Plasmapheresis in Acute Hypertriglyceridemia-Induced Pancreatitis-The PHIP-JuGa-Study.

Background And Aims: The incidence of acute pancreatitis is increasing in the Western world. About 10% of cases are caused by hypertriglyceridemia. Plasmapheresis was shown to reduce serum triglyceride (TG) levels, and current apheresis guidelines recommend its use in severe acute hypertriglyceridemia-induced pancreatitis (HIP).

Accuracy of Intraocular Lens Calculation in a Non-diffractive Extended Depth of Focus Intraocular Lens After Myopic LASIK.

Purpose: To evaluate intraocular lens (IOL) power calculation of a non-diffractive extended depth of focus (EDOF) IOL after myopic laser in situ keratomileusis (LASIK) without historical data.

Methods: In this consecutive case series, patients who had undergone lens surgery with implantation of a non-diffractive EDOF IOL after myopic laser in situ keratomileusis (LASIK) at the Department of Ophthalmology, University Hospital Frankfurt, Frankfurt, Germany, were included. Preoperative assessments included biometry and tomography using Scheimpflug technology (Pentacam; Oculus Optikgeräte GmbH).

DNA Flipping as Facile Mechanism for Transmembrane Signaling in Synthetic Cells.

Transmembrane signaling is essential for cellular communication, yet reconstituting such mechanisms in synthetic systems remains challenging. Here, we report a simple and robust DNA-based mechanism for transmembrane signaling in synthetic cells using cholesterol-modified single-stranded DNA (Chol-ssDNA). We discovered that anchored Chol-ssDNA spontaneously flips across the membrane of giant unilamellar lipid vesicles (GUVs) in a nucleation-driven, defect-mediated process.

Vortioxetine for Major Depressive Disorder in Children: 12-Week Randomized, Placebo-Controlled Study.

Objective: To evaluate efficacy, safety, and tolerability of vortioxetine in children ages 7 to 11 years with major depressive disorder.

Method: Patients meeting criteria for incomplete improvement in depressive symptoms (Children's Depression Rating Scale-Revised [CDRS-R] total score ≥40 plus <40% reduction and Parent Global Assessment Global Improvement score >2) after 4 weeks of single-blind lead-in treatment with a brief psychosocial intervention plus placebo were randomized 1:1:1:1 to 8-week double-blind treatment with brief psychosocial intervention and placebo, vortioxetine 10 mg/day, vortioxetine 20 mg/day, or fluoxetine 20 mg/day. Following preplanned interim analysis, enrollment to fluoxetine was stopped, and patients were randomized 1:1:1 to placebo, vortioxetine 10 mg, or vortioxetine 20 mg.

Epidemiology and burden of mild/moderate versus high myopia in Germany: A claims data analysis.

Purpose: This study aimed to investigate the prevalence, healthcare resource utilization (HCRU) and associated costs of myopia in Germany, comparing mild/moderate and high myopia across various age groups using real-world data.

Methods: A retrospective cross-sectional study was conducted using data from the WIG2 benchmark database. Patients with a diagnosis of myopia (ICD-10-GM H52.

Effect of Empagliflozin on the plasma lipidome in patients with type 2 diabetes mellitus: results from the EmDia clinical trial.

Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as Empagliflozin, are antidiabetic drugs that reduce glucose levels and have emerged as a promising therapy for patients with heart failure (HF), although the exact molecular mechanisms underlying their cardioprotective effects remain to be fully elucidated. The EmDia study, a randomized, double-blind trial conducted at the University Medical Center of Mainz, has confirmed the beneficial effects of Empagliflozin in HF patients after both one and twelve weeks of treatment. In this work, we aimed to assess whether changes in lipid profiles driven by Empagliflozin use in HF patients in the EmDia trial could assist in gaining a better understanding of its cardioprotective mechanisms.

News and views: lysine sorbylation enters the expanding universe of posttranslational modifications.

Opinion Letter to Sin et al (Science Advances, 2025), Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expression of inflammation genes.

Re-entrant phase behaviour of organic semiconductors.

The number of polymeric and small-molecular acceptors for organic photovoltaics has exploded in the past decade. As a result, physical insights and efforts aiming at elucidating the coupling between composition and behaviour are required more than ever. Here we present an encompassing study into the phase behaviour of 55 polymer:small-molecular acceptor blends, pivotal in determining device performance and stability.

