Mapping Excited-State Decay Mechanisms in Acetylacetone by Sub-20 fs Time-Resolved Photoelectron Spectroscopy.

Excited-State Intramolecular Hydrogen Transfer (ESIHT) is one of the fastest chemical reactions, occurring on the order of tens of femtoseconds and playing a critical role in light-driven biological processes and technological applications. Here, we investigate the early stages of coupled nuclear-electron dynamics using acetylacetone (AcAc) as a model system exhibiting ESIHT. We employ ultraviolet-extreme ultraviolet (UV-XUV) time-resolved photoelectron spectroscopy (tr-PES) with sub-20 fs resolution in combination with high-level dynamically correlated simulations (CASPT2) to map the electronic relaxation pathways and vibrational modes driving this process.

Dynamic Interference of Chirped Photoelectrons.

Dynamic interference is an elusive strong-field effect where photoelectrons from intense laser pulses interfere in time, forming rich kinetic energy patterns. Here, we present the first experimental demonstration of isolated dynamic interference using a novel two-color scheme: chirped laser-assisted dynamic interference. Isolation was achieved with a crossed-polarization setup combining an extreme ultraviolet harmonic field and an infrared pulse with tailored spectrotemporal properties.

Strain-Driven Dewetting and Interdiffusion in SiGe Thin Films on SOI for CMOS-Compatible Nanostructures.

This study provides new insight into the mechanisms governing solid state dewetting (SSD) in SiGe alloys and underscores the potential of this bottom-up technique for fabricating self-organized defect-free nanostructures for CMOS-compatible photonic and nanoimprint applications. In particular, we investigate the SSD of SiGe thin films grown by molecular beam epitaxy on silicon-on-insulator (SOI) substrates, focusing on and clarifying the interplay of dewetting dynamics, strain elastic relaxation, and SiGe/SOI interdiffusion. Samples were annealed at 820 °C, and their morphological and compositional evolution was tracked using atomic force microscopy (AFM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Raman spectroscopy, considering different annealing time steps.

Quantitative X-ray phase-contrast digital histology of liver metastases in a mouse model.

Investigating the tissue modifications occurring as a consequence of tumour development is an important goal in preclinical medical research, as it can provide a better understanding of the mechanisms behind its origin and spread. Tumor microenvironment has a supportive role in cancer development and can be exploited as a therapeutic target to prevent and contrast metastatic spread, which usually leads to a poor prognosis. In this work, a colorectal cancer model of liver metastasis is used to perform proof-of-concept quantitative investigations of the changes occurring in murine liver tissue due to the formation of metastases.

Flexible Glass: Myth and Photonic Technology.

The recent fast advances in consumer electronics, especially in cell phones and displays, have led to the development of ultra-thin, hence flexible, glasses. Once available, such flexible glasses have proven to be of great interest and usefulness in other fields, too. Flexible photonics, for instance, has quickly taken advantage of this new material.

Decitabine co-operates with the IL-33/ST2 axis modifying the tumor microenvironment and improving the response to PD-1 blockade in melanoma.

Background: IL-33 is an epithelial-derived alarmin with various roles in cancer. In melanoma, endogenous and exogenous IL-33 exert anti-tumor effects through the stimulation of several immune effector cells. In this study, we explored the combination of IL- 33 with Decitabine (DAC), a DNA methylation inhibitor that promotes immune recognition by re-activating silenced genes, for melanoma treatment.

The Support can Disguise the Catalytic Effect: The Case of Silver on Alumina in Plasma Ammonia Synthesis.

Plasma catalysis combines the high-energy chemistry of plasma with the speed and selectivity of chemical reactions in catalysis. However, unlike well-established thermal catalysis, a better understanding of fundamental mechanisms is needed, as evidenced by the contrasting results reported in the literature. One main challenge is that not only the genuine catalytic effect may play a role, but both the support and the catalyst also impact the plasma, complicating the understanding.

Disclosing Fast Detection Opportunities with Nanostructured Chemiresistor Gas Sensors Based on Metal Oxides, Carbon, and Transition Metal Dichalcogenides.

With the emergence of novel sensing materials and the increasing opportunities to address safety and life quality priorities of our society, gas sensing is experiencing an outstanding growth. Among the characteristics required to assess performances, the overall speed of response and recovery is adding to the well-established stability, selectivity, and sensitivity features. In this review, we focus on fast detection with chemiresistor gas sensors, focusing on both response time and recovery time that characterize their dynamical response.

