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http://dx.doi.org/10.1212/WNL.0000000000214171 | DOI Listing |
Biol Psychiatry
September 2025
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA; Sierra-Pacific Mental Illness Research, Education, and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 94304, USA. Electronic address: leawillia
Despite available treatments, major depressive disorder (MDD) remains one of the leading causes of disability across medical conditions. The current symptom-based diagnostic system groups patients with highly heterogeneous presentations, with no biomarkers to guide treatment-akin to diagnosing heart disease solely by chest pain, without imaging to reveal the underlying pathology. Lacking biological guidance, clinicians rely on trial-and-error prescribing.
View Article and Find Full Text PDFBrain Struct Funct
September 2025
Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey.
The anterior commissure (AC) has an anterior and posterior limb. Despite comprehensive information about the posterior limb, there is limited and conflicting information about the anterior limb in the literature. We aimed to show the anatomical relationships of the AC with neighboring structures by using white matter microdissection and magnetic resonance (MR) tractography, primarily on the anterior limb of the AC.
View Article and Find Full Text PDFJ Magn Reson Imaging
September 2025
Neuroimaging Laboratory, School of Medicine, University of Navarra, Pamplona, Spain.
Front Sports Act Living
August 2025
Faculty of Physical Education, China West Normal University, Nanchong, China.
Understanding how athletes mentally simulate and anticipate actions provides key insights into experience-driven brain plasticity. While previous studies have investigated motor imagery and action anticipation separately, little is known about how their underlying neural mechanisms converge or diverge in expert performers. This study conducted a meta-analysis using activation likelihood estimation (ALE) and meta-analytic connectivity modeling (MACM) to compare brain activation patterns between athletes and non-athletes across both tasks.
View Article and Find Full Text PDFBrain Commun
September 2025
Alzheimer's Disease Cooperative Study (ADCS), Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Several studies implicate circadian rhythm disturbances in Alzheimer's disease. However, very little is known about how circadian rhythms are associated with Alzheimer's pathological biomarkers in older adults at early stages of the disease, and how these relationships map onto cognition. This cross-sectional study used 24-h accelerometry data to investigate the relationships between circadian rhythms, amyloid-β (Aβ), tau, and cognition in 68 older adults with objective early cognitive impairment.
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