DFT Investigation of the Electronic Structure, Non-Covalent Interactions, and Muon Hyperfine Interactions in Short Adenine-Thymine Double-Strand DNA.

Muonium (Mu) trapping sites and the associated hyperfine interactions in 1, 2, 3, and 4 base-pair adenine-thymine double-strand DNA molecules were investigated using the density functional theory method. Based on relative energy analysis, C8-A is the lowest energy Mu site in the 1, 2, and 3 base-pair molecules. In the 4 base-pair molecule, N3-A has the lowest energy while C8-A sites are ranked fifth and above.

Exploring the role of catalytic triad Ser-His-Asp on the dynamics of the Lactobacillus helveticus cell-envelope proteinases.

Lactic acid bacterium (LAB) hydrolyzes milk proteins into small bioactive peptides to flourish milk nutrition value. Cell-envelope proteinases (CEPs) are vitally important to bacterial growth, the texture and flavor formation, and the generation of bioactive peptides in fermented milk. Previous literature suggested PR domain of CEP was responsible for the catalytic activity.

Alpha-particle-induced reactions on natural tin for production of Te.

The excitation function of the Sn(α,x)Te reaction was measured up to 50 MeV using the stacked-foil activation technique and high-resolution γ-ray spectrometry. The cross sections of the co-products, In, Sn,Sb, and Te, were also determined. Based on the measured cross section, the physical thick target yields of Te, Te, Te, and Te were deduced.

A Pentatricopeptide Repeat Protein Restores Fertility in Tadukan-Type Cytoplasmic Male Sterile Rice via the Cleavage of the Mitochondrial orf312 RNA.

Cytoplasmic male sterility (CMS) is associated with the inhibition of pollen and/or anther development regulated by a CMS-causing gene in the mitochondrial genome; it is a useful trait for preventing self-pollination and producing F hybrids, which can boost crop yields. Pollen and/or anther development can be recovered by the action of the RESTORER OF FERTILITY (Rf) gene, a nuclear-encoded gene. Most reported Rf genes encode pentatricopeptide repeat (PPR) proteins, which bind to RNA and promote RNA processing of the respective CMS-causing gene.

Disentangling Centrality Bias and Final-State Effects in the Production of High-p_{T} Neutral Pions Using Direct Photon in d+Au Collisions at sqrt[s_{NN}]=200 GeV.

PHENIX presents a simultaneous measurement of the production of direct γ and π^{0} in d+Au collisions at sqrt[s_{NN}]=200  GeV over a p_{T} range of 7.5 to 18  GeV/c for different event samples selected by event activity, i.e.

Removal of HCl from a gas phase by MgO under atmospheric conditions.

Ensuring the safety of researchers by protecting them from exposure to toxic gases in laboratories is of paramount importance. This study investigated the effectiveness of using high-surface-area MgO to remove HCl under atmospheric conditions. Two types of MgO were synthesized through the thermal decomposition 1-1-1, Tennodai, Tsukuba, of Mg(OH) and MgCO·2 HO.

Tuning anomalous Hall conductivity antiferromagnetic configurations in GdPtBi.

The magnetic, electronic, and topological properties of GdPtBi were systematically investigated using first-principles density functional theory (DFT) calculations. Various magnetic configurations were examined, including ferromagnetic (FM) and antiferromagnetic (AFM) states, with particular focus on AFM states where the Gd magnetic moments align either parallel (AFM) or perpendicular (AFM) to the [111] crystal direction. For AFM, the in-plane angles were varied at = 0°, 15°, and 30° (denoted as AFM, AFM, and AFM, respectively).

Overcoming the probing-depth dilemma in spectroscopic analyses of batteries with muon-induced X-ray emission (MIXE).

Battery research often encounters the challenge of determining chemical information, such as composition and elemental oxidation states, of a layer buried within a cell stack in a non-destructive manner. Spectroscopic techniques based on X-ray emission or absorption are well-suited and commonly employed to reveal this information. However, the attenuation of X-rays as they travel through matter creates a challenge when trying to analyze layers buried at depths exceeding hundred micrometers from the sample's surface.

