The relationship between adherence to 24-h movement guidelines and brain-derived neurotrophic factor in adolescents: a cross-sectional study.

Unlabelled: The objective of this study is to analyze adherence to 24-h movement behavior recommendations (combined and isolated) with brain-derived neurotrophic factor (BDNF) in adolescents. For this cross-sectional study, 155 adolescents were recruited, of whom 141 participated; 118 with valid data were analyzed (64 girls, mean age 14.9 years).

Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder.

Background: Peripartum depression (PPD) is a form of major depressive disorder (MDD) that begins during the peripartum period and poses a significant mental health challenge affecting 10 to 29% of women.

Objective: This systematic review and multimodal activation likelihood estimation (ALE) meta-analysis explored the distinct structural, functional, and metabolic features of the PPD brain as compared to female non-peripartum MDD.

Methods: For this purpose, we conducted a comprehensive literature search in PubMed, Embase and PsycINFO databases to identify peer-reviewed original studies investigating the neural correlates associated with PPD or fMDD.

On-liquid surface synthesis of diyne-linked two-dimensional polymer crystals.

The synthesis of thin crystalline two-dimensional polymers (2DPs) typically relies on reversible dynamic covalent reactions. While substantial progress has been made in solution-based and interfacial syntheses, achieving 2DPs through irreversible carbon-carbon coupling reactions remains a formidable challenge. Herein, we present an on-liquid surface (a mixture of N,N-dimethylacetamide and water, DMAc-HO) synthesis method for constructing diyne-linked 2DP (DY2DP) crystals via Glaser coupling, assisted by a perfluoro-surfactant (PFS) monolayer.

Dopamine System Dysfunction in Alzheimer's Disease.

The dopaminergic system may be at the base of some neurobehavioral symptoms, as apathy and depression, and extrapyramidal symptoms, often seen in Alzheimer's disease patients. It can also have an impact on cognitive decline, as extrapyramidal symptoms, classically linked with dopamine dysfunction, are associated with increased risk of cognitive impairment and Alzheimer's disease progression. We review the knowledge of the dopaminergic system, emphasizing changes in Alzheimer's disease.

Fermented Food Consumption Across European Regions: Protocol for the Development and Validation of the Web-Based Fermented Foods Frequency Questionnaire (3FQ).

Background: Fermented foods vary significantly by food substrate and regional consumption patterns. Although they are consumed worldwide, their intake and potential health benefits remain understudied. Europe, in particular, lacks specific consumption recommendations for most fermented foods.

Exploring Antiviral Strategies to Combat African Swine Fever.

African Swine Fever (ASF), caused by the highly contagious African swine fever virus (ASFV), poses a significant threat to domestic and wild pigs worldwide. Despite its limited host range and lack of zoonotic potential, ASF has severe socio-economic and environmental consequences. Current control strategies primarily rely on early detection and culling of infected animals, but these measures are insufficient given the rapid spread of the disease.

A causal inference framework to compare the effectiveness of life-sustaining ICU therapies-using the example of cancer patients with sepsis.

The rise in cancer patients could lead to an increase in intensive care units (ICUs) admissions. We explored differences in treatment practices and outcomes of invasive therapies between patients with sepsis with and without cancer. Adults from 2008 to 2019 admitted to the ICU for sepsis were extracted from the databases MIMIC-IV and eICU-CRD.

Experiences of disrespect and abuse during childbirth in the World Health Organization European region: A mixed-method study among 22 countries.

Objective: Despite advancements in maternity quality care worldwide, mistreatment of women during childbirth persists. Currently, there is a gap of knowledge on the occurrence of disrespect and abuse during childbirth in the World Health Organization (WHO) European region.

Methods: Within the IMAgiNE EURO (Improving Maternal Newborn Care in the WHO European Region During COVID-19 Pandemic) study, women 18 years and older who gave birth in healthcare facilities in the WHO European region, were invited to complete an online validated questionnaire regarding quality of maternity care.

Innovations in communication training for medical and nursing students: Virtual reality communication tool for application and evaluation with key stakeholders and students (VR-TALKS) - a study protocol.

Background: In healthcare education, virtual reality (VR), simulating real-world situations, is emerging as a tool to improve communication skills, particularly in sensitive scenarios involving patients and caregivers. While promising, VR-based education also poses challenges such as avatar realism, cognitive load, and the need for pedagogical grounding.

Objective: This protocol paper presents the VR-TALKS project, which aims to develop, apply, and evaluate VR scenarios designed to teach healthcare students communication skills in serious illness scenarios.

When artificial intelligence meets protein research.

The 2024 Nobel Prizes in Chemistry and Physics mark a watershed moment in the convergence of artificial intelligence (AI) and molecular biology. This article explores how AI, particularly deep learning and neural networks, has revolutionized protein science through breakthroughs in structure prediction and computational design. It highlights the contributions of 2024 Nobel laureates John Hopfield, Geoffrey Hinton, David Baker, Demis Hassabis, and John Jumper, whose foundational work laid the groundwork for AI tools such as AlphaFold.

Retrospective study of bovine besnoitiosis in the Auvergne Rhône-Alpes region in France.

