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Traumatic injury is the leading cause of death for individuals aged 1-45 in the USA. Variations in patient management based on geographic locations, community resources, and provider characteristics contribute to disparities in patient outcomes. It is estimated that 20,000 Americans lives could be saved yearly if all trauma centers performed as well as the highest-performing center, which is achievable, in part, through the reduction of inappropriate practice variation. Trauma clinical guidance currently lacks standardization, is redundant, and remains difficult to access and implement at the bedside. To explore and address these issues, the (DFI) Conference Series was developed. This conference series and complementary research aims to redesign the development, dissemination, and implementation of trauma clinical guidance with a focus on more effective and equitable systems. To do so, key community partners were convened to present clinical guidance best practices, including digital integration, resource stratification, and patient-centeredness. Conference attendees, which included partners from various provider groups, patients, dissemination and implementation scientists, public health experts, government agencies, and software developers, worked together to create a "minimum viable product" which specified key objectives for an ideal future state of trauma clinical guidance, as well as the "risk", "audience", and "key performance indicators". The next conference in the series will take place in February 2025, with a focus on translating the conceptualized priorities into tangible solutions. This paper serves to share the events from the 2024 conference proceedings.
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http://dx.doi.org/10.1136/tsaco-2024-001583 | DOI Listing |
Trauma Surg Acute Care Open
September 2025
UCHealth, Loveland, Colorado, USA.
Traumatic injury is the leading cause of death for individuals aged 1-45 in the USA. Variations in patient management based on geographic locations, community resources, and provider characteristics contribute to disparities in patient outcomes. It is estimated that 20,000 Americans lives could be saved yearly if all trauma centers performed as well as the highest-performing center, which is achievable, in part, through the reduction of inappropriate practice variation.
View Article and Find Full Text PDFTrauma Surg Acute Care Open
September 2025
Medical Center of the Rockies, Loveland, CO, USA.
Introduction: Developing and implementing trauma clinical guidance is integral to providing quality care to all trauma patients while maintaining a minimum standard of treatment. A mixed-methods novel consensus-building approach was used to identify the current barriers to developing and implementing trauma clinical guidance and highlight the priority areas for change to better support end users.
Methods: As part of year 1 of the Design for Implementation: The Future of Trauma Clinical Guidance and Research Conference Series, preconference participant surveys and hybrid, professionally facilitated, structured dialogue were used to define the ideal future state of trauma clinical guidance development and dissemination.
J Neurosurg Anesthesiol
September 2025
Anesthesiology, University of Michigan, Ann Arbor, MI.
Background: Carotid blowout syndrome (CBS) is a life-threatening emergency involving the rupture of the carotid arteries and/or branches, often following surgery and radiotherapy for head and neck cancer. Our case series aimed to describe airway management strategies, endovascular and surgical approaches, perioperative resuscitation management, and clinical outcomes in a cohort of patients with CBS at a tertiary referral academic health center.
Methods: We retrospectively identified patients presenting with CBS between 2017 and 2021.
Cochrane Database Syst Rev
September 2025
Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.
Background: Opioid use disorder (OUD) is commonly treated in specialized care settings with long-acting opioid agonists, also known as opioid agonist therapy, or OAT. Despite the rise in opioid use globally and evidence for a 50% reduction in mortality when OAT is employed, the proportion of people with OUD receiving OAT remains small. One initiative to improve the access and uptake of OAT could be to offer OAT in a primary care setting; primary care clinics are more numerous, might reduce the visibility and potential stigma of receiving treatment for OUD, and may facilitate the care of other medical conditions that are unrelated to OUD.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
Introduction: Glial fibrillary acidic protein (GFAP) may contribute to Alzheimer's pathology at early disease stages. GFAP moderation of Alzheimer's disease (AD)-related neurodegeneration and cognition is unclear.
Methods: We examined plasma GFAP moderation of AD biomarkers (amyloid beta [Aβ]-positron emission tomography [PET][A]; plasma phosphorylated tau-181 [p-tau181][T]), neurodegeneration (plasma NfL[N]; structural magnetic resonance imaging [MRI][N]), and cognition (Cog; Cog) in two cohorts: University of California San Francisco (UCSF) (N = 212, 91.