Night shift work and risk of colorectal cancer: a prospective cohort study among 56 477 female nurses in the Netherlands.

Objectives: Night shift work has been classified as probably carcinogenic to humans, possibly related to suppression of melatonin secretion. Although experimental studies suggest that melatonin inhibits intestinal tumor proliferation, epidemiological evidence for a relationship between night shift work and colorectal cancer (CRC) risk is lacking.

Methods: We prospectively examined the association between night shift work and CRC in the Nightingale Study.

Association of intraoperative end-tidal CO levels with postoperative outcomes: a patient-level analysis of two randomised clinical trials.

Background: The relationship between intraoperative end-tidal CO (etCO) levels and postoperative outcomes remains unclear. We conducted a post hoc analysis of two randomised trials in adults undergoing major surgery under general anaesthesia.

Methods: We re-analysed individual participant data comparing high or low positive end-expiratory pressure with low tidal volume intraoperative ventilation using a merged database derived from two randomised trials in non-obese (PROVHILO: ISRCTN70332574) and obese (PROBESE: NCT02148692) patients.

Risk of colorectal cancer and participation in fecal immunochemical test-based screening.

Objectives: Participation rates in fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening differ across socio-demographic subgroups. The largest health gains could be achieved in subgroups with low participation rates and high risk of CRC. We investigated the CRC risk within different socio-demographic subgroups with low participation in the Dutch CRC screening program.

Safety of surveillance endoscopy and EUS of the esophagus after neoadjuvant chemoradiotherapy: Results from the (pre)SANO trial.

Background And Study Aims: Active surveillance has been proposed for patients with esophageal cancer and a clinical complete response after neoadjuvant chemoradiotherapy (nCRT). This strategy involves repeated esophagogastroduodenoscopy (EGD) with bite-on-bite biopsies and endoscopic ultrasonography (EUS) with fine-needle aspiration (FNA) to detect tumor regrowth or residual disease. The aim of this study was to assess safety of endoscopic procedures during active surveillance.

Back-table specimen scanning using gantry-free hybrid hSPECT/LiDAR imaging: a feasibility study during PSMA-radioguided surgery.

Introduction: Prostate-specific membrane antigen (PSMA) targeted precision surgery is becoming increasingly popular. However, the relatively low levels of PSMA-receptor expression and background signal can hinder in vivo lesion detection and margin evaluation. Back-table imaging (ex vivo) potentially provides a means to confirm surgical accuracy.

Oncologic Outcomes of Template Versus Radioguided Salvage Lymph Node Dissection for Node-only Recurrent Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography Scan: Results from a Multi-institutional Collaboration.

In patients treated with salvage lymph node dissection (sLND) for nodal recurrence of prostate cancer, whether radioguided surgery (RGS) might improve oncologic outcomes as compared with template sLND remains unknown. This study included 259 patients who experienced a prostate-specific antigen (PSA) rise and nodal-only recurrence after radical prostatectomy and underwent pelvic sLND at 11 tertiary referral centers between 2012 and 2022. Lymph node recurrence was documented by prostate-specific membrane antigen positron emission tomography scans.

Consensus on the definition, components, timeframe and grading of composite outcome of postoperative pulmonary complication-protocol for an international mixed-method consensus study (PrECiSIOn).

Introduction: Postoperative pulmonary complications (PPCs) represent a significant cause of postoperative morbidity and even mortality. However, there is a lack of consensus regarding this composite endpoint, the definition of the individual components, classification and optimal outcome measures. This study aims to refine the PPCs composite framework by evaluating its construct validity, assessing the necessity and risks of a composite measure and exploring the feasibility of differentiating severity categories.

Diagnostic accuracy of CT for identifying high-risk colon cancer: a systematic review and meta-analysis.

Objectives: This systematic review and meta-analysis aimed to assess the diagnostic accuracy of CT in differentiating high-risk from low-risk colon cancer, with a focus on staging parameters and the impact of CT slice thickness.

Materials And Methods: A systematic search of Ovid MEDLINE and Embase.com was conducted from January 1, 2015, to September 24, 2024, to identify studies evaluating CT-based staging accuracy using histopathology as the reference standard.

Evaluation of Diagnostic Accuracy of Preoperative CT-Based Radiomics in Primary Retroperitoneal Sarcoma.

