Folic acid conjugated magnetic chitosan nanocomposite for the targeted delivery of dual anticancer drugs to breast cancer and hyperthermia therapy.

Increase in breast cancer has led to the search for systems that can enable, targeted, sustained and prolonged release of drugs while simultaneously reducing the side effects posed by them. In light of this, folic acid-conjugated 5-Fluorouracil and doxorubicin loaded chitosan/Fe₃O₄ (FA-dual@CS/Fe₃O₄) nanocomposite has been synthesized using the chemical method for targeted breast cancer therapy in addition to CS/FeO and dual drug encapsulated CS/FeO. FTIR and XPS studies confirm the successful drug encapsulation and FA conjugation.

Experimental design for assessing the degradation of tannery azo dyes and real-time effluent.

Tannery wastewater (TWW) is highly complex and is characterised by high contents of organic, inorganic, and nitrogenous compounds, sulphides, chromium, dissolved solids, and suspended solids. Therefore, our novelty lies in identifying the microbes which are used to degrade harmful azo dyes present in tannery effluent. Based upon the rising problems in tannery industries, the untreated effluent is discharged; to achieve zero effluent, the organisms are isolated from tannery effluent identified as (OQ690635) and screened against the degradation potential against the azo dyes and further processed the azo dye-degrading organism for 16S rRNA sequencing.

Metabolomics and network pharmacology approach to identify potential bioactive compounds from Trichoderma sp. against oral squamous cell carcinoma.

This study aimed to profile metabolites from five Trichoderma strains and assess their cytotoxic and pharmacological activities, particularly targeting oral squamous cell carcinoma (OSCC). UHPLC-TOF-MS analysis revealed the presence of 25 compounds, including heptelidic acid, viridiol isomers, and sorbicillinol from the different Trichoderma extracts. Pharmacokinetic analysis showed moderate permeability and low interaction with P-glycoprotein, suggesting good drug absorption with minimal interference in cellular uptake.

Synergistic suppression of cell growth: Phenmiazine derivatives targeting p53 and MDM2 unveiled through hybrid computational method.

Lung cancer is the leading cause of mortality in both men and women due to genetic and epigenetic modifications. Our study focuses on fabricating phenmiazine ring leads by a functional group-based drug design to inhibit p53 -7A1W and MDM2-7AU9 proteins responsible for cancer cell growth. One hundred molecules are designed and allowed to bind inside the active site of 7A1W and 7AU9 protein using a glide dock platform and subjected to find MMGBSA.

Synthesis of novel N-substituted tetrabromophthalic as corrosion inhibitor and its inhibition of microbial influenced corrosion in cooling water system.

This study investigates the efficacy of newly synthesized inhibitor with a dual function of corrosion inhibition and biocide for control of microbial influenced corrosion (MIC) in carbon steel API 5LX in the cooling tower water (CTW) environment. Four types of N-substituted tetrabromophthalic inhibitor (N-TBI) were synthesized, and the structural characterization was performed via proton nuclear magnetic resonance spectroscopy, thermogravimetric analysis and high-resolution mass spectrometry. These studies revealed the distinctive optical, thermal, and dielectric properties of the synthesized inhibitors.

Induction and comparative resuscitation of viable but nonculturable state on Vibrio parahaemolyticus serotypes O3:K6 and O1:K25.

Vibrio parahaemolyticus, an important food-borne pathogens found to be associated with seafoods and marine environs. It has been a topic of debate for many decades that most pathogens are known to enter a viable but nonculturable (VBNC) state under cold temperature and nutrient limited conditions. The present study examined the time required for the induction of VBNC state and the revival strategies of both the endemic O3:K6 and O1:K25 sporadic strains of V.

Unlocking the potential of beta-glucans: a comprehensive review from synthesis to drug delivery carrier potency.

Modernization and lifestyle changes have resulted in a number of diseases, including cancer, that require complicated and thorough treatments. One of the most important therapies is the administration of antibiotics and medicines. This is known as chemotherapy for cancer, and it is a regularly utilised treatment plan in which the medications used have negative side effects.

The Role of Optimal Electron Transfer Layers for Highly Efficient Perovskite Solar Cells-A Systematic Review.

