Tetrasaccharide Resin Glycosides with Nitric Oxide Production Inhibitory Activity from .

LC-HRMS/MS-based molecular-network-guided chemical investigation of led to the isolation of seven undescribed tetrasaccharide-type resin glycosides (-). Their structures were elucidated using 1D and 2D NMR and HRESIMS analysis. Isolated resin glycosides were comprised of d-glucose, d-fucose, d-quinovose, and l-rhamnose, and these monosaccharides were partially acylated with acetyl, isobutyryl, -hexanoyl, and niloyl organic acids.

Niabella insulamsoli sp. nov., Isolated From Soil and Showing Potential Cosmetic Functions with Flexirubin Extract.

A yellow-pigmented, non-motile, rod-shaped, and Gram-stain-negative bacterium was isolated from the soil of Yeongheung Island, Korea. The novel isolate, strain N803, was strictly aerobic, grew optimally at 30-35 °C, at pH 6.5, and in the presence of 0-2% NaCl.

Enhanced Versus Standard Dermatologic Management With Amivantamab-Lazertinib in EGFR-Mutated Advanced NSCLC: The COCOON Global Randomized Controlled Trial.

Introduction: Amivantamab plus lazertinib significantly improved progression-free and overall survival versus osimertinib in patients with previously untreated, EGFR-mutant advanced NSCLC. EGFR-targeted therapies are associated with dermatologic adverse events (AEs), which can affect quality of life (QoL). COCOON was conducted to assess prophylactic management and improve treatment experience.

Semicrystalline Polymer Donors for Simultaneous Dark Current Suppression and Photocurrent Enhancement in High-Performance Photomultiplication-Type Organic Photodetectors.

Photomultiplication-type organic photodetectors (PM-type OPDs) have recently attracted attention. However, the development of polymer donors specifically tailored for this architecture has rarely been reported. In this study, we synthesized benzobisoxazole-based polymer donors incorporating alkylated π-spacers that simultaneously enhance photocurrent density () and suppress dark current density (), leading to high responsivity () and specific detectivity (*).

Effects of Dexmedetomidine-Remifentanil on Neurodevelopment of Children after Inhalation Anesthesia: A Randomized Clinical Trial.

Background: Anesthetic exposure in young children raises concerns about neurodevelopmental safety, with preclinical evidence suggesting potential neurotoxicity of volatile anesthetics. This study aimed to assess whether the combination of dexmedetomidine and remifentanil, by reducing sevoflurane exposure, has any differential effect on neurodevelopmental outcomes in young children compared with sevoflurane alone.

Methods: This study was a prospective, double-blind, randomized clinical trial including children younger than 2 yr undergoing nonstaged, nonrepetitive surgeries.

Clinical Investigation of Rods and Rings Pattern in Anti-Nuclear Antibody Test in Korean Patients.

Background: This study investigated the clinical significance of rods and rings (RR) immunofluorescence patterns in antinuclear antibody (ANA) testing by analyzing their clinical associations.

Methods: A single-center retrospective analysis was conducted between January 2022 and December 2023, examining cases with RR patterns in ANA testing.

Results: Among 40 cases (0.

Photoluminescence and photoredox catalytic properties of cationic Ru(II) polypyridine complexes encapsulated within an InTATB metal-organic framework.

The nanoscale environment within the void spaces of metal-organic frameworks (MOFs) can significantly influence the photoredox catalytic activity of encapsulated visible-light photoredox catalysts (PCs). To compare two isostructural PC@In-MOF systems, three cationic Ru(II) polypyridine complexes were successfully encapsulated within the mesoscale channels of the anionic framework of InTATB (HTATB = 4,4',4''--triazine-2,4,6-triyltribenzoic acid), which features a doubly interpenetrated framework structure. This encapsulation yielded three heterogenized visible-light PCs, RuL@InTATB, where L = 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen), or 2,2'-bipyrazine (bpz).

Cell-Stress-Free Percutaneous Bioelectrodes.

Wearable bioelectronics have advanced dramatically over the past decade, yet remain constrained by their superficial placement on the skin, which renders them vulnerable to environmental fluctuations and mechanical instability. Existing microneedle (MN) electrodes offer minimally invasive access to dermal tissue, but their rigid, bulky design-often 100 times larger and 10,000 times stiffer than dermal fibroblasts-induces pain, tissue damage, and chronic inflammation, limiting their long-term applicability. Here, a cell-stress-free percutaneous bioelectrode is presented, comprising an ultrathin (<2 µm), soft MN (sMN) that dynamically softens via an effervescent structural transformation after insertion.