Kelvin probe force microscopy on patterned large-area biofunctionalized surfaces: a reliable ultrasensitive platform for biomarker detection.

Kelvin probe force microscopy (KPFM) allows the detection of single binding events between immunoglobulins (IgM, IgG) and their cognate antibodies (anti-IgM, anti-IgG). Here an insight into the reliability and robustness of the methodology is provided. Our method is based on imaging the surface potential shift occurring on a dense layer of ∼5 × 10 antibodies physisorbed on a 50 μm × 90 μm area when assayed with increasing concentrations of antigens in phosphate buffer saline (PBS) standard solutions, in air and at a fixed scanning location.

On the Dependency of the Electromechanical Response of Rotary MEMS/NEMS on Their Embedded Flexure Hinges' Geometry.

This paper investigates how the electromechanical response of MEMS/NEMS devices changes when the geometrical characteristics of their embedded flexural hinges are modified. The research is dedicated particularly to MEMS/NEMS devices which are actuated by means of rotary comb-drives. The electromechanical behavior of a chosen rotary device is assessed by studying the rotation of the end effector, the motion of the comb-drive mobile fingers, the actuator's maximum operating voltage, and the stress sustained by the flexure when the flexure's shape, length, and width change.

A stable physisorbed layer of packed capture antibodies for high-performance sensing applications.

Antibody physisorption at a solid interface is a very interesting phenomenon that has important effects on applications such as the development of novel biomaterials and the rational design and fabrication of high-performance biosensors. The strategy selected to immobilize biorecognition elements can determine the performance level of a device and one of the simplest approaches is physical adsorption, which is cost-effective, fast, and compatible with printing techniques as well as with green-chemistry processes. Despite its huge advantages, physisorption is very seldom adopted, as there is an ingrained belief that it does not lead to high performance because of its lack of uniformity and long-term stability, which, however, have never been systematically investigated, particularly for bilayers of capture antibodies.

Estimation of porcine pancreas optical properties in the 600-1100 nm wavelength range for light-based therapies.

This work reports the optical properties of porcine pancreatic tissue in the broad wavelength range of 600-1100 nm. Absorption and reduced scattering coefficients (µ and µ') of the ex vivo pancreas were obtained by means of Time-domain Diffuse Optical Spectroscopy. We have investigated different experimental conditions-including compression, repositioning, spatial sampling, temporal stability-the effect of the freezing procedure (fresh vs frozen-thawed pancreas), and finally inter-sample variability.

Illuminating the hidden world of calcium ions in plants with a universe of indicators.

The tools available to carry out in vivo analysis of Ca dynamics in plants are powerful and mature technologies that still require the proper controls.

Multimodal Gold Nanostars as SERS Tags for Optically-Driven Doxorubicin Release Study in Cancer Cells.

Surface Enhanced Raman Scattering (SERS) active gold nanostars represent an opportunity in the field of bioimaging and drug delivery. The combination of gold surface chemical versatility with the possibility to tune the optical properties changing the nanoparticles shape constitutes a multimodal approach for the investigation of the behavior of these carriers inside living cells. In this work, SERS active star-shaped nanoparticles were functionalized with doxorubicin molecules and covered with immuno-mimetic thiolated polyethylene glycol (PEG).

Ultrafast photoelectron spectroscopy of photoexcited aqueous ferrioxalate.

The photochemistry of metal-organic compounds in solution is determined by both intra- and inter-molecular relaxation processes after photoexcitation. Understanding its prime mechanisms is crucial to optimise the reactive paths and control their outcome. Here we investigate the photoinduced dynamics of aqueous ferrioxalate ([Fe(CO)]) upon 263 nm excitation using ultrafast liquid phase photoelectron spectroscopy (PES).

Angstrom-Resolved Interfacial Structure in Buried Organic-Inorganic Junctions.

Charge transport processes at interfaces play a crucial role in many processes. Here, the first soft x-ray second harmonic generation (SXR SHG) interfacial spectrum of a buried interface (boron-Parylene N) is reported. SXR SHG shows distinct spectral features that are not observed in x-ray absorption spectra, demonstrating its extraordinary interfacial sensitivity.