Comparison Length of Linker in Compound for Nuclear Medicine Targeting Fibroblast Activation Protein as Molecular Target.

Novel nuclear medicine therapeutics are being developed by labeling medium-molecular-weight compounds with short-lived alpha-emitting radionuclides. Fibroblast activation protein α (FAPα) is recognized as a highly useful molecular target, and its inhibitor, FAPI, is a compound capable of , both therapeutic and diagnostic, for cancer treatment. In this study, we compared the functions of two compounds that target FAPα: At-FAPI1 and At-FAPI2.

Antiproton annihilation at rest in thin solid targets and comparison with Monte Carlo simulations.

The mechanism of antiproton-nucleus annihilation at rest is not fully understood, despite substantial previous experimental and theoretical work. In this study we used slow extracted antiprotons from the ASACUSA apparatus at CERN to measure the charged particle multiplicities and their energy deposits from antiproton annihilations at rest on three different nuclei: carbon, molybdenum and gold. The results are compared with predictions from different models in the simulation tools Geant4 and FLUKA.

Signature of Proton-Hole Transfer in Hydrogen-Bonded Solids at 10 K.

Although proton transport in water ice is well understood, proton-hole transfer (PHT) involving proton abstraction by anions remains less explored. This study investigates PHT in HS and NH solids at low temperatures, aiming to determine whether these solids exhibit negative charge transport similar to that in ice. In HS and NH solids at 10 K, surface HS and NH anions in hydrogen-bonded systems trigger negative current flow, providing a clear signature of PHT.

Nearly linear orbital molecules on a pyrochlore lattice.

The interplay of spin-orbit coupling with other relevant parameters gives rise to the rich phase competition in complex ruthenates featuring octahedrally coordinated Ru. While locally, spin-orbit coupling stabilizes a nonmagnetic = 0 state, intersite interactions resolve one of two distinct phases at low temperatures: an excitonic magnet stabilized by the magnetic exchange of upper-lying = 1 states or Ru molecular orbital dimers driven by direct orbital overlap. Pyrochlore ruthenates RuO ( = rare earth, Y) are candidate excitonic magnets with geometrical frustration.

Time-resolved observation of DHR123 nano-clay radio-fluorogenic gel dosimeters by photoluminescence-detected pulse radiolysis.

The importance of real-time dose evaluation has increased for recent advanced radiotherapy. However, conventional methods for real-time dosimetry using gel dosimeters face challenges owing to the delayed dose response caused by the slow completion of radiation-induced chemical reactions. In this study, a novel technique called photoluminescence-detected pulse radiolysis (PLPR) was developed, and its potential to allow real-time dose measurements using nano-clay radio-fluorogenic gel (NC-RFG) dosimeters was investigated.

Athyrium yokoscense, a cadmium-hypertolerant fern, exhibits two cadmium stress mitigation strategies in its roots and aerial parts.

Athyrium yokoscense is hypertolerant to cadmium (Cd) and can grow normally under a high Cd concentration despite Cd being a highly toxic heavy metal. To mitigate Cd stress in general plant species, Cd is promptly chelated with a thiol compound and is isolated into vacuoles. Generated active oxygen species (ROS) in the cytoplasm are removed by reduced glutathione.

Activation cross sections of alpha-particle-induced reactions on natural rhenium up to 50 MeV.

Activation cross sections of alpha-particle-induced reactions on natural rhenium were measured. The stacked-foil activation technique and high-resolution gamma-ray spectrometry were used to derive the cross sections. The production cross sections of Ir, Os, and Re were determined up to 50 MeV.

New insight into the exotic states strongly coupled with the DD‾ from the T.

We have investigated the internal structure of the open- and hidden-charmed (DD/D¯D) molecules in the unified framework. We first fit the experimental lineshape of the T state and extract the DD interaction, from which the T is assumed to arise solely. Then we obtain the DD¯ interaction by charge conjugation.

