Obesity and nutrition risk in patients admitted to intensive care after cardiac arrest: A multicentre cohort study.

Background: The double burden of malnutrition, defined as the co-existence of overnutrition with undernutrition, is increasing in prevalence globally. Yet, little is known about its impact on patients with cardiac arrest. We examined the association between malnutrition and outcomes in patients admitted to intensive care units (ICU) after cardiac arrest.

Mortality Trends Across Key Diagnostic Groups in Australian and New Zealand ICUs Over the Past 30 Years.

Objectives: The Australia and New Zealand Intensive Care Society (ANZICS) Adult Patient Database (APD) has been operational for 3 decades. It is important to understand how mortality outcomes have changed across diagnostic groups over time to facilitate the planning of future healthcare resources. We evaluated the trends in risk-adjusted mortality for ICU patients over the last 30 years.

Association between Full Moon Day overdose-related intensive care unit admissions and hospital mortality: a medical enigma or mere myth?

Background: There is limited evidence on whether Full Moon Day is linked to drug overdoses severe enough to need intensive care unit (ICU) admissions.

Aims: To investigate the association between Full Moon Day overdose-related ICU admissions and hospital mortality.

Methods: This retrospective multicentre observational study that included data from 172 ICUs across Australia and New Zealand reported to the Australia New Zealand Intensive Care Society Adult Patient Database.

Patient and Family Engagement in Australian and New Zealand Adult Critical Care Trials.

Background: Engaging patients and families in critical care research is recognised as best practice. The extent of engagement in critical care trials in Australia and New Zealand is unknown, following introduction of national guidelines in 2016.

Objective: To assess the extent of patient and family engagement in adult critical care research studies endorsed by the Australia and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG).

Persistent critical illness and long-term survival in cardiac surgery: A multicentre cohort study.

Background: Persistent critical illness (PerCI) is associated with poorer in-hospital outcomes in patients admitted to an intensive care unit (ICU), and in patients receiving cardiac surgery, yet its association with longer-term survival remains unclear.

Objective: We investigated the association between PerCI and long-term survival in patients receiving cardiac surgery.

Methods: In this retrospective, multicentre observational cohort study using the Australia and New Zealand Intensive Care Society Adult Patient Database, we included all adults (≥16 years) admitted to 83 ICUs across Australia and New Zealand after cardiac surgery (coronary artery bypass graft, valvular replacement, or both) from January 1 2018 to December 31 2022 for Australia and 31 December 2020 for New Zealand.

The Varying Impact of Frailty With Increasing Body Mass Index on Survival Up To 3 Years After ICU Admission: A Retrospective Registry-Based Study.

Objectives: Frailty is associated with poorer outcomes in critical illness, but it is unclear if this relationship is consistent across different body mass index (BMI) levels.

Design: A retrospective multicentric registry-based observational study using the Australia New Zealand Intensive Care Society Adult Patient Database.

Setting: Criticallly ill patients admitted to 1170 ICUs between January 1, 2018, and March 31, 2022.

Outcomes of critical illness in peoples with Advanced HIV Disease: 30 years of binational data.

Background: Prior to the advent of effective Anti-Retroviral Therapy (ART), ICU admission rates for people with Advanced HIV Disease (AHD) were low, reflecting high mortality and limited treatment options. Despite improvements in ICU and HIV care, longitudinal outcome data in critically ill people with AHD are limited.

Methods: We performed a retrospective cohort study of ICU admissions in Australia and New Zealand between January 1993 and December 2022, in patients with a comorbid diagnosis of AHD.

Protocol summary and statistical analysis plan for the sodium bicarbonate for metabolic acidosis in the intensive care unit (SODa-BIC) trial.

Background: Metabolic acidosis is common in critically ill patients and is associated with increased risk of organ dysfunction, need for renal replacement therapy, and death. Despite its frequency and clinical relevance, the optimal treatment approach remains uncertain. Sodium bicarbonate is often used to correct acidosis, but its risk-benefit profile in this setting is unclear.

Frailty and Long-Term Survival in Patients With Critical Illness After Nonhome Discharge: A Retrospective Cohort Study.

Importance: Patients with frailty are more frequently discharged to rehabilitation or residential aged care facility (RACF), defined as nonhome discharge, than those without frailty. An increase in nonhome discharge is considered to be one of the collateral "costs" associated with declining hospital mortality. However, it is unclear whether this association applies to patients with frailty, particularly in the long term.

Frailty and long-term survival of non-cancer patients admitted to intensive care after surgery: a retrospective multicentre cohort study.

Background: As the global population ages and older patients undergo surgery, understanding the association between frailty and postoperative outcomes is crucial to informed decision-making and patient care. There is a lack of research assessing the association between frailty and long-term outcomes in patients admitted to ICUs after surgery.

Methods: We conducted a multicentre retrospective cohort study using Australian and New Zealand Intensive Care Society Adult Patient Database, linked with the Australian National Death Index.