Effect of Hydrothermal Treatment and Doping on the Microstructural Features of Sol-Gel Derived BaTiO Nanoparticles.

Barium Titanate (BaTiO) is one of the most promising lead-free ferroelectric materials for the development of piezoelectric nanocomposites for nanogenerators and sensors. The miniaturization of electronic devices is pushing researchers to produce nanometric-sized particles to be embedded into flexible polymeric matrices. Here, we present the sol-gel preparation of crystalline BaTiO nanoparticles (NPs) obtained by reacting barium acetate (Ba(CHCOO)) and titanium (IV) isopropoxide (Ti(OPr)).

Optical signatures of radiofrequency ablation in biological tissues.

Accurate monitoring of treatment is crucial in minimally-invasive radiofrequency ablation in oncology and cardiovascular disease. We investigated alterations in optical properties of ex-vivo bovine tissues of the liver, heart, muscle, and brain, undergoing the treatment. Time-domain diffuse optical spectroscopy was used, which enabled us to disentangle and quantify absorption and reduced scattering spectra.

Compliant Nano-Pliers as a Biomedical Tool at the Nanoscale: Design, Simulation and Fabrication.

This paper presents the development of a multi-hinge, multi-DoF (Degrees of Freedom) nanogripper actuated by means of rotary comb drives and equipped with CSFH (Conjugate Surface Flexure Hinges), with the goal of performing complex in-plane movements at the nanoscale. The design approach, the simulation and a specifically conceived single-mask fabrication process are described in detail and the achieved results are illustrated by SEM images. The first prototype presents a total overall area of (550 × 550) μm2, an active clamping area of (2 × 4) μm2, 600 nm-wide circular curved beams as flexible hinges for its motion and an aspect ratio of about 2.

Ultrasound-Assisted Hydroxyapatite-Decorated Breath-Figure Polymer-Derived Ceramic Coatings for Ti6Al4V Substrates.

The introduction of nanoparticles (NPs) into the breath-figure-templated self-assembly (BFTSA) process is an increasingly common method to selectively decorate a surface porous structure. In the field of prosthetic devices, besides controlling the morphology and roughness of the structure, NPs can enhance the osteointegration mechanism because of their specific ion release. Among the most widely used NPs, there are silica and hydroxyapatite (HAp).

Molecular Imprinted Polymers Coupled to Photonic Structures in Biosensors: The State of Art.

Optical sensing, taking advantage of the variety of available optical structures, is a rapidly expanding area. Over recent years, whispering gallery mode resonators, photonic crystals, optical waveguides, optical fibers and surface plasmon resonance have been exploited to devise different optical sensing configurations. In the present review, we report on the state of the art of optical sensing devices based on the aforementioned optical structures and on synthetic receptors prepared by means of the molecular imprinting technology.

Evidence of Large Polarons in Photoemission Band Mapping of the Perovskite Semiconductor CsPbBr_{3}.

Lead-halide perovskite (LHP) semiconductors are emergent optoelectronic materials with outstanding transport properties which are not yet fully understood. We find signatures of large polaron formation in the electronic structure of the inorganic LHP CsPbBr_{3} by means of angle-resolved photoelectron spectroscopy. The experimental valence band dispersion shows a hole effective mass of 0.

Photonic Crystal Stimuli-Responsive Chromatic Sensors: A Short Review.

Photonic crystals (PhC) are spatially ordered structures with lattice parameters comparable to the wavelength of propagating light. Their geometrical and refractive index features lead to an energy band structure for photons, which may allow or forbid the propagation of electromagnetic waves in a limited frequency range. These unique properties have attracted much attention for both theoretical and applied research.

Synthesis and Post-Annealing of CuZnSnS Absorber Layers Based on Oleylamine/1-dodecanethiol.

CuZnSnS (CZTS) nanocrystals in oleylamine (OLA) and 1-dodecanethiol (1-DDT) solvents were successfully prepared via hot-injection method, to produce inks for the deposition of absorber layers in photovoltaic cells. In this process, 1-DDT acts as a coordinating ligand to control the nucleation and growth of CZTS nanocrystals, whereas lower amounts of OLA promote a homogeneous growth of the grains in the absorber layer. X-Ray Diffraction (XRD) revealed both tetragonal and hexagonal phases of CTZS in films obtained after soft thermal treatments (labeled TT0).