[Dental status of patients depending on the presence of precancerous diseases of the oral mucosa].

Objective: To study the dental status of patients depending on the presence of precancerous diseases of the oral mucosa.

Material And Methods: For the first time in the Ryazan region 1857 people aged 18 to 89 years were examined. To assess the dental status of patients the CFE (DMFT) index and the OHI-S hygienic index (Green, Vermillion, 1964) were used, the presence of orthopedic structures was noted.

[Traumatic injuries of the rectum and anus in childhood].

Objective: To analyze treatment outcomes in children with anorectal injury.

Material And Methods: There were 31 children aged 1-18 years with traumatic injuries of the rectum and anus. Diagnostic measures included analysis of anamnesis, examination, rectal examination, bladder catheterization, X-ray methods including CT and MRI.

[The Possibilities of Predicting Left Ventricular Ejection Fraction 12 Months After ST-Segment Elevation Myocardial Infarction].

Aim    To identify predictors and develop a model for prognosis of left ventricular (LV) ejection fraction (EF) 12 months after ST-segment elevation myocardial infarction (STEMI) on electrocardiogram (ECG).Material and methods    This was a prospective registry study of patients admitted within 24 h of STEMI. Concentrations of soluble suppression of tumorigenicity 2, proprotein convertase subtilisin/kexin type 9, N-terminal pro-B-type natriuretic peptide (NTproBNP), high-sensitivity troponin I (TnI), and C-reactive protein were measured.

Screening Possibilities for Fabry Disease: Experience of the Ryazan Region.

Aim      To evaluate the possibilities of screening for Fabry disease (FD) in a particular region of the Russian Federation.Material and methods  This was an open prospective non-comparative study. The screening included patients with left ventricular (LV) hypertrophy >13 mm without severe hypertension; patients who had suffered stroke without an apparent cause; patients with peripheral pain syndrome associated with distal polyneuropathy with predominant damage to small fibers; patients with signs of FD during physical examination; coarse facial features; angiokeratomas (inner thighs, hands, abdomen, oral mucosa); thermoregulation disorders; chronic kidney disease.

[Emergency measures in the diagnosis and treatment of chronic forms of ischemic heart disease].

Coronary heart disease (CHD) is one of the most common cardiovascular diseases and the most common cause of death in Russia. Primary diagnostics of CHD involves assessing the pre-test probability of CHD. Thereafter, myocardial ischemia should be verified by visualization technique: stress echocardiography or stress single-photon emission computed tomography of the myocardium.

Senile Asthenia Syndrome in Patients With Acute Decompensation of Heart Failure: Prevalence, Impact on Quality of Life, Management Tactics, Prognosis.

Aim      To study the prevalence of senile frailty syndrome (FS), its impact on the functional activity, quality of life, management tactics, and prognosis in patients with acute decompensated heart failure (ADHF).Material and methods  The study included 108 patients (58 men and 50 women, mean age 69.2±10.

[The effect of Mexidol on the level of neurogenesis markers in acute cerebrovascular accident in the experiment].

Objective: To study the effect of Mexidol on the level of factors regulating neuroregenesis.

Material And Methods: The study was performed on male Wistar rats. Focal cerebral ischemia was reproduced by endovascular occlusion-reperfusion of the right medial cerebral artery.

Synthesis and Anti-Cancer Activity In Vitro of Synephrine Derivatives.

Glucocorticoids (GCs) are routinely used to treat hematological malignancies; however, long-term treatment with GCs can lead to atrophic and metabolic adverse effects. Selective glucocorticoid receptor agonists (SEGRAs) with reduced side effects may act as a superior alternative to GCs. More than 30 SEGRAs have been described so far, yet none of them reached clinical trials for anti-cancer treatment.

Predictors of Left Ventricular Ejection Fraction Decrease in Patients With ST-Segment Elevation Myocardial Infarction.

Aim: To identify predictors and construct a model for predicting left ventricular (LV) ejection fraction (EF) in patients with ST-segment elevation myocardial infarction (STEMI).

