Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.33963/v.phj.103770DOI Listing

Publication Analysis

Top Keywords

apply grants?
4
grants? position
4
position expert
4
expert panel
4
panel committee
4
committee science
4
science grants
4
grants committee
4
committee scientific
4
scientific analysis
4

Similar Publications

Availability of benign missense variant "truthsets" for validation of functional assays: Current status and a systematic approach.

Am J Hum Genet

September 2025

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, Fulham Road, London, UK. Electronic address:

Multiplex assays of variant effect (MAVEs) provide promising new sources of functional evidence, potentially empowering improved classification of germline genomic variants, particularly rare missense variants, which are commonly assigned as variants of uncertain significance (VUSs). However, paradoxically, quantification of clinically applicable evidence strengths for MAVEs requires construction of "truthsets" comprising missense variants already robustly classified as pathogenic and benign. In this study, we demonstrate how benign truthset size is the primary driver of applicable functional evidence toward pathogenicity (PS3).

View Article and Find Full Text PDF

Improved protocol for the vitrification and warming of rat zygotes by optimizing the warming solution and oocyte donor age.

PLoS One

September 2025

Division of Reproductive Engineering, Center for Animal Resources and Development, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan.

Zygotes are used to create genetically modified animals by electroporation using the CRISPR-Cas9 system. Such zygotes in rats are obtained from superovulated female rats after mating. Recently, we reported that in vivo-fertilized zygotes had higher cryotolerance and developmental ability than in vitro-fertilized zygotes in Sprague Dawley (SD) and Fischer 344 rats.

View Article and Find Full Text PDF

Water quality ecosystem service (ES) modeling tools help inform freshwater management across landscapes. However, the validity of such models depends on the availability of water quality data for validation and calibration, limiting their application in regions where monitoring is limited. This study presents a methodological framework that combines machine learning (ML) and spatial extrapolation to enhance ES modeling in data-scarce contexts (https://github.

View Article and Find Full Text PDF

Introduction: Submarine environments pose unique challenges to maintaining physical activity and exercise routines due to confined spaces, demanding schedules, and limited resources. This study investigated submariners' physical activity patterns, sleep quality, and perceived exercise barriers in both land- and sea-based settings, with the goal of informing targeted health interventions.

Materials And Methods: Ethics approval was granted by the Defence Science and Technology Group and Edith Cowan University review panels.

View Article and Find Full Text PDF