Reciprocity in dynamics of supramolecular biosystems for the clustering of ligands and receptors.

Multivalent binding and the resulting dynamical clustering of receptors and ligands are known to be key features in biological interactions. For optimizing biomaterials capable of similar dynamical features, it is essential to understand the first step of these interactions, namely the multivalent molecular recognition between ligands and cell receptors. Here, we present the reciprocal cooperation between dynamic ligands in supramolecular polymers and dynamic receptors in model cell membranes, determining molecular recognition and multivalent binding via receptor clustering.

Fostering culture of care for early career researchers-Building a trustful environment: Insights from a German perspective.

Early-career researchers (ECRs) play a key role in conducting animal experiments in academic research. However, they face considerable challenges, including poor working conditions, and inadequate strategies for managing distress. These difficulties are often amplified in animal research, where a lack of consensus on the 3Rs (replacement, reduction, and refinement), challenges to navigate complex regulations and ethical dilemmas can further complicate the situation.

Transportation Noise and Cardiovascular Health: Evidence, Mechanisms, and Policy Imperatives.

Environmental noise, particularly from road, rail, and aircraft traffic, is now firmly recognized as a widespread risk factor for cardiovascular disease. About 1 in 3 Europeans is exposed to chronic noise exposure above the guideline thresholds recommended by the World Health Organization (WHO), thus contributing substantially to cardiovascular morbidity and mortality. Robust evidence from recent meta-analyses links transportation noise to ischemic heart disease, heart failure, stroke, hypertension, and type 2 diabetes mellitus.

Parallel synthesis of 5'-amino-5'-deoxy-adenosine derivatives for focused chemical space exploration and their application as methyltransferase inhibitors.

Parallel syntheses and their throughput capabilities are powerful tools for the rapid generation of molecule libraries, making them highly beneficial for accelerating hit identification in early-stage drug discovery. Utilizing chemical spaces and virtual libraries enhances time and cost efficiency, enabling the faster exploitation of chemically diverse compounds. In this study, a parallel synthesis method for rapidly generating a 5'-amino-5'-deoxy adenosine-based amide and sulfonamide library of 42 compounds is described with high yields and purity, which is economical and ecological due to the reduced requirements for extensive purification.

When artificial intelligence meets protein research.

The 2024 Nobel Prizes in Chemistry and Physics mark a watershed moment in the convergence of artificial intelligence (AI) and molecular biology. This article explores how AI, particularly deep learning and neural networks, has revolutionized protein science through breakthroughs in structure prediction and computational design. It highlights the contributions of 2024 Nobel laureates John Hopfield, Geoffrey Hinton, David Baker, Demis Hassabis, and John Jumper, whose foundational work laid the groundwork for AI tools such as AlphaFold.

Gut dysbiosis is linked to severe steatosis and enhances its diagnostic performance in MASLD.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease globally, with rising prevalence linked to metabolic syndrome (MetS). Excessive liver fat accumulation (steatosis) worsens disease progression and MASLD prognosis. Moreover, gut microbiota dysbiosis might promote steatosis, accelerating the disease progression to severe stages.

-Butyl 5-{2-[2-(-ethynyl-4-methyl-benzene-sulfonamido)-phen-yl]ethyn-yl}furan-2-carboxyl-ate.

The crystal structure of an ,-dialkynyl-tosyl-aniline, CHNOS, is presented. Two essentially planar and nearly parallel branches are connected to the aniline unit and the angle between the alkynes amounts to 26 (4)°. Weak intra-molecular aromatic π-π stacking occurs.

High-power short-duration vs conventional radiofrequency ablation for atrial fibrillation in patients over 80 years of age: A propensity-score matched cohort analysis.

Background: Data on atrial fibrillation (AF) ablation using high-power short-duration (HPSD) ablation in patients over 80 years are lacking.

Objective: This study aimed to compare the safety and efficacy of paroxysmal and persistent AF ablation using an HPSD (60-90 W/4-8 sec) vs conventional ablation (30-40 W/30 sec) in a propensity score-matched cohort of patients older than 80 years.

Methods: Overall, 232 consecutive patients aged over 80 years undergoing AF ablation were included.

Isocitrate dehydrogenase mutation and microenvironment in gliomas: do immunotherapy approaches matter?

