Clinical characteristics and risk factors of metabolic dysfunction-associated steatotic liver disease in lean patients: results of the Polish Gallstone Surgery Registry.

Aim Of The Study: Data concerning the clinical manifestation and outcomes of lean metabolic dysfunction-associated steatotic liver disease (MASLD) are scarce and inconsistent. The aim of the study was to evaluate the clinical characteristics of MASLD and predictors of its occurrence.

Material And Methods: The study included patients from the Polish Gallstone Surgery Registry diagnosed with MASLD according to the current criteria.

Outcomes of severely impaired renal function patients with and without dialysis following isolated coronary artery surgery - a retrospective cohort study.

Objectives: Patients with advanced-stage chronic renal failure have poor outcomes following cardiac surgery. Our registry study aimed to compare postoperative and follow-up data between patients who underwent isolated coronary artery surgery with preoperative chronic dialysis and patients with preoperative severe renal impairment who did not require chronic dialysis.

Methods: We analyzed 157 948 consecutive adult patients in the Polish National Registry of Cardiac Surgical Procedures (KROK Registry) scheduled for isolated coronary artery surgery between January 2010 and December 2023.

Extracorporeal Cardiopulmonary Resuscitation in Hypothermic Cardiac Arrest: Severe Hypoglycemia Does Not Preclude Survival With Good Neurologic Outcome.

Objective: Prolonged hypoglycemia can cause irreversible brain damage. Clinicians may thus be reluctant to initiate extracorporeal cardiopulmonary resuscitation in hypothermic cardiac arrest patients with severe hypoglycemia. The aim of this study was to evaluate the survival rate with good neurologic outcomes of patients with hypothermic cardiac arrest and severe hypoglycemia.

Development of an SPRi Immune Method for the Quantitative Detection of Osteopontin.

Osteopontin (OPN) is a protein that plays many essential functions in the human body. It is present in most tissues and body fluids. OPN, among other things, participates in wound healing, the formation and remodeling of bone, immune response, inflammation, angiogenesis, and tumor formation.

Asiatic acid potentiates the activity of common antidepressant drugs in mice.

Rationale: Conventional pharmacotherapy for depression faces numerous challenges, including side effects. Moreover, less than 50-70% of patients fully respond to treatment, and 20-30% experience recurrence. This has led to a growing interest in alternative treatments, particularly phytotherapy.

Procedural characteristics and outcomes of patients undergoing Impella-assisted high-risk percutaneous coronary interventions in the IMPELLA-PL registry.

Background: Impella is a catheter-based, continuous blood flow left ventricle assist device used in selected patients undergoing high-risk percutaneous coronary interventions (HR PCI). We aimed to evaluate outcomes in patients undergoing Impella-assisted HR-PCI and identify independent predictors of 12-month mortality.

Methods: Consecutive HR-PCI patients enrolled in the national, multicentre, retrospective IMPELLA-PL registry (n = 253) in 20 Polish interventional cardiological centres from October 2014 until December 2021 were included in the analysis.

How does direct oral anticoagulant dosage affect long-term prognosis in patients with atrial fibrillation and heart failure? Results from the HEart failure ObsErvational Study (HEROES).

Background: Most patients with heart failure (HF) and atrial fibrillation (AF) require direct oral anticoagulants (DOACs) at appropriate doses.

Aims: We analyzed the prevalence of non-recommended DOAC prescriptions and their influence on long-term prognosis.

Material And Methods: Patients with HF were included in the Heart failure ObsErvational Study, an observational, multicenter study.

The Role of Periarticular Knee Muscle Torques in Ensuring the Body Balance of Older Adults with Balance Disturbances.

: The role of the periarticular muscles of the knee joint in ensuring body balance is still ambiguous. Therefore, we conducted clinical and biomechanical assessments on 52 older adults (36 women and 16 men, age of 67.58 ± 7.

Atrial fibrillation in patients with heart failure with reduced, mildly reduced, and preserved ejection fraction: A report from the HEart failuRe ObsErvational Study (HEROES).

Background: Heart failure (HF) and atrial fibrillation (AF) often coexist and modify each other's course. The prevalence and clinical characteristics of AF differ in specific HF subtypes.

Aims: The study aimed to evaluate the incidence and clinical features of people with AF in comparison to those with sinus rhythm in HF, across the three HF subtypes categorized by left ventricular ejection fraction (EF).

Managing diverticula: dietary changes for a more comfortable life.

Introduction: Diverticulosis is an anatomical condition with increasing incidence. Diverticula are common findings during screening colonoscopies, making diagnosis and treatment challenging in routine clinical practice. Nutritional factors have been identified as significant risk factors, and it has been suggested that diets recommended for the prevention of cardiovascular and other chronic diseases may also positively influence the clinical course of diverticulosis.

Early treatment with inhibitors of P2Y12 receptor in patients with ST-segment elevation myocardial infarction - 2023 ESC recommendations and scientific evidence. Is clinical evidence sufficient to suggest a move towards precision medicine? The ELECTRA-SIRIO 2 investigators' viewpoint.

The 2023 ESC guidelines changed previously recommended a strategy of early treatment in patients with STEMI. Pre-treatment with a P2Y12 receptor inhibitor may be considered in patients undergoing a primary PCI strategy (Class IIb, Level of evidence B). However, the available scientific evidence justifies a personalized approach differentiating the indications for pre-treatment with oral P2Y12 receptor inhibitors depending on the concomitant administration of opioids.