Adherence of Anti-Dementia Medications in Alzheimer's Disease and Related Dementia: A Nationwide Cohort Study in Korea.

Background: Readily available treatments for Alzheimer's disease and related dementia (ADRD) include acetylcholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists. Non-adherence and early discontinuation of anti-dementia medications are prevalent issues. We aimed to investigate factors associated with suboptimal usage of anti-dementia medications in ADRD.

Evidence of Overlapping Roles Between Clinics and Hospitals in Primary Care.

Background: Clinics and hospitals in South Korea are often perceived as competitors to each other. This study examines the overlapping roles in providing primary care provision between clinics and hospitals by analyzing the healthcare facility type where patients first receive diagnoses of hypertension (HTN) or diabetes mellitus (DM). We also explore the characteristics of patients that influence their choice of healthcare facility and compare healthcare utilization patterns in the first year post-diagnosis by facility type.

Facile Deep Brain Electrode Coating with MXene for Improved Electrode Performance.

Accurate brain signal recording and precise electrode placement are critical for the success of neuromodulation therapies such as deep brain stimulation (DBS). Addressing these challenges requires deep brain electrodes that provide high-quality, stable recordings while remaining compatible with high-resolution medical imaging modalities like magnetic resonance imaging (MRI). Moreover, such electrodes shall be cost-effective, easy to manufacture, and patient-compatible.

Open versus arthroscopic anterior latissimus dorsi transfer for irreparable subscapularis tear: a multicentre cohort study.

Purpose: This study aimed to compare clinical outcomes between open and arthroscopic anterior latissimus dorsi (LD) transfer techniques for treating irreparable subscapularis (SSC) tears.

Methods: We retrospectively reviewed patients who underwent open or arthroscopic anterior LD transfer for irreparable SSC tears between February 2014 and August 2020. Patients were included if they had irreparable SSC tears with Lafosse Grade 4 or higher and Goutallier Grade 3 or higher, but without advanced arthritis (Hamada Grade < 3).

Thunberg root extract inhibits atopic dermatitis-like skin symptoms.

Thunberg is a perennial herbaceous plant of the genus that belongs to the Apiaceae family and is effective in improving inflammation, gout, and dizziness. However, the skin pruritus improvement effect and mechanism of action of Thunberg root extract (PJRE) have not yet been reported. We investigated the effects of PJRE on the regulation of pruritus and inflammatory responses in compound 48/80 (C48/80)-treated mice, phorbol 12-myristate 13-acetate (PMA)/A23187-induced human skin mast cells, and LPS-stimulated mouse macrophages.

Comparative Effectiveness of Direct Oral Anticoagulants and Warfarin on Venous Thromboembolism in Cancer Patients.

Introduction: Venous thromboembolism (VTE) is a leading cause of mortality in cancer patients, and a substantial number of patients are being treated with oral anticoagulants. We aim to assess the comparative effectiveness of direct oral anticoagulants (DOACs) compared to warfarin for VTE treatment in cancer patients.

Methods: In this retrospective cohort study, we included 2,367 cancer patients who are new users of oral anticoagulants (OACs) for VTE treatment from 2009 to 2021 in NHS Scotland.

Ultra-low attachment surface enabling 3D co-culture of human B cells with CD40L-expressing stromal cells for mimicry of secondary lymphoid organs.

B cells are critical components of the adaptive immune system that proliferate and differentiate within the secondary lymphoid organs upon recognition of antigens and engagement of T cells. Traditional two-dimensional (2D) cell cultures fall short of replicating the intricate structures and dynamic evolution of three-dimensional (3D) environments found in lymphoid organs, prompting the development of more physiologically pertinent models. Our approach employs -hexanoyl glycol chitosan (HGC) coated ultra-low attachment (ULA) lattice plates to cultivate a 3D co-culture of CD40L-expressing MS5 stromal cells and naïve B cells derived from the peripheral blood mononuclear cells (PBMCs) of healthy human donors.

Green tea extract complex as a phytogenic supplement to reduce bile salt hydrolase activity and enhance growth performance in weaning pigs.

The post-weaning period is stressful for pigs due to changes in their environment and diet. The occurrence of diarrhea at this stage is high. Growth promoters such as antibiotics and zinc oxide (ZnO) have been used to not only reduce post-weaning diarrhea but also improve growth performance of weaning pigs.

Shift Work and Dietary Behaviors Among Korean Workers.

Background: Shift work is associated with irregular dietary habits and poor nutritional intake, increasing the risk of chronic diseases. This study aimed to assess dietary quality and nutritional intake according to shift work status among Korean adult workers.

