"They always disfavor me!": Parental conditional regard undermines teenage sibling relationships through raising competition and perceived disfavoritism.

Conditional regard defined as adolescents' perception that parents' affection hinges upon whether they meet parental expectations affects their skills to build stable and sustainable relationships. However, its role in sibling relationships remains unexplored. This study investigates how conditional regard relates to sibling competition, favoritism, and conflict in 201 teenage sibling dyads.

Sex and Body Mass Index differences in the incidence of vascular and cardiometabolic diseases: A retrospective cohort study including 233 730 patients in Germany.

Aims: To examine the association between elevated body mass index (BMI) and a wide range of vascular and cardiometabolic diseases in men and women.

Materials And Methods: This retrospective cohort study used data from the IQVIA Disease Analyzer database, comprising anonymized records from over 3000 office-based physicians in Germany. We included 233 730 patients aged ≥40 years with at least one recorded BMI measurement between January 2005 and December 2023.

Persistence with antidementia therapy in Germany: A retrospective cohort study of 567,815 patients.

Background: Despite the availability of these therapies, maintaining long-term adherence remains a significant challenge.

Objective: This retrospective cohort study aimed to investigate 12-month and 5-year persistence with antidementia drug therapy in Germany and to examine the association between demographic and clinical variables and the risk of therapy discontinuation.

Methods: Patients aged 60 years or older from the IQVIA Longitudinal Prescription Database who received an initial prescription for antidementia therapy between 2016 and 2023 (index date) were included.

Hair cortisol and other hair analytes decline with storage over a one-year period: A systematic, within-subject investigation.

Background: Hair analysis is increasingly utilized in psychoneuroendocrine research to assess long-term hormonal activity. A critical practical question when using this method is how long hair samples can be stored without compromising data quality, yet this issue remains insufficiently researched. Here, we report data from a first systematic, well-controlled within-subject investigation into the impact of storage duration (over 12 months) on hair cortisol and other common hair analytes.

Multiomics approach to evaluating personalized biomarkers of allergen immunotherapy.

Recent advancements in genomics and "omic" technologies have ushered in a transformative era referred to as personalized or precision medicine. This innovative approach considers the unique genetic profiles of individuals, along with a range of variability factors, to devise tailored disease treatments and prevention strategies that cater to the distinct needs of each patient. Although the terms personalized medicine and precision medicine are frequently utilized interchangeably, it is essential to delineate the subtle distinctions between them.

A Phase 1 Randomized Study: Garadacimab Pharmacokinetics, Safety, and Tolerability After Administration via Autoinjector/Pre-Filled Pen Versus Pre-Filled Syringe in Healthy Participants.

Garadacimab is a novel, fully human, anti-activated factor XII monoclonal antibody approved for long-term prophylaxis of patients with hereditary angioedema. This open-label, parallel-group, Phase 1, single-center, bridging study in healthy adults (18-55 years of age) characterized the pharmacokinetics and safety of a single 200 mg subcutaneous injection of garadacimab administered via autoinjector/pre-filled pen (AI/PFP) compared with the pre-filled syringe (PFS) used in previous studies. The aim of the study was to bridge the understanding of the PK and safety of garadacimab between PFS and AI/PFP modes of administration.

National survey on the presence of multidisciplinary meetings for interstitial lung diseases (ILD-MDM) in hospitals in Germany.

Background: Interstitial lung diseases (ILD) represent an interdisciplinary clinical challenge and are not uncommonly associated with rheumatological diseases. Interstitial lung disease multidisciplinary meetings (ILD-MDM) provide a structured platform for interdisciplinary case discussions and decision making. Despite their great importance in patient care, data on the prevalence, structure and function of ILD-MDM in Germany are lacking.

Atomic resolution structures of the methane-activating enzyme in anaerobic methanotrophy reveal extensive post-translational modifications.

Anaerobic methanotrophic archaea (ANME) are crucial to planetary carbon cycling. They oxidise methane in anoxic niches by transferring electrons to nitrate, metal oxides, or sulfate-reducing bacteria. No ANMEs have been isolated, hampering the biochemical investigation of anaerobic methane oxidation.

Outcome of systemic therapy in patients with advanced rare skin cancers: A retrospective multicenter DeCOG study of 209 patients.

Introduction: For rare skin cancers, few data exist on the outcome of systemic therapies, particularly immune checkpoint inhibition (ICI). The present study analysed the real-world use of different systemic therapies including ICI, and its outcome in patients with advanced rare skin cancers.

Methods: This retrospective multicenter study included patients who received systemic therapy for advanced, non-resectable cutaneous angiosarcoma (AS), Kaposi sarcoma (KS), pleomorphic dermal sarcoma (PDS), or cutaneous adnexal carcinoma (CAC).

