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The aim of this in-vitro study was to verify which field of view (FOV) in cone-beam computed tomography (CBCT) yields greater accuracy in the detection of internal root resorption (IRR) volume, in comparison to the gold standard of micro-computed tomography (micro-CT) and to a physical method. Twenty-five extractedsingle-rooted teeth were scanned by CBCT with two different FOV parameters (6x6-FOV and 10x10-FOV) and via micro-CT. The volume of dental hard tissue was measured on these images. A simulated IRR was produced by a demineralization protocol. After the simulated IRR, the volumes of the dental hard tissue and the simulated IRR were measured with the same scanning parameters. In addition, the volume of the simulated IRR was measured via a physical method. The simulated IRR volumes obtained by CBCT, micro-CT, and the physical method were statistically compared using one-way ANOVA. Before the simulated IRR, the mean volume of dental hard tissue obtained by 6x6-FOV, 10x10-FOV, and micro-CT were 266.64 ± 11.56, 284.78 ± 14.99, and 233.07 ± 19.91, respectively. The simulated IRR mean volumes obtained by 6x6-FOV, 10x10-FOV, micro-CT, and the physical method were 19.35 ± 5.92, 17.43 ± 5.20, 23.85 ± 6.63, and 13.51 ± 3.11, respectively. The mean volume of the simulated IRR obtained by micro-CT was similar to that of the 6x6-FOV and was significantly different from that of the 10x10-FOV and physical method. The mean volume value of simulated IRR obtained by the physical method was significantly different from those of the micro-CT and 6x6-FOV groups. In conclusion, the 6x6-FOV was better than the 10x10-FOV for the detection of IRR volume by CBCT under clinical conditions.
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http://dx.doi.org/10.1590/1807-3107bor-2025.vol39.088 | DOI Listing |
Braz Oral Res
September 2025
Ankara University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Ankara, Turkey.
The aim of this in-vitro study was to verify which field of view (FOV) in cone-beam computed tomography (CBCT) yields greater accuracy in the detection of internal root resorption (IRR) volume, in comparison to the gold standard of micro-computed tomography (micro-CT) and to a physical method. Twenty-five extractedsingle-rooted teeth were scanned by CBCT with two different FOV parameters (6x6-FOV and 10x10-FOV) and via micro-CT. The volume of dental hard tissue was measured on these images.
View Article and Find Full Text PDFAnn Neurol
September 2025
Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA.
Objective: The objective of this study was to compare the long-term safety profiles of ocrelizumab and rituximab in persons with multiple sclerosis (MS).
Methods: Using retrospective data from the University of California (UC) Health System, we simulated a target clinical trial. The primary cohort from UC San Francisco (UCSF) and a validation cohort from 5 other UC Medical Centers were analyzed.
Vaccines (Basel)
August 2025
MRC/UVRI & LSHTM Uganda Research Unit, Entebbe P.O. Box 49, Uganda.
Background: Assessment of efficacy in HIV prevention trials remains a challenge in the era of widespread use of active controls. We investigated use of counterfactual groups to assess treatment efficacy.
Methods: We used data from placebo arms of two previous HIV prevention efficacy trials (Pro2000 vaginal microbicide trial, 2005-2009: ISRCTN64716212 and dapivirine vaginal ring trial, 2013-2016: NCT01539226) and four observational cohorts (two in each of the periods; (a) during the conduct of a simulated HIV vaccine efficacy trial (SiVET), 2012-2017, and (b) prior to SiVET (2005-2011)) and compared HIV prevention efficacy trial targeted outcomes with SiVETs.
Bioresour Technol
August 2025
Department of Forest Biomaterials, College of Natural Resources, North Carolina State University, 2820 Faucette Dr, Raleigh, NC 27607 USA. Electronic address:
The worldwide demand for graphite, as the main anode material for Li-ion batteries, is expected to double by 2028 since it supports the use of electricity, including transient renewable sources, for energy storage, sustainable mobility, and automation. However, the dependence on non-renewable and external resources jeopardizes the world supply chain. This study explores the technical and economic performance of transforming lignocellulosic biomass into biographite and fuel-grade hydrocarbons through pyrolysis bio-oil upgrading.
View Article and Find Full Text PDFFront Public Health
August 2025
Department of Public Health, College of Medicine and Health Sciences, Samara University, Samara, Ethiopia.
Background: Inadequate feeding frequency during the early childhood period is responsible for more than two-thirds of global child deaths. Evidence on the rate of daily meal frequency among infants and young children at the national level is crucial for developing targeted interventions to improve feeding practices. Hence, this study aimed to identify factors associated with the rate of daily meal frequency (DMF) among children aged 6-23 months in Ethiopia.
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