Mesalazine-Induced Myocarditis in Inflammatory Bowel Disease: A Systematic Review.

Crohn's disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD). This chronic, immune-mediated disorder leads to inflammation in specific gastrointestinal tract regions. Myocarditis is a rare but significant IBD complication that affects roughly 0.

The complex role of glycine N-methyltransferase in metabolism-a review.

Background: Glycine N-methyltransferase (GNMT) is an enzyme predominantly found in the liver, playing a crucial role in various metabolic pathways. GNMT is involved in transmethylation, transsulfuration, one-carbon metabolism, energy metabolism, and DNA methylation. Deletion or Knockdown of GNMT influences the expression of several key metabolic enzymes by accumulating S-adenosylmethionine (SAM).

Prevalence and factors associated with malnutrition on patients with cancer in Bangladesh: a cross-sectional study.

Introduction: Malnutrition is related to the development of chronic diseases, including cancer and is a major cause of mortality in patients with cancer. The study aimed to understand the prevalence and factors associated with malnutrition among patients with cancer.

Methods: This cross-sectional study investigated the prevalence of malnutrition among patients with cancer and its relationship with sociodemographic status and treatments.

Aging in Bangladesh: A Wake-Up Call for Elderly Care Solutions.

Background And Aims: Bangladesh has been experiencing a rapid demographic shift from the younger population to older adults, with the older adults facing significant challenges due to the absence of residential and formal home care models. This perspective aimed to evaluate the status of residential and formal home care models and propose potential strategies to improve elderly care in Bangladesh.

Methods: This perspective utilized a narrative review approach to search existing literature on elderly care in Bangladesh on PubMed, Google Scholar, and Web of Science.

Advancing Alzheimer's Therapy: Computational strategies and treatment innovations.

Alzheimer's disease (AD) is a multifaceted neurodegenerative condition distinguished by the occurrence of memory impairment, cognitive deterioration, and neuronal impairment. Despite extensive research efforts, conventional treatment strategies primarily focus on symptom management, highlighting the need for innovative therapeutic approaches. This review explores the challenges of AD treatment and the integration of computational methodologies to advance therapeutic interventions.

Cancer driven direct medical costs in Bangladesh: Evidence from patient perspective.

Background: Cancer treatment costs are rising, and the disease is becoming a major challenge to healthcare systems in developing countries like Bangladesh. The direct medical costs of cancer have yet to be comprehensively studied in the country. Hence, the study aimed to estimate the direct medical costs associated with cancer from patients' perspective.

In Silico Identification of Emblica officinalis Compounds Inhibiting Thermolabile Hemolysin from Vibrio alginolyticus in Shrimp.

Background: Thermolabile hemolysin (TLH) is a key virulent protein of Vibrio alginolyticus, known for its hemolytic and phospholipase activities, leading to shrimp vibriosis disease. It has been suggested as a potential therapeutic candidate for vibriosis therapy.

Methods: Computational studies, including molecular docking, toxicity analysis, and molecular dynamics (MD) simulations, were conducted to investigate the inhibition of the phospholipase activity of TLH by phytochemicals from Emblica officinalis.

What aspects affect peoples perceptions of energy use? A comparison of heterogeneity versus homogeneity based on an in-depth review.

Energy consumption plays a critical role in climate change, necessitating an understanding of the factors that shape perceptions of energy use. These perceptions significantly influence the adoption and expansion of renewable energy sources. This study conducts a comprehensive review of 45 articles to identify key factors that affect energy consumption perceptions, highlight gaps in existing literature and suggest areas for future research.

Assessing Contributory Factors of Diarrhea Among Under-Five Children in Bangladesh From 2006 to 2019 and Recent Increases: A Cross-Sectional Study.

Background And Aims: One-third of all child deaths in this country are caused by diarrhea. The burden of the disease appears to be increasing in recent years in Bangladesh. This study aimed to analyze the prevalence of diarrhea and identify the factors contributing to diarrheal diseases among children aged 0-5 years in Bangladesh from 2006 to 2019, to understand the recent increase in this serious health issue.

Identifying health risk determinants and molecular targets in patients with idiopathic pulmonary fibrosis via combined differential and weighted gene co-expression analysis.

Introduction: Idiopathic pulmonary fibrosis (IPF) is a rare but debilitating lung disease characterized by excessive fibrotic tissue accumulation, primarily affecting individuals over 50 years of age. Early diagnosis is challenging, and without intervention, the prognosis remains poor. Understanding the molecular mechanisms underlying IPF pathogenesis is crucial for identifying diagnostic markers and therapeutic targets.

Electrokinetics of CO Reduction in Imidazole Medium Using RuO.SnO-Immobilized Glassy Carbon Electrode.

The pursuit of electrochemical carbon dioxide reduction reaction (CORR) as a means of energy generation and mitigation of global warming is of considerable interest. In this study, a novel RuO-incorporated SnO-fabricated glassy carbon electrode (GCE) with a Nafion binder was used for the electrochemical reduction of CO in an aqueous alkaline imidazole medium. The electrode fabrication process involved the drop-casting method, where RuO.

Centennial-scale atmospheric CO rise increased photosynthetic efficiency in a tropical tree species.

Tropical forests substantially influence the terrestrial carbon sink. Their contributions to the forest carbon sink may increase due to the stimulation of photosynthesis by rising atmospheric CO (C); however, the magnitude of this effect is poorly quantified for tropical canopy trees. We measured the ratio of two deuterium isotopomers of glucose derived from tree rings to estimate how photosynthetic efficiency (photorespiration-to-photosynthesis ratio) has responded to C rise at a centennial scale.