Nuclear clustering-manifestations of non-uniformity in nuclei.

Well-developed [Formula: see text] clusters are known to exist in light [Formula: see text] nuclei, and their properties are reasonably well described with modern nuclear structure theories. However, 'modestly' developed clusters in medium to heavy nuclei remain little understood, both theoretically and experimentally. Extension of the focus to include modestly developed clusters leads us to a concept of 'generalized clusters' and 'cluster ubiquitousness'.

Preclinical Evaluation of Biodistribution and Toxicity of [At]PSMA-5 in Mice and Primates for the Targeted Alpha Therapy against Prostate Cancer.

Astatine (At) is a cyclotron-produced alpha emitter with a physical half-life of 7.2 h. In our previous study, the At-labeled prostate-specific membrane antigen (PSMA) compound ([At]PSMA-5) exhibited excellent tumor growth suppression in a xenograft model.

Genomic view of heavy-ion-induced deletions associated with distribution of essential genes in .

Heavy-ion beam, a type of ionizing radiation, has been applied to plant breeding as a powerful mutagen and is a promising tool to induce large deletions and chromosomal rearrangements. The effectiveness of heavy-ion irradiation can be explained by linear energy transfer (LET; keV µm). Heavy-ion beams with different LET values induce different types and sizes of mutations.

Laser spectroscopy of triply charged Th isomer for a nuclear clock.

Thorium-229 (Th) possesses an optical nuclear transition between the ground state (Th) and low-lying isomer (Th). A nuclear clock based on this nuclear-transition frequency is expected to surpass existing atomic clocks owing to its insusceptibility to surrounding fields. In contrast to other charge states, triply charged Th (Th) is the most suitable for highly accurate nuclear clocks because it has closed electronic transitions that enable laser cooling, laser-induced fluorescence detection and state preparation of ions.

Production of [At]NaAt solution under GMP compliance for investigator-initiated clinical trial.

Background: The alpha emitter astatine-211 (At) is garnering attention as a novel targeted alpha therapy for patients with refractory thyroid cancer resistant to conventional therapy using beta emitter radioiodine (I). Herein, we aimed to establish a robust method for the manufacturing and quality control of [At]NaAt solution for intravenous administration under the good manufacturing practice guidelines for investigational products to conduct an investigator-initiated clinical trial.

Results: At was separated and purified via dry distillation using irradiated Bi plates containing At obtained by the nuclear reaction of Bi(He, 2n)At.

Observation of New Isotopes in the Fragmentation of ^{198}Pt at FRIB.

Five previously unknown isotopes (^{182,183}Tm, ^{186,187}Yb, ^{190}Lu) were produced, separated, and identified for the first time at the Facility for Rare Isotope Beams (FRIB) using the Advanced Rare Isotope Separator (ARIS). The new isotopes were formed through the interaction of a ^{198}Pt beam with a carbon target at an energy of 186  MeV/u and with a primary beam power of 1.5 kW.

Metallic radionuclide-labeled tetrameric 2,6-diisopropylphenyl azides for cancer treatment.

This study proposes a new method for radionuclide therapy that involves the use of oligomeric 2,6-diisopropylphenyl azides and a chelator to form stable complexes with metallic radionuclides. The technique works by taking advantage of the endogenous acrolein produced by cancer cells. The azides react with the acrolein to give a diazo derivative that immediately attaches to the nearest organelle, effectively anchoring the radionuclide within the tumor.

Demonstration of nuclear gamma-ray polarimetry based on a multi-layer CdTe Compton camera.

To detect and track structural changes in atomic nuclei, the systematic study of nuclear levels with firm spin-parity assignments is important. While linear polarization measurements have been applied to determine the electromagnetic character of gamma-ray transitions, the applicable range is strongly limited due to the low efficiency of the detection system. The multi-layer Cadmium-Telluride (CdTe) Compton camera can be a state-of-the-art gamma-ray polarimeter for nuclear spectroscopy with the high position sensitivity and the detection efficiency.