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Background: The blood-brain barrier (BBB) is the greatest challenge in the treatment of intracranial malignant tumors.

Objective: The aim of this study is to determine the role of borneol in opening the BBB and elucidate the underlying mechanisms.

Materials And Methods: Twenty Sprague-Dawley (SD) rats were randomized into borneol group intragastrically administered with 10% borneol corn oil (2 mL/kg) and control group.

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