Retention of the infrapatellar fat pad does not influence the outcome of total knee arthroplasty: a systematic review.

Introduction: To improve patient satisfaction after total knee arthroplasty (TKA), retention of the infrapatellar fat pad (IPFP) is advocated.

Source Of Data: Recently published literature identified from PubMed, EMBASE, Scopus, and Google Scholar.

Areas Of Agreement: TKA is routinely performed in patients with end-stage joint osteoarthritis, but 18% to 11% of patients are unsatisfied after surgery.

Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses.

Communication between cellular organelles is essential for mounting effective innate immune responses. The transport of organelles to pathogen penetration sites and their assembly around the host membrane, which delineates the plant-pathogen interface, are well-documented. However, whether organelles associate with these specialized interfaces, and the extent to which this process contributes to immunity, remain unknown.

Differential regulation of calcium-activated plant kinases in Arabidopsis thaliana.

The decoding of calcium signals by plant calcium-dependent kinases (CPKs) is not fully understood yet. Based on kinetic in vitro measurements of the activity of several CPK proteins, their individual activity profile was modeled and coupled to cytosolic calcium concentration changes from in vivo measurements of guard cells and epidermal leaf cells. In addition, computationally produced surrogate data were used.

Approaches for the treatment of perforated peptic ulcers: a network meta-analysis of randomized controlled trials.

Purpose: This network meta-analysis (NMA) aims to evaluate surgical and alternative treatment strategies for perforated peptic ulcers (PPU) with respect to mortality and other clinically relevant outcomes.

Methods: An NMA was conducted in accordance with PRISMA guidelines to assess treatment approaches for PPU. Randomized controlled trials (RCT) were identified through systematic searches of PubMed/MEDLINE, Cochrane Library, Embase, CINAHL, ClinicalTrials.

Elevated Soluble HLA-G Levels Associate With Dengue Severity in Vietnamese Patients.

The pathogenesis of dengue remains complex and incompletely understood. One proposed mechanism involves the virus evading host immune responses through the upregulation and/or secretion of immune-inhibitory molecules. This study investigates the association between plasma levels of soluble human leukocyte antigen G (sHLA-G), a known immunoregulatory molecule, and dengue severity in hospitalized patients.

Bleomycin Electrosclerotherapy (BEST) of Slow-Flow Vascular Malformations (SFVMs) in Children.

Rationale And Objectives: Bleomycin electrosclerotherapy (BEST) is a promising treatment for slow-flow vascular malformations (SFVMs). Due to limited paediatric data, this study aimed to assess the safety, effectiveness, and patient-reported outcomes of BEST in children with SFVMs.

Material And Methods: This monocenter cohort study included patients <18 years with symptomatic SFVMs treated by BEST.

Evaluation of the HAL® lumbar type exoskeleton in long-term care: protocol for a mixed-methods feasibility study.

Background: Lower back pain (LBP) is one of the most common occupational health issues among healthcare professionals, particularly in long-term care settings. The HAL® Lumbar Type Exoskeleton is a wearable assistive technology designed to reduce strain on the lower back during physically demanding care activities. However, evidence regarding its feasibility, usability, and acceptance in real-world long-term care settings remains limited.

Evaluation of Chunking and Embedding Strategies for Local Document Retrieval Using an Open-Source LLM in a Hospital.

Introduction: The integration of Retrieval-Augmented Generation (RAG) into domain-specific systems enables context-aware and traceable information retrieval. This study explores chunking and embedding strategies for a RAG-based question-answering system tailored to administrative documents at University Hospital Halle, focusing on model selection, parameter tuning, and retrieval performance. The insights gained from this study should serve as the foundation for the future development of a Retrieval-Augmented Generation (RAG) based chatbot system that aims to facilitate access to document pool contents for hospital staff.

Utilization of Broad Consent as an Effective Instrument for Study Recruitment.

Background: Recruiting patients for the participation in studies is a complex and time-consuming task.

Objective: The aim was to recruit patients via broad consent to participate in a questionnaire as part of the PEAK study.

Methods: Some patients agreed on the option of recontacting them for future studies as part of the Broad Consent of the Erlangen University Hospital and the University Hospital Halle (Saale).

Analysis of a non-standard finite-difference-method for the classical target cell limited dynamical within-host HIV-model - Numerics and applications.

Mathematical modeling and numerical simulation are valuable tools for getting theoretical insights into dynamic processes such as, for example, within-host virus dynamics or disease transmission between individuals. In this work, we propose a new time discretization, a so-called non-standard finite-difference-method, for numerical simulation of the classical target cell limited dynamical within-host HIV-model. In our case, we use a non-local approximation of our right-hand-side function of our dynamical system.

Plants with higher dispersal capabilities follow 'abundant-centre' distributions but such patterns remain rare in animals.

The 'abundant-centre' hypothesis posits that a species' abundance is highest at its range centre and declines towards its range edge. Recently, the hypothesis has been much debated, with supporting empirical evidence remaining limited. Here, we test the hypothesis on 3660 species using 5,703,589 abundance observations.

The Expanded LYR Motif-Containing Protein Family in Archaeplastida.

The LYR motif (LYRM)-containing proteins are small eukaryote-specific proteins that have been defined based on the presence of a Lys-Tyr-Arg amino acid motif and a conserved triplet of α-helices. Twelve LYRM proteins were described in humans. They are involved in core mitochondrial processes as subunits or assembly/stabilising factors of mitochondrial complexes.

Non-pharmacological interventions for delirium in critically ill children: a scoping review.

