Optimal estimation of power Chris-Jerry distribution parameters using ranked set sampling design with application.

Effective sample design has a major role in the quality of parameter estimation in statistical parameter estimation issues. The ranking set sampling (RSS) strategy is effective and a less costly option than simple random sampling (SRS). A novel mixture continuous lifetime distribution that has been proposed recently is the power Chris-Jerry distribution (PC-JD).

Safety and Efficacy of Lutetium-177 PSMA Therapy for Metastatic Castration-Resistant Prostate Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background And Aim: Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy using lutetium-177 has emerged as a promising treatment for metastatic castration-resistant prostate cancer (mCRPC). In this systematic review and meta-analysis, the safety and efficacy of PSMA-targeted radioligand therapy (PRLT) using lutetium-177 ([Lu]Lu-PSMA) were assessed.

Methods: This meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines.

Efficacy and safety of rechallenge therapy with [177Lu]Lu-PSMA in metastatic castration-resistant prostate cancer: a systematic review and meta-analysis.

Background: Lutetium-177 PSMA radioligand therapy ([¹⁷⁷Lu]Lu-PSMA-RLT) is an effective treatment option for patients with metastatic castration-resistant prostate cancer (mCRPC). Prospective studies reported favourable efficacy and safety outcomes of up to 6 cycles of [¹⁷⁷Lu]Lu-PSMA. This study aimed to evaluate the efficacy and safety of [¹⁷⁷Lu]Lu-PSMA rechallenge therapy in patients with mCRPC who progressed after an initial course of [¹⁷⁷Lu]Lu-PSMA-RLT.

A web-based system for real-time ECG monitoring using MySQL database and DigiMesh technology: design and implementation.

In today's world, rapid advancements in wireless sensor network (WSN) technologies hold the potential to revolutionize healthcare through future ubiquitous patient monitoring systems. Essential for continuous monitoring without restricting patient mobility, these systems comprise wearable or implanted sensors continuously tracking physiological parameters. Enabling seamless patient-doctor interaction, they monitor and transmit patient physiological data.

leaves as a promising natural remedy: focus on antioxidant, anti-inflammatory, and hepatoprotective activities.

This study investigates the phytochemical composition, antioxidant, anti-inflammatory, and hepatoprotective activity of Rubus ulmifolius leaf extract. LC-ESI-MS analysis was used to assess the phytochemical composition of the extract of . The Folin-Ciocalteu test was used to measure the total phenolic content.

Comparative assessment of endoscopic and microsurgery resection for intracranial ventricular tumors: a meta-analysis of 3059 patients.

Background And Aim: Surgical resection of ventricular brain tumors is traditionally performed via microsurgery, which requires open craniotomy and can result in significant complications. Endoscopic approaches have emerged as minimally invasive alternatives. There is a lack of consensus regarding the preferred surgical strategy for ventricular tumor resection; the technique with the optimal rates of recurrence, mortality, and complications is debatable.

AI-Driven molecule generation and bioactivity prediction: A multi-model approach combining VAE, graph and language-based neural networks.

Cancer is one of the top leading causes of death in the world according to the World Health Organization (WHO). Despite the continuous efforts, drug discovery often takes 10-15 years if done traditionally, and it costs over $2.6 billion to finally bring a single drug to market.

Corticosteroids for treating sepsis in children and adults.

Background: Sepsis occurs when an infection is complicated by organ failure. Sepsis may be complicated by impaired corticosteroid metabolism. Thus, providing corticosteroids may benefit patients.

Safety and Efficacy of Reduced Dose of Enzalutamide in Patients with Castration-Resistant Prostate Cancer: A Systematic Review.

To review the efficacy and safety of reduced dose compared to standard dose Enzalutamide treatment for patients with castration-resistant prostate cancer (CRPC). PubMed, Scopus, Web of Science, and Cochrane databases were searched for randomized controlled trials and cohort studies reporting the use of Enzalutamide in reduced and standard doses in patients with castration-resistant prostate cancer. Searches were limited to articles published in the English language.

Optimization and Formulation of an Emulgel Based on Clove Oil in Order to Evaluate Its Antibacterial and Anti-inflammatory Potential In Vitro and In Vivo for Topical Application.

Inflammation is a significant physiological response of the body to various stimuli, necessitating effective therapeutic interventions. This study focuses on the formulation and evaluation of an emulgel using clove oil, known for its important anti-inflammatory properties. The emulgel was developed by incorporating clove oil into a gel based on the presence of alginate, aiming to enhance its topical delivery and therapeutic efficacy.

A comparative study of polyethylene and silicone insoles for patient-specific conditions using computational and experimental methods.

Flatfoot is a very common condition that alters gait mechanics and is usually accompanied by pain. In this current study, two types of custom-made insoles using polyethylene and silicon, respectively, were designed to help alleviate this condition. Such insoles are tested for their functionality using advanced 3D printing and finite element analysis.

Corticosteroids for adult patients hospitalised with non-viral community-acquired pneumonia: a systematic review and meta-analysis.

Purpose: International clinical practice guidelines addressing corticosteroid treatment for patients hospitalised with non-viral community-acquired pneumonia (CAP) are inconsistent.

Methods: We conducted a systematic review of randomized controlled trials (RCTs) evaluating the use of corticosteroids in hospitalised adult patients with suspected or probable CAP. We performed random effects pairwise, Bayesian, and dose-response meta-analyses using the restricted maximum likelihood (REML) heterogeneity estimator.

Melanoma Skin Classification Using the Hybrid Approach Residual Network-Vision Transformer for Cancer Diagnosis.

