Ultrasonographic Analysis of Site-Specific Plantar Skin Thickness for Melanoma Staging and Excision.

Plantar melanomas present unique diagnostic and surgical challenges owing to substantial regional variations in skin thickness. Although the Breslow thickness remains the primary criterion for staging and surgical excision, its application on plantar melanoma is complicated by the inherent thickness of the glabrous plantar epidermis, which may lead to tumor depth overestimation. Accurate assessment of plantar skin thickness is essential for optimizing staging accuracy and refining surgical margins.

Age-related amyloid beta dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: Cross-sectional trajectories and longitudinal validation.

Introduction: We developed and validated age-related amyloid beta (Aβ) positron emission tomography (PET) trajectories using a statistical model in cognitively unimpaired (CU) individuals.

Methods: We analyzed 849 CU Korean and 521 CU non-Hispanic White (NHW) participants after propensity score matching. Aβ PET trajectories were modeled using the generalized additive model for location, scale, and shape (GAMLSS) based on baseline data and validated with longitudinal data.

The Burden of Motor Neuron Diseases in the United States, 1990-2021: A Systematic Analysis of the Global Burden of Disease Study 2021.

Introduction/aims: There is a lack of up-to-date information on the burden of motor neuron diseases (MNDs) in the United States (US). This study aimed to estimate trends in the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) for MNDs in the US from 1990 to 2021.

Methods: We performed a secondary analysis of MNDs in the US using estimates of prevalence, incidence, and mortality obtained from analyses of the Global Burden of Disease 2021 dataset.

Evanescent-Field-Guiding 2D Ultrathin Waveguides for Seamlessly Integrated Devices.

Seamless integration of active devices into photonic integrated circuits remains a challenge due to the limited accessibility of the optical field in conventional waveguides, which tightly confine light within their cores. In this study, we propose a two-dimensional (2D) ultrathin waveguide as a photonic platform that enables efficient interaction between guided light and surface-mounted devices by supporting optical modes dominated by evanescent fields. We show that the guided light in a monolayer MoS film propagates over millimeter-scale distances with more than 99.

Adult onset cryopyrin-associated periodic syndrome due to germline missense mutation in in a previously healthy middle-aged woman.

Background: Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by a gain-of-function mutation in the gene, which regulates inflammasome-mediated interleukin-1β (IL-1β) production. This leads to recurrent episodes of fever, rash, and arthritis, typically beginning in childhood.

Objective: To demonstrate the role of a missense mutation, c.

Transient electronics for sustainability: Emerging technologies and future directions.

Transient electronics are emerging as a promising class of devices designed to disappear after a defined operational period, addressing growing concerns over sustainability and long-term biocompatibility. Built from biodegradable materials that undergo hydrolysis or enzymatic degradation, these systems are particularly well suited for temporary implantable applications, such as neural monitors, wireless stimulators, and drug delivery vehicles, as well as environmentally benign electronics for soil or aquatic disposal. Despite their potential, key challenges remain in expanding the material set for diverse functionalities, achieving high-density integration for advanced operations, and enabling precise lifetime control through strategies such as protective encapsulation.

Retraction: Optimized Cu-doping in ZnO electro-spun nanofibers for enhanced photovoltaic performance in perovskite solar cells and photocatalytic dye degradation.

[This retracts the article DOI: 10.1039/D4RA01544D.].

Characterization of subsp. isolated from human vagina: prevalence, phenotypic, and genomic insights.

The genus is a heterogenous group of commensal and pathogenic bacteria. Members of this genus are classified into two major groups, the pyogenic group and the viridans group streptococci (VGS). VGS are frequently found as normal members of the human microbiome and are regarded as commensals.

Corrigendum to: Impact of the COVID-19 outbreak on the field of hematopoietic cell transplantation in the Asia-Pacific region: APBMT Activity Survey 2020/2021 [Blood Cell Therapy. 2024; 7(4): 129-137. doi:10.31547/bct-2024-020].

[This corrects the article DOI: 10.31547/bct-2024-020.].

A Literature Review and Management Approach for Severe Skin Toxicity Induced by Enfortumab Vedotin Through Sequential Adaptation and Combination With Immune Checkpoint Inhibitors.

In patients with advanced urothelial carcinoma who have progressed after platinum-based chemotherapy, enfortumab vedotin (EV) improves overall survival compared to standard chemotherapy. Additionally, for treatment-naïve patients with locally advanced or metastatic urothelial carcinoma, the combination of pembrolizumab and EV demonstrates superior efficacy over platinum-based chemotherapy. Hence, EV becomes a standard treatment option.

Mitigation of mycotoxin residues and activation of endogenous stem cells in broiler chickens using a toxin binder: Implications for meat safety and performance enhancement.

Background And Aim: Mycotoxin contamination in poultry feed, particularly with aflatoxin B1 (AFB1) and ochratoxin A (OTA), poses significant threats to broiler health, meat quality, and consumer safety. Toxin binders are commonly used to mitigate these effects; however, their impact on endogenous stem cell activity and overall broiler performance remains underexplored. This study aimed to evaluate the efficacy of a commercial toxin binder in reducing AFB1 and OTA residues in broiler meat, inducing endogenous stem cell production, and improving growth and feed performance indices.

Morphology and molecular phylogeny of from and .

The main objective of the present study is to compile and comprehensively reevaluate all known records of in order to establish a standardized framework for the accurate characterization and identification of this species. Nine isolates of obtained from and from various regions of Korea were analyzed. The morphological features of the fungus and isolated colonies were described and illustrated.

