Neuroimaging Data Informed Mood and Psychosis Diagnosis Using an Ensemble Deep Multimodal Framework.

Investigating neuroimaging data to identify brain-based markers of mental illnesses has gained significant attention. Nevertheless, these endeavors encounter challenges arising from a reliance on symptoms and self-report assessments in making an initial diagnosis. The absence of biological data to delineate nosological categories hinders the provision of additional neurobiological insights into these disorders.

Three-dimensional-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with enhanced angiogenic and osteogenic properties.

Reconstructing bone defects remains a significant challenge in clinical practice, driving the urgent need for advanced artificial grafts that simultaneously promote vascularization and osteogenesis. Addressing the critical trade-off between achieving high porosity/strength and effective bioactivity at safe ion doses, we incorporated strontium (Sr) into β-tricalcium phosphate (β-TCP) scaffolds with a triply periodic minimal surface (TPMS) structure using digital light processing (DLP)-based three-dimensional (3D) printing. Systematically screening Sr concentrations (0-10 mol%), we identified 10 mol% as optimal, leveraging the synergy between the biomimetic TPMS architecture, providing exceptional mechanical strength (up to 1.

Novel small molecule derivatives improve survivability in the cellular model of Huntington's disease improving mitochondrial fusion.

Mitochondrial dysfunction is one of the primary cellular conditions involved in developing Huntington's disease (HD) pathophysiology. The accumulation of mutant huntingtin protein with abnormal PolyQ repeats resulted in the death of striatal neurons with enhanced mitochondrial fragmentation. In search of neuroprotective molecules against HD conditions, we synthesized a set of isoxazole-based small molecules to screen their suitability as beneficial chemicals improving mitochondrial health.

Local Responses to COVID-19: The Mediating Role of Community-based Organizations in Majority-Black Neighborhoods and Immigrant Enclaves, A Case Study of Atlanta, Georgia.

This paper will present a case study of local responses to the epidemic in immigrant enclaves and majority-black neighborhoods in Atlanta, Georgia. The COVID-19 health crisis presents an unprecedented challenge for many black and brown communities in the United States which may be particularly vulnerable to the contagion because of higher rates of certain pre-existing conditions like heart disease, lack of access to adequate healthcare services, and financial pressures to continue working despite increasingly risky conditions. In the American South where burgeoning ethnic enclaves, well-establish majority-black neighborhoods, and affluent suburbs exist side by side with vastly different healthcare concerns, disorganized governmental responses to the COVID-19 epidemic highlight the importance of efforts by CBOs (i.

Hydrazineyl-linked imidazole[1,2-]pyrimidine-thiazole hybrids: design, synthesis, and biological evaluation studies.

This research work details the use of a molecular hybridization technique to create a library of four series of hydrazineyl-linked imidazo[1,2-]pyrimidine-thiazole derivatives. The structure of one of the final products, K2, was validated using single-crystal X-ray diffraction. Twenty-six novel hybrid molecules (K1-K26) were synthesized and tested for activity against the H37Rv strain.

Posthuman interventions in submerged histories: reconstructing history through memory in Rivers Solomon's .

A community's collective memory is predominantly shaped by dominant power structures that generate and contain canonical narratives. Within the post-colonial context, this social memory remains in conflict with certain ancestral or tribal memories that witnessed the violent legacies of colonization. These memories, which are transmitted across generations-termed postmemory-aims to reclaim and expose the officially silenced histories through the production of counter-memory.

Unique halogen-π association detected in single crystals of C-N atropisomeric -(2-halophenyl)quinolin-2-one derivatives and the thione analogue.

In single crystals of C-N atropisomeric -(2-halophenyl)quinolin-2-one and the thione analogue, a unique association based on a halogen-π interaction was detected. In racemic and optically pure -(2-bromo- or 2-chlorophenyl)quinolin-2-ones, homochiral layered polymers, which consist of ()- or ()-atropisomers, were formed through intermolecular halogen-π association. The halogen-π association in the racemates is due to a halogen bond (C-X···π) between a σ-hole on the halogen atom and a π-electron on the quinolinone benzene ring, while that in optically pure forms is caused by an n-π* interaction between a lone electron pair on the halogen atom and a π* orbital of the quinolinone.

Continuous-flow-enabled intensification in nitration processes: a review of technological developments and practical applications over the past decade.