Objectives: Delirium is one of the most common forms of acute cerebral dysfunction in critically ill children, leading to increased morbidity and mortality. The aim was to identify studies describing or evaluating non-pharmacological interventions to prevent or treat paediatric delirium.

Design: Scoping review.

Virtual endocast of the Late Miocene (Artiodactyla, Hoplitomerycidae) and brain evolution in insular ruminants.

Mammals often follow peculiar evolutionary trajectories on islands, with some Pleistocene insular large mammals exhibiting reduced relative brain size. However, the antiquity of this phenomenon remains unclear. Here, we report the first digital endocast of an insular artiodactyl, the five-horned ruminant from the Late Miocene Gargano palaeo-island (Apulia, Italy).

Small-Scale Stabilizing Effect of Asynchrony in Vital Rate Responses to Climate in an Imperiled Dune Thistle.

Changes in population responses to climate are usually studied at broad spatial grains, such as across species ranges. Only a handful of studies have investigated how small-scale variation, for example driven by soil conditions and microtopography, can mediate the responses of population vital rates to climate. Here, we examine responses of vital rates to climate across five subpopulations occurring in coastal dune locations that range from the foredune to the backdune.

Reliability, minimal detectable change, and standard error of measurement of functional tests for athletes: A systematic review.

Introduction: Functional tests must be validated for the target population. It is also important that the professionals applying them know which tests are the most reliable. Some tests have a standard error of measurement (SEM), which needs to be considered, as does the minimal detectable change (MDC) used to quantitatively perceive clinical improvement.

Beyond Epitaxy: Ion Implantation as a Tool for Orbital Engineering.

Manipulating electronic orbital states in quantum materials provides a powerful means of controlling their physical properties and technological functionality. Here, we demonstrate that orbital populations in strongly correlated oxide thin films can be continuously and reversibly tuned through postsynthesis He ion implantation. Using LaNiO as a model system, we show that the orbital preference can be systematically adjusted from favoring in-plane occupation toward out-of-plane states through precise control of ion fluence.

Coronal axis deviations in medial unicompartmental knee arthroplasty failures: an imaging study of patients revised for aseptic loosening.

Purpose: Aseptic loosening remains a leading cause of revision in medial unicompartmental knee arthroplasty (UKA). This imaging study aimed to identify recurrent patterns of coronal alignment deviation in patients undergoing revision to total knee arthroplasty (TKA) to explore whether subtle malalignment may contribute to biomechanical failure.

Methods: Imaging of patients who underwent revision surgery of a medial UKA to TKA for aseptic loosening of the tibial or femoral component was retrieved.

Wealth as an important (and commonly ignored) dimension of socioeconomic status in epidemiology.

Social epidemiological studies have shown for decades that wealth shows associations to various health outcomes in addition to more frequently used and established indicators like income, education and occupational status. Measurements of income alone are not able to assess the economic position and resources of individuals, while they neglect transgenerational and cumulative pathways of shaping socioeconomic status (SES) and their impact on health. Despite this established knowledge, the use of measurements of wealth in epidemiological studies is very rare and heterogeneous.

Towards consensus: The need for standardised definitions in Long (post) COVID care in 34 European countries.

Background: The COVID-19 pandemic has significantly impacted global healthcare systems, leading to challenges in managing Long COVID. Variations in definitions and diagnostic criteria across Europe hinder recognition and treatment efforts. This study aims to analyse and compare the definitions of Long COVID used in 34 European countries.

Perioperative comparison between robotic-assisted and freehand total knee arthroplasty : A quasi-randomized controlled trial.

Background: The advent of navigation, followed by robotics in knee prosthetic surgery aims, among other things, to enhance the alignment of components and to improve the control of stress forces (i.e., weight, gravity, and static and dynamic stabilizers) on the bearing surface throughout the range of motion; however, the benefits of robotic-assisted total knee arthroplasty (TKA) are debated.

Sense and sensitivity - decoding calcium signalling across cellular, autocrine, paracrine and endocrine pathways in plant resilience.

Calcium (Ca) signalling plays a central role in plant immunity, as underscored by recent findings showing that many disease resistance mechanisms result in formation of Ca-permeable pores, and that optogenetic activation of Ca influx is sufficient to trigger immune responses. This review emphasizes on Ca decoding, i.e.

Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment.

The treatment of hematological cancers with hybrid kinase and histone deacetylase (HDAC) inhibitors represents a novel strategy to overcome acquired drug resistance. We curated half-maximal inhibitory concentration (IC) datasets from the ChEMBL database, including 13 cancer cell lines (72 h cytotoxicity by MTT), inhibitors of 38 kinases, and 10 HDAC isoforms identified through target fishing and literature review. Rigorous biological and chemical curation produced datasets ranging from 76 to 8173 compounds, depending on the target.

Differential Immune Checkpoint Expression in CD4 and CD4 NKT Cell Populations During Healthy Pregnancy.

This study investigated the expression of immune checkpoint molecules on CD4 and CD4 NKT cell subpopulations throughout healthy pregnancy trimesters and in non-pregnant condition to understand their role in maternal-fetal immunotolerance. Using flow cytometry, we found that CD4 NKT cells significantly outnumbered CD4 NKT cells in all investigated groups. In the case of the immune checkpoint molecules, PD-1 receptor expression was significantly lower in CD4 NKT cells compared to CD4 counterpart cells only in non-pregnant women, while the PD-L1 ligand expression on CD4 NKT cells significantly decreased in the third trimester.