282 results match your criteria: "Department of Clinical Research and Development[Affiliation]"
Key considerations regarding veno-arterial extracorporeal membrane oxygenation for the treatment of cardiogenic shock and cardiac arrest - Letter to Son et al.
Intensive Crit Care Nurs
February 2025
Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland; Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address: Lukasz.szarpak@gmai
Adverse events associated with early initiation of Eplerenone in patients hospitalized for acute heart failure.
Int J Cardiol
November 2024
Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal; Heart Failure Clinic, Internal Medicine Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Gaia, Portugal; Université de Lorraine, INSERM,
Article Synopsis
- The HEART study examined the effects of eplerenone, a mineralocorticoid receptor antagonist, in patients hospitalized for acute heart failure (HF) over 6 months, highlighting concerns about potential adverse events like worsening renal function and hyperkalemia.
- Among 297 participants, notable adverse events were recorded, but eplerenone did not significantly raise their occurrence compared to placebo, suggesting it is a safe option for HF treatment.
- Certain patient characteristics, such as older age and existing health conditions, were linked to a higher risk of adverse events, but these factors did not diminish the benefits of eplerenone on overall outcomes.
The relationship of malnutrition, frailty, and sarcopenia in critical care.
Intensive Care Med
November 2024
Department of Clinical Research and Development, LUXMED Group, Postępu 21C, 02-676, Warsaw, Poland.
The gray-white matter ratio in adult out-of-hospital cardiac arrest patients must be assessed comprehensively.
Resuscitation
October 2024
Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland; Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address: Lukasz.szarpak@gmai
The role of fungi in inflammatory bowel disease.
Indian J Gastroenterol
August 2025
Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland.
The prediction of alterations in plasma sodium levels in acutely ill patients should be more comprehensive.
Eur J Intern Med
January 2025
Department of Clinical Research and Development, LUXMED Group, Warsaw, , Poland; Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, , Poland; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address: Lukasz.szarpak@
Further gut microbiota and critical illness issues.
Intensive Care Med
November 2024
Department of Clinical Research and Development, LUXMED Group, Postępu 21C, 02-676, Warsaw, Poland.
Efficacy of etripamil nasal spray for acute conversion of supraventricular tachycardia: a network meta-analysis.
Cardiol J
August 2024
1st Department of Cardiology, Medical University of Gdansk, Gdansk, Poland.
The Effect of Thickened Water on Ciprofloxacin Pharmacokinetics: A Comparative Study in Adult Males.
J Clin Med
August 2024
Department of Clinical Research and Development, Graduate School of Pharmacy, Showa University, Tokyo 157-8577, Japan.
Article Synopsis
- The use of food thickeners with ciprofloxacin can alter the drug’s appearance and slow down its dissolution, potentially affecting its effectiveness and posing economic concerns in healthcare.
- A study was conducted on healthy Japanese males to compare how different methods of taking ciprofloxacin (with water, thickened water, and crushed tablets in thickened water) affect drug absorption.
- Results showed that while thickened water changed drug absorption, crushed tablets in thickened water provided similar absorption metrics as tablets with regular water, though crushing may risk losing active ingredients and requires careful consideration.
A Systematic Review and Meta-Analysis of the Diagnostic Value of Galectin-3 in Acute Coronary Syndrome.
J Clin Med
August 2024
Department of Clinical Research and Development, LUX MED Group, 02-678 Warsaw, Poland.
We investigated the potential diagnostic role of galectin-3 (Gal-3) in patients presenting with suspected acute coronary syndromes (ACS). We searched PubMed Central, Scopus, EMBASE, and the Cochrane Library from inception until 20 June 2024. We measured effect sizes using odds ratios (OR) with 95% CIs for dichotomous data and mean differences (MD) with CIs for continuous data.
View Article and Find Full Text PDFLactate-to-albumin ratio in predicting neurological outcomes in patients who have survived cardiac arrest.
Am J Emerg Med
November 2024
Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland; Department of Public Health, International European University, Kyiv, Ukraine.