Perovskite solar cells (PSCs), which are constructed using organic-inorganic combination resources, represent an upcoming technology that offers a competitor to silicon-based solar cells. Electron transport materials (ETMs), which are essential to PSCs, are attracting a lot of interest. In this section, we begin by discussing the development of the PSC framework, which would form the foundation for the requirements of the ETM.

Curcumin-Assisted Synthesis of MoS Nanoparticles as an Electron Transport Material in Perovskite Solar Cells.

Recently, two-dimensional (2D) transition metal dichalcogenides (2D TMDs), such as molybdenum sulfide (MoS) and molybdenum selenide (MoSe), have been presented as effective materials for extracting the generated holes from perovskite layers. Thus, the work function of MoS can be tuned in a wide range from 3.5 to 4.

Production, optimization and characterization of partially purified anti-mycotic compound from marine soil derived streptomycetes originating at unexplored region of Bay of Bengal, India.

Sixty-eight morphologically distinct isolates of marine actinomycetes were derived from seashore, mangrove, and saltpan ecosystems located between the Palk Strait and Gulf of Mannar region, Bay of Bengal, Tamilnadu. Twenty-five (36.8%) isolates exhibited anti-mycotic activity against Candida albicans and Cryptococcus neoformans in preliminary screening, and 4 isolates with prominent activity were identified and designated at the genus level as Streptomyces sp.

GC-MS analysis, pharmacokinetic properties, molecular docking and dynamics simulation of bioactives from to target oral cancer.

Unlabelled: Oral cancer (OC) which is the most predominant malignant epithelial neoplasm in the oral cavity, is the 8th commonest type of cancer globally. Natural products are excellent sources of functionally active compounds and essential nutrients that play an important role in cancer therapeutics. Using the structure-based virtual screening, drug-likeness, toxicity, and molecular dynamics simulation, the current study focused on the evaluation of anticancer activity of bioactive compounds from .

Studies on 2-((2, 4-dihydroxybenzylidene) amino)-3-phenylpropanoic acid include antimicrobial, antidiabetic, antioxidant, anticancer, hemolysis, and theoretical QSAR.

Studies show that microorganisms resistant to numerous antibiotics spread infections, lengthen hospital stays, and increase fatalities. Amplification factors increase the demand for innovative drug-resistant disease-fighting chemicals. This research synthesised the chiral L-phenyl alanine condensed with a 2, 4-dihydroxy benzaldehyde Schiff base for biological efficacy investigations such as antimicrobial, antidiabetic, DPPH free radical, MTT assay against HeLa cells and hemolysis studies after the characterization.

Regulation of SELENOF translation by eIF4a3: Possible role in prostate cancer progression.

The levels of the SELENOF selenoprotein are dramatically reduced in prostate cancer compared to adjacent benign tissue and reducing SELENOF in prostate epithelial cells results in the acquisition of features of the transformed phenotype. It was hypothesized that the aberrant increase in the eiF4a3 translation factor, which has an established role in RNA splicing and the regulation of selenoprotein translation, contributes to the lower levels of SELENOF. Using the available databases, eIF4a3 messenger RNA (mRNA) levels are elevated in prostate cancer compared to normal tissue as is the hypomethylation of the corresponding gene.

Active and allosteric site binding MM-QM studies of Methylidene tetracyclo derivative in PCSK9 protein intended to make a safe antilipidemic agent.

Interaction of low-density lipoprotein receptors with proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a vital part in causing atherosclerosis. It is the hidden precursor of clinical myocardial infarction (MI), stroke, CVD and estimates 60% of deaths worldwide. The current need is to design small molecules to prevent the interaction between PCSK9 and LDL receptors.

Synthesis of antibacterial hydroxypropyl methylcellulose and silver nanoparticle biocomposites via solution plasma using silver electrodes.

The biocomposites of hydroxypropyl methylcellulose (HPMC)/silver nanoparticles (AgNPs) were synthesized using the solution plasma process (SPP). HPMC/AgNPs were synthesized in 1-5 % HPMC solutions using silver electrodes. UV-Vis spectroscopy showed a peak near 400 nm and the peak increased as the concentration of HPMC and discharge time increased.

Bioinformatics strategies for studying the molecular mechanisms of fungal extracellular vesicles with a focus on infection and immune responses.

