3 results match your criteria: "Key Laboratory of Protein and Peptide Pharmaceutical Institute of Biophysics[Affiliation]"
Ferritin-Based Supramolecular Assembly Drug Delivery System for Aminated Fullerene Derivatives to Enhance Tumor-Targeted Therapy.
Adv Sci (Weinh)
February 2025
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, P. R. China.
Owing to their attractive antitumor effects, aminated fullerene derivatives are emerging as promising therapeutic drugs for cancer. However, their in vivo applications are severely limited due to cation toxicity. To address this problem, human heavy chain ferritin (HFn), possessing natural biocompatibility is utilized, to develop a novel supramolecular assembly drug delivery system.
View Article and Find Full Text PDFCorrigendum to "Rapid capture and killing of bacteria by lyophilized nFeS-hydrogel for improved healing of infected wounds" [Biomater. Adv. 144 (2023) 213207].
Biomater Adv
October 2023
College of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing 211816, China; College of Food Science and Light Industry, Nanjing Tech University, Nanjing 210009, China. Electronic address:
Metal ions/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference.
J Nanobiotechnology
April 2022
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
Article Synopsis
- Ferroptosis is a potential cancer treatment that induces cell death through oxidative damage, but tumors may resist this due to their high energy metabolism.
- Researchers developed a nanoparticles platform combining iron and siRNA that responds to the tumor environment to release these components specifically within tumors.
- The platform triggers ferroptosis by increasing lipid peroxidation and decreasing a cellular enzyme while simultaneously inhibiting the glycolytic pathway, enhancing the effectiveness of the treatment against tumor cells.