The nature of fatigue in amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Objectives: Patients diagnosed with amyotrophic lateral sclerosis (ALS) typically describe symptoms of fatigue. Despite this frequency, the underlying mechanisms of fatigue are poorly understood, and are likely multifactorial. To help clarify mechanisms, the present systematic review was undertaken to determine the risk factors related to fatigue in ALS.

[Dissociation of posttraumatic arteriovenous fistula on the leg].

Widespread fragmentation shells in combat operations with frequent multiple damage to organs and systems force to use all available diagnostic methods for treating severe injuries including lesion of great vessels of extremities. One of the consequences of these lesions is arteriovenous fistula (AVF). The last one may be asymptomatic at first.

[A rare variant of celiac axis anatomy].

The authors present a rare variant of celiac axis anatomy including acute angle of departure, ultra-short length and «parallel» course of the main branches. When analyzing the literature on this problem, they found no similar reports. This clinical example once again emphasizes significant variability of celiac axis anatomy and the need for a thorough examination of patients using all possible diagnostic methods, especially before surgery.

[Staged treatment of complex pressure sores after spinal injuries].

The authors present treatment of patients with spinal injury complicated by extensive multiple pressure sores. A comprehensive preoperative management was followed by staged surgical treatment. Advisability of deep bedsore closure with full-layer flaps and staged interventions was justified.

[Surgical issues of the treatment of meningococcal disease in children].

Background: The paper addresses an important section of pediatric combustiology - generalized meningococcal infection, associated with a severe course, the risk of disabling complications, life-threatening conditions, and high mortality.

Objective: The purpose of the study was to share the experience of treating patients with the sequelae of generalized bacterial infection caused by in a children's burn center.

Material And Methods: We conducted a retrospective analysis of the medical records of 23 patients treated in the burn department for babies from 0 to 3 years of the Children's City Clinical Hospital No.

[Validation and clinical value of prognostic model for assessing the risk of severe acute pancreatitis based on inflammatory and hemostasis markers].

Objective: To validate and assess clinical efficacy of a prognostic model for predicting severe acute pancreatitis (SAP) based on inflammatory markers (IL-6, ΔIL-22), thromboelastography parameters (K-time) and the BISAP score.

Material And Methods: A prospective observational cohort study enrolled 181 patients with acute pancreatitis. Serum IL-6 and IL-22 were measured in 24 and 48 hours after clinical manifestation, respectively.

[Interleukin-6 as a biochemical marker of intestinal anastomotic leakage].

Objective: To evaluate diagnostic significance of IL-6 compared to CRP for early detection of anastomotic leakage after colon resection for colorectal cancer.

Material And Methods: The study included 277 patients who underwent total resection for colorectal cancer. Patients were retrospectively divided into three groups: without complications (=227), with anastomotic leakage (=30), and other postoperative complications (=20).

[Repeated common femoral artery bifurcation repair in patients with acute lower limb ischemia and unsatisfactory outflow pathways].

Objective: To analyze and improve postoperative outcomes in patients with acute lower limb ischemia (ALLI) and previous reconstructive infrainguinal interventions.

Material And Methods: The authors analyzed postoperative outcomes after 54 repeated interventions in patients with thrombosis of common femoral artery bifurcation, deep femoral artery and non-functioning femoropopliteal (tibial) prosthesis.

Results: External-iliac-deep femoral replacement were performed in 28 (52%) patients, extended deep femoral artery repair - in 16 (29.

[Completion pancreatectomy for postoperative complications after pancreatoduodenectomy].

Objective: To analyze the most well-known studies devoted to completion pancreatectomy (CP) for postoperative complications after pancreatoduodenectomy.

Material And Methods: We analyzed original articles and reviews between 1992 and 2023 (number of patients ≥5 (5-120)).

Results: Mean blood loss in CP ranged from 500 to 2180 ml, surgery time - from 144 to 340 min.

[Minimally invasive surgery for liver echinococcosis].

Objective: To analyze the effectiveness of minimally invasive surgery for small and medium sized liver cysts.

Material And Methods: We used minimally invasive technologies in 331 patients with echinococcal liver cysts (small cysts (<3.5 cm) - 49 (14.

[Laparoscopic appendectomy in children: results of the all-Russian survey].

Objective: To study opinions of pediatric surgeons on technical aspects of laparoscopic appendectomy in children.

Material And Methods: An anonymous survey of surgeons was used as the main research method (Google Forms platform). Invitations were sent to specialized institutions (emergency pediatric surgery departments).

[Predictors of mortality in neonatal spontaneous gastric perforation: a multiple-center study].

Objective: To analyze clinical data and predictors of mortality neonatal spontaneous gastric perforation (SGP).

Material And Methods: A two-center retrospective cohort study included neonates diagnosed with SGP between 1999 and 2023. This cohort was divided into survivors and dead neonates to identify prognostic factors of mortality.

[Treatment of cancer in tubular villous colorectal adenomas].

Objective: To study the results of treatment of cancer in tubular villous adenomas.

Material And Methods: A retrospective analysis included 51 patients with cTis-T1N0M0 between 02.2019 and 09.

[Classification criteria for anterior abdominal wall deformities].

Objective: To determine the distribution of patients with different anterior abdominal wall deformities.

Material And Methods: Physical data, CT and morphological findings were analyzed in 622 patients. The study was conducted in retro- and prospective nature.

[Xenopericardial femoral artery surgery in hybrid treatment of critical ischemia of the lower extremities].

Objective: To compare 6- and 12-month results of femoral artery repair with xenopericardial and autologous venous patch in hybrid treatment of critical lower limb ischemia.