Differential Effects of Self-Initiated, Externally Triggered, and Passive Movements on Action-Outcome Processing: Insights From Sensory and Motor-Preparatory Event Related Potentials.

Self-initiated voluntary actions are different from externally triggered or passive movements. However, it remains unclear how these movements affect action feedback processing and how they are prepared. Here, we focus on the sensory and motor-preparatory event-related potentials.

Extinction learning and return of fear in a large sample of children and adolescents with and without anxiety disorders.

Anxiety disorders are the most prevalent mental health problems in childhood and adolescence, highlighting the importance to study their underlying mechanisms. One key process in fear reduction, particularly in exposure-based cognitive behavioral therapy, is extinction learning. While extensively studied in adults, its role in youth remains underexplored.

Does proper flossing performance translate into effective plaque removal?

Objectives: Interdental hygiene plays a crucial role in maintaining oral health, yet the effectiveness of dental floss remains a subject of debate. Thus, this study aimed to assess whether improved flossing technique relates to improved cleaning efficacy.

Materials And Methods: A total of 37 adults (23.

[The potential of medical comics in rheumatology-Results of a standardized survey at the German Rheumatology Congress 2024].

Background: Comics are increasingly being discussed as an innovative means of communication in healthcare. In rheumatology there has so far been a lack of studies on the acceptance and potential use of medical comics.

Aim Of The Study: The aim of this study was to determine the acceptance of medical comics among rheumatologists and to evaluate their potential for use in clinical practice.

Age-related differences in switching highly effective disease-modifying therapy in patients with multiple sclerosis.

Background: High efficacy therapies (HET) play a crucial role in multiple sclerosis (MS) management. HET discontinuation/de-escalation is a critical decision, especially in different age groups, due to potential changes in relapse rates. We aimed at evaluating the impact of HET discontinuation on annualized relapse rates (ARRs) in people with MS (pwMS) aged ≥ 50 or < 50 years.

From protocol to practice: long-Term outcomes of single-Fraction stereotactic body radiotherapy for primary non-Small cell lung cancer.

Background: Single-fraction stereotactic body radiotherapy (SBRT) is an effective treatment option for patients with non-small cell lung cancer (NSCLC) who are ineligible for surgery. This study investigates long-term clinical outcomes, prognostic factors, and toxicity associated with high-dose single-fraction SBRT.

Materials And Methods: We retrospectively analyzed 110 patients with 116 NSCLC lesions treated with single-fraction SBRT between 2000 and 2023.

Thinking Outside the Box: Case Report of a Rare Quadricuspid Aortic Valve as an Underrecognized Cause of Heart Failure and Atrial Fibrillation.

Quadricuspid aortic valve (QAV) is a rare congenital anomaly with an estimated incidence of 0.008% to 0.043% based on autopsy and echocardiographic studies.

Differences between persistent and episodic depression in processing novel positive information.

Background: Research has pointed to important psychopathological differences between persistent and episodic depressive disorders. Here, we tested the hypothesis that people with persistent rather than episodic depression have difficulty revising established expectations in response to novel positive information. In terms of underlying mechanisms, we predicted that these differences between the two subtypes would be related to the engagement in cognitive immunization (i.

Syntheses, Single-Crystal Structures, and Structural Chemistry of Hexafluoridouranates(V), UF ( = Li-Cs, Ag, Tl, HO), and the Dodecafluoridodiuranate(V) Ba[UF]·1.36HF.

We present the syntheses of the hexafluoridouranates(V) UF ( = Li-Cs, Ag, Tl, HO) and of the dodecafluoridodiuranate(V) Ba[UF]·1.36HF. With the exception of AgUF and HOUF, all compounds were synthesized by reacting the respective metal fluorides with β-UF in anhydrous hydrogen fluoride (aHF).

Telehealth Acceptance and Perceived Barriers Among Health Professionals: Pre-Post Evaluation of a Web-Based Telehealth Course.

Background: The rapid expansion of telehealth underscores the need for comprehensive telehealth education among health care professionals. Despite increasing recognition of telehealth's importance, many practitioners remain underprepared, particularly in navigating legal aspects, technology, and patient engagement.

Objective: This study aimed to evaluate the impact of a web-based telehealth training course on health care professionals' telehealth acceptance and their perceived barriers to telehealth adoption.

Glucose and antidiabetic therapy in temozolomide resistance in glioblastoma.

Glioblastoma (GBM) remains a major clinical challenge due to limited therapeutic success despite standard treatments including surgery, radiotherapy, and temozolomide (TMZ). Recent evidence links hyperglycemia to cancer progression, and altered glucose metabolism has emerged as a key factor in GBM development. Metformin, an antidiabetic drug, has shown promise in improving survival in GBM patients, possibly due to its ability to cross the blood-brain barrier and target metabolic pathways involved in tumor growth.