Unfreezing the past: near Pan-Svalbard assessment of cryospheric hazards to Arctic cultural heritage.

Permafrost degradation is accelerating across the Arctic, posing growing risks to cultural heritage (CH) sites. This study presents the first archipelago-scale hazard assessment of CH to retrogressive thaw slumps (RTS) and thermo-erosion gullies (TEG) in Svalbard, one of the fastest-warming regions globally. By overlaying recent RTS and TEG inventories with the spatial distribution of protected CH sites, we quantify hazard exposure for 55.

Nurses' moral suffering, burnout and turnover intentions: A two-wave study.

BackgroundNurses suffered an unprecedented number of potentially morally injurious events (PMIEs) during the COVID-19 pandemic. Their long-term associations with organizational well-being remain unknown.Research aimWe aimed to assess whether psychological basic need thwarting characteristic of nurses' episodic memories of PMIEs from the pandemic, either enacted (self-PMIEs) or passively witnessed (other-PMIEs), explained unique burnout and turnover intentions variance 2 years after the events.

Single and Combined Effects of Meropenem, Valproic Acid, and Ketoprofen on Adult Zebrafish Behavior, Oxidative Stress, and Acetylcholinesterase Activity.

: Pharmaceutical compounds frequently co-occur in environmental waters, but studies on their combined effects on animals and humans remain limited. The present study investigated the individual and combined short-term effects of ketoprofen (Kp, a nonsteroidal anti-inflammatory drug inhibiting cyclooxygenase-2), valproic acid (VPA, an anticonvulsant acting as a voltage-gated sodium channel modulator), and meropenem (Mp, a β-lactam antibiotic) at environmentally relevant concentrations on zebrafish behavior, acetylcholinesterase (AChE) activity, and oxidative status. : Adult zebrafish were exposed for 4 days to Kp, VPA, Mp, and their binary and ternary mixtures.

Correction: Koush et al. Chitosan-Stabilized Lipid Vesicles with Indomethacin for Modified Release with Prolonged Analgesic Effect: Biocompatibility, Pharmacokinetics and Organ Protection Efficacy. 2025, , 523.

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Laser-Induced Ablation of Hemp Seed-Derived Biomaterials for Transdermal Drug Delivery.

Numerous studies on specific cannabis compounds (cannabinoids and phenolic acids) have demonstrated their therapeutic potential, with their administration methods remaining a key research focus. Transdermal drug delivery (TDD) systems are gaining attention due to their advantages, such as painless administration, controlled release, direct absorption into the bloodstream, and its ability to bypass hepatic metabolism. The thin films obtained via pulsed laser deposition consist of micro- and nanoparticles capable of migrating through skin pores upon contact.

Comorbidities Across Functional Neurological Disorder Subtypes: A Comprehensive Narrative Synthesis.

Background: Functional Neurological Disorder (FND) encompasses a spectrum of symptoms-including motor, cognitive, and seizure-like manifestations-that are not fully explained by structural neurological disease. Accumulating evidence suggests that comorbid psychiatric and somatic conditions significantly influence the clinical course, diagnostic complexity, and treatment response in FND.

Objective: This study systematically explores psychiatric and medical comorbidities across major FND subtypes-Functional Cognitive Disorder (FCD), Functional Movement Disorder (FMD), and Psychogenic Non-Epileptic Seizures (PNES)-with an emphasis on subtype-specific patterns and shared vulnerabilities.

Neurobehavioral Protection by Prebiotic Formulations in a Scopolamine-Induced Cognitive Impaired Zebrafish Model.

The present work evaluates the influence of two prebiotic formulations-P1 (ColonX) and P4 (a product containing AnXietate extract), at concentrations of 3 and 6 mg/L-on scopolamine (SCOP, 100 μM)-induced cognitive dysfunction and anxiety-related behaviors in adult zebrafish (Danio rerio). To assess behavioral alterations, wild-type fish were subjected to the novel tank assay (NTT), Y-maze study, and novel object recognition test protocol (NOR). The formulations were examined for potential anti-inflammatory activity and cytotoxicity.

4f-Orbital Occupancy in Tetravalent Cerium Halide Complexes from X-ray Spectroscopy and Theory.

Recent studies of lanthanide bonding have shown that small amounts of metal-ligand covalency can impact bond energies and cause magnetic behavior to deviate from the free ion values. Quantifying covalent bonding parameters is necessary to support the rational tuning of these properties in applications for lanthanides in energy and quantum information science. Here, two measurements of f-electron occupancy in CeBr are reported based on X-ray spectra at the Ce L- and Br K-edges and compared to the corresponding results for CeF and CeCl.