Material And Methods: This was a prospective registry study of patients with STEMI admitted within the first 24 hours of the disease onset. Patients were evaluated and treated according to the current clinical guidelines.

[Granulomatosis with polyangiitis. Analysis of two clinical cases from the practice of an otorhinolaryngologist].

The article presents an analysis of 2 clinical cases of granulomatosis with polyangiitis from the practice of an otorhinolaryngologist. In the first case, the pathology manifested with lesions of the middle ear and nose. In the second case, in addition to manifestations from the nose and the ear, there was a lesion of the larynx.

Relationship of Iron Deficiency, Anemia and Combination of Iron Deficiency With Anemia With Severity of Manifestations of Chronic Heart Failure. Additional Analysis of the Study "Prevalence of Iron Deficiency in Patients With Chronic Heart Failure in the Russian Federation (J-CHF-RF)".

Aim      To evaluate the role of iron deficiency (ID) identified by various criteria, anemia, and the combination of ID and anemia in determining the severity of the clinical course of chronic heart failure (CHF) in a retrospective analysis of data from 498 patients who participated in the ID-CHF-RF Russian multicenter program.Material and methods  ID was diagnosed by the following three criteria established by the European Society of Cardiology (ESC) and the Russian Society of Cardiology (RSC): 1) ferritin concentration <100 μg/l or ferritin concentration 100-299 μg/l in combination with a decreased transferrin saturation (TS) <20%; 2) ID criteria that showed a high sensitivity and specificity when compared with bone marrow morphology (BMM): TS ≤19.8% or serum iron (SI) ≤13 μmol/l; and 3) a composite index including a ferritin concentration <100 μg/l in combination with TS <20% and SI ≤13 μmol/l.

A novel preliminary metabolomic panel for IHD diagnostics and pathogenesis.

Cardiovascular disease (CVD) represents one of the main causes of mortality worldwide and nearly a half of it is related to ischemic heart disease (IHD). The article represents a comprehensive study on the diagnostics of IHD through the targeted metabolomic profiling and machine learning techniques. A total of 112 subjects were enrolled in the study, consisting of 76 IHD patients and 36 non-CVD subjects.

[Modern biochemical markers of acute mesenteric ischemia].

Objective: To analyze modern literature data on biochemical markers of critical mesenteric ischemia.

Material And Methods: We analyzed the most promising, highly specific and sensitive biochemical markers of total and segmental intestinal damage following acute mesenteric ischemia. Analysis included domestic and foreign literature data between 2015 and 2023.

[Features of the course of COVID-19 in patients with type 2 diabetes mellitus].

Aim: To identify the features of the course of COVID-19 in patients with type 2 diabetes mellitus (T2DM), depending on the intake of hypoglycemic therapy at the prehospital stage, in conjunction with the functional state of the kidneys.

Materials And Methods: A retrospective analysis of 291 case histories of patients with COVID-19 and T2DM hospitalized in the infection department of Semashko Regional Clinical Hospital from January to December 2021, including the main clinical and laboratory parameters. Results.

Synthetic 1,2,4-triazole-3-carboxamides Induce Cell Cycle Arrest and Apoptosis in Leukemia Cells.

Background: A number of studies demonstrate the efficacy of ribavirin against various cancer types in and models. However, ribavirin induces the development of multiple side effects, suggesting a high demand for ribavirin analogues with improved therapeutic indexes.

Objective: This study was focused on the analysis of ribavirin, its aglycon 1,2,4-triazole-3-carboxamide, and several of its derivatives activities in blood cancer cells .

Secreted cyclophilin A is non-genotoxic but acts as a tumor promoter.

Chronic inflammation is associated with malignant transformation and creates the microenvironment for tumor progression. Cyclophilin A (CypA) is one of the major pro-inflammatory mediators that accumulates and persists in the site of inflammation in high doses over time. According to multiomics analyses of transformed cells, CypA is widely recognized as a pro-oncogenic factor.