Fungal extracellular vesicles (EVs) are released during pathogenesis and are found to be an opportunistic infection in most cases. EVs are immunocompetent with their host and have paved the way for new biomedical approaches to drug delivery and the treatment of complex diseases including cancer. With computing and processing advancements, the rise of bioinformatics tools for the evaluation of various parameters involved in fungal EVs has blossomed.

A brief review of pre-installation requirements of earth-air heat exchanger system for space heating and cooling.

Demand for renewable energy sources has increased significantly during the past 15-20 years. Due to this demand, one positive scenario has occurred as there has been a decrease in the use of fossil fuels. Among various usages of the fuels, a significant amount of energy is being used in heating and cooling for commercial, domestic houses, etc.

Effective Multi Toxic Dyes Degradation Using Bio-Fabricated Silver Nanoparticles as a Green Catalyst.

Herein, we reported the preparation and characterization of silver nanoparticles from Kalanchoe brasiliensis leaves extract and their application in the photocatalytic degradation of Aniline Blue, Toludine Blue, Congo Red, Indigo Carmine, Auramine O, and Pyronin Y dyes. The synthesis of Kalanchoe brasiliensis extract derived silver nanoparticles (KK-AgNPs) was well characterized by several techniques. The surface plasma resonance (SPR) peak of 17 nm sized KK-AgNPs occurred at 445 nm, and the KK-AgNPs were stable for more than five months.

The Natural Ligand for Metalloproteinase-A Multifaceted Drug Target.

Metalloproteinase is one of the key components of Russell viper venom and it is the root cause of edema, blood coagulation, local tissue damage, hemorrhage, and inflammation during snakebite envenoming. Hence, finding a suitable metalloproteinase inhibitor from natural source will be of great biological importance in mitigating pathological effects. In this current study, we employed computational analysis to examine the inhibition of metalloproteinase by phytochemicals present in Andrographis paniculata.

Comprehensive Review on Rapid Diagnosis of New Infection COVID-19.

Generally, rapid detection of viral infection is necessary for preventing the virus from spreading among people in a society as a pandemic. Although there are many effective standard techniques used for virus identification, they are laborious, required skilled person to handle and time-consuming. Particularly, the detection of viral infection involved in the isolation and nucleic acid detection by collecting specimens (sample) from the appropriate sites.

Green Synthesis and Characterisation of Silver Nanoparticles Using Cassia tora Seed Extract and Investigation of Antibacterial Potential.

Nanoparticle research is fascinating and getting hold of consequences due to the wide variety of applications in the biomedical field. Green synthesis of nanoparticles is a cost-effective and eco-friendly approach. It can be synthesised using fungi, algae, plant, yeast, bacteria, microbial enzymes etc.

An evidence of microalgal peptides to target spike protein of COVID-19: In silico approach.

The outbreak of the novel coronavirus (COVID-19) has affected millions of lives and it is one of the deadliest viruses ever known and the effort to find a cure for COVID-19 has been very high. The purpose of the study was to investigate the anti-COVID effect from the peptides derived from microalgae. The peptides from microalgae exhibit antimicrobial, anti-allergic, anti-hypersensitive, anti-tumor and immune-modulatory properties.

Production of Oligoalginate via Solution Plasma Process and Its Capability of Biological Growth Enhancement.

The objective of the study was to depolymerize alginate into short-length oligoalginates, adopting the simple solution plasma process (SPP) technique, for successful use in free radical scavenging and growth promotion in cell culture and agricultural practices. Alginate at various concentrations was depolymerized to oligoalginates using SPP by discharging for various times. The depolymerization into oligoalginates was proved by DNS, TLC, FT-IR, and HPAEC analyses and caused decrease in viscosity.

Experimental studies on natural convection open and closed solar drying using external reflector.

For low temperature agricultural crop and meat drying, dryers utilizing the renewable energy source (solar energy) appear to be an efficient technique as it is ecofriendly, energy efficient, and available in free of cost. This work presents the experimental investigation on a solar food dryer equipped with external reflectors to enhance the rate of drying efficiency by removing the moisture content available in the anchovy fish. A comparison of conventional open solar drying is carried out to assess the parameters such as drying efficiency, moisture removal rate, and heat energy required for drying the anchovy fish using the modified solar dryer using the natural convection technique.