German Barcode of Life reveals unexpected diversity of Ceraphronoidea (Hymenoptera).

Insect populations still experience marked declines globally, contributing to the ongoing biodiversity crisis. Counteracting these declines requires sound taxonomic and ecological knowledge on all levels of biodiversity, from genes to species to ecosystems. The superfamily Ceraphronoidea (Hymenoptera) has remained relatively obscure due to complex challenges in exploring its diversity and ecological roles.

α-Ketoglutaric acid-derived carbon nanodots doped with manganese as fluorescent and MRI contrast agents.

Carbon nanodots (CNDs) are a class of nanomaterials under 10 nm known for their distinctive optical properties. In this work, we introduce α-ketoglutaric acid (KGA) as a novel carbon precursor for the hydrothermal synthesis of CNDs (KGA-CNDs), yielding particles with an average size of 1.9 nm.

Efficiency of biological versus mesoporous adsorbents for gadolinium removal from wastewater.

Gadolinium application in industry and medicine results in generation of large volumes of gadolinium-containing wastewater, which can present hazard for humans and environment. Adsorption proved to be an efficient way of metal removal from wastewater. Two adsorbents of different origin, yeast biomass and titanosilicate ETS-10, were applied for gadolinium removal from synthetic wastewater under different experimental conditions.

Sepsis Induces Long-Term Muscle and Mitochondrial Dysfunction due to Autophagy Disruption Amenable by Urolithin A.

Background: Sepsis survivors often experience sustained muscle weakness, leading to physical disability, with no pharmacological treatments available. Despite these well-documented long-term clinical consequences, research exploring the cellular and molecular mechanisms is sorely lacking.

Methods: Bioinformatic analysis was performed in the vastus lateralis transcriptome of human ICU survivors 7 days after ICU discharge (D7), 6 months (M6) and age- and sex-matched controls.

Pyrrolo-Fused Phenanthridines as Potential Anticancer Agents: Synthesis, Prediction, and Biological Evaluation.

We report the synthesis of four novel monoquaternary salts and four fused pyrrolo-phenanthridine compounds, fully characterized by NMR, FT-IR, and mass spectrometry. Guided by theoretical predictions, including molecular docking studies, we assessed their cytotoxic activity and biocompatibility. The docking results revealed notably stronger binding affinities compared to Phenstatin, a known anticancer agent, suggesting high therapeutic promise.

Cellulose Ether/Citric Acid Systems Loaded with SrTiO Nanoparticles with Solvent-Tailored Features for Energy-Related Technologies.

This work aimed to advance the knowledge in the field of eco-friendly dielectrics with applicative relevance for future energy-related technologies. New multicomponent composites were prepared by using a cellulose ether/citric acid mixture as the matrix, which was gradually filled with strontium titanate nanoparticles (5-20 wt%). In this case, citric acid can act as a crosslinking agent for the polymer but also can react differently with the other counterparts from the composite as a function of the solvent used (HO and HO).

Solvatochromic and Computational Study of Three Benzo-[f]-Quinolinium Methylids with Photoinduced Charge Transfer.

The solvatochromic properties of 48 solvents of three benzo-[f]-quinolinium methylids (BfQs) were analyzed within the theories of the variational model and Abe's model of the liquid. The electro-optical properties of BfQs in the first excited state were determined based on the charge transfer process that occurs from the ylid carbon to the nitrogen atom. The dipole moments and the polarizabilities in the first excited state were calculated according to the two models.

Magnetic resonance imaging characteristics of small cell and non-small cell lung cancer brain metastases: a retrospective study.

Brain metastases (BMs) from bronchopulmonary tumors are a major cause of morbidity and mortality and significantly reduce the quality of life in oncology patients. Their treatment depends on imaging features (size, number, location) and their genetic mutation subtype, small-cell lung cancer (SCLC) or non-small cell lung cancer (NSCLC). In patients with SCLC, prophylactic whole-brain radiotherapy (WBRT) with hippocampal sparing (HS) is recommended, whereas in patients with NSCLC, systemic targeted therapy is preferred.

Blurred Identity, Rising Distress: A Serial Mediation Approach to Social Media and Depression.

This study examines a serial mediation framework to gain a deeper understanding of how social media use affects mental health. Many young people experience a sense of emotional overload from constant connectivity (i.e.

A downscaled examination of drought vulnerability and self-reported preparedness among livestock farmers in the northeast of Romania.