Purpose Of Review: Gliomas with mutations in the gene for isocitrate dehydrogenase (IDH) display a unique immune microenvironment that is distinct from IDH-wildtype gliomas. This unique immune microenvironment is shaped by 2-hydroxyglutarate (2-HG), an oncometabolite produced by mutant IDH. These features provide an opportunity to develop and test targeted immunotherapies for IDH-mutant gliomas.

Psychiatric Diagnoses in Prehospital Emergency Care and Sociodemographic Characteristics of the Incident Location at the District Level.

Background: The aim of this study was to analyze the prevalence of psychiatric symptoms in prehospital emergency care and the characteristics of this patient group as well as the association with deprivation in the district, self-assessment of health status, and the frequency of emergency calls due to or accompanied by psychiatric diagnoses.

Methods: A retrospective cross-sectional study descriptively and analytically evaluated all ground-based Emergency Medical Service and rescue service incidents dispatched by the Integrated Regional Control Center (IRLS) in the period from January 1, 2021 through December 31, 2021. In addition to the clinical parameters and the demographic data of the patients, the sociodemographic characteristics of the incident location at the district level, unemployment rate, net equivalent household income, and the proportion of single-person households, as well as personal assessment of mental health and overall well-being, were included in the study.

Oleandrin-mediated suppression of MELK induces apoptosis, autophagy, and ferroptosis in human non-small cell lung cancer cells.

Background: Non-small-cell lung cancer NSCLC is the major diagnosed type of lung cancers in the USA and Europe. It is generally related to poor prognosis and low rates of survival. Oleandrin is a cardiac glycoside occurring naturally in Nerium oleander (Apocynaceae).

Determination of neonicotinoids in honey and pollen with probabilistic risk assessment for humans and pollinators in South Korea.

Neonicotinoid insecticides have been identified as significant contributors to the decline of pollinators. To evaluate potential exposure of pollinators to neonicotinoids in South Korea, 79 honey samples and 27 pollen samples were obtained from agricultural, mountain, and urban areas. These samples were analyzed for 17 compounds, including neonicotinoids and their metabolites using liquid chromatography coupled with mass spectrometry.

Male Reproductive Senescence in Mammals Is Pervasive and Aligned With the Slow-Fast Continuum.

Reproductive senescence, the decline in any component of offspring recruitment with increasing age, has been well documented in mammalian females. Male reproductive senescence, however, is much less understood, partly due to the past complexities of getting reliable paternity assignment in the wild. Through a standardised literature search, we compiled age-specific reproductive data on both mating and reproductive success on 57 species encompassing 73 populations.

Epidemiology, Real-World Treatment, and Economic Burden of Waldenström Macroglobulinemia: A Comprehensive Analysis Based on Anonymized Claims Data Between 2010 and 2022.

Objectives: This study aimed to provide evidence on the epidemiology, real-world treatment patterns, overall survival, and economic burden of Waldenström macroglobulinemia (WM).

Methods: A retrospective analysis of an anonymized large German claims database from January 1, 2010, to June 30, 2022, identified incident WM cases based on a 12-month diagnosis-free period before the first confirmed WM diagnosis (ICD-10-GM code C88.0).

Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a NM umbrella trial.

Advances in molecular understanding and diagnostic precision of glioblastoma enable the identification of key genetic alterations in a timely manner and, in principle, allow treatments with targeted compounds based on molecular markers. Here we report the results of the phase 1/2 umbrella trial NCT Neuro Master Match (NM), which evaluated targeted treatments in 228 patients with newly diagnosed glioblastoma without O6-methylguanine DNA-methyltransferase promoter hypermethylation. Stratification for treatment was conducted by a trial-specific molecular tumor board across five subtrials, each evaluating a targeted therapy-alectinib, idasanutlin, palbociclib, vismodegib or temsirolimus-selected according to the best-matching molecular alteration.

National survey on the presence of multidisciplinary meetings for interstitial lung diseases (ILD-MDM) in hospitals in Germany.

Background: Interstitial lung diseases (ILD) represent an interdisciplinary clinical challenge and are not uncommonly associated with rheumatological diseases. Interstitial lung disease multidisciplinary meetings (ILD-MDM) provide a structured platform for interdisciplinary case discussions and decision making. Despite their great importance in patient care, data on the prevalence, structure and function of ILD-MDM in Germany are lacking.