3 results match your criteria: "Jiangxi Provincial Engineering Research Center of Development and Evaluation of TCM Classic Prescriptions[Affiliation]"
Pien-Tze-Huang ameliorates autoimmune hepatitis by promoting hepatocyte autophagy via inhibiting miR-342-3p/mTOR signal.
J Ethnopharmacol
August 2025
Jiangxi Provincial Engineering Research Center of Development and Evaluation of TCM Classic Prescriptions, Nanchang, 330004, Jiangxi Province, China; Key Laboratory of Prevention and Treatment of Immunological and Metabolic Diseases Related to Prescription and Syndrome, Nanchang, 330004, Jiangxi Pro
Ethnopharmacological Relevance: Pien Tze Huang (PTH), as a national protected species with a history of more than 450 years, is known for its efficacy in heat clearance, detoxification, blood cooling, blood stasis removal, and is commonly used in the treatment of liver-related diseases. However, it remains unclear whether PTH regulates autophagy by modulating miR-342-3p/mTOR signaling pathway for the treatment of autoimmune hepatitis (AIH).
Aim Of The Study: To explore the therapeutic effects and molecular mechanisms of PTH on AIH, focusing on the analysis of its regulatory effects on miR-342-3p/mTOR pathway and autophagy.
Investigating the therapeutic potential of naringin in MK-801-induced schizophrenia model: focus on cognitive impairment and miR-25-3p-regulated pathways.
Int J Neurosci
March 2025
Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine (TCM), Nanchang, Jiangxi Province, China.
Aim: The aim of this study was to assess the ameliorative effects of naringin (NR) on cognitive impairment in schizophrenia(SZ) from multiple perspectives using behavioral, histopathological and molecular biological approaches.
Materials And Methods: SZ models were established in rats acute intraperitoneal injection of MK-801 in all groups except the control group, which received saline. Cognitive function was assessed using the Morris water maze test 21 days after prophylactic NR administration.
Formononetin alleviates ulcerative colitis via reshaping the balance of M1/M2 macrophage polarization in a gut microbiota-dependent manner.
Phytomedicine
December 2024
College of Acupuncture and Tuina, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China; College of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China; Laboratory Animal Science and Technology Center, Jiangxi Univ
Article Synopsis
- Ulcerative colitis (UC) is a challenging inflammatory bowel disease, and this study explores the effectiveness of the natural compound Formononetin (FN), which has anti-inflammatory and antioxidant properties, against UC.
- The researchers used a mouse model of colitis induced by dextran sulfate sodium (DSS) and treated them with FN to assess its impact on macrophage activity and gut microbiota.
- Results showed that FN reduced inflammation and improved gut microbiota balance, but lost effectiveness after gut flora depletion, indicating that FN's benefits rely on healthy gut microbiota.