Recent European drought events have highlighted that vulnerability and preparedness play a pivotal role in shaping both the potential impacts of drought and its management. This study aims to take an in-depth look at drought vulnerability and preparedness, their spatial distribution, and the relationships between them, local landforms, and farm settings. The case study focuses on livestock farmers who face challenges related to drought impacts due to significant drought exposure, but whose needs and interests are often overlooked by mitigation strategies and compensation schemes.

Development of Modified Drug Delivery Systems with Metformin Loaded in Mesoporous Silica Matrices: Experimental and Theoretical Designs.

Mesoporous silica materials, particularly KIT-6, offer promising features, such as large surface area, tunable pore structures, and biocompatibility, making them ideal candidates for advanced drug delivery systems. The aims of this study were to develop and evaluate an innovative modified-release platform for metformin hydrochloride (MTF), using KIT-6 mesoporous silica as a matrix, to enhance oral antidiabetic therapy. KIT-6 was synthesized using an ultrasound-assisted sol-gel method and subsequently loaded with MTF via adsorption from alkaline aqueous solutions at two concentrations (1 and 3 mg/mL).

Exploring Non-Pharmacologic Adjunctive Therapies for Patients with Neurodegenerative Diseases.

: Alternative therapies, such as non-invasive neuromodulation techniques, cognitive therapies, virtual reality-based interventions, and psychological support, represent promising approaches for treating and supporting the management plan for patients with neurodegenerative disorders. Recent research has focused on the effectiveness of neuromodulation therapies, as they show improvements in both emotional and cognitive functions in patients with neurodegenerative disorders. : A literature review was conducted by searching Google Scholar, PubMed, Scopus, and Web of Science in February 2025.

Streamlining First-Order Reversal Curves Analysis of Molecular Magnetism Bistability Using a Calorimetric Approach.

We present an alternative to the classical SQUID magnetometric measurements for the First-Order Reversal Curve (FORC) diagram approach by employing differential scanning calorimetry (DSC) experiments. After discussing the main results, the advantages and limitations of the magnetometric FORCs, we introduce the calorimetric method. We argue that, while the results are comparable to those obtained via magnetometry, the calorimetric method not only significantly simplifies the required mathematical computations but also detects subtle or overlapping phase transitions that might be hard to distinguish magnetically.

Neurobehavioral and Oxidative Stress Effects of SiO Nanoparticles in Zebrafish and the Protective Role of N-Acetylcysteine.

Silicon dioxide nanoparticles (SiONPs) do not exist in isolation in the environment but can interact with other substances, thus influencing their toxic effects on aquatic organisms. We assessed the combined impact of SiONPs and N-acetylcysteine (NAC), an antioxidant with the potential to counteract nanoparticle-induced oxidative stress (OS). : Behavioral assessments, including the social interaction test and color preference test, were performed to evaluate neurobehavioral changes.

From Jumping Gene to Cancer: Revisiting the Role of JTB Protein.

Jumping translocations (JTs) are rare chromosomal abnormalities that play a crucial role in the pathogenesis of various cancer types. These rearrangements, especially those involving chromosome 1q, are frequently associated with tumor progression, therapeutic resistance, and poor prognosis. One gene of particular interest, human Jumping Translocation Breakpoint (), has been identified at the site of translocation breakpoints and exhibits complex, context-dependent roles in cancer biology.

Post-Concussion Syndrome and Functional Neurological Disorder: Diagnostic Interfaces, Risk Mechanisms, and the Functional Overlay Model.

Background: Post-concussion syndrome (PCS) and Functional Neurological Disorder (FND), including Functional Cognitive Disorder (FCD), are two frequently encountered but diagnostically complex conditions. While PCS is conceptualized as a sequela of mild traumatic brain injury (mTBI), FND/FCD encompasses symptoms incompatible with recognized neurological disease, often arising in the absence of structural brain damage. Yet, both conditions exhibit considerable clinical overlap-particularly in the domains of cognitive dysfunction, emotional dysregulation, and symptom persistence despite negative investigations.

An Ytterbium-Pyrazine Square [(CHMe)Yb(pyz)] Formed by Reversible Electron Transfer and Concomitant Self-Assembly.

Pyrazine (pyz) has been used extensively in coordination chemistry to manifest electron delocalization in mixed-valent compounds and strongly coupled materials. In the current work, using a Yb precursor, [(CHMe)Yb(THF)] (), a molecular square [(CHMe)Yb(pyz)]·/(CHF) () was synthesized by metal-ligand redox cooperativity. Complex shows evidence of charge transfer from Yb to pyrazine in a range of studies including structural analysis, magnetometry, vibrational spectroscopy, X-ray absorption near-edge structure spectroscopy, and electronic structure calculations.