Prevalence, Timing, and Predictors of Patients Who Had New and/or Updated Goals of Care While in the ICU: A Multicenter Retrospective Study.

Objectives: Timely documentation of patient-concordant goals of care (GOC) in the ICU aims to promote patient autonomy and patient-centered care where the harms of interventions outweigh the potential benefits. This study examined the prevalence, timing, and predictors of ICU patients undergoing new and updated GOC documentation events while in the ICU.

Design: Multicenter retrospective study.

An index of the initial blood pressure response to angiotensin II treatment and its association with clinical outcomes in vasodilatory shock.

Background: No standardized index exists to assess cardiovascular responsiveness to angiotensin-II. We hypothesized that a standardized index of initial blood pressure response to angiotensin-II treatment would be associated with clinical outcomes.

Methods: Using data from the Angiotensin Therapy for High Output Shock (ATHOS-3) trial, we developed an Angiotensin-II Initial MAP Response Index of Treatment Effect (AIMRITE) defined as (MAP at hr1 - MAP at baseline)/study drug dose.

Comparison of colorectal cancer surgery patients in intensive care between rural and metropolitan hospitals in Australia: a national cohort study.

Purpose: A small proportion of colorectal cancer (CRC) surgical patients will require an admission to an intensive care unit (ICU) within the early postoperative period. This study aimed to compare the characteristics and outcomes of patients admitted to an ICU following CRC surgery per hospital type (metropolitan vs. rural) over a decade in Australia.

Severe sepsis-associated acute kidney injury and outcomes: a longitudinal cohort study.

Background: Sepsis-associated acute kidney injury (SA-AKI) is common among patients admitted to the intensive care unit (ICU) with sepsis.

Aims: This study aimed to demonstrate an association between an episode of SA-AKI and progression to dialysis dependence, with a view to identifying a cohort who may be suitable for intensive nephrology follow-up.

Methods: Design: Retrospective data-linkage cohort study.

Outcomes after cystectomy in Australian rural and metropolitan hospitals by intensive care admissions.

Objectives: To examine demographics and in-hospital outcomes for patients admitted to Australian intensive care units (ICUs) following cystectomy of the urinary bladder. Additionally, to compare outcomes between metropolitan and rural hospitals.

Patients And Methods: A retrospective cohort analysis was undertaken of all adult patients admitted to participating Australian ICUs (Australian and New Zealand Intensive Care Society Adult Patient Database) following cystectomy/cystoprostatectomy between January 2011 and December 2021.

The interplay between frailty status and persistent critical illness on the outcomes of patients with critical COVID-19: A population-based retrospective cohort study.

Objectives: Persistent critical illness (PerCI) occurs when the patient's prolonged intensive care unit (ICU) stay results in complications that become the primary drivers of their condition, rather than the initial reason for their admission. Patients with frailty have a higher risk of developing and dying from PerCI. We aimed to investigate the interplay of frailty and PerCI in critically ill patients with COVID-19.

Long-term survival comparison of patients admitted to the intensive care unit following in-hospital cardiac arrest in perioperative and ward settings. A multicentre retrospective cohort study.

Purpose: Perioperative in-hospital cardiac arrests (Perioperative IHCAs) may have better outcomes than IHCAs in the ward (Ward IHCAs), due to enhanced monitoring and faster response. However, quantitative comparisons of their long-term outcomes are lacking, posing challenges for prognostication.

Methods: This retrospective multicentre study included adult intensive care unit (ICU) admissions from theatre/recovery or wards with a diagnosis of cardiac arrest between January 2018 and March 2022.

Outcomes for people admitted to Australian and New Zealand intensive care units with primary, exacerbating, or incidental SARS-CoV-2 infections, 2022-23: a retrospective analysis of ANZICS data.

Objectives: To compare in-hospital mortality and intensive care unit (ICU) length of stay for people admitted to Australian and New Zealand ICUs during 2022-23 with coronavirus disease 2019 (COVID-19) pneumonitis, incidental or exacerbating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, or without SAR-CoV-2 infections.

Study Design: Retrospective cohort study; analysis of Australian and New Zealand Intensive Care Society (ANZICS) Adult Patient Database data.

Setting, Participants: Adults (16 years or older) admitted to participating ICUs in Australia or New Zealand, 1 January 2022 - 30 June 2023.

Epidemiology of Renal Replacement Therapy for Critically Ill Patients across Seven Health Jurisdictions.

Introduction: Acute kidney injury (AKI) requiring treatment with renal replacement therapy (RRT) is a common complication after admission to an intensive care unit (ICU) and is associated with significant morbidity and mortality. However, the prevalence of RRT use and the associated outcomes in critically patients across the globe are not well described. Therefore, we describe the epidemiology and outcomes of patients receiving RRT for AKI in ICUs across several large health system jurisdictions.