Comparison of Breast Reconstruction Strategies Using Exclusive Lipofilling or Prosthesis After Total Mastectomy for Breast Cancer: Satisfaction and Morbidity After More Than 2 Years.

Background: Total mastectomy for breast cancer is an impactful procedure, and breast reconstruction plays a crucial role for women diagnosed with the disease.

Objectives: The objective of our study is to compare satisfaction, morbidity, and timelines of two breast reconstruction techniques after breast cancer: breast prosthesis and exclusive lipofilling.

Methods: This is a comparative, retrospective, unicentric study on patients who underwent total mastectomy between May 2014 and May 2020.

Expanded senescent CD8 T-cells in IMID patients are associated with distinct inflammatory cytokines.

Introduction: Immunosenescence remodels immune functions and was first described with aging. It is present in 25% of cancer patients but has also been described in patients with Immune-mediated inflammatory diseases (IMIDs). This study aims at quantifying cells exhibiting a phenotype of senescence in CD4+ (T4sen) and CD8+ (T8sen) T cells, analyzing its potential drivers and the effect of anti-TNF treatment in a prospective cohort of patients with rheumatoid arthritis (RA), spondyloarthritis (SpA) and Sjögren disease (SjD).

Poliovirus surveillance in Mayotte, Indian Ocean, reveals encephalomyocarditis virus type 1 and a wide diversity of non-polio enteroviruses.

Background: In 2023, Mayotte, a French department in the Mozambique channel, experienced a long drought that led to potable water restrictions. Although the French vaccination schedule makes polio vaccination compulsory for children, the large proportion of migrants on the island coupled with the water crisis raised concerns about the establishment of poliovirus transmission chains. Therefore, a surveillance was implemented to detect polioviruses in sewage sampled in the two main wastewater treatment plants.

Cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome: data from the ESC EORP Registry Of Pregnancy And Cardiac disease (ROPAC) III.

Background And Aims: Data on cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome is limited. We examine the cardiovascular and pregnancy outcomes in these women and analyze aortic growth throughout pregnancy.

Methods: The ROPAC III is a global, prospective, observational registry that enrolled pregnancies of women pre-pregnancy known with Turner syndrome from 2018 to 2023.

Finerenone according to insulin resistance in heart failure: Insights from the FINEARTS-HF trial.

Aims: The estimated glucose disposal rate (eGDR) is a simple, non-invasive measure of insulin resistance. In this exploratory analysis of FINEARTS-HF, we evaluated whether lower eGDR, reflecting greater insulin resistance, is associated with adverse outcomes in heart failure (HF).

Methods And Results: The eGDR was calculated at baseline using waist circumference, glycated haemoglobin, and hypertension status.

Translating French mathematics and lobbying the horse-drawn carriage trade (USA, 1869-1877).

In the United States, in the second half of the nineteenth century, the reforming institutions of the horse-drawn-carriage trade prescribed descriptive geometry to their workshops in order to modernize the drawing process for modern carriages. This injunction, institutionally supported by the builder's national association, professional newspapers, and education, was part of a wider movement to organize production at a time when the carriage trade was booming. In order to facilitate the circulation of theoretical knowledge within workshops that were reluctant to mathematize their environment, two trade journals translated, in the space of a few years, and on three occasions (once by one journal and twice by the other), the same French treatise on descriptive geometry written by a Parisian carriage woodworker.

Pancreatic Islet Transplantation in Extrahepatic Sites: Evaluation of the Venous Sac in Large Mammal Models.

Background: The long-term clinical efficacy of intraportal islet transplantation is hampered by islet loss due to inflammation, oxidative stress, and insufficient vascularization. This study explores the venous sac as an alternative implantation site for islet transplantation in large animal models.

Methods: An immunosuppressed, diabetic cynomolgus monkey received allogeneic islet implants in its mesenteric venous sac, with metabolic assessments over 112 days.

Investigation of protonation induced metal-to-metal electron transfer in a cyano-bridged Mn-Fe dinuclear complex.

Reaction of [Mn(salophen)Cl] {salophen = -phenylenediamine bis(salicylidenaminato)} with a tricyano Fe(III) precursor complex, [Fe(bbp)(CN)] {Hbbp = bis(2-benzimidazolyl)pyridine}, affords a dinuclear cyano-bridged heterometallic Mn-(μ-NC)-Fe fragment in the complex salt [Mn(salophen)(HO)][Mn(salophen)(HO)(μ-NC)Fe(bbp)(CN)]·4HO (1). The title compound shows field-induced slow relaxation of magnetization below 2.8 K.

Aluminum surface lattice resonances for enhanced near-infrared performance in asymmetric environments.

Aluminum (Al) is a cost-effective alternative to noble metals for plasmonics, particularly in the ultraviolet (UV) and visible regions. However, in the near-infrared (NIR) region, its performance is hindered by interband transitions (IBTs) at around 825 nm, leading to increased optical losses and broad resonances. Surface lattice resonances (SLRs) offer a promising solution by enhancing the plasmonic quality factor (-factor) through coherent coupling of localized surface plasmon (LSP) modes with Rayleigh anomalies.

Electrocatalytic water oxidation with bioinspired cubane-type Co complexes.

Synthesis, characterization, and electrocatalytic water oxidation studies of the cubane-type complexes [(μ-)CoCl(MeOH)] (1) and [(μ-)CoCl(MeOH)] (2) are herein reported. Cubanes 1 and 2 were obtained in high yields under mild conditions by self-assembly of the ligands = 1--2-benzimidazolylmethanol and = 1-methyl-2-benzimidazolylmethanol with CoCl·6HO in basic methanolic solution. Both compounds feature a cubane-type structure in which the central {CoO} units are built by four Co centers coordinated by alkoxide-bridged oxygen and nitrogen atoms from the deprotonated ligands and stabilized by MeOH molecules and chloride ions.