Unveiling host plant associations and cryptic genetic diversity of (Aphididae: Lachninae) on cherry trees in South Korea.

This study presents the first record of Kanturski & Lee, 2024 (Aphididae: Lachninae) in South Korea, thereby extending its known distribution beyond Japan and identifying a new host plant, (Rosaceae). We describe diagnostic morphological traits across multiple life stages and compare them with those of Japanese populations. Comparative analyses with Japanese populations demonstrated consistent morphological differentiation, notably elevated ratios of the ultimate rostral segment to antennal segments across multiple morphs in the Korean population, indicating potential ecological adaptation.

Clinical Characteristics of Individuals with COPD, Pre-COPD, Smokers with Normal Lung Function in Korea: Updated Analysis of the KOCOSS Cohort.

Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disease characterized by persistent airflow limitation and is a leading cause of mortality worldwide. Pre-COPD refers to a pre-disease state associated with an increased risk of COPD development. This study aims to evaluate the clinical characteristics of individuals with COPD, pre-COPD, and smokers with normal lung function in South Korea, and to provide an updated analysis of the KOCOSS cohort data.

An infographic on laboratory animal veterinarians.

Background: Laboratory animal veterinarians play a crucial role as a bridge between the ethical use of laboratory animals and the advancement of scientific and medical knowledge in biomedical research. They alleviate pain and reduce distress through veterinary care of laboratory animals. Additionally, they enhance animal welfare by creating environments that mimic natural habitats through environmental enrichment and social associations.

Evaluating the ergonomic aspects of laparoscopic energy devices: combination of a survey and a kinesiologic experiment.

Introduction: This study aimed to evaluate surgeons' ergonomic satisfaction when using laparoscopic energy devices and to investigate how prolonged use affects muscle fatigue and surgical performance.

Methods: A two-part study, including a survey and a kinesiologic experiment, was conducted to compare 4 laparoscopic energy devices (D1-D4). Thirty surgeons completed a structured survey assessing ergonomic factors such as device weight, grip strength, handle design, comfort, and trigger location.

Antitumor Effects of Doxorubicin-Loaded Cellulose Nanoparticles in the Rabbit VX2 Liver Tumor Model.

Purpose: To evaluate the preclinical efficacy and safety of transarterial chemoembolization (TACE) using doxorubicin-loaded biocompatible cellulose nanoparticles in a rabbit VX2 liver tumor model.

Materials And Methods: Following institutional animal care committee approval, 23 rabbits with VX2 liver tumors were randomized into three groups: Group A (n = 9) received doxorubicin-loaded cellulose nanoparticles with ethiodized oil; Group B (n = 9) received doxorubicin with ethiodized oil; and Group C (n = 5) served as untreated controls. Tumor size was monitored via ultrasound for 4 weeks, and serum liver enzymes (aspartate transaminase and alanine transaminase) were measured on days 1, 3, and 7 to assess hepatotoxicity.

Enhancing Mindfulness-Based Cognitive Therapy in a Virtual Reality: A Prospective Interventional Study.

The increasing prevalence of depression has highlighted Mindfulness-Based Cognitive Therapy (MBCT) as an effective treatment. However, conventional MBCT has several limitations, including barriers to access, the need for trained professionals, and inconsistent levels of participant engagement. The feasibility of using Virtual Reality (VR) for MBCT has emerged as a promising solution, but further research is needed to assess its therapeutic potential.

Uptake characterization of soil arsenic species and its effects on nitrogen cycle in soybean (Glycine max (L.) Merrill) cultivation: A comparison with cadmium.

This study aimed to elucidate the effects of arsenic species [As(III)/As(V)] and cadmium [Cd(II)] on nitrification and nitrogen fixation in soybean (Glycine max (L.) Merrill) cultivation, and to identify nitrogen cycle disruption mechanisms in realistic soil environments with a focus on soil-metal-plant-microbe interactions. We examined heavy metal(loid)s uptake in plant tissues, changes in nitrogen species in porewater, nitrogenase activity, the contents of essential trace metals (Mo and Fe) in nitrogenase, and nitrogen-related microbial communities.

ONAC005 enhances salt stress tolerance by promoting suberin deposition in root endodermis.

Salt stress impairs photosynthetic efficiency and consequently reduces the growth, development, and grain yield of crop plants. The formation of hydrophobic barriers in the root endodermis, including the suberin lamellae and Casparian strips, is a key adaptive strategy for salt stress tolerance. In this study, we identified the role of the rice NAC transcription factor, ONAC005, in salt stress tolerance.

Outcomes following transition from ibrutinib to zanubrutinib in patients with Waldenström macroglobulinemia from ASPEN.

Zanubrutinib is a next-generation covalent Bruton tyrosine kinase (BTK) inhibitor designed to provide complete and sustained BTK occupancy for efficacy across disease-relevant tissues, with fewer off-target adverse events (AEs) than other covalent BTK inhibitors. In the phase 3 ASPEN study (BGB-3111-302), comparable efficacy and a favorable safety profile versus ibrutinib were demonstrated in patients with MYD88-mutated Waldenström macroglobulinemia (WM), leading to approval of zanubrutinib for patients with WM. BGB-3111-LTE1 (LTE1) is a long-term extension study to which eligible patients, including patients from comparator treatment arms, could enroll following participation in various parent studies of zanubrutinib to treat B-cell malignancies.