Long-term inhaled corticosteroid treatment in patients with chronic obstructive lung disease, cardiovascular disease, and recent hospitalization for exacerbation.
Eur J Intern Med
November 2024
Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland; Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address: Lukasz.szarpak@gmai
VISCERAL SENSITIVITY INDEX (VSI-IT): Italian Adaptation and Validation.
Eur J Investig Health Psychol Educ
July 2024
Post-Graduate School of Occupational Medicine, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, 00168 Rome, Italy.
Article Synopsis
- * A study tested the Italian VSI on 500 participants, including patients with Crohn's disease, ulcerative colitis, IBS, and healthy controls, ensuring accurate translation and implementation through an online survey.
- * The results showed that the Italian VSI is reliable and valid, effectively identifying differences in sensitivity and correlating with symptoms, thus aiding in better understanding and treatment of gastrointestinal disorders in Italy.
Neurogranin as a biomarker in differentiating traumatic brain injury: A systematic review and meta-analysis.
Am J Emerg Med
November 2024
Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA; Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland. Electronic address:
Does Exposure to Ambient Air Pollution Affect Gestational Age and Newborn Weight?-A Systematic Review.
Healthcare (Basel)
June 2024
Department of Reproductive Health, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
Current evidence suggests that airborne pollutants have a detrimental effect on fetal growth through the emergence of small for gestational age (SGA) or term low birth weight (TLBW). The study's objective was to critically evaluate the available literature on the association between environmental pollution and the incidence of SGA or TLBW occurrence. A comprehensive literature search was conducted across Pubmed/MEDLINE, Web of Science, Cochrane Library, EMBASE, and Google Scholar using predefined inclusion and exclusion criteria.
View Article and Find Full Text PDFNetwork meta-analysis (NMA) of dextromethorphan-bupropion (AXS-05) efficacy and safety in major depressive disorder.
Eur Neuropsychopharmacol
September 2024
Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Tunlametinib (HL-085) plus vemurafenib in patients with advanced BRAF V600-mutant solid tumors: an open-label, single-arm, multicenter, phase I study.
Exp Hematol Oncol
June 2024
Clinical Pharmacology Research Center, State Key Laboratory of Complex Severe and Rare Diseases, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK and PD Investigation for Innovative Drugs, Peking Union Medical College Hospital, Chinese Academy o
Article Synopsis
- Tunlametinib (HL-085) is a new MEK inhibitor that shows promise for treating patients with NRAS-mutant melanoma and was tested in combination with vemurafenib for patients with advanced BRAF V600-mutant solid tumors.
- In the phase I trial involving 72 patients, there were no significant safety issues, and the recommended dose for future studies was established as 9 mg of tunlametinib with 720 mg of vemurafenib, administered twice daily.
- Results showed a 60.6% objective response rate for non-small cell lung cancer patients, with a median progression-free survival of 10.5 months, although treatment-related adverse events were common, especially anemia and increased blood
Plasma pentraxin-3 levels as a diagnostic marker of patients with colorectal cancer: A systematic review and meta-analysis.
Indian J Gastroenterol
April 2025
Colorectal Cancer Unit, Maria Sklodowska-Curie Bialystok Oncology Center, Bialystok, Poland.
Core needle biopsy for thyroid nodules assessment-a new horizon?
World J Clin Oncol
May 2024
Department of Oncology, Botkin Hospital, Moscow 125284, Russia.
Ultrasound-guided fine-needle aspiration is the standard for evaluating thyroid nodules with a high safety profile and a relatively low number of non-diagnostic cytological findings. Nevertheless, this diagnostic method traditionally has its weak points. Several diagnostic categories such as Bethesda I, III and IV are not reliable for thyroid carcinoma risk assessment.
View Article and Find Full Text PDFSafety, pharmacokinetics and pharmacodynamics of SHR-1703, an innovative long-acting anti-interleukin-5 monoclonal antibody, in healthy subjects: a randomized, double-blind, dose-escalation, placebo-controlled phase I study.
