Unravelling therapeutic potentials of fruits: antiplasmodial, hepatoprotective, and anti-oxidative stress activities, semi-purification, GC-MS, and in silico profiling.

Background: The high prevalence rate of malaria due to the proliferation of drug-resistant strains of could mitigate the realization of sustainable development goals in Nigeria, necessitating research on the discovery of novel chemotherapies against resistant strains of the parasite. However, with ethnopharmacological claims could foster this breakthrough, prompting an investigation on the antiplasmodial and hepatoprotective activities of the plant's fruit, semi-purification and characterization of its constituents, as well as in silico studies on its compounds.

Methods: Standard protocols were employed for the semi-purification and characterization; evaluation of antiplasmodial and hepatoprotective assays; retrieval of target proteins from PDB, ADMET, and docking studies.

Evaluation of (lemongrass) leaf extract: phytochemical screening, antimicrobial activities, cytotoxicity, antioxidant properties, and toxicological assessment.

This study evaluates the phytochemical composition, antimicrobial activity, cytotoxicity, antioxidant potential, and toxicity profile of (lemongrass) leaf extract. The extract demonstrated antimicrobial activity with inhibition zones ranging from 14.33 ± 0.

Studies on the medical safety of botanical medicines: Novel toxic metals and microbial contamination approach.

The utilization of herbal therapies is increasing globally, prompting investigations into the health complications that may arise from drug side effects. A total of 160 herbal medicines (HMs), were used for this study, and their toxic heavy metal content, microbial load and dielectric properties were evaluated. The results obtained revealed that the crude HMs exhibited a greater proportion of heavy metals, microorganisms and a higher dielectric constant (ɛ') value, in comparison to the refined HMs.

A review on manganese and its effect on health and distribution in selected African countries.

Manganese (Mn), an essential trace element, is important in various biochemical and physiological processes such as proper growth and development, digestion, immune response, energy metabolism, homeostasis, reproduction, and defense against oxidative stress through the enzyme manganese superoxide dismutase (MnSOD) in mitochondria of body cells. This review highlights the biological role and effects of manganese on human health as well as health condition associated with manganese. Furthermore, it discusses Mn distribution among people in Nigeria, Ghana and Egypt taking into cognizant the Mn status of food with a view of assessing their health status with respect to Mn.

Advanced chitosan-based biopolymer systems for probiotic microencapsulation: stability enhancement and targeted release approaches.

Context: Probiotic microencapsulation is an advanced technique designed to protect live probiotic microorganisms by enclosing them within a protective matrix, typically composed of biocompatible biopolymers.

Objective: This review provides a comprehensive analysis of recent advancements in bio-polymer coatings for probiotic microencapsulation, with a focus on chitosan and its synergistic combinations with other materials.

Methods: This methods highlights the necessity for continued innovation in bio-polymer coatings, emphasizing the development of bio-responsive materials, AI-driven formulation strategies, and next-generation encapsulation technologies to meet the evolving demands of functional foods and precision therapeutics.

Sustainable storage of Cocoyam Cormels using Ash lined clay pits for post harvest preservation.

This study evaluated the efficacy of plant-derived ash treatments on cocoyam cormels' storage life and nutritional quality. A novel underground cellar with composite walls comprising clay and plant material ash was developed. Various ash treatments, including Iroko tree bark (IR) and feathery Pennisetum Grass (G2), significantly reduced moisture uptake and weight loss (< 28% and 28.

Adaptive DDoS detection mode in software-defined SIP-VoIP using transfer learning with boosted meta-learner.

The Internet has continued to provision its infrastructure as a platform for competitive marketing, enhanced productivity, and monetization efficacy. However, it has become a means for adversaries to exploit unsuspecting users and, in turn, compromise network resources. The utilization of filters, gateways, firewalls, and intrusion detection systems has only minimized the effects of adversaries.

The Role of Nurses in Promoting Awareness and Access to Contraceptive Methods in Underserved Communities: Case of Isare Health District.

Underserved communities often face significant reproductive health challenges, including limited access to contraceptive methods. In the Isare health district, rates of unwanted pregnancies and sexually transmitted diseases are high due to insufficient information and resources. To explore how nurses can play a crucial role in improving knowledge, awareness and accessibility of contraceptive methods within underserved communities.