Spatiotemporal changes in prevalence of Sodalis glossinidius, Spiroplasma spp. and trypanosome species in wild Glossina tachinoides from Sora-Mboum animal African trypanosomiasis focus in northern Cameroon.

Sterile Insect Technique (SIT) has proven effective to reduce tsetse population density in large infected areas where animal African trypanosomosis (AAT) and human African trypanosomiasis (HAT) elimination was difficult to achieve. However, the decrease in mass production of insectary-reared tsetse and the limited but incomplete knowledge on symbiont-trypanosome interaction over time, impede large-scale use of SIT. We investigated the spatiotemporal changes in symbiont prevalence and symbiont-trypanosome interactions in wild tsetse of Sora-Mboum AAT focus in northern Cameroon, collected in 2019 and 2020, to provide insights into the mass production of refractory tsetse.

Optimization of the measurement method for airborne endotoxins in workplace atmospheres: experiments using laboratory-generated bioaerosols.

Endotoxins are components of the outer membrane of bacteria that can become airborne during aerosol-generating work activities and cause adverse effects on workers' health. Filtration is the sampling method recommended by the EN 14031 standard for endotoxin measurements in workplace atmospheres. However, there are still differences in terms of practice regarding certain parameters of the measurement method.

Switch to bictegravir/emtricitabine/tenofovir alafenamide in people living with HIV aged 65 years or older: BICOLDER study - IMEA 057.

Background: Polymedication and comorbidities are frequent in aging people with HIV (PWH) and often associated with elevated incidences of adverse events (AEs) and drug-drug interactions (DDIs). The objective of this study was to evaluate the efficacy, safety and practicality of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), an antiretroviral (ARV) therapy with limited DDIs, in an elderly virologically-controlled PWH population.

Materials And Methods: This study was prospective, multicentric, single-arm conducted in HIV-1 controlled PWH aged over 65 years who switched from a ritonavir- or cobicistat-boosted containing regimen to B/F/TAF.

Bridging lab and field: Tracking environmentally relevant nanoplastics in crops using Py-GC/MS.

The increasing presence of nanoplastics (NPs) in terrestrial environments raises concerns about their bioavailability and potential impacts on crops. This study investigates the uptake and translocation of environmentally relevant polystyrene nanoplastics (eNPs-PS) in Hordeum vulgare L. via soil.

Performance of the ELITe InGenius system for hepatitis B virus DNA quantification.

Measurement of hepatitis B virus (HBV) DNA levels is the standard of care for diagnosis active HBV infection, assessing disease severity and prognosis, and guiding treatment decisions and monitoring response to therapy. In the study, the analytical and clinical performance of the ELITe InGenius System for quantifying HBV DNA was evaluated. A total of 377 of archived EDTA plasma or serum specimens were tested.

Social determinants of health, quality of life, and productivity outcomes among adults with vitiligo in Brazil, China, India, and South Africa.

Objectives: Vitiligo is an autoimmune disease resulting in skin depigmentation and individuals report substantial psychosocial burden. However, vitiligo-related quality of life impacts appear heterogeneous and may be influenced by social determinants of health. This cross-sectional survey aimed to describe characteristics and vitiligo-related quality of life impacts among adults in Brazil, China, India, and South Africa.

Predominance of L. monocytogenes Lineage I Clones in Wastewater, Ruminants, and Natural Environments.

Listeria monocytogenes is a saprophytic bacterium and a foodborne pathogen of humans and animals. Little is known about its distribution and genetic diversity across different environments within the same geographical region. We conducted a large-scale longitudinal study in southeastern Spain monitoring Listeria spp.

Extracellular Vesicles in Lung Transplantation: Biomarkers, Pathophysiological Players, and Therapeutic Weapons?

In the field of lung transplantation (LTx), the survival of lung transplant recipients (LTRs) is limited by events such as primary graft dysfunction (PGD), infections, and acute rejection (AR), which promote the development of chronic lung allograft dysfunction (CLAD). Extracellular vesicles (EVs), including exosomes and microvesicles, have emerged as key players in LTx because of their roles in immune regulation, inflammation, and antigen presentation. EVs carry immunologically active molecules such as MHC class I/II proteins, cytokines, and lung self-antigens (SAgs), suggesting their involvement in infections and both AR and CLAD.

Widely Distributed Pigeon Paramyxovirus Sub-Genotypes Pose a Risk to Immunocompromised Humans.

Introduction: Pigeon paramyxovirus type 1 (PPMV-1) is an antigenic variant of Avian Orthoavulavirus 1 (AOAV-1) (Newcastle disease virus) with a global distribution that causes lethal infections in pigeon and dove species. AOAV-1's infecting humans normally cause mild, self-limiting conjunctivitis, but since 2003, PPMV-1 has been associated with an increased number of severe and lethal respiratory and neurological infections in immunocompromised persons in the Netherlands, the USA, France, China and Australia.

Methods: PPMV-1's isolated from free-living pigeons and doves across South Africa from 2012 to 2024 were sequenced using conventional or next generation technologies.

Attitudes and perceptions of biomedical journal editors in chief towards the use of artificial intelligence chatbots in the scholarly publishing process: a cross-sectional survey.

Background: Artificial intelligence chatbots (AICs) are designed to mimic human conversations through text or speech, offering both opportunities and challenges in scholarly publishing. While journal policies of AICs are becoming more defined, there is still a limited understanding of how Editors in chief (EiCs) of biomedical journals' view these tools. This survey examined EiCs' attitudes and perceptions, highlighting positive aspects, such as language and grammar support, and concerns regarding setup time, training requirements, and ethical considerations towards the use of AICs in the scholarly publishing process.