Background: Obtaining an accurate preoperative diagnosis in retroperitoneal sarcoma (RPS) is challenging, and radiomics-based models may offer a valid option to achieve this outcome. This study evaluated the accuracy of radiomics-based preoperative CT models at predicting tumour histology and grade in patients with primary RPS.

Methods: Data on consecutive patients who underwent surgery for primary retroperitoneal liposarcoma (RLPS) and leiomyosarcoma (RLMS) were analysed.

The perks of combining extension and Gleason score of positive surgical margins after robot-assisted radical prostatectomy.

Background: The role of positive surgical margins' (PSM) features in terms of cancer control outcomes is unclear. We aimed to test the association between PSM extension combined to highest Gleason score (GS) at margin and PSA persistence, biochemical recurrence (BCR) and clinical recurrence (CR) in prostate cancer (PCa) patients undergone robot-assisted radical prostatectomy (RARP).

Materials And Methods: 2617 PCa patients treated with RARP at six European centers were stratified according to the PSM status and features, as follows): (a) negative SM; (b) focal PSM-GS 3; (c) extensive PSM-GS 3; (d) focal PSM-GS 4-5; (d) extensive PSM-GS 4-5.

Antibiotic Prophylaxis Is Not Required Before MRI-Guided Transperineal Prostate Biopsy.

Objective: To evaluate rates of infectious and non-infectious complications after transperineal prostate biopsy (TPBx) without antibiotic prophylaxis (ABP) and to identify potential risk factors for post-biopsy infections.

Methods: We conducted an observational cohort study among patients who underwent TPBx without ABP at two high-volume diagnostic prostate cancer centers in an outpatient setting between February 2020 and October 2023. The primary outcome was post-TPBx infection, defined as an antibiotic prescription for urinary tract infection within 2 weeks post-biopsy or inpatient care for infection within 30 days.

Real World Effectiveness of Durvalumab in Stage III Unresectable Non-small Cell Lung Cancer: What is the Role of PD-L1 Expression?

Purpose: Although the European Medicines Agency approved durvalumab post-chemoradiation (CRT) only for stage III unresectable non-small cell lung cancer (UR-NSCLC) patients with PD-L1 tumor proportion scores (TPS) ≥ 1%, the Netherlands offers reimbursement irrespective of PD-L1 status. This real-world study compares survival between durvalumab-treated patients with PD-L1 TPS < 1% vs. ≥ 1%, and also evaluates its effectiveness against a historic-cohort.

Current practices and variability in dynamic sentinel node biopsy for penile cancer: A survey of European Referral Centers.

Background: Dynamic sentinel node biopsy (DSNB) is the currently preferred staging method of high-risk penile cancer (PeCa) patients with cN0 disease. Recently, there have been advancements in the surgical approach and techniques. This study aims to compare the contemporary DSNB practice and techniques amongst European referral centers.

LC-MS/MS method development and validation for novel targeted anticancer therapies adagrasib, capmatinib, ensartinib, entrectinib, larotrectinib, lorlatinib, pralsetinib, selpercatinib and sotorasib.

A reversed-phase liquid chromatography-tandem mass spectrometry method was developed and validated for quantifying nine novel oral targeted anticancer agents mainly indicated for non-small cell lung cancer: adagrasib, capmatinib, ensartinib, entrectinib, larotrectinib, lorlatinib, pralsetinib, selpercatinib and sotorasib in human plasma for therapeutic drug monitoring. Chromatographic separation used an Acquity BEH C18 column with step gradient of 0.1 % formic acid in water and acetonitrile-methanol (50:50, v/v), at a 0.

Staging Laparoscopy in Gastric Cancer Patients Treated with Curative Intent: A European GASTRODATA Cohort Study.

Background: In current guidelines, staging laparoscopy (SL) is recommended in patients with locally advanced gastric cancer (GC). This study aimed to assess the clinical practice of SL and its association with administration of systemic treatment in a European cohort of GC patients (GASTRODATA).

Methods: In this retrospective cohort study, patients with locally advanced GC who underwent multimodal treatment in 24 European centers were analyzed.

DNA methylation testing for vulvar cancer risk stratification in patients with high-grade vulvar intraepithelial neoplasia: a population-based cohort study.