Integrative investigation on Hippocratea africana root: insights from cardio-protective, anti-oxidative stress activities, isolation, GC/MS, and pharmacological significance profiling.

Background: Hippocratea africana root is scientifically used in cardiotoxicity treatment; therefore, this study was designed to validate this claims through the evaluation of its cardioprotective activity, isolation, and characterization of its constituents, as well as in silico profiling of these ligands against antioxidant enzymes.

Methods: Standard protocols were followed in the extraction, fractionation, isolation, characterization, evaluation of cardio-protective activity (marker enzymes, oxidative stress markers, and histological section), retrieval of target proteins (SOD, CAT, GPx, and GSH), ADMET, and docking studies. Column and thin layer chromatography as well as GC/MS aided the isolation and characterization of compounds; SWISSADME and ADMET lab 2 enhanced the evaluation of pharmacokinetic properties; PyRx for docking analysis; Biovia discovery studio and PyMol software for 2D and 3D visualization of the ligand-protein interactions.

Germ cells and the aging niche: a systems approach to reproductive longevity.

The intersection of aging and reproductive decline presents a significant challenge in human health, with fertility rates decreasing sharply in later life for both sexes. This review delves into the intricate relationship between germ cells, the fundamental units of reproduction, and their surrounding microenvironment, known as the niche. Emphasizing that reproductive longevity is not solely determined by the intrinsic properties of germ cells, but rather by the complex interplay with their niche, a dynamic system that changes with age.

Carrageenan-Based Hydrogels for Advanced Wound Healing and Controlled Drug Delivery in Tissue Engineering.

Carrageenan (CGN) is a high molecular weight polysaccharide that is extracted from red seaweeds. It is made up of D-galactose residues connected by β-1,4 and α-1,3 galactose-galactose bonds. As a result of its ability to thicken, emulsify, and stabilize food, it is frequently used as a food additive in processed food.

Emerging nanotechnologies and their role in early ovarian cancer detection, diagnosis and interventions.

Ovarian cancer presents a significant public health challenge, often being diagnosed at advanced stages due to the limitations of current detection methods. This systematic review addresses the urgent need for innovative approaches to enhance early detection and diagnosis of ovarian cancer. We systematically evaluate recent advancements in nanotechnology, focusing specifically on their novel applications and potential in comparison to traditional diagnostic modalities.

Smart Probiotic Solutions for Mycotoxin Mitigation: Innovations in Food Safety and Sustainable Agriculture.

Mycotoxin contamination poses severe risks to food safety and agricultural sustainability. Probiotic-based interventions offer a promising strategy for mitigating these toxic compounds through adsorption, biodegradation, and gut microbiota modulation. This review examines the mechanisms by which specific probiotic strains inhibit mycotoxin biosynthesis, degrade existing toxins, and enhance host detoxification pathways.

Quercetin prevents single prolonged stress-induced posttraumatic stress disorder and neurochemical changes via antioxidant, antiinflammatory and antiapoptotic mechanisms in rats.

Posttraumatic stress disorder (PTSD) is a debilitating condition characterized by neurochemical imbalances and behavioral disruptions. Emerging evidence suggests that quercetin, a naturally occurring flavonoid, may possess neuroprotective properties. This study investigates the potential effects of quercetin on neurochemical dynamics associated with single prolonged stress (SPS)-induced PTSD in rats.

Food, Health, and Environmental Impact of Lactic Acid Bacteria: The Superbacteria for Posterity.

Lactic acid bacteria (LAB) are Gram-positive cocci or rods that do not produce spores or respire. Their primary function is to ferment carbohydrates and produce lactic acid. The two primary forms of LAB that are currently recognized are homofermentative and heterofermentative.

Gastrointestinal-Ocular Toxicity Following Systematic Ingestion of Nickel-Cadmium Contaminated Water in Wistar Rats Demonstrates Possible Health Complications Characterized by Oxidative Stress, Inflammatory and Histological Changes.