Application of multi-indexing approach within a GIS framework to investigate the quality and contamination of ground water in Barisal sadar, Bangladesh.

Groundwater quality and contamination pose significant challenges in coastal regions such as Barisal Sadar, Bangladesh, where dependency on groundwater is crucial for potable and agricultural uses. This study employed a multi-indexing approach inside a GIS framework to assess water quality, contamination scenarios, and health risks. It evaluates the physicochemical properties of groundwater samples, including heavy metals, to identify potential issues.

Unlocking the secrets of the human gut microbiota: Comprehensive review on its role in different diseases.

The human gut microbiota, a complex and diverse community of microorganisms, plays a crucial role in maintaining overall health by influencing various physiological processes, including digestion, immune function, and disease susceptibility. The balance between beneficial and harmful bacteria is essential for health, with dysbiosis - disruption of this balance - linked to numerous conditions such as metabolic disorders, autoimmune diseases, and cancers. This review highlights key genera such as , , , , , , (including and ), and due to their well-established roles in immune regulation and metabolic processes, but other bacteria, including , , , and , are also implicated in dysbiosis and various diseases.

Emerging burden of post-cancer therapy complications on unplanned hospitalisation and costs among Australian cancer patients: a retrospective cohort study over 14 years.

Cancer treatment using systemic therapy and radiotherapy may cause post-therapy complications, resulting in increased unplanned hospitalisation. The evidence on such complications, their impact on unplanned hospitalisations, and associated costs is scant in Australia. We aimed to estimate the prevalence of post-therapy complications, evaluate their impact on unplanned hospitalisation, length of stay (LOS) and investigate the associated medical costs.

A systematic review of single-cell RNA sequencing applications and innovations.

Bulk RNA sequencing is one type of RNA sequencing technique, as well as targeted RNA sequencing and whole transcriptome sequencing. It provides valuable insights into gene expression in specific cell populations or regions. However, these methods often miss the diversity of cells within complex tissues.

Analyzing and forecasting under-5 mortality trends in Bangladesh using machine learning techniques.

Background: Under-5 mortality remains a critical social indicator of a country's development and economic sustainability, particularly in developing nations like Bangladesh. This study employs machine learning models, including Linear Regression, Ridge Regression, Lasso Regression, Bayesian Ridge, Decision Tree, Gradient Boosting, XGBoost, and CatBoost, to forecast future trends in under-5 mortality. By leveraging these models, the study aims to provide actionable insights for policymakers and health professionals to address persistent challenges.

Exploring urban-rural inequalities of maternal healthcare utilization in Bangladesh.

Background: Bangladesh has made significant progress across various sectors, including healthcare. However, noticeable disparities persist in the healthcare sector, particularly in maternal healthcare between urban and rural areas. Despite substantial advancements in maternal healthcare services (MHCS), such as Antenatal care (ANC), Facility-Based Delivery (FBD), and Skilled Birth Attendants (SBA), utilization depends on various socioeconomic factors.

Navigating the currents: understanding awareness, attitudes, and menstrual hygiene management challenges in Bangladesh's Haor Region.

Menstrual hygiene management (MHM) is an important but often neglected aspect of women's health worldwide, especially in developing and disaster-prone countries, such as Bangladesh. This qualitative study aimed to investigate awareness, attitudes, and practices related to MHM among girls in the Haor region, particularly during floods. The study adopts a phenomenological approach, and data were collected using purposive sampling from 33 women aged 15 years and above who resided in the Haor region.

Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics.

The PI3K/AKT/mTOR pathway is central in regulating key cellular processes such as proliferation, survival, metabolism, and angiogenesis. Dysregulation of this pathway, particularly in the AKT2 isoform, is commonly observed in cancers such as breast, ovarian, and pancreatic cancers, leading to enhanced tumor progression, metastasis, and therapeutic resistance. Therefore, targeting AKT2 for inhibition is a promising strategy for cancer therapy.

Investigating the prevalence and associated factors of elevated liver enzymes and dyslipidemia during pregnancy.

Liver dysfunctions during pregnancy can either be pregnancy-specific or preexisting in acute or chronic form. Data on the prevalence of abnormal liver functions and dyslipidemia during pregnancy in Bangladesh are scarce since these tests are not typically done in routine prenatal screening. This study aims to investigate the prevalence of elevated liver enzymes and dyslipidemia and associated risk factors in a cohort of pregnant women in Bangladesh.

Synthesis, antimicrobial evaluation, ADMET prediction, molecular docking and dynamics studies of pyridine and thiophene moiety-containing chalcones.

In this study, three pyridine- and four thiophene-containing chalcone derivatives were synthesized via Claisen-Schmidt condensation reaction, where five derivatives were new. Different spectral analyses (IR, H NMR, HRMS) clarified the structures and these proposed compounds were screened for antimicrobial activity by the agar disc diffusion technique. Compound was conspicuously active against most of the bacterial and fungal strains.

Chia () Seed Oil Modulates the Haemato-Immunological Response, Antioxidative Status and Cytokine Gene Expression of Tropical Freshwater Teleost, .

The present investigation attempts to evaluate the impact of the dietary inclusion of chia () seed oil (CSO) on the indices of haemato-immunology, metabolic enzymes, and expression of immune-responsive cytokine genes in (rohu) fingerlings. The responses were observed in a 60-day feeding trial, set up with a total of 180 rohu fingerlings (19.74 ± 0.