Bovine besnoitiosis is a parasitic disease caused by the parasite . It was classified as an emerging disease by EFSA in 2010, due to the appearance of new cases in several European countries. The clinical presentation can be acute or chronic, but most animals remain asymptomatic, acting as reservoirs.

Brazilian version of the Brief Screener for Substance and Behavioral Addiction.

Introduction: Excessive and compulsive behaviors, including substance and behavioral addictions, represent a growing global concern. In Brazil, the increasing prevalence of these behaviors underscores the need for effective screening tools to identify individuals at risk. The Brief Screener for Substance and Behavioral Addiction (SSBA) has been recognized internationally for its utility in both clinical assessment and public health surveillance.

Gut dysbiosis is linked to severe steatosis and enhances its diagnostic performance in MASLD.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease globally, with rising prevalence linked to metabolic syndrome (MetS). Excessive liver fat accumulation (steatosis) worsens disease progression and MASLD prognosis. Moreover, gut microbiota dysbiosis might promote steatosis, accelerating the disease progression to severe stages.

Cardiac Rehabilitation in Patients with Coronary Heart Disease - Provision, Attendance, and Outcomes: Results from the INTERASPIRE Survey from Fourteen Countries Across Six WHO Regions.

Background: INTERASPIRE was an observational study of patients with coronary heart disease (CHD) from 88 hospitals in 14 countries across all six WHO regions. The objective was to describe the proportions of patients referred to and attending cardiac rehabilitation (CR) programmes and to compare lifestyle and risk factor target achievement according to participation in a CR programme.

Methods: Patients 18-80 years of age, with a first or recurrent coronary hospitalisation (acute coronary syndrome and/or revascularisation procedure) were identified and invited to an interview and examination, between six months and two years after the index hospitalisation.

Primary health care policy investments in the Latin America context: Health systems experiences from Brazil, Chile, and Colombia.

This study examines the policy investments in Primary Health Care (PHC) within the health systems of Brazil, Chile, and Colombia, highlighting their contributions toward achieving Universal Health Coverage (UHC). Employing a qualitative methodology, the research includes an institutional historical review and interviews with key stakeholders to analyze the development of PHC financing policies and practices in these countries. Brazil, with its Unified Health System (SUS), demonstrates federal leadership through initiatives like Requalifica UBS and the new PAC, albeit facing challenges in regional equity and monitoring.

Enhancing the multifunctional properties of polycaprolactone/chitosan films with zirconium dioxide nanoparticles for biomedical and flexible optoelectronic applications.

This study addresses the growing need for sustainable and multifunctional materials by developing novel polycaprolactone (PCL)/chitosan (CS)/zirconium dioxide (ZrO) nanocomposite films. While PCL and CS offer biocompatibility and biodegradability, their combined use presents limitations for advanced applications requiring specific functional features. The incorporation of ZrO nanoparticles aims to overcome these limitations and create materials with enhanced mechanical, electrical, optical, and antibacterial properties.

Synthetic scaffolds functionalized with mesenchymal stem/stromal cells-derived extracellular matrix for bone tissue engineering: a review.

Bone-related injuries represent a major global challenge, particularly for the aging population. While bone has self-healing capabilities, large defects and non-union fractures often fail to completely regenerate, leading to long-term disability and the need for surgical intervention. Autologous bone grafts remain the gold standard for such procedures, but challenges such as limited donor availability and donor site comorbidity persist.

Comparative study of the impact of heat treatment on the microstructure, morphology, optical and dielectric properties of nanostructured Co-Mn ferrite.

Nanoscale materials are attracting a great deal of attention due to their exceptional properties, making them indispensable for many advanced applications. Among these materials, spinel ferrites stand out for their potential applications in electronic, optoelectronic, energy storage and other devices. This is why the development of a synthesis process combined with rigorous optimization of annealing conditions is provided to be an essential approach to control nanoparticle formation and fine-tuning their structural, morphological and functional characteristics.

Informing future seasonal influenza and COVID-19 vaccination campaigns based on past experience: a mixed-method approach with eligible populations and healthcare professionals.

Background: Seasonal vaccination campaigns against influenza and COVID-19 are critical for protecting vulnerable populations. Scientific evidence on past campaigns is essential for the effectiveness of future campaigns. This study aims to: (1) assess predictors of influenza and COVID-19 vaccination intentions (2) explore perceived barriers and facilitators of 2023-2024 seasonal vaccination campaign.

The Impact of Glacial Disturbance History Upon the Genetic Diversity of and in Europe and Implications for Conservation.

Historically, the thick-shelled river mussel ( agg. complex) was considered a single, widespread species across Europe. However, recent phylogenetic taxonomic revisions have delineated 12 species from this complex, including (s.

CT-Optimal Stimulation Modulates Somatosensory Processing.

Touch has an affective dimension, conveyed through low-threshold mechanoreceptors known as C-tactile (CT) afferents, which are activated by gentle, caress-like contact. While there is evidence that these fibers modulate nociceptive input, their influence on the processing of other somatosensory afferent activity remains largely unknown. In this study, we explored how slow brushing (CT-optimal stimulation) modulates somatosensory evoked potentials (SEPs) elicited by electrical stimulation of the median nerve (occurring at 0.