Dietary Patterns and Nutritional Status in Bariatric Surgery Candidates-A Cross-Sectional Study.

Background/objectives: Observing a patient's dietary behaviour before bariatric surgery may help to predict their diet (and indirectly, the rate of weight loss) after the procedure. Consequently, the aim of this study was to identify dietary patterns (DPs) in bariatric surgery candidates, as well as to assess the relationship between DPs, degree of obesity, and body composition.

Methods: The participants were comprised of 117 bariatric surgery candidates.

Combining Sulfonylureas with Anticancer Drugs: Evidence of Synergistic Efficacy with Doxorubicin In Vitro and In Vivo.

Sulfonylureas (SUs)-a class of drugs primarily used to treat type 2 diabetes-have recently attracted interest for their potential anticancer properties. While some studies have explored the chemical modification or design of new SU derivatives, our work instead centers on biological evaluations of all commercially available SUs in combination with doxorubicin (DOXO). These antidiabetic agents act by stimulating insulin secretion via K channel inhibition, and because K channels share structural features with ATP-binding cassette (ABC) transporters involved in multidrug resistance (e.

The evaluation of the flow re-direction endoluminal device (FRED) for the treatment of selected intracranial aneurysms: a Polish multicenter study.

This Polish multicenter study aims to evaluate the effectiveness and safety of the Flow Direction Endoluminal Device (FRED) in treating selected unruptured intracranial aneurysms. The FRED Poland Study was an observational, multicenter, prospective study conducted in 8 Polish investigational sites. Imaging results were independently assessed by a Corelab and adverse events were adjudicated by a Clinical Events Committee (CEC).

Percutaneous coronary intervention and coronary artery bypass grafting in myocardial infarction complicated by cardiogenic shock.

Background: Cardiogenic shock (CS) remains the leading cause of poor prognosis in patients with acute myocardial infarction (AMI), sustaining a high mortality rate of 40 to 50% within 30 days.

Aims: In this unique analysis of two national all-comers, real-life registries including patients with AMI complicated by CS, for whom early revascularization was planned, we aimed to compare the effect of percutaneous coronary revascularization (PCI) and coronary artery bypass grafting (CABG) on 30-day and 1-year all-cause mortality.

Methods: The study included consecutive patients with AMI complicated by CS included in the Polish Registry of Acute Coronary Syndromes (PL-ACS) and the Polish National Registry of Cardiac Surgical Procedures (KROK), treated with PCI and CABG, respectively.

The effects of hyperbaric treatment on perianal fistula activity in patients with Crohn's disease.

Introduction: Crohn's disease is a chronic, complex inflammatory disorder of the gastrointestinal tract. Among its most challenging complications are perianal fistulas.

Aim: This study aims to explore the efficacy of hyperbaric oxygen therapy (HBOT) in reducing the activity of perianal fistulas in Crohn's disease patients.

Outcomes of extracorporeal life support in hypothermic cardiac arrest: Revisiting ELSO guidelines.

Aim Of The Study: Predictive factors for poor outcomes in hypothermic cardiac arrest (HCA) differ from those in normothermic out-of-hospital cardiac arrest (OHCA). This study aimed to evaluate the outcomes of extracorporeal life support (ECLS) in HCA patients who may not be considered eligible based on the guidelines set by the Extracorporeal Life Support Organization (ELSO).

Methods: A retrospective multicentre study included 127 HCA patients, divided into two groups: those meeting the ELSO eligibility criteria for ECLS, and those with at least one of the following ELSO exclusion criteria: age over 70 years, unwitnessed cardiac arrest, or asystole.

High-frequency shear wave MR elastography of parotid glands: custom driver design and preliminary results.

Parotid glands are one of the most common sites for salivary gland tumors. Conventional imaging techniques have limited usefulness in the quantitative assessment of the parotid glands, making it difficult to differentiate between healthy tissue and tumors, as well as between benign and malignant tumors. Magnetic resonance elastography (MRE) is a non-invasive technique that may potentially overcome these limitations.

Application of Surface Plasmon Resonance Imaging Biosensors for Determination of Fibronectin, Laminin-5, and Type IV Collagen in Plasma, Urine, and Tissue of Renal Cell Carcinoma.

Laminin, fibronectin, and collagen IV are pivotal extracellular matrix (ECM) components. The ECM environment governs the fundamental properties of tumors, including proliferation, vascularization, and invasion. Given the critical role of cell-matrix adhesion in malignant tumor progression, we hypothesize that the concentrations of these proteins may be altered in the plasma of patients with clear cell renal cell carcinoma (ccRCC).

Long-term outcomes of DCB and DES for the treatment of in-stent restenosis in relation to the vessel size.

Background: Percutaneous coronary intervention (PCI) with drug-coated balloons (DCB) or drug-eluting stents (DES) are well-established treatments for in-stent restenosis, however little is known about the impact of vessel size on the outcomes. The study aimed to evaluate the efficacy and safety profile of DCB versus DES in DES in-stent restenosis depending on the vessel size.

Methods: Consecutive patients with DES in-stent restenosis who underwent PCI between January 2010 and February 2018 entered the registry with a long-term follow-up.

Use of 3D-printed model to plan the surgical management of a patient with isolated orbital floor fracture: a case report.

Background: Orbital floor fractures typically manifest as eyeball mobility disorders with double vision (diplopia), enophthalmia, and infraorbital paresis. Surgical treatment of these fractures involves orbital floor reconstruction. The procedure involves freeing the trapped tissues from the lumen of the maxillary sinus and rebuilding the orbital floor.