Expert Opin Investig Drugs
July 2024
Department of Pulmonary and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
Objective: SHR-1703 is a novel humanized IgG1 monoclonal antibody with high IL-5 affinity and prolonged half-life, aiming to control eosinophil-related diseases. The study intended to evaluate pharmacokinetics, pharmacodynamics, immunogenicity, safety, and tolerability of SHR-1703 in healthy subjects.
Methods: A single-center, randomized, double-blind, placebo-controlled, single-dose escalation phase I study was conducted.
Investigating and Practicing Orthopedics at the Intersection of Sex and Gender: Understanding the Physiological Basis, Pathology, and Treatment Response of Orthopedic Conditions by Adopting a Gender Lens: A Narrative Overview.
Biomedicines
April 2024
Orthopedics and Orthopedic Oncology, Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padova, 35128 Padova, Italy.
Article Synopsis
- Differentiating between sex and gender is essential in the biomedical field, particularly in orthopedics, to improve understanding of musculoskeletal conditions and personalize treatments.
- The review emphasizes how hormonal differences affect the structure and function of bones and other tissues, with specific examples illustrating the distinct orthopedic issues faced by different sexes, such as higher rates of certain deformities and osteoporosis in women.
- It calls for improved research practices to include sex and gender disaggregation and to acknowledge the needs of sexual minority and gender-diverse individuals in orthopedic care for better health outcomes.
Identifying the Trends of Urinary microRNAs within Extracellular Vesicles for Esophageal Cancer.
Cancers (Basel)
April 2024
Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Article Synopsis
- A study analyzed urinary microRNAs in patients with esophageal squamous cell carcinoma (ESCC) to find potential biomarkers for monitoring tumor burden during treatment.
- Researchers compared microRNA expressions among patients who underwent different treatments (esophagectomy and endoscopic submucosal resection) and healthy individuals to identify significant differences.
- Out of 205 selected microRNAs, 18 showed consistent changes related to tumor burden and 3 of these indicated a trend with tumor recurrence, suggesting they could be useful for tracking ESCC progression and treatment response.
Rationale and Design of Prospective, Multicenter, Double-Arm Clinical Trial to Investigate the Efficacy of Tofogliflozin on Left Ventricular Diastolic Dysfunction in Patients with Heart Failure with Preserved Ejection Fraction and Type 2 Diabetes Mellitus (TOP-HFPEF Trial).
Cardiovasc Drugs Ther
February 2025
Hanwa Memorial Hospital, 3-5-8 Minamisumiyoshi, Sumiyoshi-Ku, Osaka, 558-0041, Japan.
Background: Recent large clinical trials have revealed that sodium-glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular outcomes not only in patients with heart failure with reduced ejection fraction, but also in patients with heart failure with mildly reduced or preserved ejection fraction (HFpEF). However, the effect of SGLT2 inhibitors on left ventricular (LV) diastolic function is still controversial.
Methods And Results: The TOP-HFPEF trial (Efficacy of Tofogliflozin on Left Ventricular Diastolic Dysfunction in Patients with Heart Failure with Preserved Ejection Fraction and Type 2 Diabetes Mellitus) is a multicenter, double-arm, open-label, confirmatory, investigator-initiated clinical study to investigate the effect of SGLT2 inhibitor on LV diastolic function in patients with HFpEF and type 2 diabetes mellitus.
sp. nov., isolated from faeces of heart failure mouse model.
Int J Syst Evol Microbiol
May 2024
Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Article Synopsis
- Strain TC023 is a new species of Gram-positive, anaerobic bacteria discovered in a heart failure mouse model, characterized by its long, rod shape and spore-forming ability.
- It formed distinct greyish-white colonies on a specific growth medium and showed close genetic similarities to existing strains MMM721 and MOL361 based on 16S rRNA gene sequencing.
- Genomic analysis revealed that TC023 has unique DNA characteristics, leading to its classification as a novel species within its genus, with TC023 designated as the type strain.
Does the SVEAT score truly represent the future of risk stratification for acute chest pain?
Am J Emerg Med
June 2024
Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX 77030, USA.