Flow chemistry technology has demonstrated significant potential in advancing the green transformation of the chemical industry while enhancing inherent process safety. Safety, cost-effectiveness, and operational efficiency serve as pivotal drivers for advancing flow chemistry in nitration processes. This review provides a comprehensive analysis of the continuous-flow nitration technology - a process historically recognized as one of the most hazardous industrial operations - focusing on its technological advancements in process design, reaction kinetics characterization, and practical implementation over the past decade.

The Case for Limiting "Sequences of Concern" to Those with Demonstrated Pathogenic Function.

Screening synthetic nucleic acid orders for sequences of concern is a necessary part of a healthy biosecurity regime, but it exacts costs for nucleic acid providers. Taxonomy is and will remain a critical part of the decision-making process for screening, especially for viral sequences. But, moving forward, the function of a sequence will also be determinative of its level of concern, or lack thereof.

Sudden-Onset Severe Thrombocytopenia Secondary to Trimethoprim-Sulfamethoxazole.

Drug-induced immune thrombocytopenia (DITP) is a rare but life-threatening condition characterized by a sudden and serious drop in the number of platelets from drug-dependent antibodies against platelet glycoproteins. We report the case of a 57-year-old man who developed severe thrombocytopenia and mucocutaneous bleeding following a short course of trimethoprim-sulfamethoxazole (TMP-SMX) for presumed tick-borne disease. The patient experienced bleeding gums, pinpoint rashes, bruising, and extreme fatigue.

Leaving Academia: Dual-Career Relationships and Partners' Attrition from Academic Careers.

Background: More than one third of academics are coupled with another academic, with more women being in such dual-career relationships. Little is known about how these couples' experiences affect their attrition from or persistence in academia.

Methods: We analyzed survey data of academics at 100 U.

Tuning the dimensionality of functional thiazolo[5,4-]thiazole based supramolecular polymers competitive interactions.

The supramolecular organization of functional molecules at the mesoscopic level influences their material properties. Typically, planar π-conjugated (disc- or linear-shaped) molecules tend to undergo one-dimensional (1D) stacking, whereas two-dimensional (2D) organization from such building blocks is seldom observed in spite of their technological potential. Herein, we rationally achieve both 1D and 2D organizations from a single planar, π-conjugated molecular system competitive interactions.

The QGIS project: Spatial without compromise.

The QGIS project is a prominent open-source geographic information system (GIS) that has evolved over two decades, contributing significantly to the geospatial community. This paper presents the development, governance, and operational challenges faced by QGIS, providing an in-depth analysis of its growth from a hobby project to a global platform. We examine the project's organizational structure, release management, and infrastructure, alongside the financial model that sustains its development.

A view of the sustainable computing landscape.

This article presents a holistic research agenda to address the significant environmental impact of information and communication technology (ICT), which accounts for 2.1%-3.9% of global greenhouse gas emissions.

Plasmene nanosheets assembled from "plasmonic molecules".

Entropy-driven drying-mediated self-assembly of plasmonic nanocrystals (termed "plasmonic atoms") has emerged as a general strategy for fabricating plasmene nanosheets from a wide range of monodisperse nanocrystals. However, extending this approach to binary systems remains challenging due to the complex nanoscale interactions between dissimilar nanocrystal shapes. Here, we introduce a combined enthalpy- and entropy-driven strategy to achieve an orderly mixed two-dimensional (2D) binary nanoassemblies from complementary reacting polymer-ligated nanocrystals.

Atomically Dispersed Palladium Promoted Suzuki-Miyaura Cross Coupling.

The palladium-catalyzed Suzuki-Miyaura cross coupling reaction to forge carbon-carbon bonds fundamentally changes the practice of organic synthesis. Herein an isolated palladium catalyst supported on polymeric carbon nitride (Pd/PCN) for efficient cross coupling of bromobenzene and phenylboronic acid at room temperature is reported. It is demonstrated that the Pd/PCN catalyst with a 2 wt% Pd loading achieves the highest mole-specific activity.

Purinergic signaling by ATP induces exercise-like effects and ameliorates insulin resistance in HT22 mouse hippocampal cells.