Introduction: Computer-aided diagnosis using deep neural networks allows for the analysis and processing of images or videos of different pathologies, providing valuable reference data to physicians for the diagnosis or screening of conditions such as skin cancer.

Methods: In this work, we highlight the contribution of Convolutional Neural Networks, pre-trained models, and Vision Transformer architectures in the classification of skin melanoma. The experimental aspect will therefore involve the contribution of the classical CNN, as well as models inspired by this CNN, namely, Inception V3, ResNet 50, AlexNet, and EfficientNet in addition to the hybrid architecture.

Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial.

Purpose: To determine whether hydrocortisone improves mortality in severe community-acquired pneumonia (CAP).

Methods: In an international adaptive randomized controlled platform trial testing multiple interventions, adults admitted to the intensive care unit (ICU) with severe CAP were randomized to a 7-day course of intravenous hydrocortisone (50 mg every 6 h) or control (no corticosteroid). The primary end point was 90-day all-cause mortality, analyzed iteratively by a Bayesian hierarchical model estimating distinct treatment effects for patients presenting with influenza (Y/N) and shock (Y/N).

DFT Insights Into the Structural, Stability, Elastic, and Optoelectronic Characteristics of NaLiZF (Z = Ir and Rh) Double Perovskites for Sustainable Energy.

Halide perovskites have gained significant attention due to their tunable bandgaps and environmentally friendly properties, making them strong candidates for advanced optoelectronic applications. In this study, we employed the FP-LAPW method to explore the structural, electronic, and optical properties of NaLiZF (Z = Ir and Rh). Our findings confirm the stability of the cubic phase through a Goldschmidt tolerance factor of 0.

phytochemical profiling, drug-likeness, and antibacterial activity against gram-positive and gram-negative bacteria: and insights.

Background: extracts have a rich phytochemical profile and therapeutic properties. The plant contains bioactive compounds, such as catechins, flavonoids, and phenolic acids, which are associated with various health benefits, including antioxidant, anti-inflammatory, and anticancer activities.

Aim: To investigate the bioactive potential of a extract, particularly its antibacterial activity against Gram-positive and Gram-negative bacteria and its drug-like properties.

Pharmacoeconomic Analysis and Considerations for the Management of Kawasaki Disease in the Arab Countries-A Multinational, Multi-Institutional Project of the Kawasaki Disease Arab Initiative (Kawarabi) (A Project Methodology Paper).

Objective: Kawasaki disease (KD) poses a significant risk of childhood-acquired coronary artery disease. There is a notable scarcity of comprehensive KD data from low- and middleincome Arab countries, giving rise to concerns about the underestimation of KD outcomes. To bridge these gaps, the Kawasaki disease Arab initiative (Kawarabi) was established to reinforce education, advocacy, and enhance patients' health outcomes.

Cardiometabolic and obesity risk outcomes of dawn-to-dusk, dry intermittent fasting: Insights from an umbrella review.

Background & Aims: This umbrella review comprehensively and systematically summarizes meta-analyses on the impact of dawn-to-dusk, dry intermittent fasting of Ramadan (RIF) on cardiometabolic and glucose homeostasis indicators.

Methods: Twenty meta-analyses were examined on the effects of RIF on body fat percentage (BFP), fat mass, fat-free mass, body mass index (BMI), body weight (BW), waist circumference (WC), systolic and diastolic blood pressure (SBP, DBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), and very low-density lipoprotein cholesterol (VLDL-C), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), insulin resistance (HOMA-IR), serum insulin, leptin, and adiponectin. Results of continuous outcomes were pooled from included meta-analyses.

Enhanced Cement Foam Composite with Biochar for Eriochrome Black T Dye Removal.

Cement-based foam composites have gained attention as innovative and high-performing adsorbents for wastewater treatment due to their lightweight, porous, and structurally robust properties. This study investigates the adsorption of Eriochrome Black T dye onto biochar-modified cement foam, providing a cost-effective solution for industrial wastewater management. The integration of biochar into cement foam enhances its surface area and adsorption capabilities while maintaining structural stability and tunable porosity.

' laminated layer immunomodulates nitric oxide, cytokines, and MMPs in PBMC from rheumatoid arthritis patients.

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that affects the joints. Treatments are symptomatic and can induce side effects in some patients. In this sense and based on previous studies, our aim was to investigate the ex vivo immunoregulatory effect of the laminated layer (LL) during rheumatoid arthritis.

Cross-linked chitosan/H-ZSM-5 zeolite composite film for chromium removal from aqueous solutions: optimization using response surface methodology and adsorption mechanism assessment.

The present work investigates, for the first time, the synthesis of a composite film based on glutaraldehyde-cross-linked chitosan (GA-CS) and a natural zeolite (H-ZSM-5) and its application for the removal of hexavalent chromium (Cr(VI)) from aqueous solutions under wide experimental conditions. The composite film (GA-CS-ZEO) characterization by using various analytical techniques confirms its successful production with promising physical, chemical, and thermal properties. The use of the response surface methodology (RSM) for the optimization of the Cr(VI) adsorption by this composite shows that that the maximum removal efficiency (82.

"The NET effect": Neutrophil extracellular traps-a potential key component of the dysregulated host immune response in sepsis.

Neutrophils release neutrophil extracellular traps (NETs) as part of a healthy host immune response. NETs physically trap and kill pathogens as well as activating and facilitating crosstalk between immune cells and complement. Excessive or inadequately resolved NETs are implicated in the underlying pathophysiology of sepsis and other inflammatory diseases, including amplification of the inflammatory response and inducing thrombotic complications.