Background: High-grade vulvar intraepithelial neoplasia (VIN) is the precursor of vulvar cancer and is divided into human papillomavirus (HPV)-associated high-grade squamous intraepithelial lesion (HSIL) and HPV-independent VIN, often clinically referred to as differentiated VIN (dVIN) and associated with vulvar dermatoses, usually lichen sclerosus. Surgical treatment of high-grade VIN often leads to genital deformity, reduced quality of life and reduced sexual function, which has a major impact on quality of life. To optimize clinical management, accurate biomarkers providing information on the cancer risk of high-grade VIN are needed.

Perioperative Outcomes in Open Versus Minimally Invasive Gastrectomy For Gastric Cancer: A European Multicenter Study Based on the GASTRODATA Registry.

Objective: To evaluate morbidity and mortality after minimally invasive (MIG) versus open gastrectomy (OG) for gastric cancer (GC) in a large European population, with a subgroup analysis comparing total and subtotal gastrectomy.

Summary Background Data: Real-world European studies comparing postoperative outcomes between MIG and OG are lacking.

Methods: This retrospective study included GC patients undergoing curative-intent gastrectomy between 2017 and 2021 at 24 high-volume European centers participating in the GASTRODATA registry.

Malignancy classification of thyroid incidentalomas using 18F-fluorodeoxy-d-glucose PET/computed tomography-derived radiomics.

Background: Thyroid incidentalomas (TIs) are incidental thyroid lesions detected on fluorodeoxy-d-glucose (18F-FDG) PET/computed tomography (PET/CT) scans. This study aims to investigate the role of noninvasive PET/CT-derived radiomic features in characterizing 18F-FDG PET/CT TIs and distinguishing benign from malignant thyroid lesions in oncological patients.

Materials And Methods: We included 46 patients with PET/CT TIs who underwent thyroid ultrasound and thyroid surgery at our oncological referral hospital.

Cancer outcomes in women without upfront surgery for ductal carcinoma in situ: observational cohort study.

Objective: To determine the risk of subsequent ipsilateral invasive breast cancer in women who do not receive upfront surgery on diagnosis of ductal carcinoma in situ (DCIS).

Design: Observational cohort study using data abstracted directly from patients' medical records and from a national cancer registry in patients with primary DCIS diagnosed between 2008 and 2015.

Setting: Commission on Cancer accredited facilities (n=1330) in the US.

Increased incidence of primary metastatic prostate cancer in the era of PSMA PET/CT: a population-based analysis.

Purpose: To evaluate the effects of prostate-specific membrane antigen (PSMA) PET/CT use for primary staging on nationwide stage-specific prostate cancer (PCa) incidence rates and treatment patterns.

Methods: For this population-based cohort study, all men diagnosed with PCa in the Netherlands from 2010 to 2023 were identified in the Netherlands Cancer Registry. Year of diagnosis was used as proxy measure for PSMA PET/CT availability and use for primary staging.

Exogenous Hormones, Tumor Intrinsic Subtypes, and Breast Cancer.

Importance: Etiologic heterogeneity in breast carcinogenesis needs to be well characterized for targeted prevention. Associations between menopausal hormonal therapy (MHT) and oral contraceptive (OC) use and breast cancer intrinsic-like subtypes are not well understood.

Objective: To examine whether exogenous hormone use is differentially associated with breast cancer subtypes and to evaluate heterogeneity by intrinsic-like subtypes.

Selection of patients for proton therapy to reduce risk of second primary lung and breast cancer.

Aim: We previously published selection criteria for proton therapy (PT) in the Netherlands for breast cancer (BC) and thoracic lymphoma patients, based upon the Absolute Excess Risk (AER) for acute coronary events. The aim of the current paper was to define additional criteria to select BC and thoracic lymphoma patients for PT, to reduce the risk of second primary BC and lung cancer (LC).

Methods: Based on a literature review, we identified Excess Relative Risks (ERR)/Gy mean organ dose of second primary BC and LC, for selected patient groups.

The role of primary tumour site surgery in metastatic UTUC: a systematic review and meta-analysis.

Objective: To assess the impact of primary tumour surgery on survival outcomes in patients with metastatic upper urinary tract urothelial carcinoma (mUTUC) by conducting a systematic review and meta-analysis.

Methods: A systematic search was conducted using the PubMed/Medline, Embase, Web of Science, and Cochrane Library databases for studies published up to January 2025, using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Eligible studies included adult patients (≥18 years) diagnosed with mUTUC (cM+ excluding cN + M0).