Methods: Data from 15,121 adult workers aged ≥20 years from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted between 2013 and 2021 were analyzed.

Sevoflurane or remimazolam anaesthesia and emergence agitation after nasal surgery in adults: A randomised clinical trial.

Background: Emergence agitation is common after nasal surgery under general anaesthesia. Remimazolam, a novel ultra-short-acting benzodiazepine, allows haemodynamic stability and prompt postoperative recovery, but the specific impact of remimazolam on emergence agitation is not well understood.

Objectives: The primary aim of this study was to compare the effects of remimazolam-based total intravenous anaesthesia (TIVA) and sevoflurane-based volatile induction and maintenance of anaesthesia (VIMA) on the occurrence of emergence agitation.

Immediate complications and risk factors following radial arterial catheterisation in paediatric patients at a tertiary centre.

Background: Arterial catheterisation is a critical procedure in paediatric patients undergoing surgery; however, it poses certain risks. Complications such as thrombus formation, arterial stenosis and haematoma may occur, yet their true incidence and contributing factors remain incompletely understood.

Objective: To assess the incidence of complications and identify associated risk factors following radial arterial catheterisation in paediatric patients.

All-3D-Printed Multi-Environment Modular Microrobots Powered by Large-Displacement Dielectric Elastomer Microactuators.

Microrobots are expected to push the boundaries of robotics by enabling navigation in confined and cluttered environments due to their sub-centimeter scale. However, most microrobots perform best only in the specific conditions for which they are designed and require complete redesign and fabrication to adapt to new tasks and environments. Here, fully 3D-printed modular microrobots capable of performing a broad range of tasks across diverse environments are introduced.

Bioprosthetic valve replacement for concomitant aortic and mitral positions.

Objective: To compare the clinical outcomes of double-valve replacement (DVR) using bovine pericardial and porcine bioprostheses, using a nationwide administrative claims database.

Methods: Adult patients (age ≥40 years) who underwent bioprosthetic DVR between 2003 and 2018 were identified from the Korean National Health Insurance Service database. The outcomes of interest were all-cause mortality, cardiac mortality, and valve-related events, including the incidences of reoperation, endocarditis, systemic thromboembolism, and major bleeding.

Quantitative assessment of fixation strength in combined thread lifting: Comparative analysis of bidirectional-multidirectional versus double bidirectional thread combinations.

Background: The efficacy of thread lifting procedures for facial rejuvenation is significantly influenced by thread fixation strength and tissue stabilization capabilities. This study presents a quantitative biomechanical comparison between bidirectional threads (epiticon® BI, JETEMA Co., Ltd.

Real-Time Visualisation of Reaction Kinetics and Dynamics: Single-Molecule Insights into the Iminium-Catalysed Diels-Alder Reaction.

Investigation of the fundamental microscopic processes occurring in organic reactions is essential for optimising both organocatalysts and synthetic strategies. In this study, single-molecule fluorescence microscopy was employed to study the Diels-Alder reaction catalysed by a first-generation MacMillan catalyst, providing direct insights into its kinetic dynamics. This reaction proceeds via a series of reversible processes under equilibrium conditions (S ⇄ IM ⇄ IM → P, IM and IM: N,O-acetal and iminium ion intermediates, respectively).

Concentration-Dependent Nanosheet and Nanotube Networks: Ice-Water Interface Control for Antifreeze Application.

Cyclic peptides (CPs) are versatile building blocks whose conformational constraints foster ordered supramolecular architectures with potential in biomedicine, nanoelectronics, and catalysis. Herein, we report the development of biomimetic antifreeze materials by conjugating CPs bearing ice-binding residues to 4-arm polyethylene glycol (PEG) via click chemistry. The concentration-dependent self-assembly of these CP-PEG conjugates induces programmable morphological transitions, forming nanotube networks above the critical aggregation concentration (CAC) and two-dimensional nanosheet networks near the CAC.

Case report of extranodal NK/T-cell lymphoma mimicking Behcet syndrome.

Rationale: Extranodal natural killer (NK)/T-cell lymphoma is an uncommon non-Hodgkin lymphoma, prevalent in Asia. It often involves the nasal and upper airway regions but can disseminate to other sites like skin, soft tissue, testis, and gastrointestinal tract, characterized by Epstein-Barr virus association.

Patient Concerns: This report discusses a 48-year-old male initially diagnosed with Behcet syndrome with dry mouth, uveitis, pruritic macules, and human leukocyte antigen-B51 positivity.