Material And Methods: A retrospective analysis included 60 patients with critical lower limb ischemia who underwent hybrid treatment (balloon angioplasty and stenting of iliac arteries and open reconstruction of femoral arteries). Patients were divided into 2 groups by 30 people depending on femoral artery repair (group 1 - autologous venous patch, group 2 - xenopericardial patch).

[Endoscopic treatment of patients with adenomas of the major duodenal papilla and familial adenomatous polyposis].

Objective: To demonstrate the effectiveness and safety of intraluminal endoscopic treatment of patients with adenomas of the major duodenal papilla and familial adenomatous polyposis.

Material And Methods: Over the past 4 years, 13 patients with adenomas of the major duodenal papilla and familial adenomatous polyposis underwent surgery in our hospital. Of these, 7 patients had exclusively extrapapillary adenomas without signs of spread to the ducts.

Emergent Dirac fermions in graphene and underlying Au monolayer with two-dimensional ferrimagnetism.

Using angle-resolved photoemission spectroscopy (ARPES) with spin resolution, scanning tunneling microscopy/spectroscopy (STM/STS) and density functional theory (DFT) methods, we study the electronic structure of graphene-covered and bare Au/Co(0001) systems and reveal intriguing features, arising from the ferrimagnetic order in graphene and the underlying gold monolayer. In particular, a spin-polarized Dirac-cone-like state, intrinsically related to the induced magnetization of Au, was discovered at point. We have obtained a good agreement between experiment and theory for bare and graphene-covered Au/Co(0001) and have proven that both Au ferrimagnetism and the Dirac-cone-like band are intimately linked to the triangular loop dislocations present at the Au/Co interface.

De Novo HNRNPU Pathogenic Variant Related to Developmental Epileptic Encephalopathy With Inherited KANSL1 Loss-of-Function Variant Resolved by RNA Analysis.

Background: Developmental and epileptic encephalopathies (DEEs) comprise a diverse range of disorders that can arise from both genetic and non-genetic causes. Genetic DEEs are linked to pathogenic variants in various genes with different molecular functions. The wide clinical and genetic variability found in DEEs poses a considerable challenge for accurate diagnosis even with the use of comprehensive diagnostic approaches such as whole genome sequencing (WGS).

Absorption properties of boron nitride quantum dots: effects of solvents.

Boron nitride quantum dots combine several unique properties, including chemical stability, biocompatibility, and low cytotoxicity. These properties and tunable optical characteristics make them promising for use in boron neutron capture therapy simultaneously as therapeutic agents and fluorescent markers for cancer cells. In this paper we present a case study, in which the electronic structure of these dots is analyzed using DFT and TD-DFT methods providing a deeper understanding of their absorption properties.

Allogeneic Treg-derived artificial vesicles: A promising therapeutic modality for multiple sclerosis.

Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). CD4 CD25 Tregs, which normally suppress immune responses, exhibit impaired function in MS. Treg-derived extracellular vesicles (EVs) carry immunoregulatory proteins and miRNAs that modulate T-cell activity.

Simulation-Based Training in Aortic Aneurysm Surgery: Toward a New Educational Standard.

Simulation-based training is transforming the education of vascular surgeons in the management of aortic aneurysms (AAs), addressing limitations in traditional apprenticeship models amid declining open surgical volumes and increasing reliance on complex endovascular techniques. This review explores the current landscape of simulation technologies, including computational modeling, fluid-structure interaction, patient-specific 3D printing, artificial intelligence, and robotic platforms. These tools enable high-fidelity, anatomically accurate, and physiologically realistic training environments.

Functional and health-promoting bioactivities of fractions derived from chicken embryo hydrolysates.

Hen eggs are rich in proteins, which are a potential source of bioactive peptides. Incubation of fertilized egg changes the egg protein, which may affect the properties and activity of derived peptides. To understand these metamorphoses, hydrolysate fractions of 10-day incubated chicken embryo (CE) proteins of 0.

ZnO, CuO and TiO nanoparticles impacts on natural phytoplankton community (in vitro).

The emergence of new types of pollutants and the increase of anthropogenic load on the environment provoked an increased interest of researchers to study the toxic effects of pollutants on living organisms. This study is devoted to investigate the physiological response of the Black Sea phytoplankton community to the effects of ZnO, CuO and TiO nanoparticles (NPs) of different concentrations by creating in vitro model microcosms. Trends of changes in the ratio between phytoplankton groups (cyanobacteria-picoeukaryotic algae-nano-microphytoplankton), species composition, growth rates and functional state of cells under the influence of the studied nanoparticles were revealed.

Phosphorylated Derivatives of Quaternary Ammonium Salts: Synthesis, X-Ray Crystal Structure, Antimicrobial Activity and Ecotoxicity.

Phosphorylated structural analogs of Benzalkonium Chloride-diisopropoxyphosphorylmethane (dimethyldodecylammonium) bromide 1 (phosphorylated quaternary ammonium salt) and isopropoxyphosphorylmethane (dimethylalkylammonium) 2 (phosphorylated betaine) were synthesized. The structure of compound 1 was confirmed by single crystal X-ray diffraction study. The antibacterial, antifungal, and ecotoxicological profiles of the synthesized compounds were evaluated against aquatic organisms and flowering plants.

An analysis of Russian-produced clinical practice guidelines using the RIGHT reporting checklist: The case of direct oral anticoagulants for coronavirus disease 2019.

ObjectiveThe objective of the study was to compare the results of quality assessment of Russian-produced clinical practice guidelines on the use of direct oral anticoagulants in the treatment and prophylaxis of coronavirus disease 2019 using the RIGHT checklist and AGREE II instrument.MethodsWe assessed six relevant clinical practice guidelines published between 2020 and 2023 in Russian databases using the RIGHT checklist. We compared the results of using the RIGHT tool with the results obtained using the AGREE II instrument.