psychotherapies for depression may enhance their efficacy. We conducted a randomised controlled trial of smartphone cognitive-behavioural therapy (CBT) among 4,469 adults in Japan (RESiLIENT trial, UMIN-CTR UMIN000047124). Participants received one of nine CBT skills or combinations, or a health information control (HI), over six weeks.

Virtual reality-related exercise for people with chronic kidney disease undergoing haemodialysis.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of virtual reality (VR)-based exercise for improving mental health, physical function, and quality of life (QoL), as well as assessing adverse events during dialysis, in people with chronic kidney disease (CKD) undergoing haemodialysis compared to exercise interventions without VR or standard treatment alone.

Scalp cooling for the prevention of chemotherapy-induced alopecia in women with early breast cancer.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of scalp cooling for the prevention of hair loss from adjuvant or neoadjuvant chemotherapy in women with early breast cancer.

Understanding the relationship between life priorities and life satisfaction in individuals with mental disorders.

Aim: Mental healthcare has recently shifted from focusing solely on treating psychiatric symptoms to enhancing patients' subjective well-being. However, research on the factors contributing to life satisfaction among individuals with mental disorders remains limited. This study investigated the life aspects that patients with schizophrenia, depression, and bipolar disorder considered important, their satisfaction with these aspects, and how these factors affect overall life satisfaction.

Advance care planning for adults with cancer.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of advance care planning (ACP) in people with cancer compared with standard care (without ACP).

Clinical utility of diaphragmatic ultrasound for mechanical ventilator liberation in adults: a systematic review and meta-analysis.

Background: Prolonged mechanical ventilation is associated with an increased incidence of complications and higher mortality rates. Therefore, it is crucial to wean patients from mechanical ventilation as soon as possible. Recently, diaphragmatic ultrasound has been used in this decision-making process.

Post-transplant maintenance with blinatumomab for children, adolescents, and young adults with relapsed and refractory B-cell acute lymphoblastic leukemia: results of phase I in SCT-ALL-BLIN21.

Not available.

Advance care planning for children with life-limiting and life-threatening conditions.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of ACP for children with LLCs and LTCs.

Sparse coding-based multiframe superresolution for efficient synchrotron radiation microspectroscopy.

In nanostructure extraction, advanced techniques like synchrotron radiation and electron microscopy are often hindered by radiation damage and charging artifacts from long exposure times. This study presents a multiframe superresolution method using sparse coding to enhance synchrotron radiation microspectroscopy images. By reconstructing high-resolution images from multiple low-resolution ones, exposure time is minimized, reducing radiation effects, thermal drift, and sample degradation while preserving spatial resolution.

Ripple effect of temporary self-sampling HPV test on screening uptake in the next round: A secondary analysis of the ACCESS randomized controlled trial.

The self-sampling human papillomavirus (HPV) test improves participation in cervical cancer screening. However, the ripple effect of this test on participation in the next screening round has not yet been examined. This study, a secondary analysis of the Accelerating Cervical Cancer Elimination by Self-Sampling test (ACCESS) trial, aims to clarify this effect.

Coarse-Grained Hawkes Processes.

When analyzing real-world event data, it is often the case that bin-count processes are observed instead of precise event time-stamps along a continuous timeline, owing to practical limitations in measurement accuracy. In this work, we propose a modeling framework for aggregated event data generated by multivariate Hawkes processes. The introduced model, termed the coarse-grained Hawkes process, effectively captures the second-order statistical characteristics of the bin-count representation of the Hawkes process, particularly when the bin size is large relative to the typical support of the excitation kernel.

Multidomain interventions for preventing cognitive decline in older adults with type 2 diabetes and mild cognitive impairment: Secondary analysis of the J-MINT: Multidomain intervention in type 2 diabetes.

Aims: To identify subgroups who may be more likely to respond well to a multidomain intervention among older adults with type 2 diabetes.

Materials And Methods: This study was a secondary analysis of the Japan Multimodal Intervention Trial for Prevention of Dementia. A total 531 participants aged 65-85 years with mild cognitive impairment were randomized into intervention (vascular risk management, exercise, nutritional counseling, and cognitive training) and control (health-related information) groups.

Regional Clinical Alliance Path for Secondary Prevention of Acute Coronary Syndrome - Impact on Low-Density Lipoprotein Cholesterol Levels.

Background: The prognosis for survivors of acute coronary syndrome (ACS) remains substantially worse compared with the general population. In Japan, regional clinical alliance paths (RCAPs) have been promoted to support the secondary prevention of ACS within community settings. However, the implementation of RCAPs is currently low, and their clinical efficacy has not been established.