Neuronal insulin signaling is essential for regulating glucose metabolism and cognitive functions in the brain. Disruptions cause neuronal insulin resistance, potentially causing type 2 diabetes (T2D) and Alzheimer's disease (AD). Therefore, we investigated alternative pathways that maintain glucose homeostasis beyond traditional insulin signaling.

A unique hybrid of vanadium carbide and oxycarbide derived carbon from a preceramic polymer route with faradaic and supercapacitive charge storage.

Polymer-derived ceramics are a versatile class of multifunctional materials synthesized the high-temperature treatment of a preceramic polymer. In this work, we report the synthesis of a vanadium carbide-embedded carbonaceous hybrid by pyrolyzing a modified preceramic polymer incorporating vanadium acetylacetonate in a polysilsesquioxane followed by hydrofluoric acid etching. The structural and microscopic characterisation confirmed the uniform distribution of nanoparticulate vanadium carbide in the matrix.

High-activity Ce-CoB porous electrocatalysts cerium doping for superior OER performance.

Ce-doped cobalt boride (Ce-CoB) was synthesized a ZIF-67-derived boridation strategy, where Ce incorporation synergistically tunes the electronic structure to accelerate oxygen evolution kinetics. The Ce-CoB achieves an overpotential of 320 mV at 10 mA cm, outperforming benchmark CoB by 15.8% ( 350 mV) with remarkable robustness.

Synthesis and late-stage C-H functionalization of papaverines.

An efficient synthesis and late-stage C-H functionalization of papaverine under volatile solvent-free conditions are reported. This methodology demonstrates significant potential for applications in the active pharmaceutical ingredient (API) industry, particularly for the sustainable and solvent-free synthesis of papaverine. A plausible reaction mechanism was meticulously elucidated through comprehensive control experiments.

Treatment of Aquaculture Wastewater by Utilizing Single and Symbiotic Systems of Microalgae-Based Technology and Strigolactone Induction.

This study investigated the efficacy of two microalgae treatment systems (Chlorella vulgaris monoculture and a Chlorella vulgaris-S395-2-Clonostachys rosea symbiotic system) in treating aquaculture wastewater, under varying concentrations of synthetic strigolactone analog (GR24). By exposing the systems to four GR24 doses (0, 10, 10, and 10 M), we examined the impact on biomass growth, photosynthesis, and wastewater treatment. Elevated GR24 concentrations bolstered metabolism and photosynthesis in the systems, fostering rapid symbiont growth and enhanced treatment efficiency.

Carbazole-dansyl conjugate for latent fingerprint visualization and detection of date rape drugs.

An imino-linked dansyl-carbazole molecular system, DASH, is designed and synthesized. This system (DASH) is rationalized in such a way that it works as a suitable template for the detection of date rape drugs, gamma-butyrolactone (GBL) and gamma-valerolactone (GVL), in addition to latent fingerprint detection. Both rape drug and latent fingerprint detection are important aspects of drug abuse-related crimes in forensic analysis.

Ru-amidobis(phosphine) catalyzed alkylation of indole and epoxide opening followed by α-alkylation through alcohol oxidation.

Herein, we report a simple, microwave-assisted and open-air strategy for gram-scale C3-alkylation of indoles, along with an economically viable strategy for epoxide opening followed by α-alkylation, using the [RuCl(bpy){-PhPCHCONCHPPh-}-κ-(,,,,)] complex (hereafter referred to as [PNP-Ru]). This transformation proceeds an alcohol dehydrogenation (oxidation) mechanism, with water being the sole byproduct in both reactions, underscoring the environmentally benign and sustainable nature of the methodology. The protocol efficiently delivers both mono- and bis(indolyl) derivatives in good to excellent yields.

Role of heteroatom substitution on the stability and reactivity of mononuclear Cu(II)-alkylperoxo complexes.

Motivated by copper's essential role in biology and its wide range of applications in catalytic and synthetic chemistry, this work aims to understand the effect of heteroatom substitution on the overall stability and reactivity of biomimetic Cu(II)-alkylperoxo complexes. In particular, we designed a series of tetracoordinated ligand frameworks based on iso-BPMEN = (,-bis(2-pyridylmethyl)-','-dimethylethane-1,2-diamine) with varying the primary coordination sphere using different donor atoms (N, O, or S) bound to Cu(II). The copper(II) complexes bearing iso-BPMEN and their modified heteroatom-substituted ligands were synthesized and structurally characterized.