The study evaluated the biochemical and histopathological alterations of subacute nickel (Ni) and cadmium (Cd) exposure on the gastrointestinal and ocular systems of male Wistar albino rats via ingestion of contaminated water. Four groups of six rats each were exposed to uncontaminated water (group A as control), 100 mg/L of Cd (group B), 100 mg/L of Ni (group C), and a combination of 100 mg/L Cd and Ni (group D) for 28 days. The stomach, intestinal, and ocular weights were recorded and were significantly reduced (p ≤ 0.

Effects of abattoir sludge on cyanide status of cassava effluent and cassava effluent contaminated soil.

Cassava cyanide effluent arising from cassava processing contaminate soil, leading to increased concentration of cyanide in soil and water, posing a risk to plant, aquatic life, and human health. Hence, the aim of this study is to investigate the impact of abattoir sludge on cyanide concentration of cassava effluent and soils receiving cassava effluent. In this study, soil samples were carried out following standard protocol.

Potential Roles of Natural Antioxidants in Modulating Neurodegenerative Disease Pathways.

Neurodegenerative diseases, including Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis, are increasingly prevalent among aging populations. Oxidative stress contributes to these diseases, leading to cellular damage and neuronal death. Natural antioxidants are being explored as preventive measures.

Therapeutic potential of microbiome modulation in reproductive cancers.

The human microbiome, a complex ecosystem of microbial communities, plays a crucial role in physiological processes, and emerging research indicates a potential link between it and reproductive cancers. This connection highlights the significance of understanding the microbiome's influence on cancer development and treatment. A comprehensive review of current literature was conducted, focusing on studies that investigate the relationship between microbiome composition, reproductive cancer progression, and potential therapeutic approaches to modulate the microbiome.

Adoption of sustainable fuels and renewable energy in logistics: Examining the role of stakeholder theory in supply chain strategy.

In contemporary society, sustainability is a key issue that borders on overall human existence, and it has been rigorously argued that extensive efforts are needed to ensure the survival of the human race. Such efforts include corporate bodies changing the ways they operate to ensure that their activities do not yield negative impacts on the environment and the human race in general. In view of this, this research was conducted to assess the influence of stakeholder theory (consumers' demand, suppliers' collaboration, and regulatory pressure) on the decision of companies in the logistics sector to adopt sustainable fuel and renewable energy in their operations.

Chitosan: An overview of its properties, solubility, functional technologies, food and health applications.

The properties and potential applications of chitosan have attracted a lot of interest; each year, the number of publications and patents based on this polymer increases. A significant obstacle to the application of chitosan is its limited solubility in basic and neutral solutions. The fact that chitosan is a series of molecules with variations in size, content, and monomer distribution rather than a single polymer with a well-defined structure and a natural origin is another significant barrier.

Assessment of salinity trends in a coastal aquifer in Guzelyurt, North Cyprus.

Salinity is a serious concern with groundwater use in irrigation that is very close to a coastal aquifer. The study aims to do a comparative analysis of the physiochemical parameters of groundwater samples obtained from 10 irrigational wells in Guzelyurt. In this study, 10 groundwater samples were collected from irrigational wells in the Guzelyurt aquifer area and were analyzed for important groundwater physiochemical parameters such as pH, EC, Na, Ca, K, Na, Mg, HCO , SO , and Cl.

Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health.

This review paper delves into the role of probiotics and food bioactives in influencing gut health and overall well-being, within the context of probiotics and food bioactives, emphasizing their roles in modulating inflammation, gut microbiota, and metabolic health. Probiotics are defined as live microorganisms that confer health benefits to the host, primarily through their impact on the gut microbiome; a complex community of microorganisms crucial for maintaining health. The review aims to elucidate how probiotics, incorporated into both traditional and modern food systems, can enhance gut health and address metabolic disorders.

Advances in bio-polymer coatings for probiotic microencapsulation: chitosan and beyond for enhanced stability and controlled release.

This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations with other materials. Probiotic microencapsulation is essential for protecting probiotics from environmental stresses, enhancing their stability, and ensuring effective delivery to the gut. The review begins with an overview of probiotic microencapsulation, highlighting its significance in safeguarding probiotics through processing, storage, and gastrointestinal transit.