Systemic indocyanine green administration to detect bile leakage after liver surgery: a prospective clinical trial, using historical controls.

Objective: The aim of this study was to evaluate the clinical impact of intraoperative indocyanine green (ICG) assessment and subsequent interventions on the total bilirubin concentration in postoperative drainage fluid after hepatectomy. Specifically, this study was conducted to determine whether systemic ICG administration and near-infrared (NIR) imaging to detect and address bile leakage (BL) during liver surgery could improve postoperative outcomes in an intervention group compared with a historical control group.

Design: This was a prospective clinical trial with historical controls that involved inverse probability of treatment weighting (IPTW) analysis to adjust for potential confounding biases resulting from nonrandomised treatment assignments.

Exercise interventions for the treatment of lower limb lymphoedema after treatment for gynaecological cancers.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of load exercise therapy with complex decongestive therapy compared with complex decongestive therapy alone for lower limb lymphoedema after gynaecological cancer treatment.

Distinct immunity dynamics of natural killer cells in mild and moderate COVID-19 cases during the Omicron variant phase.

Background: The SARS-CoV-2 Omicron variant is associated with milder COVID-19 symptoms than previous strains. This study analyzed alterations in natural killer (NK) cell-associated immunity dynamics in mild and moderate COVID-19 cases during the Omicron phase of the COVID-19 pandemic.

Methods: We conducted a retrospective observational cohort study of patients aged ≥16 with confirmed SARS-CoV-2 infection who were hospitalized at Tottori University Hospital between January 2022 and May 2022.

Point-of-care testing for diagnosing hypofibrinogenemia in postpartum hemorrhage: Systematic review and meta-analysis.

Background: Postpartum hemorrhage (PPH) can rapidly cause hypofibrinogenemia, requiring prompt coagulation factor replacement. Point-of-care testing (POCT) is gaining interest for early diagnosis for hypofibrinogenemia, despite limited evidence. This systematic review evaluated the diagnostic accuracy of POCT for hypofibrinogenemia in PPH.

Evaluation of Data Quality and Utility of the Japan Drug Information Institute in Pregnancy (JDIIP) Consultation Case Database for Pregnancy Pharmacovigilance.

Introduction: Ensuring medication safety during pregnancy is crucial for protecting maternal and fetal health. However, fragmented data sources and the lack of comprehensive databases present substantial barriers to effective pharmacovigilance. The Japan Drug Information Institute in Pregnancy (JDIIP) database, which contains data on drug treatment counseling for pregnant women, is expected to help address the lack of comprehensive databases for pregnancy pharmacovigilance (PregPV).

Intracellular dark endothelial spots: A new imaging biomarker for the development of bullous keratopathy after cataract surgery.

Purpose: Intracellular dark endothelial spots (IDES) on specular microscopy indicate corneal endothelial stress, and can be an imaging biomarker for subsequent endothelial cell density (ECD) loss after endothelial keratoplasty. This study evaluated the risk factors for the development of bullous keratopathy (BK) by comparing low ECD patients with or without IDES before cataract surgery.

Methods: This retrospective study included 106 consecutive patients who underwent cataract surgery with a preoperative ECD of less than 1000 cells/mm.

Cognitive behavioral therapy skills via a smartphone app for subthreshold depression among adults in the community: the RESiLIENT randomized controlled trial.

Subthreshold depression, defined as a depressive status falling short of the diagnostic threshold for major depression, is common, disabling and constitutes a risk factor for future depressive episodes. Cognitive behavioral therapies (CBT) have been shown to be effective but are usually provided as packages of various skills. Little research has been done to investigate whether all their components are beneficial and contributory to mental health promotion.

Impact of exporter proteins and their engineering on the productivity of Corynebacterium.

Enhancing product efflux is crucial in improving fermentative bioproduction. Despite advancements in metabolic engineering guided by the design-build-test-learn cycle, membrane transport engineering of product efflux remains underdeveloped, limiting the efficient production of target chemicals. This review explores the historical findings on product efflux, regardless of passive or active transport, in fermentation engineering, focusing on Corynebacterium species, and highlights the potential of multidrug transporters as valuable screening sources for efflux improvement.

Music-based interventions for people with chronic kidney disease undergoing haemodialysis.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of music-based interventions on fatigue, blood pressure, depression, pain, anxiety, stress, QoL, and sleep quality in people with CKD receiving HD.