Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
H2A.Z-nucleosomes are stabilized by the superhelicity-dependent DNA binding of the C-terminal tail of the histone variant.
Nucleus
December 2025
Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Using an in situ nucleosome stability assay based on salt extraction, we identified distinct stability features of H2A.Z-containing nucleosomes linked to alternative interactions of the histone variant's C-terminal tail (Imre et al., Nat.
View Article and Find Full Text PDFDeciphering the unique autoregulatory mechanisms and substrate specificity of the understudied DCLK3 kinase linked to neurodegenerative diseases.
J Biol Chem
September 2025
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602; Institute of Bioinformatics, University of Georgia, Athens, GA, 30602. Electronic address:
Protein kinases represent one of the largest and most druggable protein families. Despite considerable progress in their understanding, approximately one-third of human kinases remain poorly characterized, known as the "dark" kinome. Doublecortin-like kinase 3 (DCLK3), a member of this elusive group, has emerged for its involvement in neuroprotection in Huntington's disease and other neurodegenerative disorders.
View Article and Find Full Text PDF18-Crown-6-ether Utilizes Distinct Allosteric Interactions to Uncouple Transport by the Multidrug Efflux Pump EmrE.
Biochemistry
September 2025
Biochemistry Department, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
The recent discovery that the model multidrug efflux pump from , EmrE, can perform multiple types of transport suggests that this may be a compelling target for therapeutic intervention. Initial studies have identified several small-molecule substrates capable of inducing transporter-dependent susceptibility rather than the well-known antibiotic resistance phenotype. However, many questions regarding the underlying mechanism and regulation of this transporter still remain.
View Article and Find Full Text PDFIntrinsic disorder and fuzzy interactions drive multiple functions of HMGB1.
Trends Biochem Sci
September 2025
Chromatin Dynamics Unit, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy; School of Medicine, Università Vita-Salute San Raffaele, Milan, Italy. Electronic address:
HMGB1, a multitasking protein, is scrutinized here through the lens of the 'fuzzy interactions' driven by its intrinsically disordered regions (IDRs). Although the multiple intracellular and extracellular functions of this protein have been studied for decades, viewing HMGB1 as fuzzy and dynamic provides a novel perspective. Recent breakthroughs emphasize the crucial role of its IDRs, especially the acidic C-terminal tail, in mediating dynamic multivalent interactions.
View Article and Find Full Text PDFLight-induced conformational switching and magnetic sensitivity of Drosophila cryptochrome.
Structure
August 2025
Department of Chemistry, University of Oxford, Physical and Theoretical Chemistry Laboratory, Oxford OX1 3QZ, UK; Kavli Institute for Nanoscience Discovery, Biochemistry Building, Oxford OX1 3QU, UK. Electronic address:
Cryptochromes are light-sensitive flavoproteins with various biological roles, including a proposed function in magnetoreception. This mechanism rests on a magnetically sensitive photochemical reaction of the flavin chromophore with a chain of tryptophan residues within the protein scaffold. However, the protein-mediated mechanisms of magnetic signal transduction are unclear.
View Article and Find Full Text PDF