A randomized controlled study protocol to determine the safety and efficacy of Sivanarvembu Kuzhithailam in the management of Psoriasis (Kalanjagapadai).

Background: Psoriasis is a chronic skin disorder with a substantial global burden, affecting over 100 million people worldwide. Conventional treatments, including topical and systemic therapies, have their own limitations and side effects. Siddha medicine, deeply rooted with comprehensive principles, offers an alternative approach in Psoriasis management.

Non-invasive management of Thandaga vaatham (lumbar spondylosis) through Siddha Varmam therapy - A case report.

A 32-year-old female homemaker came with a complaints of chronic low back pain, radiating to both lower limbs, stiffness especially in the morning difficulty in walking and standing with intensified pain during household chores for two years. She was diagnosed with Tantaka vātam, one of the eighty types of vātam disease which is equivalent to lumbar spondylosis. She was treated with therapeutic Varmam manipulations in every 7 days for a period of 48 days and followed for six months.

Molecular docking analysis of aldose reductase with herbal compounds from selected siddha medicine for anti-cataract treatment.

Cataracts are a major cause of blindness and it is due to protein aggregation in the eye lens that is accelerated by aldose reductase (AR)-induced sorbitol accumulation. Therefore, it is of interest to evaluate the anti-cataract potential of six phytochemicals from Siddha medicinal herbs (carinol, voacangine, berberine, piperine, sesamin and isoamericanin A) using molecular docking analysis with human aldose reductase (PDB ID: 4GCA) where epalrestat is used as the standard compound. Analysis shows that berberine, piperine, sesamin and carinol have optimal binding interactions with aldose reductase, performing similar to the standard drug epalrestat having estimated free energy values of -10.

Molecular docking analysis of bioactive molecules from herbs with snake venom phospholipase A2.

Snake venom, particularly phospholipase A2 (PLA2), exerts profound pathological effects, necessitating the development of potent therapeutic interventions. Therefore, it is of interest to the inhibitory potential of bioactive phytoconstituents from select medicinal herbs with PLA2. Analysis showed that Gymnemic acid, Aristolochic acid, Lupeol and Tocopherol are the best PLA2 inhibitors with strong binding and molecular interactions for further consideration.

analysis of phytochemicals from with cyp-17α-hydroxylase enzyme.

Polycystic ovarian syndrome (PCOS) affects 9.2% of women of reproductive age and has doubled in prevalence, rising from 6 million cases in 1990 to 12.13 million in 2019.

anti-cancer activity of siddha metallo-mineral formulation from Thanga uram with Hela cell lines.

The second most common malignant tumour in women worldwide, cervical cancer seriously jeopardizes their health. It has been established that a high-risk Human papillomavirus (HPV) infection is the cause of cervical cancer. Cervical cancer is associated with several risk factors, including reproductive, behavioural and sexual characteristics.

Siddha COVID Care Centers in Tamil Nadu, India: Coverage, Workload, and Knowledge Gaps.

Introduction The COVID-19 pandemic has significantly impacted India since March 2020. The Siddha system of medicine is one of the oldest medical systems and originated in Tamil Nadu. It is popular among countries where Tamil-speaking populations live.

Treatment of early-stage diabetic nephropathy with Siddha drug Sirupeelai Kudineer: A case series.

Diabetic Nephropathy is one of the major microvascular complications of Diabetes Mellitus, which can be detected in the earlier stage by investigating urinary microalbumin excretion levels and estimating ACR and GFR. Early treatment can delay or prevent the progression of diabetic Nephropathy. Monoherbal Siddha formulation Sirupeelai Kudineer indicated for the complications of Diabetes Mellitus is selected for this Case study.

In silico network pharmacology analysis and molecular docking validation of Swasa Kudori tablet for screening druggable phytoconstituents of asthma.

Traditional medicines are impactful in treating a cluster of respiratory-related illnesses. This paper demonstrates screening active, druggable phytoconstituents from a classical Siddha-based poly-herbal formulation called Swasa Kudori Tablet to treat asthma. The phytoconstituents of Swasa Kudori are identified as Calotropis gigantea, Piper nigrum, and (Co-drug) Abies webbiana.

In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19.

Immunosenescence is a pertinent factor in the mortality rate caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The changes in the immune system are strongly associated with age and provoke the deterioration of the individual's health. Traditional medical practices in ancient India effectively deal with COVID-19 by boosting natural immunity through medicinal plants.

(Kadarpassi chooranam) Phytochemical analysis and biological significance - a novel Siddha drug.

Objectives: To evaluate biological activity and the phytochemical analysis of kadarpassi chooranam. Seaweeds are the marine macro algae, species belonging to Protista kingdom that has no true system, internal vascular systems, seeds and flowers. It has a lot of biological activity and has been proven to have a lot of medicinal benefits.

Morbidity profile of patients attended Siddha Regional Research Institute, Puducherry in 2017-A cross-sectional study.

Background: In India, understanding the patterns of utilization of AYUSH care has been considered vital for increased focus on its mainstreaming and integration with prevailing biomedical systems. This paper aims to evaluate the morbidity profiling of the patients attended Siddha Regional Research Institute (SRRI), Puducherry in 2017.

Methods: A cross-sectional study in the patients conducted from January to December 2017.